{"id":96266,"date":"2019-02-20T00:00:50","date_gmt":"2019-05-17T08:00:02","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/96266\/"},"modified":"2019-05-17T16:00:04","modified_gmt":"2019-05-17T08:00:04","slug":"340e245eed","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/96266\/","title":{"rendered":"K\u836f\u4e34\u5e8a\u9047\u632b \u9ed8\u6c99\u4e1c\u80a1\u4ef7\u4e0b\u8dcc\u5f15\u62c5\u5fe7"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"__bg_gif\"         width=\"auto\" style=\"text-align: center;white-space: normal;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;z-index: -1;cursor: pointer;font-size: 14px;line-height: 22.4px;width: 558px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558080003.jpeg\" alt=\"K\u836f\u4e34\u5e8a\u9047\u632b \u9ed8\u6c99\u4e1c\u80a1\u4ef7\u4e0b\u8dcc\u5f15\u62c5\u5fe7\" title=\"K\u836f\u4e34\u5e8a\u9047\u632b \u9ed8\u6c99\u4e1c\u80a1\u4ef7\u4e0b\u8dcc\u5f15\u62c5\u5fe7\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p>\u3000\u3000\u9ed8\u6c99\u4e1c\u7684Keytruda\uff08K\u836f\uff09\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684Opdivo\uff08O\u836f\uff09\u6bcb\u5eb8\u7f6e\u7591\u662f\u76ee\u524dPD-1(L1)\u514d\u75ab\u6cbb\u7597\u6297\u4f53\u836f\u7269\u9886\u57df\u7684\u4f7c\u4f7c\u8005\uff0c\u5176\u4e2dK\u836f\u5bf9O\u836f\u201c\u76f8\u7231\u76f8\u6740\u201d\u4e0a\u6f14\u7684\u5f2f\u9053\u8d85\u8f66\u5927\u620f\uff0c\u4e00\u76f4\u88ab\u4e1a\u754c\u6d25\u6d25\u4e50\u9053\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u7136\u800c\uff0c\u591a\u4e2a\u9002\u5e94\u75c7\u9886\u57df\u9891\u9891\u62a5\u559c\u7684K\u836f\uff0c\u4e5f\u540c\u6837\u906d\u9047\u5230\u4e34\u5e8a\u8bd5\u9a8c\u63a2\u7d22\u7684\u632b\u6298\u3002\u5f53\u5730\u65f6\u95f42\u670819\u65e5\uff0c\u9ed8\u6c99\u4e1c\u5b98\u65b9\u6b63\u5f0f\u5bf9\u5916\u53d1\u5e03\u9488\u5bf9\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08KEYNOTE-240\uff09\u7ed3\u679c\uff0c\u6570\u636e\u663e\u793a\uff0c\u5305\u62ec\u751f\u5b58\u671f\uff08OS\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5728\u5185\u7684\u590d\u5408\u4e3b\u8981\u7597\u6548\u6307\u6807\uff08Co-Primary endpoint\uff09\uff0c\u5747\u672a\u80fd\u8fbe\u5230\u8bd5\u9a8c\u4e34\u5e8a\u7ec8\u70b9\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558080003.jpeg\" alt=\"K\u836f\u4e34\u5e8a\u9047\u632b \u9ed8\u6c99\u4e1c\u80a1\u4ef7\u4e0b\u8dcc\u5f15\u62c5\u5fe7\" title=\"K\u836f\u4e34\u5e8a\u9047\u632b \u9ed8\u6c99\u4e1c\u80a1\u4ef7\u4e0b\u8dcc\u5f15\u62c5\u5fe7\"  \/><\/p>\n<p>\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"border-left: 5px solid #ef7060;font-weight: bold;line-height: 32px;color: #666666;padding: 5px 10px;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: #ef7060;\">\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: #ef7060;\">\u6ca1\u6709\u7edf\u8ba1\u5b66\u5dee\u5f02<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p>\u3000\u3000<br  \/><\/p>\n<p>\u3000\u3000\u9ed8\u6c99\u4e1c\u5b98\u65b9\u8d44\u6599\u4fe1\u606f\u663e\u793a\uff0cKEYNOTE-240\u662f\u4e00\u9879\u2162\u671f\u3001\u968f\u673a\u3001\u53cc\u76f2\u8bd5\u9a8c\uff08ClinicalTrials.gov\uff0cNCT02702401\uff09\uff0c\u603b\u8ba1\u5165\u7ec4413\u540d\u60a3\u8005\uff0c\u7814\u7a76\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u8bc4\u4f30K\u836f+\u6700\u4f73\u652f\u6301\u6cbb\u7597\u4e0e\u5b89\u6170\u5242+\u6700\u4f73\u652f\u6301\u6cbb\u7597\u7684\u665a\u671f\u809d\u764c\u60a3\u8005\u505a\u7597\u6548\u5bf9\u6bd4\uff0c\u4e3b\u8981\u7ec8\u70b9\u662f\u603b\u751f\u5b58\u671f\uff08OS\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3001\u7f13\u89e3\u6301\u7eed\u65f6\u95f4(DOR)\u3001\u75be\u75c5\u63a7\u5236\u7387(DCR)\u548c\u80bf\u7624\u8fdb\u5c55\u65f6\u95f4\uff08TTP\uff09\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u5728\u8be5\u7814\u7a76\u7684\u6700\u7ec8\u6570\u636e\u5206\u6790\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u4f7f\u7528K\u836f\u6cbb\u7597\u7684\u60a3\u8005OS\u6709\u6240\u6539\u5584\uff0c\u4f46\u662f\u8fd9\u4e00\u6570\u636e\u5e76\u672a\u80fd\u6ee1\u8db3\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u5dee\u5f02\uff08HR = 0.78 [95\uff05CI\uff0c0.611- 0.998]; p = 0.0238\uff09\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0cK\u836f\u7ec4\u7684PFS\u7ed3\u679c\u4e5f\u663e\u793a\u51fa\u6539\u5584\uff0c\u4f46\u540c\u6837\u6ca1\u6709\u663e\u793a\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08HR = 0.78 [95\uff05CI\uff0c0.61-0.99]; p = 0.0209\uff09\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u9664\u6b64\u4e4b\u5916\uff0c\u7531\u4e8e\u8bd5\u9a8c\u7ed3\u679c\u6ca1\u6709\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u76f8\u6bd4\u5b89\u6170\u5242\u800c\u8a00\u8bd5\u9a8c\u6570\u636e\u6ca1\u6709\u53d6\u5f97\u4f18\u52bf\uff0c\u56e0\u6b64\u6ca1\u6709\u5206\u6790ORR\u7b49\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u800c\u836f\u7269\u5b89\u5168\u6027\u4e0e\u6b64\u524dK\u836f\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u544a\u7684\u7814\u7a76\u7ed3\u679c\u4fdd\u6301\u4e00\u81f4\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4e8b\u5b9e\u4e0a\uff0c\u4e1a\u5185\u5bf9\u4e8eK\u836f\u5728\u809d\u764c\u6cbb\u7597\u9886\u57df\u7684\u671f\u5f85\u4e0d\u662f\u6ca1\u6709\u6839\u636e\u3002\u53bb\u5e742018 ASCO GI\u5927\u4f1a\uff0c\u62a5\u544a\u4e86Keynote-224\u8bd5\u9a8c\uff0c\u8be5\u2161\u671f\u8bd5\u9a8cK\u836f\u7528\u4e8e\u4e00\u7ebf\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u8fdb\u5c55\u540e\u665a\u671fHCC\u60a3\u8005\uff0c\u7ed3\u679c\u663e\u793a\uff0cORR\u4e3a16.3%\uff0c\u4e2d\u4f4dPFS\u4e3a8\u4e2a\u6708\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u53bb\u5e747\u6708\uff0cKeytruda\u51ed\u501fKeynote-224\u8bd5\u9a8c\u7ed3\u679c\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\uff0c\u5e76\u572811\u6708\u4efd\u83b7\u6279\u589e\u52a0\u65b0\u9002\u5e94\u75c7\uff0c\u7528\u4e8e\u6cbb\u7597\u5df2\u63a5\u53d7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4ec5\u4ec5\u8fc7\u53bb\u4e0d\u52304\u4e2a\u6708\uff0c\u4e00\u5e06\u98ce\u987a\u7684K\u836f\u5c31\u5728\u809d\u764c\u9886\u57df\u9047\u632b\uff0c\u8fd9\u53ef\u80fd\u4f1a\u5bf9\u5176\u5feb\u901f\u589e\u957f\u7684\u9500\u552e\u524d\u666f\u9020\u6210\u538b\u529b\u3002<\/p>\n<p>\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"border-left: 5px solid #ef7060;font-weight: bold;line-height: 32px;color: #666666;padding: 5px 10px;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: #ef7060;\">\u91cd\u78c5\u54c1\u79cd\u75af\u72c2\u6492\u7f51<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: #ef7060;\">\u5927\u764c\u79cd\u63a2\u7d22\u6301\u7eed<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p>\u3000\u3000<br  \/><\/p>\n<p>\u3000\u3000\u4eca\u5e742\u6708\uff0c\u9ed8\u6c99\u4e1c\u516c\u5e032018\u5e74\u8d22\u62a5\uff0c\u5168\u5e74\u8425\u6536423\u4ebf\u7f8e\u5143\uff0c\u5176\u4e2d\u5236\u836f\u4e1a\u52a1\u6536\u5165376.89\u4ebf\u7f8e\u5143\uff1b\u91cd\u78c5\u54c1\u79cdKeytruda\u5feb\u901f\u5d1b\u8d77\uff0c\u5168\u5e74\u9500\u552e\u989d\u8fbe\u523071.71\u4ebf\u7f8e\u5143\uff0c\u5b9e\u73b0\u4e86\u5bf9\u201cO\u836f\u201d\u7684\u8d85\u8d8a\u3002\u4e1a\u5185\u751a\u81f3\u4e50\u89c2\u9884\u8ba1\uff0cK\u836f\u5c06\u57282019\u5e74\u8de8\u5165\u201c\u767e\u4ebf\u91cd\u78c5\u201d\u95e8\u69db\uff0c\u800c\u8fd9\u4ec5\u4ec5\u82b1\u8d39\u4e86\u4e0d\u52306\u5e74\u65f6\u95f4\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u76ee\u524d\uff0c\u5728\u80ba\u764c\u6cbb\u7597\u9886\u57df\uff0cK\u836f\u56e0\u4e3a\u62e5\u6709\u4e00\u7ebf\u201c\u6807\u7b7e\u201d\u5df2\u7ecf\u5360\u5c71\u4e3a\u738b\uff0c\u8986\u76d6\u4e86EGFR+\uff0fALK+\u5916\u7684\u6240\u6709\u2163\u671f\u80ba\u764c\u60a3\u8005\uff1b\u6b64\u5916\uff0c\u8fd1\u671f\u53d1\u5e03\u7684Keytruda+\u963f\u6614\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u2162\u671fKEYNOTE-426\u7814\u7a76\u4e5f\u5c55\u793a\u51fa\u7684\u79ef\u6781\u6570\u636e\uff0c\u4ee4K\u836f\u518d\u5ea6\u5c55\u73b0\u738b\u8005\u4e4b\u6c14\uff0c\u52bf\u5982\u7834\u7af9\u653b\u4e0b\u80be\u764c\u4e00\u7ebf\uff0c\u6709\u671b\u201c\u8d62\u5bb6\u901a\u5403\u201d\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4e0e\u4e4b\u5f62\u6210\u9c9c\u660e\u5bf9\u6bd4\uff0c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\uff08IO\uff09\u9886\u57df\u5728\u521a\u521a\u8fc7\u53bb\u76842018\u5e74\u53ef\u4ee5\u8bf4\u4e0d\u662f\u5927\u5e74\uff0c\u56f4\u7ed5\u591a\u4e2a\u5927\u764c\u79cd\u6cbb\u7597\u9886\u57df\u7684\u63a2\u7d22\u5747\u5931\u8d25\u544a\u7ec8\uff1a\u5fb7\u56fd\u9ed8\u514b\/\u8f89\u745e\u5ba3\u5e03Avelumab\u7684\u2162\u671fJAVELIN Lung 200\u7814\u7a76\u672a\u80fd\u5230\u8fbe\u4e3b\u8981\u7ec8\u70b9\uff0cAvelumab\u4f5c\u4e3a\u4e8c\u7ebf\u7597\u6cd5\u76f8\u6bd4\u591a\u897f\u4ed6\u8d5b\u672a\u80fd\u663e\u8457\u6539\u5584PD-L1\u9633\u6027\u80ba\u764c\uff08PD-L1\u8868\u8fbe\u6c34\u5e73\u22651%\uff09\u60a3\u8005\u7684OS\uff1b\u963f\u65af\u5229\u5eb7\u5ba3\u5e03Imfinzi\u4e00\u7ebf\u6cbb\u7597\u2163\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76MYSTIC\u672a\u80fd\u663e\u8457\u5ef6\u957fOS\uff1b\u7f57\u6c0f\u4ece\u7f8e\u56fd\u3001\u6b27\u76df\u64a4\u56de\u4e86Tecentriq\u8054\u5408Avastin\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\uff08RCC\uff09\u7684\u76d1\u7ba1\u7533\u8bf7\u2026\u2026<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u67d0\u79cd\u7a0b\u5ea6\u6765\u770b\uff0c\u9ed8\u6c99\u4e1c\u4e00\u76f4\u4ee5\u6765\u7684\u4e34\u5e8a\u7b56\u7565\u7a76\u7adf\u662f\u4ec0\u4e48\u539f\u56e0\u4fc3\u4f7f\u5176\u80fd\u591f\u5728\u51e0\u4e4e\u5b8c\u5168\u7a7a\u767d\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u83b7\u5f97\u5982\u6b64\u4f17\u591a\u7684\u9002\u5e94\u75c7\u5f00\u53d1\u6210\u679c\uff0c\u96be\u4ee5\u4ee4\u4e1a\u754c\u53c2\u900f\u3002\u6709\u4e00\u79cd\u58f0\u97f3\u8ba4\u4e3a\uff0c\u6b63\u662f\u7531\u4e8e\u9ed8\u6c99\u4e1c\u5728\u80bf\u7624\u9886\u57df\u8fc7\u53bb\u6ca1\u6709\u5f3a\u52bf\u54c1\u79cd\uff0c\u5b64\u6ce8\u4e00\u63b7\u62bc\u5b9dK\u836f\uff0c\u5168\u529b\u4ee5\u8d74\u75af\u72c2\u6492\u7f51\uff0c\u5916\u5ef6\u5c3d\u53ef\u80fd\u4e30\u5bcc\u7684\u7597\u6cd5\u7ec4\u5408\uff0c\u6700\u7ec8\u4ee4\u5176\u9669\u4e2d\u5f97\u80dc\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4e0d\u8fc7\uff0c\u4e0e\u5e74\u62a5\u62ab\u9732\u7684\u4e50\u89c2\u5f62\u52bf\u5f62\u6210\u9c9c\u660e\u53cd\u5dee\uff0c\u8d44\u672c\u5e02\u573a\u662f\u6b8b\u9177\u4e14\u53cd\u5e94\u8fc5\u901f\u7684\uff0c\u5c31\u5728\u9ed8\u6c99\u4e1c\u516c\u5e03\u809d\u764c\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4e4b\u540e\uff0c\u516c\u53f8\u80a1\u4ef7\u8fc5\u901f\u4e0b\u8dcc\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u8d44\u672c\u5e02\u573a\u7684\u62c5\u5fe7\u4e0d\u65e0\u9053\u7406\u3002\u5c31\u5728\u51e0\u5468\u524d\uff0c\u793c\u6765\u516c\u5e03\u4e86\u6297\u764c\u836fLartruvo\u786e\u8bc1\u6027\u2162\u671f\u4e34\u5e8a\u7814\u7a76ANNOUNCE\u7684\u7ed3\u679c\uff0cLartruvo\u4e0e\u963f\u9709\u7d20\u7ec4\u5408\u7597\u6cd5\u672a\u80fd\u8868\u73b0\u51fa\u4e34\u5e8a\u7597\u6548\uff0c\u5bfc\u81f4\u793c\u6765\u4e0d\u5f97\u4e0d\u8003\u8651\u6682\u505cLartruvo\u7684\u8425\u9500\uff0c\u8fdb\u4e00\u6b65\u548c\u7f8e\u56fdFDA\u6c9f\u901a\u4ea7\u54c1\u4e8b\u5b9c\u3002\u4e0eK\u836f\u76f8\u4f3c\uff0cLartruvo\u4e5f\u662f\u901a\u8fc7\u2161\u671f\u8bd5\u9a8c\u7ed3\u679c\u83b7\u5f97\u4f18\u5148\u5ba1\u8bc4\u5f97\u4ee5\u5feb\u901f\u83b7\u6279\u9002\u5e94\u75c7\u3002<\/p>\n<p 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