{"id":96972,"date":"2019-03-25T00:00:50","date_gmt":"2019-05-17T08:04:58","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/96972\/"},"modified":"2019-05-17T16:04:59","modified_gmt":"2019-05-17T08:04:59","slug":"275e410826","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/96972\/","title":{"rendered":"\u5168\u7403\u9996\u4e2a\uff01\u541b\u5b9e\u751f\u7269BTLA\u5355\u6297\u5728\u7f8e\u7533\u8bf7\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u53d7\u7406"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"__bg_gif\"         width=\"auto\" style=\"text-align: center;white-space: normal;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;z-index: -1;cursor: pointer;font-size: 14px;line-height: 22.4px;width: 558px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558080298.jpeg\" alt=\"\u5168\u7403\u9996\u4e2a\uff01\u541b\u5b9e\u751f\u7269BTLA\u5355\u6297\u5728\u7f8e\u7533\u8bf7\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u53d7\u7406\" title=\"\u5168\u7403\u9996\u4e2a\uff01\u541b\u5b9e\u751f\u7269BTLA\u5355\u6297\u5728\u7f8e\u7533\u8bf7\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u53d7\u7406\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p>\u3000\u30003\u670825\u65e5\uff0c\u541b\u5b9e\u751f\u7269\u5ba3\u5e03\u5f00\u53d1\u51fa\u5168\u7403\u9996\u4e2a\uff08First in human, FIH\uff09\u7279\u5f02\u6027\u9488\u5bf9B-\u548cT-\u6dcb\u5df4\u7ec6\u80de\u8870\u51cf\u56e0\u5b50\uff08BTLA\uff09\u7684\u91cd\u7ec4\u4eba\u6e90\u5316IgG4\u03ba\u5355\u514b\u9686\u6297\u4f53\uff08TAB004\uff0c\u6216JS004\uff09\u3002\u5176\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\u5df2\u4e8e3\u670822\u65e5\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u53d7\u7406\uff0c\u62df\u9002\u7528\u4e8e\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\uff0c\u5305\u62ecPD-1\u6297\u4f53\u8010\u836f\u60a3\u8005\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000BTLA\u662f2003\u5e74\u53d1\u73b0\u7684\u8868\u8fbe\u4e8e\u6d3b\u5316T\u3001B\u6dcb\u5df4\u7ec6\u80de\u7684\u4e00\u4e2a\u91cd\u8981\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\uff0c\u4e0e\u5176\u4ed6\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\u5982PD-1\u548cCTLA-4\u5177\u6709\u7c7b\u4f3c\u7684\u7ed3\u6784\uff08\u5355\u4e00\u7684\u514d\u75ab\u7403\u86cb\u767d\u53ef\u53d8\u533aIgV\u7ec6\u80de\u5916\u7ed3\u6784\u57df\uff09\u548c\u76f8\u8fd1\u7684\u7ec6\u80de\u5185\u7684\u4fe1\u53f7\u4f20\u5bfc\u673a\u5236\uff08\u80de\u8d28\u5185\u4e24\u4e2aITIM\u7ed3\u6784\u57df\u52df\u96c6\u6d3b\u5316SHP-1\u548cSHP-2\u78f7\u9178\u9176\u6291\u5236\u6dcb\u5df4\u7ec6\u80de\u529f\u80fd\uff09\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000TNF\u53d7\u4f53\u5bb6\u65cf\u7684HVEM\uff08Herpesvirus entry mediator\uff0c\u75b1\u75b9\u75c5\u6bd2\u8fdb\u5165\u4e2d\u4ecb\u4f53\uff09\u57282005\u5e74\u88ab\u9274\u5b9a\u4e3aBTLA\u7684\u914d\u4f53\uff0c\u5e7f\u6cdb\u5730\u8868\u8fbe\u4e8e\u4eba\u4f53\u514d\u75ab\u7ec6\u80de\uff0c\u5982T\u7ec6\u80de\u3001B\u7ec6\u80de\u3001NK\u7ec6\u80de\u3001\u9ad3\u6837\u7ec6\u80de\u548c\u6811\u7a81\u7ec6\u80de\uff0c\u4ee5\u53ca\u591a\u79cd\u80bf\u7624\u7ec6\u80de\uff08\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u7ed3\u80a0\u76f4\u80a0\u764c\u548c\u6dcb\u5df4\u7624\uff09\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u5728\u6b63\u5e38\u751f\u7406\u60c5\u51b5\u4e0b\uff0cBTLA\u4e0e\u5176\u914d\u4f53HVEM\u7ed3\u5408\u540e\uff0c\u53ef\u4ee5\u6291\u5236\u4f53\u5185\u6dcb\u5df4\u7ec6\u80de\u7684\u8fc7\u5ea6\u6d3b\u5316\uff0c\u9632\u6b62\u514d\u75ab\u7cfb\u7edf\u5bf9\u81ea\u8eab\u7684\u635f\u4f24\u3002\u800c\u5728\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u7ed3\u80a0\u76f4\u80a0\u764c\u548c\u6dcb\u5df4\u7624\u7b49\u80bf\u7624\u7ec6\u80de\u901a\u8fc7\u9ad8\u8868\u8fbeHVEM\uff0c\u4e0e\u80bf\u7624\u7279\u5f02\u7684\u6740\u4f24\u6027\u6dcb\u5df4\u7ec6\u80de\u8868\u8fbe\u7684BTLA\u7ed3\u5408\u540e\uff0c\u53ef\u6291\u5236\u6dcb\u5df4\u7ec6\u80de\u7684\u514d\u75ab\u529f\u80fd\u3002HVEM\u7684\u80bf\u7624\u9ad8\u8868\u8fbe\u4e0e\u4e0d\u826f\u9884\u540e\u76f8\u5173\u8054\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u5728\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u6765\u6e90\u7684\u7ec6\u80de\u4f53\u5916\u8bd5\u9a8c\u4e2d\u53d1\u73b0\uff0cBTLA\u548cPD-1\u901a\u8def\u7684\u5171\u540c\u963b\u65ad\u663e\u8457\u589e\u52a0\u80bf\u7624\u7279\u5f02\u7684\u6740\u4f24\u6027\u6dcb\u5df4\u7ec6\u80de\u7684\u6570\u91cf\u548c\u529f\u80fd\uff0c\u8fdc\u4f18\u4e8e\u5355\u72ec\u7684PD-1\u963b\u65ad\u6548\u679c\uff0c\u8868\u660eBTLA\u901a\u8def\u5728\u80bf\u7624\u5fae\u73af\u5883\u7684\u6fc0\u6d3b\u662fPD-1\u6297\u4f53\u7684\u6f5c\u5728\u8010\u836f\u673a\u5236\u4e4b\u4e00\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u8fd9\u4e9b\u7ed3\u679c\u663e\u793a\uff0c\u5bf9\u4e8eBTLA\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\u7684\u963b\u65ad\uff0c\u53ef\u4ee5\u8fdb\u4e00\u6b65\u6539\u5584\u6dcb\u5df4\u7ec6\u80de\u529f\u80fd\uff0c\u5c24\u5176\u662f\u548c\u6297PD-1\u5355\u6297\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u6709\u53ef\u80fd\u8fdb\u4e00\u6b65\u63d0\u9ad8\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u7684\u7597\u6548\uff0c\u6269\u5927\u514d\u75ab\u6cbb\u7597\u5730\u53d7\u76ca\u4eba\u7fa4\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u541b\u5b9e\u751f\u7269\u5f00\u53d1\u51fa\u7684\u5168\u7403\u9996\u4e2a\u7279\u5f02\u6027\u9488\u5bf9BTLA\u7684\u91cd\u7ec4\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53JS004\uff0c\u62df\u9002\u7528\u4e8e\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\uff08\u5305\u62ec\u6dcb\u5df4\u7624\uff09\u7684\u6cbb\u7597\u3002\u4f53\u5916\u548c\u4f53\u5185\u7814\u7a76\u8868\u660e\uff0cJS004\u53ef\u4ee5\u4fc3\u8fdb\u80bf\u7624\u7279\u5f02\u6027T\u6dcb\u5df4\u7ec6\u80de\u589e\u6b96\u548c\u63d0\u9ad8\u6dcb\u5df4\u7ec6\u80de\u529f\u80fd\uff0c\u5728BTLA\u4eba\u6e90\u5316\u5c0f\u9f20\u7684\u80bf\u7624\u6a21\u578b\u91cc\u51cf\u8f7b\u80bf\u7624\u8d1f\u8377\u5e76\u63d0\u9ad8\u5b58\u6d3b\u7387\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u541b\u5b9e\u751f\u7269\u8ba1\u5212\u5728PD-1\u6297\u4f53\u8010\u836f\u7684\u5b9e\u4f53\u7624\u75c5\u4eba\u91cc\u5c55\u5f00JS004 I\u671f\u722c\u5761\u8bd5\u9a8c\uff0c\u5e76\u5728I\u671f\u6269\u5c55\u7ec4\u8fdb\u884c\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\uff08\u6297PD-1\u5355\u6297\uff09\u7684\u8054\u5408\u6cbb\u7597\u7684\u5c1d\u8bd5\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: left;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558080298.jpeg\" alt=\"\u5168\u7403\u9996\u4e2a\uff01\u541b\u5b9e\u751f\u7269BTLA\u5355\u6297\u5728\u7f8e\u7533\u8bf7\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u53d7\u7406\" title=\"\u5168\u7403\u9996\u4e2a\uff01\u541b\u5b9e\u751f\u7269BTLA\u5355\u6297\u5728\u7f8e\u7533\u8bf7\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u53d7\u7406\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558080298.jpg\" alt=\"\u5168\u7403\u9996\u4e2a\uff01\u541b\u5b9e\u751f\u7269BTLA\u5355\u6297\u5728\u7f8e\u7533\u8bf7\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u53d7\u7406\" title=\"\u5168\u7403\u9996\u4e2a\uff01\u541b\u5b9e\u751f\u7269BTLA\u5355\u6297\u5728\u7f8e\u7533\u8bf7\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u53d7\u7406\"  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u30003\u670825\u65e5\uff0c\u541b\u5b9e\u751f\u7269\u5ba3\u5e03\u5f00\u53d1\u51fa\u5168\u7403\u9996\u4e2a\uff08First in human, FIH\uff09\u7279\u5f02\u6027\u9488\u5bf9B-\u548cT-\u6dcb\u5df4\u7ec6 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":96973,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/96972"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=96972"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/96972\/revisions"}],"predecessor-version":[{"id":96977,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/96972\/revisions\/96977"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/96973"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=96972"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=96972"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=96972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}