{"id":9519,"date":"2018-06-08T01:00:00","date_gmt":"2018-07-27T09:39:19","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e8%af%84%e4%bb%b7yk-029a%e7%89%87%e5%9c%a8%e6%99%9a%e6%9c%9f%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%ef%bc%88nsclc%ef%bc%89\/"},"modified":"2018-07-27T17:39:20","modified_gmt":"2018-07-27T09:39:20","slug":"%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e8%af%84%e4%bb%b7yk-029a%e7%89%87%e5%9c%a8%e6%99%9a%e6%9c%9f%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%ef%bc%88nsclc%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9519\/","title":{"rendered":"\u3010\u62db\u52df\u60a3\u8005\u3011\u8bc4\u4ef7YK-029A\u7247\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u548c\u521d\u6b65\u7597\u6548\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c"},"content":{"rendered":"
\n

1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n

YK-029A\u7247<\/span>\u662f\u7b2c\u4e09\u4ee3<\/span>EGFR<\/span>\u6291\u5236\u5242\u3002<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>\u5bf9\u7ecf\u65e2\u5f80<\/span>EGFR-TKI<\/span>\u6cbb\u7597\u540e\u7531<\/span>T790M<\/span>\u57fa\u56e0\u7a81\u53d8\u83b7\u5f97\u6027\u8010\u836f\u548c\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/span>\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u8bc4\u4ef7<\/span>YK-029A<\/span>\u7247\u7684\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08<\/span>MTD<\/span>\uff09\u3001\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08<\/span>DLT<\/span>\uff09\uff0c\u786e\u5b9a<\/span>II<\/span>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8350\u7684\u7ed9\u836f\u65b9\u6848\u548c\u5242\u91cf\u3002\u7814\u7a76<\/span>YK-029A<\/span>\u7247\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u5206\u6790\u836f\u4ee3\u52a8\u529b\u5b66\u53ca\u5176\u4e0e\u836f\u6548\uff08<\/span>PK\/PD<\/span>\uff09<\/span>\/<\/span>\u6bd2\u6027\uff08<\/span>PK\/AE<\/span>\uff09\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u68c0\u6d4b\u4ee3\u8c22\u4ea7\u7269\u3002<\/span><\/span><\/p>\n

\u8bc4\u4ef7<\/span>YK-029A<\/span>\u7247\u6cbb\u7597\u5bf9\u7ecf\u65e2\u5f80\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53<\/span>–<\/span>\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08<\/span>EGFR-TKI<\/span>\uff09\u6cbb\u7597\u540e<\/span>T790M<\/span>\u7a81\u53d8\u83b7\u5f97\u6027\u8010\u836f\u548c\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u521d\u6b65\u7597\u6548\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

 \u8bd5\u9a8c\u5206\u7c7b\uff1a\u5176\u4ed6<\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> I<\/span>\u671f<\/span><\/span><\/p>\n

  <\/span>\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5355\u81c2\u8bd5\u9a8c<\/span> <\/span><\/span><\/p>\n

 \u968f\u673a\u5316\uff1a<\/span>   <\/span>\u975e\u968f\u673a\u5316<\/span><\/span><\/p>\n

  <\/span>\u76f2\u6cd5\uff1a<\/span>       <\/span>\u5f00\u653e<\/span><\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u8303\u56f4\uff1a\u56fd\u5185\u8bd5\u9a8c<\/span><\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span> 30<\/span><\/span>\u4eba<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u81ea\u613f\u5165\u7ec4\u5e76\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff0c\u540c\u610f\u9075\u5faa\u8bd5\u9a8c\u6cbb\u7597\u65b9\u6848\u548c\u8bbf\u89c6\u8ba1\u5212\u3002<\/span><\/span><\/p>\n

2  <\/span>\u7537\u6027\u6216\u5973\u6027\uff0c\u5e74\u9f84<\/span>18-65<\/span>\u5468\u5c81\uff08\u542b<\/span>18<\/span>\u548c<\/span>65<\/span>\uff09\uff0c<\/span>Ib<\/span>\u671f\u53ef\u653e\u5bbd\u81f3<\/span>75<\/span>\u5c81\uff08\u542b\uff09\u3002<\/span><\/span><\/p>\n

3  <\/span>\u75c5\u7406\u786e\u8bca\u4e3a\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<\/span>NSCLC<\/span>\u60a3\u8005\u3002<\/span><\/span><\/p>\n

4  ECOG<\/span>\u8bc4\u5206<\/span>0-1<\/span>\u5206\uff0c\u9884\u671f\u751f\u5b58\u4e0d\u5c11\u4e8e<\/span>12<\/span>\u5468\u3002<\/span><\/span><\/p>\n

5  <\/span>\u65e2\u5f80\u63a5\u53d7\u7b2c\u4e00\u4ee3\u6216\u4e8c\u4ee3<\/span>EGFR<\/span>\u6291\u5236\u5242\uff08\u5982\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\u7b49\uff09\u6cbb\u7597\u540e\u51fa\u73b0\u83b7\u5f97\u6027\u8010\u836f\u548c\u75be\u75c5\u8fdb\u5c55\uff08\u6709\u5f71\u50cf\u5b66\u4f9d\u636e\uff09\u7684\u80ba\u764c\u60a3\u8005\u3002<\/span><\/span><\/p>\n

6  <\/span>\u7ecf\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u5bf9\u6d3b\u68c0\u80bf\u7624\u7ec4\u7ec7\u6216\u8840\u6d46<\/span>ctDNA<\/span>\u6807\u672c\u8fdb\u884c<\/span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\uff0c\u786e\u8ba4\u4e3a<\/span>T790M<\/span>\u9633\u6027\u7684\u80ba\u764c\u60a3\u8005\u3002<\/span> <\/span><\/span><\/p>\n

7  <\/span>\u6839\u636e<\/span>RECIST1.1<\/span>\u5b9e\u4f53\u80bf\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff0c\u60a3\u8005\u81f3\u5c11\u6709\u4e00\u5904\u5f71\u50cf\u5b66\u53ef\u8bc4\u4f30\u75c5\u7076\uff08<\/span>Ia<\/span>\u671f\uff09\u6216\u53ef\u6d4b\u91cf\u75c5\u7076\uff08<\/span>Ib<\/span>\u671f\uff09\u3002<\/span><\/span><\/p>\n

8  <\/span>\u5668\u5b98\u529f\u80fd\u6c34\u5e73\u5fc5\u987b\u7b26\u5408\u4e0b\u5217\u8981\u6c42\uff1a\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u2265<\/span>1.5×10 9\/L<\/span>\uff0c\u8840\u5c0f\u677f\u8ba1\u6570\u2265<\/span>90×109\/L<\/span>\uff0c\u8840\u7ea2\u86cb\u767d\uff08<\/span>HGB<\/span>\uff09\u2265<\/span>90 g\/L<\/span>\uff1b\u8840\u6e05\u603b\u80c6\u7ea2\u7d20\u2264<\/span>1.5<\/span>\u500d\u6b63\u5e38\u503c\u4e0a\u9650\uff08<\/span>ULN<\/span>\uff09\uff1b\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<\/span>AST<\/span>\uff09\u548c\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<\/span>ALT<\/span>\uff09\u2264<\/span>2.5<\/span>\u500d<\/span>ULN<\/span>\uff0c\u5b58\u5728\u809d\u8f6c\u79fb\u65f6<\/span>ALT<\/span>\u6216<\/span>AST<\/span>\u2264<\/span>5<\/span>\u500d<\/span>ULN<\/span>\uff1b\u808c\u9150\u2264<\/span>1.5<\/span>\u500d<\/span>ULN<\/span>\u6216\u808c\u9150\u6e05\u9664\u7387\u2265<\/span>50ml\/min<\/span>\uff08\u6839\u636e<\/span>Cockcroft<\/span>\u548c<\/span>Gault<\/span>\u8ba1\u7b97\uff09\u3002<\/span><\/span><\/p>\n

9  <\/span>\u5bf9\u4e8e\u7edd\u7ecf\u524d\u6709\u751f\u80b2\u53ef\u80fd\u7684\u5987\u5973\uff0c\u5fc5\u987b\u5728\u5f00\u59cb\u6cbb\u7597\u4e4b\u524d\u7684<\/span>7<\/span>\u5929\u5185\u505a\u598a\u5a20\u8bd5\u9a8c\uff0c\u8840\u6e05\u598a\u5a20\u8bd5\u9a8c\uff08<\/span>HCG<\/span>\u68c0\u6d4b\uff09\u5fc5\u987b\u4e3a\u9634\u6027\uff0c\u5fc5\u987b\u4e3a\u975e\u54fa\u4e73\u671f\uff1b\u6240\u6709\u5165\u7ec4\u60a3\u8005\uff08\u4e0d\u8bba\u7537\u6027\u6216\u5973\u6027\uff09\u5747\u5e94\u5728\u6574\u4e2a\u6cbb\u7597\u671f\u95f4\u53ca\u6cbb\u7597\u7ed3\u675f\u540e<\/span>3<\/span>\u4e2a\u6708\u91c7\u53d6\u5145\u5206\u7684\u5c4f\u969c\u907f\u5b55\u63aa\u65bd\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d\u7684<\/span>4<\/span>\u5468\u5185\uff0c\u66fe\u884c\u91cd\u5927\u624b\u672f\uff0c\u4f46\u7814\u7a76\u8005\u5224\u65ad\u4e0d\u5f71\u54cd\u53c2\u52a0\u8bd5\u9a8c\u7684\u5c0f\u624b\u672f\uff08\u4f8b\u5982\uff1a\u62d4\u7259\u7b49\uff09\u9664\u5916\u3002<\/span><\/span><\/p>\n

2  <\/span>\u5bf9\u4e8e\u7edd\u7ecf\u524d\u6709\u751f\u80b2\u53ef\u80fd\u7684\u5987\u5973\uff0c\u5fc5\u987b\u5728\u5f00\u59cb\u6cbb\u7597\u4e4b\u524d\u7684<\/span>7<\/span>\u5929\u5185\u505a\u598a\u5a20\u8bd5\u9a8c\uff0c\u8840\u6e05\u598a\u5a20\u8bd5\u9a8c\uff08<\/span>HCG<\/span>\u68c0\u6d4b\uff09\u5fc5\u987b\u4e3a\u9634\u6027\uff0c\u5fc5\u987b\u4e3a\u975e\u54fa\u4e73\u671f\uff1b\u6240\u6709\u5165\u7ec4\u60a3\u8005\uff08\u4e0d\u8bba\u7537\u6027\u6216\u5973\u6027\uff09\u5747\u5e94\u5728\u6574\u4e2a\u6cbb\u7597\u671f\u95f4\u53ca\u6cbb\u7597\u7ed3\u675f\u540e<\/span>3<\/span>\u4e2a\u6708\u91c7\u53d6\u5145\u5206\u7684\u5c4f\u969c\u907f\u5b55\u63aa\u65bd\u3002<\/span><\/span><\/p>\n

3  <\/span>\u5728\u9996\u6b21\u7ed9\u836f\u524d<\/span>14<\/span>\u5929\u5185\u9488\u5bf9\u9aa8\u8f6c\u79fb\u66fe\u653e\u7597\u3002<\/span><\/span><\/p>\n

4  <\/span>\u66fe\u4f7f\u7528\u8fc7\u7b2c\u4e09\u4ee3<\/span>EGFR<\/span>\u6291\u5236\u5242\u7c7b\u836f\u7269\uff08\u5982<\/span>AZD9291<\/span>\u3001<\/span>CO-1686<\/span>\u3001<\/span>HM61713<\/span>\u3001<\/span>EGF816<\/span>\u3001<\/span>PF-06747775<\/span>\u3001\u7532\u78fa\u9178\u827e\u6c1f\u66ff\u5c3c\u3001<\/span>BPI-15086<\/span>\u3001\u9a6c\u6765\u9178\u827e\u7ef4\u66ff\u5c3c\u7b49\uff09\u3002<\/span><\/span><\/p>\n

5  <\/span>\u66fe\u4f7f\u7528\u8fc7\u7b2c\u4e09\u4ee3<\/span>EGFR<\/span>\u6291\u5236\u5242\u7c7b\u836f\u7269\uff08\u5982<\/span>AZD9291<\/span>\u3001<\/span>CO-1686<\/span>\u3001<\/span>HM61713<\/span>\u3001<\/span>EGF816<\/span>\u3001<\/span>PF-06747775<\/span>\u3001\u7532\u78fa\u9178\u827e\u6c1f\u66ff\u5c3c\u3001<\/span>BPI-15086<\/span>\u3001\u9a6c\u6765\u9178\u827e\u7ef4\u66ff\u5c3c\u7b49\uff09\u3002<\/span><\/span><\/p>\n

6  <\/span>\u7814\u7a76\u836f\u7269\u7ed9\u836f\u524d\uff0c\u7b2c\u4e00\u4ee3\u6216\u8005\u7b2c\u4e8c\u4ee3<\/span>EGFR-TKI<\/span>\u6cbb\u7597\uff08\u4f8b\u5982\uff1a\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\uff09\u505c\u836f\u5c11\u4e8e<\/span>8<\/span>\u5929\u6216<\/span>5<\/span>\u4e2a\u534a\u8870\u671f\uff08\u53d6\u65f6\u95f4\u8f83\u957f\u8005\uff09\u3002<\/span><\/span><\/p>\n

7  <\/span>\u7814\u7a76\u836f\u7269\u7ed9\u836f\u524d<\/span>14<\/span>\u5929\u5185\u4f7f\u7528\u4e86\u4efb\u4f55\u9488\u5bf9\u6cbb\u7597<\/span>NSCLC<\/span>\u7684\u7ec6\u80de\u6bd2\u836f\u7269\u6216\u5176\u4ed6\u6297\u80bf\u7624\u836f\u7269\u3002<\/span><\/span><\/p>\n

8  <\/span>\u7814\u7a76\u6cbb\u7597\u5f00\u59cb\u65f6\uff0c\u65e2\u5f80\u6cbb\u7597\u4ecd\u6709\u672a\u6108\u6bd2\u6027\u53cd\u5e94\uff0c\u5e76\u4e14\u300a\u4e0d\u826f\u4e8b\u4ef6\u901a\u7528\u672f\u8bed\u6807\uff08<\/span>CTCAE<\/span>\uff09\u300b\u7ea7\u522b\u8d85\u8fc7<\/span>1<\/span>\u7ea7\uff08\u8131\u53d1\u9664\u5916\uff09\u3002<\/span><\/span><\/p>\n

9  <\/span>\u6709\u75c7\u72b6\u7684\u80f8\u8154\u79ef\u6db2\u548c\u5fc3\u5305\u79ef\u6db2\u3002<\/span><\/span><\/p>\n

10  <\/span>\u6709\u75c7\u72b6\u7684\u8111\u8f6c\u79fb\u548c\u8111\u819c\u8f6c\u79fb\uff0c\u6216\u5728\u9996\u6b21\u7ed9\u836f\u524d<\/span>14<\/span>\u5929\u5185\u66fe\u653e\u7597\u3002<\/span><\/span><\/p>\n

11  <\/span>\u4f34\u968f\u5176\u5b83\u6076\u6027\u80bf\u7624\uff08\u4e34\u5e8a\u6cbb\u6108\u7684\u5bab\u9888\u539f\u4f4d\u764c\u3001\u57fa\u5e95\u7ec6\u80de\u6216\u9cde\u72b6\u4e0a\u76ae\u7ec6\u80de\u76ae\u80a4\u764c\u9664\u5916<\/span>)<\/span>\u3002<\/span><\/span><\/p>\n

12  <\/span>\u6709\u4efb\u4f55\u63d0\u793a\u60a3\u6709\u4e2d\u5ea6\u4ee5\u4e0a\u6216\u672a\u63a7\u5236\u7684\u5168\u8eab\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u4f9d\u636e\uff0c\u4e14\u7814\u7a76\u8005\u8ba4\u4e3a\u4e0d\u9002\u5408\u5165\u7ec4\u8005\uff0c\u4f8b\u5982\u63a7\u5236\u4e0d\u4f73\u7684\u9ad8\u8840\u538b\u3001\u80be\u75c5\u3002<\/span><\/span><\/p>\n

13  <\/span>\u6d3b\u52a8\u6027\u611f\u67d3\u5982\u4e59\u578b\u809d\u708e\uff08<\/span>HBeAg<\/span>\uff09\u3001\u4e19\u578b\u809d\u708e\uff08<\/span>HCV<\/span>\uff09\u3001\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08<\/span>HIV<\/span>\uff09\u611f\u67d3\u3002<\/span><\/span><\/p>\n

14  <\/span>\u4efb\u4f55\u5f71\u54cd\u53d7\u8bd5\u8005\u541e\u670d\u836f\u7269\u7684\u60c5\u51b5\uff0c\u4ee5\u53ca\u4e25\u91cd\u5f71\u54cd\u8bd5\u9a8c\u836f\u7269\u5438\u6536\u6216\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\u7684\u60c5\u51b5\uff0c\u5305\u62ec\u4efb\u4f55\u79cd\u7c7b\u96be\u4ee5\u63a7\u5236\u7684\u6076\u5fc3\u548c\u5455\u5410\u3001\u6162\u6027\u80c3\u80a0\u75be\u75c5\u3001\u65e0\u6cd5\u541e\u54bd\u53d7\u8bd5\u836f\u7269\u3001\u80c3\u80a0\u9053\u5207\u9664\u6216\u624b\u672f\u53f2\u3002<\/span><\/span><\/p>\n

15  <\/span>\u7b26\u5408\u4e0b\u5217\u4efb\u4e00\u5fc3\u810f\u6807\u51c6\uff1a\u5728\u9759\u606f\u72b6\u6001\u4e0b\uff0c\u5fc3\u7535\u56fe\uff08<\/span>ECG<\/span>\uff09\u68c0\u67e5\u5f97\u51fa\u7684\u5e73\u5747\u6821\u6b63<\/span>QT<\/span>\u95f4\u671f\uff08<\/span>QTc<\/span>\uff09<\/span>>470 msec<\/span>\uff08\u7b2c<\/span>1<\/span>\u6b21\u5f02\u5e38\u65f6\uff0c\u590d\u6d4b<\/span>1<\/span>\u6b21\uff0c\u4ee5<\/span>2<\/span>\u6b21\u5e73\u5747\u7ed3\u679c\u8ba1\u7b97\uff09\u3002\u5404\u79cd\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5fc3\u5f8b\u3001\u4f20\u5bfc\u3001\u9759\u606f<\/span>ECG<\/span>\u5f62\u6001\u5f02\u5e38\uff0c\u4f8b\u5982\u5b8c\u5168\u6027\u5de6\u675f\u652f\u4f20\u5bfc\u963b\u6ede\uff0c<\/span>III<\/span>\u5ea6\u4f20\u5bfc\u963b\u6ede\uff0c<\/span>II<\/span>\u5ea6\u4f20\u5bfc\u963b\u6ede\uff0c<\/span>PR<\/span>\u95f4\u671f<\/span>>250 msec<\/span>\u3002<\/span><\/span><\/p>\n

 16  <\/span>\u53ef\u80fd\u589e\u52a0<\/span>QTc<\/span>\u5ef6\u957f\u98ce\u9669\u6216\u5fc3\u5f8b\u5931\u5e38\u4e8b\u4ef6\u98ce\u9669\u7684\u5404\u79cd\u56e0\u7d20\uff0c\u4f8b\u5982\u5fc3\u529b\u8870\u7aed\uff0c\u4f4e\u94be\u8840\u75c7\uff0c\u5148\u5929\u6027\u957f<\/span>QT<\/span>\u7efc\u5408\u5f81\uff0c\u5bb6\u65cf\u53f2\u4e2d\u4e00\u7ea7\u4eb2\u5c5e\u6709\u957f<\/span>QT<\/span>\u7efc\u5408\u5f81\u6216\u4e0d\u5230<\/span>40<\/span>\u5c81\u5c31\u4e0d\u660e\u539f\u56e0\u731d\u6b7b\uff0c\u6b63\u5728\u4f7f\u7528\u4efb\u4f55\u5df2\u77e5\u5ef6\u957f<\/span>QTc<\/span>\u95f4\u671f\u7684\u836f\u7269\u3002<\/span><\/span><\/p>\n

17  <\/span>\u7814\u7a76\u8005\u5224\u65ad\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73\u7684\u7cd6\u5c3f\u75c5\u3002<\/span><\/span><\/p>\n

18  <\/span>\u5165\u7ec4\u65f6\u5b58\u5728\u89d2\u819c\u708e\u6216\u7814\u7a76\u8005\u8ba4\u4e3a\u4e0d\u9002\u5408\u5165\u7ec4\u7684\u5176\u5b83\u773c\u79d1\u5f02\u5e38\u3002<\/span><\/span><\/p>\n

19  <\/span>\u6709\u4e0b\u5217\u65e2\u5f80\u53f2\uff1a\u95f4\u8d28\u6027\u80ba\u75c5\uff0c\u836f\u7269\u6027\u95f4\u8d28\u6027\u80ba\u75c5\uff0c\u9700\u8981\u7c7b\u56fa\u9187\u6cbb\u7597\u7684\u653e\u5c04\u6027\u80ba\u708e\uff0c\u5177\u4e34\u5e8a\u8bc1\u636e\u7684\u6d3b\u52a8\u6027\u95f4\u8d28\u6027\u80ba\u75c5\u3002<\/span><\/span><\/p>\n

20  <\/span>\u7814\u7a76\u8005\u5224\u5b9a\u5176\u5b83\u539f\u56e0\u4e0d\u9002\u5408\u53c2\u52a0\u672c\u7814\u7a76\u7684\u53d7\u8bd5\u8005\uff08\u5982\u4e0d\u613f\u610f\u9075\u5b88\u7814\u7a76\u7684\u5404\u9879\u6d41\u7a0b\u3001\u9650\u5236\u548c\u8981\u6c42\u7b49\uff09\u3002<\/span><\/span><\/p>\n

21  <\/span>\u53d7\u8bd5\u8005\u6709\u5bf9\u7814\u7a76\u836f\u7269\u975e\u6d3b\u6027\u8f85\u6599\uff08\u4e73\u7cd6\u3001\u5fae\u6676\u7ea4\u7ef4\u7d20\u3001\u4f4e\u53d6\u4ee3\u7f9f\u4e19\u7ea4\u7ef4\u7d20\u3001\u786c\u8102\u9178\u9541\uff09\u6709\u4e25\u91cd\u8fc7\u654f\u53cd\u5e94\u53f2\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n


<\/p>\n\n\n<\/tr>\n<\/tbody>\n<\/table>\n
\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u738b\u6d01\uff0c\u535a\u58eb <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u4efb\u533b\u5e08 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02\u671d\u9633\u533a\u6f58\u5bb6\u56ed\u5357\u91cc17\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

100021 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u8d75\u519b\uff0c\u535a\u58eb <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u4efb\u533b\u5e08 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02\u6d77\u6dc0\u533a\u961c\u6210\u8def52\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

100037 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u5218\u5586\uff0c\u535a\u58eb <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u4efb\u533b\u5e08 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02\u901a\u5dde\u533a\u5317\u9a6c\u538297\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

101149 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u80f8\u79d1\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u9996\u6b21\u514d\u8d39\u63a8\u9001\uff08\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\uff09\uff0c\u5176\u4ed6\u5546\u4e1a\u5408\u4f5c\u4e5f\u53ef\u4ee5\u53d1\u6b64\u90ae\u7bb1\uff01<\/span><\/span><\/p>\n

\n


<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u4fe1\u606f <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

1.       \u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb YK-029A\u7247\u662f […]<\/p>\n","protected":false},"author":1,"featured_media":9520,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9519"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9519"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9519\/revisions"}],"predecessor-version":[{"id":9521,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9519\/revisions\/9521"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9520"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9519"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9519"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}