{"id":9585,"date":"2018-06-08T01:00:00","date_gmt":"2018-07-27T09:40:07","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e8%b0%81%e6%98%af%e4%bb%8a%e5%b9%b4asco%e7%9a%84%e6%9c%80%e5%a4%a7%e8%b5%a2%e5%ae%b6%ef%bc%9f\/"},"modified":"2018-07-27T17:40:10","modified_gmt":"2018-07-27T09:40:10","slug":"%e8%b0%81%e6%98%af%e4%bb%8a%e5%b9%b4asco%e7%9a%84%e6%9c%80%e5%a4%a7%e8%b5%a2%e5%ae%b6%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9585\/","title":{"rendered":"\u8c01\u662f\u4eca\u5e74ASCO\u7684\u6700\u5927\u8d62\u5bb6\uff1f"},"content":{"rendered":"
\n

\"\u8c01\u662f\u4eca\u5e74ASCO\u7684\u6700\u5927\u8d62\u5bb6\uff1f\"<\/p>\n

 <\/span><\/p>\n

\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a (ASCO) <\/span>\u5e74\u4f1a\u662f\u6bcf\u5e74\u80bf\u7624\u5b66\u9886\u57df\u6700\u91cd\u8981\u7684\u4e00\u6b21\u4f1a\u8bae\u3002ASCO\u5e74\u4f1a\u4e2d\u516c\u5e03\u7684\u6570\u636e\u4e0d\u4ec5\u80fd\u591f\u5f71\u54cd\u80bf\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u6cbb\u7597\uff0c\u76f8\u5173\u5236\u836f\u516c\u53f8\u7684\u80a1\u4ef7\u4e5f\u53ef\u80fd\u4f1a\u968f\u7740\u6570\u636e\u7684\u516c\u5e03\u800c\u5f3a\u70c8\u6ce2\u52a8\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u79d1\u7814\u7684\u8fdb\u5ea6\u603b\u662f\u6bd4\u5927\u591a\u6570\u4eba\u60f3\u8c61\u4e2d\u7684\u8981\u6162\u5f88\u591a\uff0c\u800c\u4e14\u5728\u5236\u836f\u516c\u53f8\u63d0\u4ea4\u7684\u4e3a\u6570\u4f17\u591a\u7684\u6458\u8981\u548c\u62a5\u544a\u4e2d\uff0c\u771f\u6b63\u80fd\u591f\u4e3a\u8be5\u9886\u57df\u5e26\u6765\u53d8\u9769\u7684\u7814\u7a76\u5176\u5b9e\u4e5f\u5e76\u4e0d\u591a\u3002<\/span>\u4f46\u4e0e\u6b64\u540c\u65f6\u4e5f\u786e\u5b9e\u6709\u4e00\u4e9b\u516c\u53f8\u7684\u7814\u7a76\u80fd\u591f\u63a8\u52a8\u80bf\u7624\u5b66\u7684\u8fdb\u5c55\uff0c\u5bf9\u60a3\u8005\u7684\u4e34\u5e8a\u6cbb\u7597\u4ea7\u751f\u5f88\u5927\u5f71\u54cd\uff0c\u540c\u65f6\u4e5f\u6709\u4e00\u4e9b\u5236\u836f\u516c\u53f8\u5728\u672c\u6b21\u4f1a\u8bae\u4e2d\u906d\u53d7\u4e86\u65e0\u6570\u7684\u8d28\u7591\uff0c\u80a1\u4ef7\u5927\u8dcc\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u90a3\u4e48\u7a76\u7adf\u54ea\u5bb6\u516c\u53f8\u624d\u662f\u4eca\u5e74ASCO\u7684\u8d62\u5bb6\u5462\uff1f<\/span><\/p>\n


<\/p>\n

\n
\n

\u9ed8\u6c99\u4e1c<\/span><\/p>\n<\/section>\n<\/section>\n


<\/p>\n

\u6beb<\/span>\u65e0\u7591\u95ee\u9ed8\u6c99\u4e1c\u662f\u672c\u5c4aASCO\u5e74\u4f1a\u7684\u6700\u5927\u8d62\u5bb6\u3002\u5728\u4eca\u5e74\u7684ASCO\u4f1a\u8bae\u4e0a\u7f57\u6c0f\u516c\u5e03\u4e86atezolizumab\u8054\u5408\u5316\u7597\u6cbb\u7597\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c (IMpower131) \u7684\u6570\u636e\u3002Atezolizumab\u8054\u5408\u5316\u7597 (\u5361\u94c2\uff0c\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187)<\/span> \u7ec4\u60a3\u8005\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a6.3\u4e2a\u6708\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a5.6\u4e2a\u6708\u3002\u8be5\u65b9\u6848\u80fd\u591f\u5c06\u60a3\u8005\u80bf\u7624\u8fdb\u5c55\u7684\u98ce\u9669\u964d\u4f4e29%\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u89c2\u5bdf\u5230\u751f\u5b58\u671f\u83b7\u76ca\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u662f\u514d\u75ab\u7597\u6cd5\u5728\u665a\u671f\u80ba\u764c\u4e2d\u7684\u6700\u540e\u4e00\u5757\u5fc5\u4e89\u4e4b\u5730\u3002\u867d\u7136atezolizumab\u7684\u6570\u636e\u5df2\u7ecf\u8db3\u591f\u4f18\u79c0\uff0c\u4f46\u9ed8\u6c99\u4e1c\u7684\u6570\u636e\u5374\u5177\u6709\u538b\u5012\u6027\u7684\u4f18\u52bf\uff1a\u5728\u65b0\u786e\u8bca\u7684\u9cde\u72b6NSCLC\u60a3\u8005\u4e2d\uff0cKeytruda\u8054\u5408\u5316\u7597\u76f8\u6bd4\u5316\u7597\u5355\u836f\u80fd\u591f\u5c06\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e36%\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u8c01\u662f\u4eca\u5e74ASCO\u7684\u6700\u5927\u8d62\u5bb6\uff1f\"<\/p>\n


<\/p>\n

JP Morgan\u5206\u6790\u5e08Chris Schott\u79f0\u8fd9\u9879\u7814\u7a76\u518d\u4e00\u6b21\u5de9\u56fa\u4e86\u9ed8\u6c99\u4e1c\u5728NSCLC\u9886\u57df\u7684\u9738\u4e3b\u5730\u4f4d\uff0cNSCLC\u7684\u9886\u57df\u7684\u5e02\u573a\u9ad8\u8fbe120\u4ebf\u7f8e\u5143\uff0c\u800c\u9ed8\u6c99\u4e1c\u672a\u6765\u5c06\u6709\u53ef\u80fd\u5728\u8be5\u9886\u57df\u5360\u636e70%\u7684\u5e02\u573a\u4efd\u989d\u3002<\/span>\u5206\u6790\u5e08\u9884\u8ba1\u672a\u6765\u51e0\u5e74Keytruda\u7684\u5e74\u9500\u552e\u989d\u5c06\u8fbe\u5230120\u4ebf\u7f8e\u5143\uff0c\u800cOpdivo\u7684\u9500\u552e\u989d\u9884\u8ba1\u4e3a90\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n

Loxo Oncology<\/span><\/p>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

Loxo Oncology<\/span>\u5df2\u8fde\u7eed\u4e24\u5e74\u6210\u4e3aASCO\u5e74\u4f1a\u4e2d\u6700\u4eae\u773c\u7684\u660e\u661f\u516c\u53f8\u3002\u53bb\u5e74Loxo\u516c\u5e03\u4e86larotrectinib\u7684\u6570\u636e\uff0c\u5176\u54cd\u5e94\u7387\u9ad8\u8fbe77%\u3002Larotrectinib\u80fd\u591f\u9776\u5411\u4e00\u79cd\u7f55\u89c1\u7684\u80bf\u7624\u53d8\u5f02\uff1aTRK\u57fa\u56e0\u878d\u5408\uff0c\u800c\u4eca\u5e74\u516c\u5e03\u7684\u53e6\u4e00\u6b3e\u836f\u7269Loxo-292\u5219\u662f\u9776\u5411\u53e6\u4e00\u79cd\u7f55\u89c1\u7684\u57fa\u56e0\u53d8\u5f02\uff1aRET\u57fa\u56e0\u878d\u5408\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Loxo-292\u7684\u6570\u636e\u540c\u6837\u51fa\u8272\uff0c\u9488\u5bf9\u5b58\u5728RET\u878d\u5408\u53d8\u5f02\u7684\u80bf\u7624\u60a3\u8005\u5176\u603b\u4f53\u7f13\u89e3\u7387\u4e3a77%\u3002\u5165\u7ec4\u7684\u75c5\u4eba\u4e2d\u5927\u90e8\u5206\u60a3\u6709\u80ba\u90e8\u80bf\u7624\uff0c\u4e5f\u5305\u62ec\u4e00\u4e9b\u7532\u72b6\u817a\u764c\u4ee5\u53ca\u80f0\u817a\u764c\u60a3\u8005\u3002\u9664\u4e86RET\u878d\u5408\u53d8\u5f02Loxo\u8fd8\u62db\u52df\u4e8629\u540d\u5b58\u5728RET\u7a81\u53d8\u7684\u7532\u72b6\u817a\u9ad3\u6837\u764c\u60a3\u8005\uff0c\u8be5\u90e8\u5206\u75c5\u4eba\u7684\u54cd\u5e94\u7387\u4e3a45%\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u800c\u4e14\u8fd9\u4e9b\u75c5\u4eba\u5bf9\u4e8eLoxo-292\u7684\u54cd\u5e94\u65f6\u95f4\u5f88\u957f\u3002\u622a\u81f3\u76ee\u524d\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u4e2d\u5c1a\u6ca1\u6709\u60a3\u8005\u590d\u53d1\u3002\u4e0e\u6b64\u540c\u65f6\u8be5\u836f\u7269\u7684\u5b89\u5168\u6027\u4e5f\u6bd4\u8f83\u51fa\u8272\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u4eca\u5e74\u56db\u6708\u4efdBluePrint Medicines\u516c\u5e03\u4e86\u8be5\u516c\u53f8\u7684RET\u6291\u5236\u5242BLU-667\u7684\u6570\u636e\uff0c\u4f46\u4ece\u8fd9\u4e9b\u6570\u636e\u6765\u770bBLU-667\u76f8\u6bd4Loxo-292\u4f1a\u900a\u8272\u8bb8\u591a\uff1a\u5b58\u5728RET\u878d\u5408\u53d8\u5f02\u7684NSCLC\u60a3\u8005\u5bf9BLU-667\u7684\u5e94\u7b54\u7387\u4e3a50%\uff0c\u800c\u5b58\u5728RET\u7a81\u53d8\u7684\u7532\u72b6\u817a\u9ad3\u6837\u764c\u60a3\u8005\u7684\u54cd\u5e94\u7387\u4e3a40%\u3002<\/span><\/p>\n

 <\/span><\/p>\n

RET\u878d\u5408\u5b58\u5728\u4e8e\u5927\u7ea62%\u7684\u80ba\u764c\u60a3\u8005\u7684\u80bf\u7624\u4e2d\uff0c10-20%\u7684\u7532\u72b6\u817a\u764c\u60a3\u8005\u4ee5\u53ca\u5927\u7ea660%\u7684\u7532\u72b6\u817a\u9ad3\u6837\u764c\u60a3\u8005\u4e5f\u5b58\u5728\u8fd9\u7c7b\u80bf\u7624\u7a81\u53d8\u3002\u7531\u4e8e\u662f\u9776\u5411\u7f55\u89c1\u7684\u57fa\u56e0\u53d8\u5f02\uff0c\u56e0\u6b64\u5373\u4f7f\u8be5\u836f\u7269\u987a\u5229\u83b7\u6279\u4e0a\u5e02\uff0c\u5176\u80fd\u591f\u5360\u9886\u591a\u5927\u7684\u5e02\u573a\u4efd\u989d\u73b0\u5728\u4e5f\u8fd8\u662f\u672a\u77e5\u6570\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4f46Loxo\u63a5\u8fde\u7684\u6210\u529f\u5df2\u7ecf\u8db3\u591f\u8ba9\u6295\u8d44\u8005\u5bf9\u8fd9\u5bb6\u516c\u53f8\u7684\u672a\u6765\u611f\u5230\u4fe1\u5fc3\u5341\u8db3\u3002<\/span>\u65e9\u5728\u4e0a\u4e2a\u6708ASCO\u6458\u8981\u516c\u5e03\u4e4b\u540eLoxo\u7684\u80a1\u7968\u5c31\u5df2\u7ecf\u4e0a\u6da8\u4e8630%\uff0cLoxo\u80a1\u4ef7\u5728\u5468\u4e00\u5f00\u76d8\u4e0a\u6da812%\u81f3$211\uff0c\u4f7f\u5176\u5e02\u503c\u4e00\u5ea6\u8d85\u8fc760\u4ebf\u7f8e\u5143\u3002\u5bf9\u4e8e\u4e00\u4e2a\u8fd8\u6ca1\u6709\u4efb\u4f55\u836f\u7269\u4e0a\u5e02\u7684\u516c\u53f8\u6765\u8bf4\u8fd9\u4e00\u6570\u5b57\u6beb\u65e0\u7591\u95ee\u662f\u975e\u5e38\u9ad8\u7684\u3002\u800c\u5728\u6b64\u4e4b\u540e\u90e8\u5206\u6295\u8d44\u8005\u5957\u73b0\u79bb\u573a\uff0c\u5176\u80a1\u4ef7\u4e0b\u8dcc\u5e76\u7ef4\u6301\u5728$180\u9644\u8fd1\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n

Bluebird Bio<\/span><\/p>\n<\/section>\n<\/section>\n


<\/p>\n

\u867d<\/span>\u7136Bluebird Bio\u5728\u8fd9\u5c4aASCO\u4e0a\u516c\u5e03\u7684\u6570\u636e\u5df2\u8db3\u4ee5\u8bc1\u660eBB2121\u7684\u6f5c\u529b\uff0c\u4f46\u8fd9\u4e9b\u6570\u636e\u4f9d\u7136\u4f4e\u4e8e\u6295\u8d44\u8005\u4e4b\u524d\u7684\u9884\u671f\u3002<\/span>Bluebird Bio\u7684CAR-T\u7597\u6cd5BB2121\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff0c\u5728\u9ad8\u5242\u91cf\u7ec4\u4e2d\u80fd\u591f\u5c06\u80bf\u7624\u8fdb\u5c55\u7684\u65f6\u95f4\u63a8\u8fdf\u5c06\u8fd1\u4e00\u5e74\u7684\u65f6\u95f4\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a11.8\u4e2a\u6708\u3002<\/span><\/p>\n

 <\/span><\/p>\n

22\u540d\u63a5\u53d7\u6700\u9ad8\u5242\u91cfBB2121\u6cbb\u7597\u7684\u75c5\u4eba\u4e2d21\u4eba\u4ea7\u751f\u4e86\u5e94\u7b54\uff0c11\u4eba\u5b8c\u5168\u5e94\u7b54\u3002\u6700\u9ad8\u5242\u91cf\u7ec4\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a11.8\u4e2a\u6708\uff0c\u800c\u4f4e\u5242\u91cf\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u53ea\u67091.9\u4e2a\u6708\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u4f46\u57fa\u4e8e\u4e4b\u524d\u7684\u6570\u636e\uff0c\u5f88\u591a\u4eba\u63a8\u6d4b\u8be5\u7597\u6cd5\u80fd\u591f\u5c06\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u5ef6\u957f\u81f315\u4e2a\u6708\u5de6\u53f3\u3002\u7136\u800cBluebird\u7684CEO Nick Leschly\u8fa9\u89e3\u79f0\u5165\u7ec4\u63a5\u53d7\u6cbb\u7597\u7684\u75c5\u4eba\u75c5\u60c5\u90fd\u5df2\u7ecf\u975e\u5e38\u4e25\u91cd\uff0c\u8fd9\u4e9b\u75c5\u4eba\u6b64\u524d\u5e73\u5747\u63a5\u53d7\u8fc77\u79cd\u7597\u6cd5\uff0c\u6bcf\u4f4d\u75c5\u4eba\u90fd\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u6b21\u5e72\u7ec6\u80de\u79fb\u690d\uff0c\u5bf9\u4e8e\u8fd9\u4e9b\u60a3\u8005\u6765\u8bf4\u8fd9\u6837\u7684\u6570\u636e\u5df2\u7ecf\u8db3\u591f\u4f18\u79c0\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u9879\u7814\u7a76\u4e2d\u5165\u7ec4\u7684\u75c5\u4eba\u91cc\u67098\u540d\u75c5\u4eba\u7684\u591a\u53d1\u9aa8\u9ad3\u7624\u7ec6\u80de\u7684BCMA\u8868\u8fbe\u6c34\u5e73\u5f88\u4f4e\u3002\u4e4b\u524d\u5f88\u591a\u4eba\u62c5\u5fc3\u8fd9\u4e9b\u75c5\u4eba\u5bf9\u8be5\u7597\u6cd5\u7684\u54cd\u5e94\u53ef\u80fd\u4f1a\u5b58\u5728\u95ee\u9898\uff0c\u4f46\u4ece\u76ee\u524d\u516c\u5e03\u7684\u6570\u636e\u770b\u6240\u6709\u76848\u540d\u75c5\u4eba\u5747\u80fd\u591f\u4ea7\u751f\u5e94\u7b54\uff0c\u800c\u4e14CR\u8fbe\u5230\u4e8638%\u3002\u8fd9\u9879\u7814\u7a76\u7684\u6700\u7ec8\u7ed3\u679c\u6700\u65e9\u5c06\u5728\u660e\u5e74\u516c\u5e03\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n

Forty Seven<\/span><\/p>\n<\/section>\n<\/section>\n


<\/p>\n

\u4ece<\/span>\u516c\u53f8\u7684\u540d\u5b57\u5c31\u80fd\u542c\u51fa\u6765Forty Seven\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8eCD47\u8fd9\u4e00\u9776\u70b9\u7684\u516c\u53f8\u3002CD47\u80fd\u591f\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u8fc7\u8868\u8fbe\uff0c\u4ece\u800c\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u76d1\u89c6\u4ee5\u53ca\u5de8\u566c\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\u3002\u6291\u5236CD47\u6709\u53ef\u80fd\u4f7f\u5de8\u566c\u7ec6\u80de\u66f4\u5bb9\u6613\u541e\u566c\u80bf\u7624\u7ec6\u80de\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u76ee\u524d\u8be5\u516c\u53f8\u9488\u5bf9CD47\u7684\u7597\u6cd5\u4e3b\u8981\u5206\u4e3a\u4e09\u4e2a\u65b9\u5411\uff1a\u5355\u836f\uff0c\u8054\u7528\u6cbb\u7597\u6027\u6297\u4f53\u836f\u7269\uff0c\u4ee5\u53ca\u8054\u7528T\u7ec6\u80de\u68c0\u67e5\u70b9\u6291\u5236\u5242\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5728\u63a5\u53d75F9\u5355\u836f\u6cbb\u7597\u7684\u75c5\u4eba\u4e2d\uff0c18\u540d\u590d\u53d1\u6027AML\u60a3\u8005\u67097\u4eba\u9aa8\u9ad3\u6837\u672c\u4e2d\u767d\u8840\u75c5\u7ec6\u80de\u51cf\u5c11(39%)\uff0c\u5176\u4e2d\u4e00\u4eba\u75be\u75c5\u7a33\u5b9a11.8\u4e2a\u6708\u540e\u75be\u75c5\u8fdb\u5c55\u3002\u5728\u63a5\u53d720 mg\/kg\u6216\u8005\u66f4\u9ad8\u5242\u91cf5F9\u5355\u836f\u6cbb\u7597\u768421\u540d\u5375\u5de2\u764c\u4ee5\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d2\u540d\u60a3\u8005\u4ea7\u751f\u5e94\u7b54\u3002<\/span><\/p>\n

 <\/span><\/p>\n

5F9\u8054\u7528\u6cbb\u7597\u6027\u6297\u4f53\u836f\u7269\u7684\u903b\u8f91\u662f\uff1a\u901a\u8fc7\u6291\u5236\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684CD47\u6765\u6291\u5236\u764c\u7ec6\u80de\u201c\u522b\u5403\u6211\u201d\u7684\u4fe1\u53f7\uff0c\u800c\u901a\u8fc7\u6cbb\u7597\u6027\u6297\u4f53\u6807\u8bb0\u80bf\u7624\u7ec6\u80de\uff0c\u4f7f\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u201c\u5403\u6211\u201d\u7684\u4fe1\u53f7\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u524d\u51e0\u5929Forty Seven\u5728ASCO\u4e0a\u516c\u5e03\u4e865F9\u8054\u7528\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6570\u636e(n=22)\uff0cORR\u4e3a50%\uff0cCR\u4e3a36%\u3002\u5165\u7ec4\u7684\u8fd9\u4e9b\u75c5\u4eba\u7ecf\u5386\u8fc7\u591a\u7ebf\u836f\u7269\u6cbb\u7597\u5931\u8d25\uff0c\u56e0\u6b64\u5927\u5bb6\u5bf9\u8fd9\u4e9b\u6570\u636e\u7684\u53cd\u5e94\u4e5f\u76f8\u5bf9\u6bd4\u8f83\u79ef\u6781\u3002<\/span><\/p>\n


<\/p>\n

<\/span><\/strong><\/span><\/p>\n

\u6709\u4eba\u6b22\u559c\u6709\u4eba\u6101\u3002\u5982\u679c\u8bf4\u4ee5\u4e0a4\u5bb6\u7b97\u662f\u672c\u5c4aASCO\u7684\u5927\u8d62\u5bb6\uff0c\u90a3\u4e48\u4e0b\u9762\u8fd9\u4e24\u5bb6\u516c\u53f8\u5c31\u662f\u8f93\u5bb6\u4e86\u3002<\/span><\/p>\n


<\/p>\n

\n
\n

Nektar<\/span> <\/span>Therapeutic<\/span>s<\/span><\/span><\/p>\n<\/section>\n<\/section>\n


<\/p>\n

N<\/span>ektar\u7684\u9ad8\u7ba1\u6700<\/span>\u8fd1\u8fd9\u51e0\u5929<\/span>\u53ef\u80fd\u8fc7\u7684\u4e0d\u4f1a\u5f88\u5f00\u5fc3\uff0c\u56e0\u4e3a\u8be5\u516c\u53f8\u5728\u672c\u5c4aASCO\u5e74\u4f1a\u4e2d\u516c\u5e03\u7684NKTR-214\u7684\u4e34\u5e8a\u6570\u636e\u906d\u53d7\u4e86\u5f88\u591a\u7684\u8d28\u7591\u3002\u5982\u679c\u8bf4Nektar\u60f3\u5728\u4eca\u5e74\u7684ASCO\u5e74\u4f1a\u4e2d\u8bc1\u660eNKTR-214\u8054\u7528Opdivo\u7684\u7597\u6548\u660e\u663e\u4f18\u4e8eOpdivo\u5355\u836f\u7684\u8bdd\uff0c\u4ed6\u4eec\u663e\u7136\u6ca1\u6709\u8fbe\u5230\u8fd9\u4e00\u76ee\u7684\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u65e9\u671f\u7684\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c13\u540d\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7ecf\u8fc7\u6cbb\u7597\u4e4b\u540e\u54cd\u5e94\u7387\u80fd\u591f\u8fbe\u523085%\u3002\u7136\u800c\u5728Nektar\u62db\u52df\u4e86\u53e6\u591615\u540d\u75c5\u4eba\u5165\u7ec4\u4e4b\u540eORR\u663e\u8457\u4e0b\u964d\u3002\u5728\u672c\u5c4aASCO\u5e74\u4f1a\u516c\u5e03\u7684\u6570\u636e\u4e2d\uff0c28\u540d\u60a3\u8005\u91cc\u670914\u540d\u75c5\u4eba\u4ea7\u751f\u5e94\u7b54\uff0c\u800c\u8fd9\u4e5f\u610f\u5473\u7740\u65b0\u5165\u7ec4\u768415\u4eba\u4e2d\u53ea\u67093\u4eba\u4ea7\u751f\u4e86\u5e94\u7b54\u3002\u4e5f\u6b63\u662f\u8fd9\u4e00\u6570\u636e\u8ba9\u5916\u754c\u4e25\u91cd\u8d28\u7591\u8be5\u7ec4\u5408\u7597\u6cd5\u7684\u6709\u6548\u6027\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Nektar\u540c\u65f6\u4e5f\u516c\u5e03\u4e86\u80be\u764c\u60a3\u8005\u7684\u6570\u636e\uff0c\u8be5\u7c7b\u60a3\u8005\u6700\u521d\u7684\u54cd\u5e94\u7387\u4e3a64%\uff0c\u4e5f\u5c31\u662f\u8bf411\u540d\u60a3\u8005\u4e2d\u67097\u4eba\u4ea7\u751f\u5e94\u7b54\u3002\u4f46\u53e6\u5916\u62db\u52df\u768415\u540d\u80be\u764c\u75c5\u4eba\u5165\u7ec4\u4e4b\u540e\u53ea\u67095\u540d\u60a3\u8005\u4ea7\u751f\u5e94\u7b54\uff0c\u4f7f\u603b\u4f53\u6709\u6548\u7387\u4e0b\u964d\u5230\u4e8646%\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Nektar\u4ee5\u53caBMS\u89e3\u91ca\u79f0\u7531\u4e8e\u6cbb\u7597\u65f6\u95f4\u8f83\u77ed\u5e94\u7b54\u7387\u5c06\u4f1a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u8fdb\u4e00\u6b65\u63d0\u5347\uff0c\u4f46\u4ee5\u76ee\u524d\u7684\u6570\u636e\u6765\u770b\u8981\u8fbe\u5230\u4e4b\u524d\u7684ORR\u6c34\u5e73\u7684\u53ef\u80fd\u6027\u5e76\u4e0d\u9ad8\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5c3d\u7ba1Nektar\u7684\u8d1f\u8d23\u4eba\u79f0\u8be5\u7ec4\u5408\u7597\u6cd5\u7684\u7597\u6548\u4f1a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u54cd\u5e94\u7387\u63d0\u5347\u3002\u4e5f\u8bb8Nektar\/BMS\u5bf9\u6539\u836f\u7269\u7684\u672a\u6765\u5145\u6ee1\u4fe1\u5fc3\uff0c\u4f46\u663e\u7136\u6295\u8d44\u8005\u5e76\u4e0d\u4e70\u8d26\uff0c\u81ea\u672c\u5468\u4e00\u8d77Nektar\u7684\u80a1\u4ef7\u5df2\u7ecf\u4e0b\u8dcc40%\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u4f46\u6bd4\u8f83\u6709\u610f\u601d\u7684\u662fNKTR-214\u80fd\u591f\u5728PD-L1\u9634\u6027\u60a3\u8005\u7fa4\u4f53\u4e2d\u4ea7\u751f\u5e94\u7b54\uff0c\u800c\u8fd9\u90e8\u5206\u60a3\u8005\u901a\u5e38\u5f88\u96be\u5bf9PD-1\u6291\u5236\u5242\u4ea7\u751f\u54cd\u5e94\u300212\u540dPD-L1\u9634\u6027\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u67095\u4eba\u4ea7\u751f\u4e86\u5e94\u7b54\u3002\u800c\u572817\u540dPD-L1\u9634\u6027\u7684\u80be\u764c\u60a3\u8005\u4e2d\uff0c\u670953%\u7684\u60a3\u8005\u4ea7\u751f\u5e94\u7b54\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5f88\u591a\u4eba\u5728\u8d28\u7591BMS\u4e3a\u4e86\u8ffd\u8d76\u9ed8\u6c99\u4e1c\uff0c\u5bf9NKTR-214\u7684\u6240\u91c7\u53d6\u52a8\u4f5c\u592a\u8fc7\u8fc5\u901f\u3002\u4f46\u4ece\u8fd9\u5c4aASCO\u516c\u5e03\u7684\u8fd9\u4e9b\u6570\u636e\u6765\u770b\uff0cNKTR-214\u53ef\u80fd\u5f88\u96be\u6539\u53d8Opdivo\u4e0eKeytruda\u7684\u7ade\u4e89\u683c\u5c40\u3002<\/span><\/p>\n


<\/span><\/p>\n

BMS\/Nektar\u5c06\u8fdb\u884c\u975e\u5e38\u6602\u8d35\u7684\u5927\u89c4\u6a21III\u671f\u4e34\u5e8a\uff0c\u53ef\u80fd<\/span>BMS\u9009\u62e9\u5728NKTR-214\/Opdivo\u8054\u7528\u65b9\u6848\u4e0a\u4e0b\u5982\u6b64\u5927\u7684\u8d4c\u6ce8\u4f1a\u4f7f\u8fd9\u5bb6\u516c\u53f8\u9762\u4e34\u7740\u5f88\u9ad8\u7684\u98ce\u9669\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/span><\/p>\n

Opdivo\u663e\u7136\u662fBMS\u8fd1\u51e0\u5e74\u6765\u6700\u91cd\u8981\u7684\u4e00\u6b3e\u836f\u7269\uff0c\u4f46\u5bf9BMS\u6765\u8bf4\u9ed8\u6c99\u4e1c\u7684Keytruda\u662f\u4e00\u4e2a\u6781\u5927\u7684\u5a01\u80c1\u3002\u800c\u4eceNKTR-214\/Opdivo\u7684\u51b3\u7b56\u4e2d\u4e5f\u80fd\u591f\u770b\u51faBMS\u7684\u7126\u8651\u3002<\/span><\/p>\n

\n
\n
\n

Jounce Therapeutics<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

J<\/span>ounce\u7684\u80a1\u4ef7<\/span>\u5728ASCO\u7684\u6458\u8981\u516c\u5f00\u4e4b\u540e\u5c31\u5f00\u59cb\u4e0b\u8dcc\uff0c\u4ece\u4e0a\u670816\u65e5\u7684\u5927\u7ea6$17\u8dcc\u81f3\u76ee\u524d\u7684$7\u9644\u8fd1\u3002\u8be5\u516c\u53f8\u7684JTX-2011\u662fICOS\u6fc0\u52a8\u5242\uff0cJounce\u8ba4\u4e3a\u901a\u8fc7JTX-2011\u7684ICOS\u6fc0\u52a8\u4f5c\u7528\u80fd\u591f\u6d3b\u5316CD4 T\u7ec6\u80de\uff0c\u6291\u5236Treg\u529f\u80fd\u3002<\/span><\/p>\n

 <\/span><\/p>\n

JTX-2011\u76ee\u524d\u5904\u4e8eI\/II\u671f\u4e34\u5e8a(ICONIC)\uff0cICONIC \u7684I\u671f\u4e34\u5e8a\u90e8\u5206\u4e3b\u8981\u7814\u7a76JTX-2011\u7684PK\u4ee5\u53caPD\uff0c\u800cII\u671f\u4e34\u5e8a\u7814\u7a76\u90e8\u5206\u4e3b\u8981\u662f\u7814\u7a76\u8be5\u836f\u5728ICOS\u9ad8\u8868\u8fbe\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\u7a0b\u5ea6\u8f83\u9ad8\u7684\u4e00\u4e9b\u7c7b\u578b\u7684\u80bf\u7624\u4e2d\u7684\u7597\u6548\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u672c\u5c4aASCO\u516c\u5e03\u4e86ICONIC\u7684\u90e8\u5206\u6570\u636e\u3002JTX-2011\u4f5c\u4e3a\u5355\u836f\u4f7f\u75287\u540d\u80c3\u764c\u60a3\u8005\u4e2d\u53ea\u6709\u4e00\u540d\u60a3\u8005\u4ea7\u751f\u5e94\u7b54\uff0c\u800c\u4e0eOpdivo\u8054\u7528\u4e4b\u540e19\u540d\u60a3\u8005\u4e2d\u67092\u4eba\u4ea7\u751f\u5e94\u7b54\uff0c\u54cd\u5e94\u7387\u4e3a11%\u3002\u800c\u4e14\u6cbb\u7597\u4e09\u9634\u4e73\u817a\u764c\u7684\u6570\u636e\u4e5f\u540c\u6837\u5f88\u96be\u770b\uff0c15\u540d\u4e09\u9634\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u53ea\u6709\u4e00\u4eba\u4ea7\u751f\u90e8\u5206\u5e94\u7b54\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Jounce\u7684\u8d1f\u8d23\u4eba\u89e3\u91ca\u79f0\u5165\u7ec4\u7684\u75c5\u4eba\u90fd\u662f\u4e4b\u524d\u63a5\u53d7\u8fc7\u591a\u79cd\u7597\u6cd5\u6cbb\u7597\u8fc7\u7684\u75c5\u4eba\uff0c\u4f46\u4f9d\u7136\u65e0\u6cd5\u8bf4\u670d\u6295\u8d44\u8005\uff0c\u5728\u6458\u8981\u516c\u5e03\u4e4b\u540e\u5c31\u80a1\u4ef7\u5c31\u4e0b\u8dcc\u4e86\u5c06\u8fd130%\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u867d\u7136\u672c\u5c4aASCO\u4e2d\u5173\u4e8e\u80bf\u7624\u514d\u75ab\u7ec4\u5408\u7597\u6cd5\u7684\u6570\u636e\u5f88\u591a\uff0c\u4f46\u9664\u4e86\u8054\u7528\u5316\u7597\u4ee5\u53ca\u8054\u7528\u5df2\u4e0a\u5e02\u7684Yervoy\uff0c\u76ee\u524d\u4f9d\u7136\u5f88\u96be\u770b\u6e05\u695a\u7ec4\u5408\u7597\u6cd5\u7a76\u7adf\u80fd\u6709\u591a\u5927\u7684\u6f5c\u529b (\u89c1\uff1a<\/span>\u80bf\u7624\u514d\u75ab\u7ec4\u5408\u7597\u6cd5\u7684\u63a2\u7d22\u4e4b\u8def<\/a><\/span>)\u3002<\/span><\/p>\n


<\/span><\/p>\n

Nektar\u7684NKTR-214\u76f8\u5173\u6570\u636e\u8ba9\u4eba\u6478\u4e0d\u7740\u5934\u8111\uff0cJounce\u7684JTX-2011\u65e0\u8bba\u662f\u5355\u836f\u8fd8\u662f\u8054\u7528\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5176\u54cd\u5e94\u7387\u90fd\u975e\u5e38\u4f4e\uff0cDynavax\u7684TLR9\u6fc0\u52a8\u5242SD-101\u7684\u6570\u636e\u4e5f\u540c\u6837\u5f88\u8ba9\u4eba\u5931\u671b\u3002\u800c\u4e14\u672c\u5c4aASCO\u4e2d\u516c\u5f00\u7684IDO\u6291\u5236\u5242\u6570\u636e\u6bd4\u9884\u60f3\u7684\u66f4\u7cdf\u7cd5\uff0c\u4e24\u7ec4\u60a3\u8005\u7684K-M\u66f2\u7ebf\u51e0\u4e4e\u91cd\u5408\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/span><\/p>\n

\"\u8c01\u662f\u4eca\u5e74ASCO\u7684\u6700\u5927\u8d62\u5bb6\uff1f\"<\/p>\n

<\/span>
<\/p>\n

<\/span><\/p>\n

\n

 <\/span><\/p>\n

\u5982\u679c\u8bf4\u8fd9\u4e9b\u6570\u636e\u662f\u8ba9\u4eba\u5931\u671b\u7684\u8bdd\uff0c\u90a3\u9ed8\u6c99\u4e1c\u5728\u6458\u8981\u4e2d\u516c\u5e03\u7684\u4e00\u7ec4\u6570\u636e\u5374\u8ba9\u6211\u89c9\u5f97\u6709\u4e9b\u96be\u8fc7\u3002\u867d\u7136\u76ee\u524dKeytruda\u5df2\u7ecf\u670910\u4e2a\u9002\u5e94\u75c7\u83b7\u6279\uff0c\u4f46\u8be5\u836f\u7684\u957f\u671f\u968f\u8bbf\u6570\u636e\u5374\u5e76\u4e0d\u591a\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u9ed8\u6c99\u4e1c\u5411ASCO\u4f1a\u8bae\u9012\u4ea4\u4e86\u4e00\u9879\u6458\u8981\u516c\u5e03\u4e86KN001\u4e2d\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u957f\u8fbe5\u5e74\u7684\u968f\u8bbf\u6570\u636e\u3002\u5927\u7ea6\u4e94\u5e74\u4e4b\u540e655\u540d\u5165\u7ec4\u7684\u60a3\u8005\u4e2d412\u540d\u60a3\u8005\u6b7b\u4ea1\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u4e3a34%\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u4e3a23.8\u4e2a\u6708\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u9ed1\u8272\u7d20\u7624\u7b97\u662f\u5bf9\u514d\u75ab\u7597\u6cd5\u54cd\u5e94\u7a0b\u5ea6\u5f88\u9ad8\u7684\u4e00\u7c7b\u80bf\u7624\u4e86\uff0c\u4f46\u7528\u836f\u60a3\u8005\u7684\u751f\u5b58\u7387\u4f9d\u7136\u4e0d\u9ad8\uff0c\u76f8\u5bf9\u800c\u8a00\u56fd\u5185\u9ad8\u53d1\u7684\u6d88\u5316\u9053\u80bf\u7624\u5bf9\u8be5\u836f\u7684\u54cd\u5e94\u7a0b\u5ea6\u66f4\u4f4e\uff0c\u80fd\u591f\u5bf9\u60a3\u8005\u4ea7\u751f\u7684\u5f71\u54cd\u4e5f\u53ef\u80fd\u76f8\u5bf9\u66f4\u5c0f\u3002<\/span>Keytruda\u5e76\u4e0d\u662f\u5f88\u591a\u60a3\u8005\u60f3\u8c61\u4e2d\u7684\u795e\u836f\uff0c\u514d\u75ab\u7597\u6cd5\u672a\u6765\u4e5f\u4f9d\u7136\u6709\u5f88\u957f\u7684\u8def\u8981\u8d70\u3002<\/span><\/p>\n


<\/p>\n

<\/span><\/p>\n

5\u670816-6\u67085\u65e5\u90e8\u5206ASCO\u76f8\u5173\u516c\u53f8\u5e02\u503c\u53d8\u5316 \uff08\u767e\u4e07\u7f8e\u5143\uff09<\/span><\/p>\n

<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u516c\u53f8<\/span><\/p>\n<\/td>\n

\n

\u80a1\u4ef7\u53d8\u5316<\/span><\/p>\n<\/td>\n

\n

\u5e02\u503c\u53d8\u5316<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Deciphera   Pharmaceuticals <\/span><\/p>\n<\/td>\n

\n

55%<\/span><\/p>\n<\/td>\n

\n

460<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Foundation Medicine <\/span><\/p>\n<\/td>\n

\n

33%<\/span><\/p>\n<\/td>\n

\n

995<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Northwest   Biotherapeutics <\/span><\/p>\n<\/td>\n

\n

33%<\/span><\/p>\n<\/td>\n

\n

29<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Loxo   Oncology <\/span><\/p>\n<\/td>\n

\n

31%<\/span><\/p>\n<\/td>\n

\n

1290<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Aslan  Pharmaceuticals <\/span><\/p>\n<\/td>\n

\n

29%<\/span><\/p>\n<\/td>\n

\n

61<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Immunomedics <\/span><\/p>\n<\/td>\n

\n

29%<\/span><\/p>\n<\/td>\n

\n

937<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

MEI  Pharma <\/span><\/p>\n<\/td>\n

\n

27%<\/span><\/p>\n<\/td>\n

\n

33<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Idera   Pharmaceuticals <\/span><\/p>\n<\/td>\n

\n

8%<\/span><\/p>\n<\/td>\n

\n

33<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Seattle Genetics <\/span><\/p>\n<\/td>\n

\n

8%<\/span><\/p>\n<\/td>\n

\n

720<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Immunogen <\/span><\/p>\n<\/td>\n

\n

6%<\/span><\/p>\n<\/td>\n

\n

93<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Bluebird   Bio <\/span><\/p>\n<\/td>\n

\n

6%<\/span><\/p>\n<\/td>\n

\n

564<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Fibrogen <\/span><\/p>\n<\/td>\n

\n

5%<\/span><\/p>\n<\/td>\n

\n

226<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Merck   & Co <\/span><\/p>\n<\/td>\n

\n

3%<\/span><\/p>\n<\/td>\n

\n

4412<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Bristol-Myers Squibb <\/span><\/p>\n<\/td>\n

\n

-1%<\/span><\/p>\n<\/td>\n

\n

-474<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Celgene <\/span><\/p>\n<\/td>\n

\n

-4%<\/span><\/p>\n<\/td>\n

\n

-2457<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Abbvie <\/span><\/p>\n<\/td>\n

\n

-6%<\/span><\/p>\n<\/td>\n

\n

-9204<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Roche <\/span><\/p>\n<\/td>\n

\n

-7%<\/span><\/p>\n<\/td>\n

\n

-17400<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Pharmamar <\/span><\/p>\n<\/td>\n

\n

-9%<\/span><\/p>\n<\/td>\n

\n

-42<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Celldex   Therapeutics <\/span><\/p>\n<\/td>\n

\n

-9%<\/span><\/p>\n<\/td>\n

\n

-9<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Mersana   Therapeutics <\/span><\/p>\n<\/td>\n

\n

-12%<\/span><\/p>\n<\/td>\n

\n

-47<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Blueprint Medicines <\/span><\/p>\n<\/td>\n

\n

-13%<\/span><\/p>\n<\/td>\n

\n

-486<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Tesaro <\/span><\/p>\n<\/td>\n

\n

-13%<\/span><\/p>\n<\/td>\n

\n

-347<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Dynavax   Technologies <\/span><\/p>\n<\/td>\n

\n

-18%<\/span><\/p>\n<\/td>\n

\n

-212<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Innate Pharma <\/span><\/p>\n<\/td>\n

\n

-19%<\/span><\/p>\n<\/td>\n

\n

-86<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

G1   Therapeutics <\/span><\/p>\n<\/td>\n

\n

-24%<\/span><\/p>\n<\/td>\n

\n

-381<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Syndax   Pharmaceuticals <\/span><\/p>\n<\/td>\n

\n

-30%<\/span><\/p>\n<\/td>\n

\n

-84<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Nektar   Therapeutics <\/span><\/p>\n<\/td>\n

\n

-35%<\/span><\/p>\n<\/td>\n

\n

-5114<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Noxxon   Pharma <\/span><\/p>\n<\/td>\n

\n

-35%<\/span><\/p>\n<\/td>\n

\n

-4<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Jounce   Therapeutics <\/span><\/p>\n<\/td>\n

\n

-57%<\/span><\/p>\n<\/td>\n

\n

-326<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/span>\u6570\u636e\u6765\u6e90\uff1aEP Vantage<\/span><\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u533b\u836f\u9b54\u65b9 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  \u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a (ASCO) \u5e74\u4f1a\u662f\u6bcf\u5e74\u80bf\u7624\u5b66\u9886\u57df\u6700\u91cd\u8981\u7684\u4e00\u6b21\u4f1a\u8bae\u3002ASC […]<\/p>\n","protected":false},"author":1,"featured_media":9586,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9585"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9585"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9585\/revisions"}],"predecessor-version":[{"id":9591,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9585\/revisions\/9591"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9586"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9585"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9585"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}