{"id":9576,"date":"2018-06-11T01:00:00","date_gmt":"2018-07-27T09:40:01","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e9%bb%98%e6%b2%99%e4%b8%9c%e3%80%81bms%e3%80%81%e7%bd%97%e6%b0%8f%e7%9a%84pd-1-pd-l1%e8%8d%af%e7%89%a9%e7%a9%b6%e7%ab%9f%e6%9c%89%e4%bd%95%e4%b8%8d%e5%90%8c%ef%bc%9f\/"},"modified":"2018-07-27T17:40:02","modified_gmt":"2018-07-27T09:40:02","slug":"%e9%bb%98%e6%b2%99%e4%b8%9c%e3%80%81bms%e3%80%81%e7%bd%97%e6%b0%8f%e7%9a%84pd-1-pd-l1%e8%8d%af%e7%89%a9%e7%a9%b6%e7%ab%9f%e6%9c%89%e4%bd%95%e4%b8%8d%e5%90%8c%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9576\/","title":{"rendered":"\u9ed8\u6c99\u4e1c\u3001BMS\u3001\u7f57\u6c0f\u7684PD-1\/PD-L1\u836f\u7269\u7a76\u7adf\u6709\u4f55\u4e0d\u540c\uff1f"},"content":{"rendered":"
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\u9ed8\u6c99\u4e1c\u7684I-O\u660e\u661fKeytruda\u5728ASCO2018\u4e0a\u5c55\u73b0\u51fa\u7684\u6570\u636e\u582a\u79f0\u60ca\u8273\uff0c\u51e0\u4e4e\u6240\u6709\u7684\u4eba\u90fd\u8ba4\u4e3aKeytruda\u6beb\u65e0\u7591\u95ee\u62a2\u5360\u4e86\u80ba\u764c\u514d\u75ab\u7597\u6cd5\u9886\u57df\u7684\u738b\u5ea7\uff08\u89c1\uff1a<\/span>\u8c01\u662f\u4eca\u5e74ASCO\u7684\u6700\u5927\u8d62\u5bb6\uff1f<\/a><\/span>\uff09\u3002\u7136\u800c\uff0c\u7ade\u4e89\u5bf9\u624b\u5bf9\u6b64\u4f3c\u4e4e\u9887\u4e0d\u4ee5\u4e3a\u7136\u3002\u5728\u4ed6\u4eec\u770b\u6765\uff0c\u81ea\u5df1\u7684\u836f\u7269\u4e0eKeytruda\u4e4b\u95f4\u7684\u5dee\u5f02\u5f88\u5c0f\uff0c\u6216\u8005\u8bf4\u6839\u672c\u4e0d\u5b58\u5728\u5dee\u5f02\u3002<\/span><\/span>
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Genentech\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5f00\u53d1\u526f\u603b\u88c1\u517c\u5168\u7403\u8d1f\u8d23\u4ebaDan Chen\u8ba4\u4e3a\uff0c\u5c31\u4ed6\u6240\u770b\u5230\u7684\u6570\u636e\uff0cPD-1\u548cPD-L1\u7597\u6cd5\u201c\u975e\u5e38\u76f8\u4f3c\u201d\u3002<\/span><\/p>\n


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\u201c\u7f57\u6c0f\u7684Tecentriq\uff0c\u963f\u65af\u5229\u5eb7\u7684Imfinzi\uff0cBMS\u7684Opdivo\u548cKeytruda\u4e4b\u95f4\u6709\u5dee\u522b\u5417\uff1f\u4e5f\u8bb8\u6709\uff0c\u4f46\u4e4b\u95f4\u7684\u5dee\u5f02\u90fd\u53ef\u80fd\u975e\u5e38\u5c0f\u201d\uff0cDan Chen\u81ea\u95ee\u81ea\u7b54\u9053\uff0c<\/span>\u201c\u4ece\u7edf\u8ba1\u4e0a\u8bf4\uff0c\u5982\u679c\u4ed6\u4eec\u90fd\u5b8c\u5168\u4e00\u6837\uff0c\u4f60\u53ef\u80fd\u53c8\u60f3\u77e5\u9053\u4e34\u5e8a\u8bd5\u9a8c\u4e0a\u7684\u5dee\u5f02\u3002\u201d<\/span><\/p>\n


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\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u9996\u5e2d\u6267\u884c\u5b98Giovanni Caforio\u5728\u63a5\u53d7\u5916\u5a92CNBC\u91c7\u8bbf\u65f6\u8bf4\u7684\u66f4\u52a0\u76f4\u767d\uff0c\u201c\u5f53\u4f60\u770b\u5230\u6574\u4e2a\u6570\u636e…… Keytruda\u548cOpdivo\uff0c<\/span>\u8fd9\u4e24\u79cd\u836f\u7269\u4e4b\u95f4\u786e\u5b9e\u6ca1\u6709\u4ec0\u4e48\u533a\u522b\u3002\u201d<\/span><\/p>\n


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\u8003\u8651\u5230Keytruda\u8d8a\u6765\u8d8a\u591a\u7684\u6709\u5229\u6570\u636e\u7ed9<\/span>\u7ade\u4e89\u5bf9\u624b\u5e26\u6765\u7684\u538b\u529b\uff0c\u8fd9\u4e24\u4e2a\u4eba\u8fd9\u4e48\u8bf4\u5b8c\u5168\u53ef\u4ee5\u7406\u89e3\u3002\u4e0d\u8fc7\u9ed8\u6c99\u4e1c\u8fd8\u662f\u575a\u5b9a\u5730\u8ba4\u4e3a\u81ea\u5df1\u7684\u4ea7\u54c1\u7565\u80dc\u4e00\u7b79\u3002<\/span><\/p>\n


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\u867d\u7136\u7f57\u6c0f\u4e5f\u5728ASCO\u4e0a\u53d1\u5e03\u4e86Tecentriq\u5728<\/span>\u9cde\u72b6\u80ba\u764c\u7684\u9633\u6027\u6570\u636e\uff0cBMS\u4e5f\u5f3a\u8c03\u4e86Opdivo\u5728\u65b0\u751f\u7269\u6807\u5fd7\u7269\u7fa4\u4f53\u4e2d\u7684\u51fa\u8272\u8868\u73b0\u3002\u4f46\u7531\u4e8eKeytruda\u7684\u6700\u65b0\u80dc\u5229\u63a9\u76d6\u4e86\u524d\u4e24\u8005\u7684\u5149\u8292\uff0c\u6295\u8d44\u8005\u5bf9\u8fd9\u4e24\u5bb6\u4f01\u4e1a\u7684\u70ed\u60c5\u663e\u7136\u4e0d\u53ca\u9ed8\u6c99\u4e1c\u3002<\/span><\/p>\n


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Dan Chen\u8868\u793a\uff0c\u76ee\u524d3\u79cd\u836f\u7269\u7ed9\u5927\u5bb6\u9020\u6210\u8f83\u5927\u5dee\u5f02\u7684\u9519\u89c9\u5e94\u8be5\u5f52\u548e\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u7684\u8bbe\u8ba1\u3002\u9ed8\u6c99\u4e1cKeytruda\u5355\u836f\u5728\u80ba\u764c\u4e00\u7ebf\u7597\u6cd5\u83b7\u80dc\uff0c\u800cOpdivo\u5219\u906d\u9047\u5931\u8d25\uff0c\u4e0d\u6392\u9664\u540e\u8005\u7528\u7684\u662f\u201c\u5907\u4efd\u201d\u673a\u5236\u3002<\/span><\/span><\/span><\/span>\u201c\u8fd9\u4e9b\u4e34\u5e8a\u7814\u7a76\u7684\u8fd0\u8425\u7b56\u7565\u6709\u5f88\u591a\u4e0d\u540c\u70b9\uff0c\u201d\u4ed6\u8865\u5145\u9053\uff0c\u201c\u66f4\u91cd\u8981\u7684\u662f\u770b\u6574\u4f53\u8bc1\u636e\u3002\u8b6c\u5982Tecentriq\u5728\u4e09\u9879\u4e00\u7ebf\u80ba\u764c\u7814\u7a76\u4e2d\u7684\u6570\u636e\u4e5f\u662f\u79ef\u6781\u7684\u3002<\/span>\u201d<\/span><\/p>\n


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\u7136\u800c\uff0c\u5206\u6790\u5e08\u4eec\u627e\u6765\u7684\u8bc1\u636e\u4f3c\u4e4e\u5e76\u4e0d\u8ba4\u53efDan Chen\u8ba4\u4e3a\u201cPD-1\/PD-L1\u836f\u7269\u6ca1\u6709\u5dee\u5f02\u201d\u7684\u770b\u6cd5\u3002<\/span><\/span>\u8b6c\u5982FDA\u57281\u5e74\u524d\u505c\u6b62\u4e86Keytruda\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08Keynote-183\u548cKeynote-185\u7814\u7a76\uff09\uff0c\u6700\u8fd1\u5374\u89e3\u9664\u4e86Opdivo\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u8bd5\u9a8c\u90e8\u5206\u7ec4\u5408\u7597\u6cd5\u7684\u4e34\u5e8a\u671f\u9650\u3002\u8fd9\u4e00\u4e3e\u52a8\u6216\u8bb8\u8bf4\u660e\uff0c\u201c\u5916\u754c\u7b80\u5355\u5730\u8ba4\u4e3aPD-1\/L1\u836f\u7269\u5dee\u4e0d\u591a\uff0c\u6216\u8005\u8bf4\u662f\u53ef\u4ee5\u4e92\u6362\u7684\u201d\u8fd9\u4e00\u89c2\u70b9\u5e76\u4e0d\u6b63\u786e\uff08\u89c1\uff1a<\/span>PD-1\/PD-L1\u540e\u8fdb\u8005\u8fd8\u6709\u673a\u4f1a\u5417\uff1f<\/a><\/span>\uff09\u3002<\/span><\/span><\/p>\n


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\u4e0e\u6b64\u540c\u65f6\uff0c\u5e02\u573a\u89c2\u5bdf\u5bb6\u81f3\u4eca\u4e00\u76f4\u6ca1\u80fd\u627e\u51fa\u4e00\u4e9bPD-1\/PDL1\u836f\u7269\u7684\u5931\u8d25\u539f\u56e0\u3002\u5305\u62ecFDA\u52a0\u901f\u6279\u51c6Keytruda\u6cbb\u7597\u5934\u9888\u764c\u540e\uff0c<\/span><\/span>Keytruda\u5374\u5728\u4e00\u9879III\u671f\u4e34\u5e8a\uff08KN012\uff09\u4e2d\u5931\u8d25\u4e86\uff1b\u540c\u6837\u4ee4\u4eba\u8d39\u89e3\u7684<\/span>\u5931\u8d25\u8fd8\u6709Opdivo\u7684\u80ba\u764cIII\u671f\u4e34\u5e8a<\/span>CM026\u8bd5\u9a8c\uff0c\u4ee5\u53caTecentriq\u7684\u8180\u80f1\u764cIII\u671f\u4e34\u5e8a<\/span>IMvigor211\u8bd5\u9a8c\uff08\u89c1\uff1a<\/span>\u7f57\u6c0fPD-L1\u906d\u9047\u5371\u673a\uff1a\u4e00\u9879\u8180\u80f1\u764cIII\u671f\u7814\u7a76\u5931\u8d25<\/a><\/span>\uff09\u3002<\/span><\/span><\/p>\n


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\u201c\u53bb\u5e74\u6211\u66fe\u8bf4\u8fc7\uff0c\u81f3\u5c11\u6709\u4e24\u79cd\u4e0d\u540c\u7684\u80bf\u7624\u9002\u5e94\u75c7\u4e0a\u9ed8\u6c99\u4e1c\u6210\u529f\u4e86\uff0c\u800c\u5176\u4ed6\u4f01\u4e1a\u90fd\u5931\u8d25\u4e86……\u4e0d\u6392\u9664\u9ed8\u6c99\u4e1c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u7b56\u7565\u4e0a\u6bd4\u5176\u4ed6\u4f01\u4e1a\u8981\u9ad8\u660e\u4e00\u4e9b\u7684\u53ef\u80fd\u6027\u3002\u201dEvercore ISI\u5206\u6790\u5e08Umer Raffat<\/span>\u8868\u793a\uff0c\u201c\u4f46\u4eca\u5e74\uff0cKeytruda\u662f\u80ba\u764c\u4e00\u7ebf\u7597\u6cd5\u4e2d\u552f\u4e00\u663e\u793a\u5355\u836f\u6cbb\u7597\u751f\u5b58\u4f18\u52bf\u7684PD-1\u836f\u7269\uff0c\u4e14\u5728\u6240\u6709\u5177\u6709\u8180\u80f1\u764c\u7684PD-1\/PD-L1\u4e2d\uff0c<\/span><\/span><\/span><\/span>\u53ea\u6709Keytruda\u5728\u4e8c\u7ebf\u8180\u80f1\u764c\u663e\u793a\u751f\u5b58\u4f18\u52bf\u3002\u6709\u6ca1\u6709\u53ef\u80fd\u662f\u56e0\u4e3a\u836f\u7269\u672c\u8eab\u7684\u7ec6\u5fae\u5dee\u5f02\u5bfc\u81f4\u7684\u4e34\u5e8a\u7ed3\u679c\u4e0d\u4e00\u81f4\u6027\uff1f\u73b0\u5728\u770b\u6765\u5e76\u4e0d\u6392\u9664\u8fd9\u79cd\u53ef\u80fd\u6027\u3002\u201d<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1aHow different are I-O stars from Merck, Roche and Bristol-Myers? Depends who you ask<\/span><\/p>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u533b\u836f\u9b54\u65b9 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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