{"id":96579,"date":"2019-03-06T00:00:50","date_gmt":"2019-05-17T08:02:10","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/96579\/"},"modified":"2019-05-17T16:02:12","modified_gmt":"2019-05-17T08:02:12","slug":"9be7c54948","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/96579\/","title":{"rendered":"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;text-align: center;\"><img class=\"__bg_gif\"         width=\"auto\" style=\"letter-spacing: 0.544px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;z-index: -1;cursor: pointer;font-size: 14px;line-height: 22.4px;width: 558px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558080130.jpeg\" alt=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\" title=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u8fc7\u53bb\u4e8c\u5341\u5e74\uff0c\u4eba\u7c7b\u9057\u4f20\u5b66\u3001\u57fa\u56e0\u7ec4\u5b66\u3001\u751f\u7269\u4fe1\u606f\u5b66\u7b49\u9886\u57df\u7684\u53d1\u5c55\u4e3a\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\u5960\u5b9a\u4e86\u57fa\u7840\uff0c\u73b0\u4ee3\u533b\u5b66\u7814\u7a76\u5b9e\u73b0\u4e86\u524d\u6240\u672a\u6709\u7684\u5de8\u5927\u98de\u8dc3\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u75be\u75c5\u6cbb\u7597\u5f00\u59cb\u6539\u53d8\u4f20\u7edf\u7684\u5916\u90e8\u5e72\u9884\u65b9\u5f0f\uff0c\u8f6c\u800c\u7814\u7a76\u901a\u8fc7\u8c03\u52a8\u4eba\u4f53\u5185\u5728\u673a\u5236\u6765\u6cbb\u7597\u75be\u75c5\u3002<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u5728\u4f17\u591a\u7814\u7a76\u9886\u57df\u4e2d\uff0c\u4eba\u4f53\u5185\u5728\u7684\u6c27\u6c14\u8c03\u8282\u673a\u5236\u4e00\u76f4\u4ee5\u6765\u662f\u79d1\u5b66\u5bb6\u4eec\u91cd\u70b9\u7814\u7a76\u7684\u5bf9\u8c61\u3002\u8eab\u4f53\u5185\u7684\u7ec6\u80de\u548c\u7ec4\u7ec7\u5982\u4f55\u8c03\u8282\u548c\u9002\u5e94\u6c27\u6c14\u6c34\u5e73\u7684\u53d8\u5316\uff1f\u76f4\u81f320\u4e16\u7eaa90\u5e74\u4ee3\uff0cHIF\uff08\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff09\u901a\u8def\u88ab\u53d1\u73b0\uff0c\u8c1c\u9898\u624d\u88ab\u89e3\u5f00\u3002<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"margin-top: 10px;margin-bottom: 10px;padding: 5px 10px;border-left: 5px solid rgb(239, 112, 96);font-weight: bold;line-height: 32px;color: rgb(102, 102, 102);box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: rgb(239, 112, 96);\">\u521b\u65b0HIF\u673a\u5236\u5982\u4f55\u88ab\u53d1\u73b0\uff1f<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\">\u3000\u3000<br  \/><\/p>\n<p style=\"white-space: normal;\">\u3000\u30001992\u5e74, \u7f8e\u56fd\u79d1\u5b66\u5bb6Gregg Semenza\u5728\u52a8\u7269\u7ec6\u80de\u5185\u9996\u6b21\u53d1\u73b0\u4e00\u79cd\u5728\u4f4e\u6c27\u6761\u4ef6\u4e0b\u53ef\u589e\u52a0\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08EPO\uff09\u8f6c\u5f55\u7684\u86cb\u767d\u2014HIF-1\uff0c\u52a8\u7269\u7ec6\u80de\u5185\u5728\u6c27\u6c14\u8c03\u8282\u673a\u5236HIF\u9996\u6b21\u8fdb\u5165\u4eba\u7c7b\u89c6\u91ce\u30022002\u5e74\uff0c\u7f8e\u56fd\u79d1\u5b66\u5bb6William Kaelin \u548c\u82f1\u56fd\u79d1\u5b66\u5bb6Peter Ratcliff\u7684\u56e2\u961f\u53d1\u73b0\u812f\u6c28\u9170\u7f9f\u5316\u9176\uff08PHD\uff09\u80fd\u591f\u8c03\u8282HIF\u7684\u6d3b\u6027\u548c\u7a33\u5b9a\u6027\uff0c\u662f\u6253\u901aHIF\u901a\u8def\u7684\u201c\u5f00\u5173\u201d<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">1<\/span><\/sup>\u3002<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u7814\u7a76\u53d1\u73b0\uff0cHIF-1\u4e3b\u8981\u7531HIF-1\u03b1\u548cHIF-1\u03b2\u4e24\u4e2a\u4e9a\u5355\u4f4d\u7ec4\u6210\u3002\u6b63\u5e38\u6c27\u542b\u91cf\u6761\u4ef6\u4e0b\uff0cHIF-1\u03b1\u4f1a\u900f\u8fc7PHD\u7f9f\u57fa\u5316\uff0c\u88ab\u6cdb\u7d20\u4e00\u86cb\u767d\u9176\u6c34\u89e3\u590d\u5408\u4f53\u964d\u89e3\u3002\u5728\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0cPHD\u88ab\u6291\u5236\uff0cHIF-1\u7a33\u5b9a\u8868\u8fbe\uff0c\u8fdb\u800c\u53d1\u6325\u5176\u8c03\u8282\u591a\u79cd\u57fa\u56e0\u7684\u8f6c\u5f55\u7684\u4f5c\u7528<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">2<\/span><\/sup>\u3002<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u5168\u65b0HIF\u673a\u5236\u7684\u53d1\u73b0\u4e0d\u4ec5\u5e2e\u52a9\u79d1\u5b66\u5bb6\u8fdb\u4e00\u6b65\u4e86\u89e3\u8eab\u4f53\u7684\u5185\u5728\u673a\u5236\uff0c\u66f4\u4e3a\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5982\u8d2b\u8840\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u764c\u75c7\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u601d\u8def<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">3<\/span><\/sup>\u30022016\u5e74\uff0cGregg Semenza\u3001William Kaelin\u548cPeter Ratcliff\u4e5f\u56e0\u53d1\u73b0HIF\u901a\u8def\u800c\u83b7\u5f97Lasker\u57fa\u7840\u533b\u5b66\u5956\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558080131.jpg\" alt=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\" title=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;color: rgb(79, 129, 189);\">\u4ece\u5de6\u81f3\u53f3\u5206\u522b\u662fGregg L. Semenza\uff0cWilliam G. Kaelin, Jr.Peter J. Ratcliffe<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\uff08\u56fe\u7247\u6765\u6e90\uff1alaskerfoundation.org\uff09<\/span><\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"margin-top: 10px;margin-bottom: 10px;padding: 5px 10px;border-left: 5px solid rgb(239, 112, 96);font-weight: bold;line-height: 32px;color: rgb(102, 102, 102);box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: rgb(239, 112, 96);\">HIF\u673a\u5236\u4e34\u5e8a\u5e94\u7528\u9996\u4e2a\u7a81\u7834\uff1a<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: rgb(239, 112, 96);\">\u80be\u6027\u8d2b\u8840\u6cbb\u7597<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\">\u3000\u3000<br  \/><\/p>\n<p style=\"white-space: normal;\">\u3000\u3000HIF\u673a\u5236\u5df2\u88ab\u53d1\u73b0\uff0c\u5982\u4f55\u5c06HIF\u673a\u5236\u771f\u6b63\u5e94\u7528\u4e8e\u4e34\u5e8a\u533b\u5b66\u968f\u5373\u6210\u4e3a\u503c\u5f97\u63a2\u7d22\u7684\u5168\u65b0\u9886\u57df\u3002\u5176\u4e2d\uff0cHIF-\u812f\u6c28\u9170\u7f9f\u5316\u9176\u7814\u7a76\u5e73\u53f0\u5960\u57fa\u4eba\u4e4b\u4e00\u7684\u6797\u8dc3\u535a\u58eb\u548c\u5176\u56e2\u961f\uff0c\u82b1\u8d39\u4e86\u591a\u5e74\u65f6\u95f4\u7814\u7a76HIF-PHD\u53ca\u5176\u6291\u5236\u5242\u7684\u5e94\u7528\uff0c\u6700\u7ec8\u5728\u8d2b\u8840\u6d4b\u8bd5\u4e2d\u627e\u5230\u4e86\u7b54\u6848\uff1a\u201c\u6211\u4eec\u505a\u8840\u6db2\u8bd5\u9a8c\u7684\u65f6\u5019\uff0c\u4e5f\u60f3\u5230\u4e86\u505a\u8d2b\u8840\u7684\u6d4b\u8bd5\u3002\u5b9e\u9a8c\u4e2d\u95f4\uff0c\u767d\u9f20\u7684\u989c\u8272\u90fd\u662f\u767d\u8272\u7684\uff0c\u6e10\u6e10\u5b83\u7684\u76ae\u80a4\u5f00\u59cb\u53d8\u7ea2\uff0c\u767d\u91cc\u900f\u7ea2\u800c\u4e14\u8d8a\u900f\u8d8a\u7ea2\uff0c\u9ad8\u5242\u91cf\u7684\u66f4\u7ea2\u3002\u6211\u4eec\u5c31\u77e5\u9053\uff0c\u6709\u7ed3\u679c\u4e86\u3002\u201d<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u812f\u6c28\u9170\u7f9f\u5316\u9176\u6291\u5236\u5242\uff08HIF-PHI\uff09\u80fd\u6a21\u62df\u4eba\u4f53\u5185\u5728\u7684\u751f\u7406\u72b6\u6001\uff0c\u901a\u8fc7\u6291\u5236PHD\u800c\u6fc0\u6d3bHIF\u901a\u8def\uff0c\u523a\u6fc0\u809d\u810f\u5408\u6210EPO\uff0c\u540c\u65f6\u8fd8\u80fd\u901a\u8fc7\u6291\u5236\u94c1\u8c03\u7d20\u800c\u589e\u52a0\u94c1\u7684\u5438\u6536\u4e0e\u5229\u7528\uff0c\u8fd9\u4e00\u7279\u70b9\u5bf9\u4e8e\u6162\u6027\u80be\u810f\u75c5\uff08CKD\uff09\u60a3\u8005\u7684\u8d2b\u8840\u7ea0\u6b63\u5177\u6709\u91cd\u8981\u610f\u4e49<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">4<\/span><\/sup>\uff0c\u8fd9\u4e5f\u542f\u53d1\u4e86\u7814\u7a76\u8005\u5c06\u80be\u6027\u8d2b\u8840\u6cbb\u7597\u4f5c\u4e3aHIF\u4e34\u5e8a\u5e94\u7528\u7814\u7a76\u7684\u91cd\u8981\u7a81\u7834\u65b9\u5411\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558080131.jpg\" alt=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\" title=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;color: rgb(79, 129, 189);\">HIF-PHI\u5206\u5b50\u5f0f<\/span><\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"margin-top: 10px;margin-bottom: 10px;padding: 5px 10px;border-left: 5px solid rgb(239, 112, 96);font-weight: bold;line-height: 32px;color: rgb(102, 102, 102);box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: rgb(239, 112, 96);\">30\u5e74\u672a\u6709\u521b\u65b0\u7597\u6cd5\uff0c<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: rgb(239, 112, 96);\">\u80be\u6027\u8d2b\u8840\u6cbb\u7597\u8fbe\u6807\u7387\u4f4e\u4e0b<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\">\u3000\u3000<br  \/><\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u80be\u6027\u8d2b\u8840\u662fCKD\u60a3\u8005\u5e38\u89c1\u7684\u5e76\u53d1\u75c7\u4e4b\u4e00\uff0c\u4e3b\u8981\u6307\u7531\u4e8e\u80be\u529f\u80fd\u7684\u8870\u9000\u548c\u94c1\u4ee3\u8c22\u7684\u7d0a\u4e71\u5f15\u8d77EPO\u7684\u76f8\u5bf9\u6216\u7edd\u5bf9\u4e0d\u8db3<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">5<\/span><\/sup>\u3002\u8c03\u67e5\u663e\u793a\uff0c\u4e2d\u56fd\u900f\u6790\u60a3\u8005\u4e2d\uff0c\u8d2b\u8840\u6cbb\u7597\u5e73\u5747\u8fbe\u6807\u6bd4\u4f8b\u53ea\u670921.3%<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">6<\/span><\/sup>&nbsp;\u3002\u4f20\u7edf\u7684\u80be\u6027\u8d2b\u8840\u6cbb\u7597\u4e2d\uff0c\u901a\u8fc7\u6ce8\u5c04\u4fc3\u7ea2\u7d20\u3001\u94c1\u5242\u8865\u5145\u548c\u8f93\u8840\u8fd9\u6837\u7684\u5916\u90e8\u65b9\u5f0f\u4e3a\u60a3\u8005\u8865\u5145EPO\uff0c\u4f46\u662f\u8fd9\u4e9b\u6cbb\u7597\u624b\u6bb5\u5b58\u5728\u4e00\u5b9a\u5c40\u9650\u3002<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u5bf9\u4e8e\u4f20\u7edf\u6cbb\u7597\u624b\u6bb5\u6cbb\u7597\u8fbe\u6807\u7387\u4f4e\u7684\u539f\u56e0\uff0c\u7a7a\u519b\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u7684\u5b59\u4e16\u4ec1\u6559\u6388\u89e3\u91ca\uff0c\u7531\u4e8e\u80be\u6027\u8d2b\u8840\u75c5\u56e0\u590d\u6742\uff0c\u53d1\u751f\u673a\u5236\u5e76\u4e0d\u9650\u4e8e EPO \u4e0d\u8db3\uff0c\u8fd8\u53d7\u5f88\u591a\u5176\u5b83\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u4f8b\u5982\u708e\u75c7\u548c\u94c1\u7684\u5438\u6536\u3002\u73b0\u6709\u6cbb\u7597\u65b9\u6848\u5b58\u5728\u4e00\u5b9a\u5c40\u9650\u6027\uff0c\u4e34\u5e8a\u4f7f\u7528\u65f6\u4e5f\u5b58\u5728\u7528\u836f\u5b89\u5168\u6027\u8003\u91cf\u3002\u56e0\u6b64\uff0c\u7a81\u7834\u73b0\u6709\u6cbb\u7597\u836f\u7269\u7684\u5c40\u9650\u6027\uff0c\u53d1\u5c55\u5168\u65b0\u673a\u5236\u7684\u6cbb\u7597\u836f\u7269\u975e\u5e38\u6709\u5fc5\u8981<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">7<\/span><\/sup>\u3002<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u534e\u5c71\u533b\u9662\u6797\u5584\u952c\u6559\u6388\u6307\u51fa\uff0c\u542f\u52a8\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u53ef\u4ee5\u7ea0\u6b63CKD\u8d2b\u8840\uff0c\u51cf\u8f7b\u591a\u79cd\u80be\u810f\u75be\u75c5\u52a8\u7269\u6a21\u578b\u75c5\u53d8\u7a0b\u5ea6\u3002\u5bf9\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u7684\u7814\u7a76\uff0c\u4ee5\u53ca\u9776\u70b9\u836f\u7269\u7684\u7814\u53d1\uff0c\u5728\u80be\u810f\u75c5\u7684\u6cbb\u7597\u65b9\u9762\u5177\u6709\u8f83\u5927\u524d\u666f<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">8<\/span><\/sup>\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558080131.jpg\" alt=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\" title=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;color: rgb(79, 129, 189);\">\u6797\u5584\u952c\u6559\u6388<\/span><\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"margin-top: 10px;margin-bottom: 10px;padding: 5px 10px;border-left: 5px solid rgb(239, 112, 96);font-weight: bold;line-height: 32px;color: rgb(102, 102, 102);box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: rgb(239, 112, 96);\">HIF-PHI\u4e34\u5e8a\u4f18\u52bf\u663e\u8457\uff0c<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 18px;\"><strong style=\"caret-color: red;\"><span style=\"color: rgb(239, 112, 96);\">\u9769\u65b0\u80be\u6027\u8d2b\u8840\u6cbb\u7597<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\">\u3000\u3000<br  \/><\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u76ee\u524d\uff0c\u57fa\u4e8eHIF\u673a\u5236\u7684HIF-PHI\u7c7b\u836f\u7269\u5df2\u9646\u7eed\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u5176\u4e2d\uff0c\u7f57\u6c99\u53f8\u4ed6\u7387\u5148\u5728\u4e2d\u56fd\u5b8c\u6210\u4e34\u5e8a\u8bd5\u9a8c\u5e76\u4e14\u83b7\u6279\uff0c\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u80be\u75c5\u900f\u6790\u60a3\u8005\u7684\u80be\u6027\u8d2b\u8840\u6cbb\u7597\uff0c\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u83b7\u6279\u7684\u57fa\u4e8eHIF\u673a\u5236\u7684\u521b\u65b0\u836f\u3002<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000\u5728\u89e3\u8bfb\u7f57\u6c99\u53f8\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u65f6\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662\u9648\u6960\u6559\u6388\u4ecb\u7ecd\uff0c\u7f57\u6c99\u53f8\u4ed6\u5bf9\u4e8e\u900f\u6790\u548c\u975e\u900f\u6790\u60a3\u8005\u90fd\u53ef\u4ee5\u5e73\u7a33\u5347\u9ad8\u8840\u7ea2\u86cb\u767d\uff08Hb\uff09\uff0c\u6709\u6548\u6027\u4e0d\u53d7\u708e\u75c7\u72b6\u6001\u5f71\u54cd\uff0c\u964d\u4f4e\u94c1\u8c03\u7d20\u6c34\u5e73\uff0c\u5e76\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u6709\u6548\u4e14\u5b89\u5168\u5730\u7ea0\u6b63\u8d2b\u8840<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">9<\/span><\/sup>\u3002\u540c\u65f6\uff0c\u7f57\u6c99\u53f8\u4ed6\u91c7\u53d6\u53e3\u670d\u65b9\u5f0f\u51cf\u8f7b\u6cbb\u7597\u75db\u82e6\uff0c\u5c06\u6709\u52a9\u4e8e\u63d0\u9ad8\u60a3\u8005\u6cbb\u7597\u4f9d\u4ece\u6027\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558080131.jpg\" alt=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\" title=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;color: rgb(79, 129, 189);\">\u9648\u6960\u6559\u6388\u57282018 \u7f8e\u56fd\u80be\u810f\u5b66\u4f1a\uff08ASN\uff09\u80be\u810f\u75c5\u5468\u4e0a\u5206\u4eab\u7f57\u6c99\u53f8\u4ed6\u4e2d\u56fd\u4e09\u671f\u4e34\u5e8a\u7ed3\u679c<\/span><\/p>\n<p style=\"white-space: normal;\">\u3000\u3000<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000HIF-PHI\u7c7b\u836f\u7269\u5728\u80be\u6027\u8d2b\u8840\u4e34\u5e8a\u6cbb\u7597\u4e2d\u7684\u6210\u529f\u5e94\u7528\uff0c\u4e3aHIF\u673a\u5236\u5728\u5176\u4ed6\u75be\u75c5\u9886\u57df\u7684\u5e94\u7528\u5e26\u6765\u66f4\u591a\u53ef\u80fd\u6027\u3002\u4e00\u4e9b\u7814\u7a76\u62a5\u9053\u8868\u660e\uff0cHIF-PHI\u6216\u5c06\u4f7f\u5176\u4ed6\u75be\u75c5\u9886\u57df\u83b7\u76ca\uff0c\u5982\uff1a\u7f3a\u8840\u7f3a\u6c27\u635f\u4f24\uff0c\u611f\u67d3\u3001\u4f24\u53e3\u6108\u5408\u3001\u708e\u75c7\uff0c\u708e\u6027\u75be\u75c5\u548c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7b49<sup><span style=\"font-size: 14px;font-family: Calibri, sans-serif;\">10<\/span><\/sup>\u3002\u6b64\u5916\uff0c\u6797\u5584\u7430\u6559\u6388\u8868\u793a\uff0cHIF\u673a\u5236\u8fd8\u6709\u5f88\u5927\u7684\u4e34\u5e8a\u6f5c\u80fd\u5c1a\u672a\u6316\u6398\uff0c\u4f8b\u5982\u964d\u4f4e\u8840\u8102\u548c\u80c6\u56fa\u9187\uff0c\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7597\u548c\u6025\u6027\u5927\u624b\u672f\u540e\u80be\u529f\u80fd\u6062\u590d\u7b49\uff0c\u8fd9\u4e9b\u90fd\u662f\u53ef\u4ee5\u5c55\u671b\u7684\u65b9\u5411\u3002<\/p>\n<p style=\"white-space: normal;\">\u3000\u3000<\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u672c\u6587\u4f5c\u8005\uff1a\u5f20\u4f36\u4fd0\uff0c\u4e1c\u90e8\u6218\u533a\u603b\u533b\u9662\u836f\u54c1\u79d1\uff0c\u4e3b\u7ba1\u836f\u5e08\uff1b\u989c\u5efa\u5468\uff0c\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u56fd\u5bb6\u7814\u7a76\u4e2d\u5fc3\uff0c\u8bb2\u5e08\uff09<\/span><\/p>\n<p style=\"white-space: normal;text-align: left;\"><br  \/><\/p>\n<section class=\"_135editor\"  style=\"white-space: normal;border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"margin: 0.5em 1em 1em;overflow: hidden;\">\n<section style=\"padding-bottom: 0.4em;border-bottom: 1px solid rgb(0, 0, 0);\">\n<section style=\"padding-left: 0.2em;border-left: 0.2em solid rgb(224, 38, 58);\"><span style=\"font-size: 19px;line-height: 30.72px;\"><strong>&nbsp;\u53c2\u8003\u6587\u732e<\/strong><\/span><\/section>\n<\/section>\n<section class=\"135brush\" style=\"margin-top: 1em;\">\n<p><br  \/><\/p>\n<p><span style=\"font-size: 15px;\">1.Jillian H. Hurst . William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award. J Clin Invest. 2016;126(10):3628-3638.&nbsp;<\/span><\/p>\n<p><span style=\"font-size: 15px;\">2.Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda). 2004, 19 (4): 176\u201382<\/span><\/p>\n<p><span style=\"font-size: 15px;\">3.Jillian H. Hurst . William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award. J Clin Invest. 2016;126(10):3628-3638.&nbsp;<\/span><\/p>\n<p><span style=\"font-size: 15px;\">4.\u6ed5\u83f2, \u674e\u96ea\u6885. \u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u4e0e\u80be\u6027\u8d2b\u8840[J]. \u4e2d\u534e\u80be\u810f\u75c5\u6742\u5fd7, 2017, 33(1):63<\/span><\/p>\n<p><span style=\"font-size: 15px;\">5.\u4f59\u96ef\u67ab, \u4f59\u6bc5. \u80be\u6027\u8d2b\u8840\u7684\u8bca\u6cbb\u8fdb\u5c55[J]. \u4e16\u754c\u4e34\u5e8a\u836f\u7269, 2018<\/span><\/p>\n<p><span style=\"font-size: 15px;\">6.\u5f20\u51ac\uff0c\u5168\u56fd\u8840\u6db2\u900f\u6790\u75c5\u4f8b\u4fe1\u606f\u767b\u8bb0\u7cfb\u7edf\u7684\u5efa\u7acb\u53ca\u8840\u6db2\u900f\u6790\u60a3\u8005\u8d2b\u8840\u6cbb\u7597\u60c5\u51b5\u5206\u6790\uff0c\u9648\u9999\u7f8e\u4e3b\u7f16\uff0c\u5185\u79d1\u5b66\uff08\u80be\u75c5\uff09\uff1a\u519b\u533b\u8fdb\u4fee\u5b66\u9662 \u89e3\u653e\u519b\u603b\u533b\u9662\uff0c\u519b\u533b\u8fdb\u4fee\u5b66\uff0c2012<\/span><\/p>\n<p><span style=\"font-size: 15px;\">7.\u80be\u5185\u65f6\u95f4\uff0cHIF \u6765\u4e86\uff01| \u5341\u95ee\u5341\u7b54\uff0c\u4e86\u89e3\u80be\u6027\u8d2b\u8840\u8bca\u6cbb\u73b0\u72b6\uff0chttp:\/\/www.sohu.com\/a\/280335514_685374\uff0c2018<\/span><\/p>\n<p><span style=\"font-size: 15px;\">8.\u533b\u8109\u901a\u80be\u5185\u9891\u9053\uff0c\u80be\u6027\u8d2b\u8840\u6cbb\u7597\u9886\u57df\u7684\u65b0\u8fdb\u5c55\u2014\u2014\u80be\u6027\u8d2b\u8840\u4e0d\u4ec5\u4ec5\u662fEPO\u548c\u94c1\u7f3a\u4e4f\uff0chttps:\/\/mp.weixin.qq.com\/s\/ad69SN2dW8U0oi1ob8JMpQ\uff0c2018<\/span><\/p>\n<p><span style=\"font-size: 15px;\">9.\u80be\u5185\u65f6\u95f4\uff0c\u5168\u7403\u9996\u521b\uff0c\u5168\u65b0\u673a\u5236\u2014\u2014\u521b\u65b0\u836f\u5f15\u9886\u80be\u6027\u8d2b\u8840\u6cbb\u7597\u65b0\u65f6\u4ee3\uff0chttps:\/\/www.sohu.com\/a\/205761173_685374\uff0c2017<\/span><\/p>\n<p><span style=\"font-size: 15px;\">10.Kaplan J M, Sharma N ,Dikdan S . Hypoxia-Inducible Factor and Its Role in the Management of Anemia in Chronic Kidney Disease[J]. International Journal of Molecular Sciences, 2018 29;19(2). pii: E389.<\/span><\/p>\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"width: 0px;height: 0px;clear: both;\"><\/section>\n<\/section>\n<p style=\"white-space: normal;text-align: left;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><strong style=\"color: rgb(62, 62, 62);font-size: 16px;max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"color: rgb(62, 62, 62);max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"color: rgb(62, 62, 62);max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25a0\u5f20\u4f36\u4fd0 \u989c\u5efa\u5468<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558080131.jpeg\" alt=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\" title=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558080132.jpg\" alt=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\" title=\"\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u8282\u673a\u5236HIF-PHI\uff0c\u5f00\u542f\u80be\u75c5\u6cbb\u7597\u65b0\u901a\u8def\"  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u3000\u8fc7\u53bb\u4e8c\u5341\u5e74\uff0c\u4eba\u7c7b\u9057\u4f20\u5b66\u3001\u57fa\u56e0\u7ec4\u5b66\u3001\u751f\u7269\u4fe1\u606f\u5b66\u7b49\u9886\u57df\u7684\u53d1\u5c55\u4e3a\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\u5960\u5b9a\u4e86\u57fa\u7840\uff0c\u73b0\u4ee3\u533b\u5b66\u7814\u7a76\u5b9e\u73b0\u4e86\u524d\u6240 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":96580,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/96579"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=96579"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/96579\/revisions"}],"predecessor-version":[{"id":96588,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/96579\/revisions\/96588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/96580"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=96579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=96579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=96579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}