{"id":97149,"date":"2019-04-01T00:00:50","date_gmt":"2019-05-17T08:06:12","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/97149\/"},"modified":"2019-05-17T16:06:14","modified_gmt":"2019-05-17T08:06:14","slug":"975fc2f30f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/97149\/","title":{"rendered":"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"__bg_gif\"         width=\"auto\" style=\"text-align: center;white-space: normal;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;z-index: -1;cursor: pointer;font-size: 14px;line-height: 22.4px;width: 558px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558080373.jpeg\" alt=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\" title=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"width: 100%;\" >\n<section style=\"width: 100%;border-left:0.2em solid #957e72;box-sizing: border-box;\" >\n<section style=\"padding: 1em 1em 1.5em;background: #ffffff;box-sizing: border-box;\">\n<section style=\"display: flex;justify-content: space-between;align-items: center;\">\n<section style=\"width: 180px;\"><img class=\"\"      style=\"display: block;\" title=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558080373.jpeg\" alt=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\"  \/><\/p>\n<section style=\"text-align: center;font-size: 12px;\"><strong>\u7acb\u523b\u626b\u7801\uff01<\/strong><\/section>\n<\/section>\n<section style=\"width: 100%;margin-left: 1em;\" >\n<p style=\"color: rgb(147, 96, 70);font-size: 15px;margin-bottom: 5px;line-height: normal;\"><span style=\"font-size: 18px;\"><strong><span style=\"color: #ef7060;\">\u7275\u624b\u533b\u5c4a\u5927\u5496<\/span><\/strong><\/span><\/p>\n<p style=\"color: rgb(147, 96, 70);font-size: 18px;margin-top: 6px;margin-bottom: 5px;line-height: normal;\"><strong><span style=\"color: rgb(239, 112, 96);\">\u805a\u7126\u5b66\u672f\u524d\u6cbf<\/span><\/strong><\/p>\n<p style=\"color: rgb(147, 96, 70);font-size: 18px;margin-top: 6px;\"><span style=\"color: #000000;font-size: 14px;\"><strong>\u8bf7\u5173\u6ce8<br  \/><\/strong><\/span><\/p>\n<p style=\"font-size: 18px;margin-top: 6px;\"><span style=\"color:#ef7060;color: #000000;font-size: 14px;\"><strong>\u5b50\u53f7\u201c<span style=\"color: rgb(79, 129, 189);\">\u514d\u75ab\u65f6\u95f4<\/span>\u201d<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"width: 100%;\" ><img class=\"\"      style=\"width: 100%;display: block;margin-top: -1.1em;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558080373.png\" alt=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\" title=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\"  \/><\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<blockquote class=\"js_blockquote_wrap\"     >\n<section class=\"js_blockquote_digest\">\n<p>\u6765\u6e90\uff1a\u514d\u75ab\u65f6\u95f4<\/p>\n<\/section>\n<\/blockquote>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u541b\u5b9e\u751f\u7269\u65e5\u524d\u5ba3\u5e03\uff0c\u5168\u7403\u9996\u4e2a\uff08First-in-class\uff09\u7279\u5f02\u6027\u9488\u5bf9B\u3001T\u6dcb\u5df4\u7ec6\u80de\u8870\u51cf\u56e0\u5b50\uff08BTLA\uff09\u7684\u91cd\u7ec4\u4eba\u6e90\u5316IgG4\u03ba\u5355\u514b\u9686\u6297\u4f53\uff08TAB004\u6216JS004\uff09\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\u5df2\u4e8e3\u670822\u65e5\u83b7\u5f97\u7f8e\u56fdFDA\u53d7\u7406\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u201c<\/span><span style=\"max-width: 100%;font-size: 16px;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u541b\u5b9e\u751f\u7269\u7684\u4f7f\u547d\u662f\u89e3\u51b3\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u6548\u679c\u66f4\u597d\u3001\u82b1\u8d39\u66f4\u4f4e\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/strong><\/span><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6211\u4eec\u805a\u7126\u80bf\u7624\u514d\u75ab\u6838\u5fc3\u9886\u57df\uff0c\u5bf9\u5f88\u591a\u65b0\u673a\u5236\u548c\u65b0\u9776\u70b9\u8fdb\u884c\u4e86\u9879\u76ee\u8bc4\u4f30\uff0c\u4e0d\u65ad\u6269\u5145\u4ea7\u54c1\u7ba1\u7ebf\u3002\u201d\u541b\u5b9e\u751f\u7269\u526f\u603b\u7ecf\u7406\u59da\u76db\u5728\u63a5\u53d7\u91c7\u8bbf\u65f6\u8868\u793a\uff0c\u6309\u7167\u516c\u53f8\u7684\u8ba1\u5212\uff0cBTLA\u6297\u4f53\u836f\u7269\u5c06\u6309\u7167\u201c\u4e2d\u7f8e\u53cc\u62a5\u201d\u7684\u76ee\u6807\u6765\u63a8\u8fdb\u5f00\u53d1\uff0c\u5148\u5728\u7f8e\u56fdFDA\u542f\u52a8IND\u7533\u62a5\uff0c\u5f85\u65f6\u673a\u6210\u719f\uff0c\u4eca\u5e74\u4e0b\u534a\u5e74\u5c06\u63d0\u4ea4\u4e2d\u56fdIND\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\"   style=\"white-space: normal;max-width: 100%;box-sizing: border-box;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-width: 8px 1px 1px;border-style: solid;border-color: rgb(99, 135, 146) rgb(204, 204, 204) rgb(204, 204, 204);box-shadow: rgb(204, 204, 204) 0px 0px 8px;overflow-wrap: break-word !important;\">\n<section style=\"padding: 5px 10px;max-width: 100%;box-sizing: border-box;font-size: 24px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9ad8\u4e34\u5e8a\u5173\u8054\u6027<\/span><\/section>\n<section style=\"padding: 10px;max-width: 100%;box-sizing: border-box;border-top: 1px solid rgb(204, 204, 204);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">JS004\u5c55\u73b0\u5355\u836f\u548c\u8054\u7528\u6f5c\u529b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000First-in-class\u521b\u65b0\u53d1\u610f\u5473\u7740\u98ce\u9669\u4e0e\u673a\u9047\u5e76\u5b58\uff0c\u5c06\u65b0\u673a\u5236\u3001\u65b0\u9776\u70b9\u7684\u6297\u4f53\u836f\u7269\u4ece\u4e34\u5e8a\u524d\u7814\u7a76\u63a8\u5411\u4e34\u5e8a\u5f00\u53d1\uff0c\u5e76\u5b8c\u6210\u2160\u3001\u2161\u3001\u2162\u671f\u8bd5\u9a8c\uff0c\u5168\u7a0b\u6bcf\u4e00\u4e2a\u8282\u70b9\u90fd\u610f\u5473\u7740\u6311\u6218\u548c\u56f0\u96be\u3002\u7ad9\u5728\u539f\u521b\u65b0\u53d1\u7684\u5929\u5e73\u9762\u524d\uff0c\u541b\u5b9e\u751f\u7269\u5fc5\u987b\u5c3d\u53ef\u80fd\u589e\u52a0\u6210\u529f\u7684\u781d\u7801\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u5171\u523a\u6fc0\u4fe1\u53f7\u5728\u6297\u539f\u7279\u5f02\u6027\u514d\u75ab\u5e94\u7b54\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002\u6fc0\u6d3b\u5171\u523a\u6fc0\u4fe1\u53f7\u5982CD28\u548cICOS\u53ef\u4fc3\u8fdb\u514d\u75ab\u5e94\u7b54\uff0c\u5df2\u53d1\u73b0\u7684\u6291\u5236\u6027\u5171\u523a\u6fc0\u5206\u5b50\u53d7\u4f53\u5305\u62ecCTLA-4\u3001PD-1\u3001TIM-3\u7b49\uff0c\u800cBTLA\u662f2003\u5e74\u53d1\u73b0\u7684\u96b6\u5c5e\u4e8eB7-CD28 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style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u59da\u76db\u4ecb\u7ecd\uff0c\u541b\u5b9e\u751f\u7269\u7684BTLA\u6297\u4f53\u836f\u7269\u7814\u53d1\u57282014\u5e74\u6b63\u5f0f\u7acb\u9879\u5e76\u542f\u52a8\u5206\u5b50\u7b5b\u9009\uff0c\u5f53\u65f6\u5728\u516c\u53f8\u5185\u90e8\u4e5f\u8bc4\u4f30\u4e86\u5f88\u591a\u9776\u70b9\uff0cIDO\u3001TIM-3\u3001LAG-3\u7b49\u90fd\u66fe\u8003\u8651\u8fc7\uff0c<\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e4b\u6240\u4ee5\u6700\u7ec8\u4f18\u5148\u9009\u62e9\u7814\u53d1BTLA\u6297\u4f53\uff0c\u6838\u5fc3\u8003\u8651\u56e0\u7d20\u662fBTLA\u514d\u75ab\u6291\u5236\u673a\u5236\u975e\u5e38\u6e05\u6670\uff0c\u4e34\u5e8a\u5173\u8054\u6027\uff08clinical correlation\uff09\u5f88\u5f3a\uff0c\u800c\u4e14\u5355\u836f\u6210\u836f\u6027\u66f4\u7406\u60f3<\/span><\/strong><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u6765\u81ea\u9ed1\u8272\u7d20\u7624\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de(PBMC)\u7684\u7814\u7a76\u8868\u660e\uff0cBTLA\u5728\u80bf\u7624\u7279\u5f02\u6027CTL\uff08\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff09\u4e0a\u8fdb\u884c\u9ad8\u6c34\u5e73\u8868\u8fbe\uff0c\u5e76\u5728\u80bf\u7624\u8868\u8fbe\u7684HVEM\uff08\u75b1\u75b9\u75c5\u6bd2\u5165\u4fb5\u4ecb\u5bfc\u86cb\u767d\uff09\u53c2\u4e0e\u540e\u6291\u5236T\u7ec6\u80de\u529f\u80fd\uff0c\u8868\u660eBTLA\u963b\u65ad\u5f88\u53ef\u80fd\u6539\u5584T\u7ec6\u80de\u529f\u80fd\u548c\u6297\u80bf\u7624\u514d\u75ab\u529b\u3002BTLA\u8fd8\u4e0ePD-1\u5728\u9ed1\u8272\u7d20\u7624\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u80bf\u7624\u7279\u5f02\u6027CTL\u4e0a\u5171\u8868\u8fbe\u3002\u6b64\u5916\uff0cBTLA\u548cPD-1\u901a\u8def\u7684\u5171\u540c\u963b\u65ad\u589e\u52a0\u6740\u4f24\u9ed1\u8272\u7d20\u7624\u7279\u5f02\u6027CTL\u7684\u9891\u7387\u53ca\u6548\u5e94\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\uff0c\u800c\u5355\u72ec\u7684BTLA\u6216PD-1\u7684\u963b\u65ad\u6548\u679c\u6709\u9650\uff0c\u8868\u660eBTLA\u901a\u8def\u662f\u91c7\u7528\u6297PD-1\u5355\u4e00\u7597\u6cd5\u65e0\u6548\u7684\u60a3\u8005\u7684\u6f5c\u5728\u8010\u836f\u673a\u5236\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u201c<\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e34\u5e8a\u524d\u5b9e\u9a8c\u5df2\u7ecf\u53ef\u4ee5\u770b\u5230\uff0cBTLA\u963b\u65ad\u4e4b\u540e\u5bf9\u4e8eT\u7ec6\u80de\u7684\u529f\u80fd\u589e\u5f3a\u662f\u5341\u5206\u663e\u8457\u7684\u3002<\/span><\/strong><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201d\u59da\u76db\u5766\u8a00\uff0c\u5f00\u53d1\u4e00\u4e2a\u65b0\u673a\u5236\u3001\u65b0\u9776\u70b9\u836f\u7269\uff0c\u5982\u679c\u60f3\u8981\u83b7\u5f97\u8054\u5408\u6cbb\u7597\u6548\u679c\uff0c\u4ecd\u9700\u5177\u5907\u5355\u836f\u6d3b\u6027\uff0c\u5982\u679c\u5355\u836f\u6d3b\u6027\u4e0d\u8db3\uff0c\u53ef\u80fd\u9700\u8981\u518d\u8c28\u614e\u659f\u914c\uff0c\u7814\u53d1\u91cd\u70b9\u5e94\u8be5\u9488\u5bf9\u8fd9\u4e9b\u5177\u5907\u5355\u836f\u6210\u836f\u53ef\u80fd\u6027\u7684\u9776\u70b9\uff0c\u800cBTLA\u6297\u4f53JS004\u5c31\u5177\u5907\u8fd9\u4e9b\u8981\u7d20\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u541b\u5b9e\u751f\u7269\u5f00\u53d1\u51fa\u7684\u5168\u7403\u9996\u4e2a\u7279\u5f02\u6027BTLA\u91cd\u7ec4\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53JS004\uff0c\u62df\u9002\u7528\u4e8e\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\uff08\u5305\u62ec\u6dcb\u5df4\u7624\uff09\u7684\u6cbb\u7597\u3002\u4f53\u5916\u548c\u4f53\u5185\u7814\u7a76\u8868\u660e\uff0cJS004\u53ef\u4ee5\u4fc3\u8fdb\u80bf\u7624\u7279\u5f02\u6027T\u6dcb\u5df4\u7ec6\u80de\u589e\u6b96\u548c\u63d0\u9ad8\u6dcb\u5df4\u7ec6\u80de\u529f\u80fd\uff0c\u5728BTLA\u4eba\u6e90\u5316\u5c0f\u9f20\u7684\u80bf\u7624\u6a21\u578b\u91cc\u51cf\u8f7b\u80bf\u7624\u8d1f\u62c5\u5e76\u63d0\u9ad8\u5b58\u6d3b\u7387\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\"   style=\"white-space: normal;max-width: 100%;box-sizing: border-box;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-width: 8px 1px 1px;border-style: solid;border-color: rgb(99, 135, 146) rgb(204, 204, 204) rgb(204, 204, 204);box-shadow: rgb(204, 204, 204) 0px 0px 8px;overflow-wrap: break-word !important;\">\n<section style=\"padding: 5px 10px;max-width: 100%;box-sizing: border-box;font-size: 24px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 18px;box-sizing: 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!important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u4ece\u5185\u90e8\u7acb\u9879\uff0c\u5230\u542f\u52a8\u6297\u4f53\u5019\u9009\u7269\u7b5b\u9009\uff0c\u541b\u5b9e\u751f\u7269\u5168\u7403\u9996\u521b\u65b0\u836f\u7684\u201c\u79cd\u5b50\u201d\uff0c\u4ece\u8bbe\u5728\u7f8e\u56fd\u9a6c\u91cc\u5170\u548c\u65e7\u91d1\u5c71\u7684\u5b9e\u9a8c\u5ba4\u840c\u82bd\uff0c\u4f9d\u6258\u6210\u719f\u7684\u9776\u70b9\u5f00\u53d1\u3001\u6297\u4f53\u65e9\u671f\u7b5b\u9009\u548c\u6742\u4ea4\u7624\u5e73\u53f0\uff0c\u8de8\u8d8a\u5927\u6d0b\u5f7c\u5cb8\u4e00\u6b65\u6b65\u8d70\u5411\u503c\u5f97\u671f\u5f85\u53c8\u5145\u6ee1\u672a\u77e5\u7684\u5c06\u6765\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u5230\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9636\u6bb5\u6027\u8de8\u8d8a\uff0c\u63a2\u7d22\u8fc7\u7a0b\u7684\u559c\u60a6\u548c\u5174\u594b\uff0c\u6beb\u65e0\u7591\u95ee\u6b63\u662f\u533b\u5b66\u521b\u65b0\u8f6c\u5316\u7684\u60ca\u5947\u5386\u7a0b\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u636e\u4e86\u89e3\uff0cBTLA\u6700\u5f00\u59cb\u7684\u9776\u70b9\u7814\u7a76\u5728\u9a6c\u91cc\u5170\u5b9e\u9a8c\u5ba4\u5b8c\u6210\uff0c\u968f\u540e\u7531\u65e7\u91d1\u5c71\u5b9e\u9a8c\u5ba4\u6742\u4ea4\u7624\u5e73\u53f0\u8fdb\u884c\u5206\u5b50\u7b5b\u9009\uff0c\u4ece\u7b5b\u9009\u51fa\u76841000~2000\u4e2a\u6297\u4f53\u4e2d\u6311\u51fa20~30\u4e2a\u5019\u9009\u7269\uff0c\u63a5\u4e0b\u6765\uff0c\u8fd9\u4e9b\u767e\u91cc\u6311\u4e00\u7684\u201c\u5e78\u8fd0\u513f\u201d\u88ab\u8f6c\u79fb\u5230\u9a6c\u91cc\u5170\u7684\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u529f\u80fd\u6027\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u7ecf\u8fc7\u6dcb\u5df4\u7ec6\u80de\u7cfb\uff08reporter cell line\uff09\u548c\u4eba\u539f\u4ee3\u7ec6\u80de\uff08human primary cell\uff09\u7684\u529f\u80fd\u6027\u7b5b\u9009\u548c\u5728\u4ebaBTLA knock-in\u5c0f\u9f20\u7684\u80bf\u7624\u6a21\u578b\u7684\u4f53\u5185\u836f\u6548\u8bc4\u4f30\uff0c\u4ee5\u53ca\u4eba\u6e90\u5316\u548c\u6297\u4f53\u4eb2\u548c\u529b\u6210\u719f\uff08affinity maturation\uff09\u7684\u8fc7\u7a0b\uff0c\u6700\u7ec8\u5f97\u5230\u7684BTLA\u6297\u4f53JS004\u5177\u6709\u9ad8\u5ea6\u4eba\u6e90\u5316\u3001\u8f83\u9ad8\u4eb2\u548c\u529b\u548c\u4f53\u5185\u4f53\u5916\u529f\u80fd\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u59da\u76db\u8fdb\u4e00\u6b65\u6307\u51fa\uff0c\u7ecf\u8fc7\u4e00\u7cfb\u5217\u4e34\u5e8a\u524d\u5206\u5b50\u7b5b\u9009\u7814\u7a76\u4e4b\u540e\uff0cJS004\u8fd8\u8981\u505a\u957f\u6bd2\u5b9e\u9a8c\uff0c\u540c\u65f6\uff0c\u7531\u4f4d\u4e8e\u82cf\u5dde\u5434\u6c5f\u7684\u7814\u53d1\u4e0e\u751f\u4ea7\u57fa\u5730\u540c\u6b65\u5f00\u5c55\u5de5\u827a\u5f00\u53d1\uff0c\u5305\u62ec\u7ec6\u80de\u682a\u5efa\u7acb\u3001\u4e0a\u4e0b\u6e38\u751f\u4ea7\u3001\u7a33\u5b9a\u6027\u7814\u7a76\u7b49\u3002\u201cJS004\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7528\u836f\u5c06\u5168\u90e8\u5728\u6ee1\u8db3\u56fd\u9645\u836f\u54c1\u751f\u4ea7\u7ba1\u7406\u89c4\u8303\uff08cGMP)\u7684\u5434\u6c5f\u751f\u4ea7\u57fa\u5730\u751f\u4ea7\u3002\u6b64\u524d\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u7f8e\u56fd\u7684\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7528\u836f\u5c31\u7531\u6211\u4eec\u5434\u6c5f\u5de5\u5382\u751f\u4ea7\uff0c\u5434\u6c5f\u751f\u4ea7\u57fa\u5730\u8fd8\u627f\u62c5\u4e86\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u4e2d\u56fd\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u3002\u201d<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558080373.jpg\" alt=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\" title=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u541b\u5b9e\u751f\u7269\u82cf\u5dde\u5434\u6c5f\u751f\u4ea7\u57fa\u5730<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u968f\u7740\u4e2d\u56fd\u836f\u54c1\u76d1\u7ba1\u90e8\u95e8\u52a0\u5165ICH\uff0c\u5ba1\u8bc4\u5ba1\u6279\u9010\u6b65\u63a5\u8f68\u56fd\u9645\u6807\u51c6\uff0c\u4e2d\u56fd\u533b\u836f\u4ea7\u4e1a\u5bf9\u4e8e\u672c\u571f\u836f\u7269\u7684\u6d77\u5916\u7533\u62a5\u548c\u4e2d\u7f8e\u53cc\u62a5\u70ed\u5207\u671f\u76fc\uff0c\u4f17\u591a\u8ba8\u8bba\u56f4\u7ed5\u5982\u4f55\u52a0\u901f\u65b0\u673a\u5236\u3001\u65b0\u9776\u70b9\u7684First-in-class\u539f\u521b\u65b0\u836f\u5728\u56fd\u5185\u7684\u63a2\u7d22\u6027\u7814\u53d1\u3002<\/span><span style=\"max-width: 100%;font-size: 16px;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u884c\u4e1a\u666e\u904d\u8ba4\u4e3a\uff0c\u4e2d\u56fd\u4f01\u4e1a\u53ef\u4ee5\u901a\u8fc7\u5148\u5728\u6d77\u5916\u7533\u62a5\uff0c\u83b7\u5f97\u4e00\u5b9a\u7684\u6c9f\u901a\u7ecf\u9a8c\u548c\u8bd5\u9a8c\u6570\u636e\u540e\uff0c\u518d\u5411\u56fd\u5185\u76d1\u7ba1\u90e8\u95e8\u7533\u62a5\uff0c\u8fd9\u5c06\u6709\u52a9\u4e8e\u4ea7\u54c1\u5728\u56fd\u5185\u7684\u4e34\u5e8a\u7533\u8bf7<\/strong><\/span><span style=\"max-width: 100%;font-size: 16px;color: rgb(84, 141, 212);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u59da\u76db\u4e5f\u8ba4\u540c\u8fd9\u4e00\u770b\u6cd5\uff0c\u4ed6\u8868\u793a\uff0c\u65b0\u9776\u70b9\u3001\u65b0\u673a\u5236\u7684\u539f\u521b\u65b0\u836f\uff0c\u5982\u679c\u5728\u56fd\u5185\u63d0\u4ea4IND\u7533\u62a5\u65f6\u80fd\u591f\u63d0\u4f9b\u4e00\u4e9b\u7f8e\u56fdFDA\u7684IND\u5ba1\u8bc4\u53cd\u9988\u610f\u89c1\uff0c\u5c06\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u5177\u6709\u53c2\u8003\u610f\u4e49\u3002\u201c\u5ba2\u89c2\u800c\u8a00\uff0c\u7f8e\u56fdFDA\u4e34\u5e8a\u5ba1\u6279\u4f1a\u7a0d\u5feb\u4e00\u4e9b\uff0c\u6309\u7167\u8ba1\u5212\uff0c30\u65e5\u540e\u9ed8\u8bb8\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6b63\u5e38\u60c5\u51b53\u4e2a\u6708\u5185\u5165\u7ec4\u9996\u4f8b\u53d7\u8bd5\u8005\uff0c\u5305\u62ec\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u533b\u9662\u3001MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7b49\u5728\u5185\u768420\u591a\u5bb6\u5408\u4f5c\u4e34\u5e8a\u8bd5\u9a8c\u673a\u6784\uff0c\u6211\u4eec\u4f1a\u8fc5\u901f\u542f\u52a8\u2160\u671f\u4e34\u5e8a\u7684\u5242\u91cf\u722c\u5761\uff0c\u9884\u8ba1\u5c06\u4e8e\u4eca\u5e74\u4e0b\u534a\u5e74\u5728\u56fd\u5185\u8fdb\u884c\u4e34\u5e8a\u7814\u7a76\u7533\u8bf7\u3002\u201d<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3000\u3000\u4e2d\u56fd\u9700\u8981\u521b\u65b0\uff0c\u521b\u65b0\u91cd\u5728\u7a81\u7834\u3002\u65e0\u8bba\u662f\u79d1\u5b66\u5bb6\u3001\u533b\u5b66\u5bb6\uff0c\u8fd8\u662f\u516c\u53f8\u7ba1\u7406\u8005\uff0c\u5168\u7403\u9996\u521b\u65b0\u836f\u7684\u7814\u53d1\u610f\u4e49\uff0c\u4e0d\u4ec5\u5728\u4e8e\u6253\u7834\u4f20\u7edfMe-too\u3001Me-better\u4eff\u521b\u6a21\u5f0f\u7684\u540c\u8d28\u5316\u7ade\u4e89\uff0c\u80cc\u540e\u66f4\u4f53\u73b0\u51fa\u5168\u65b0\u4e2d\u56fd\u5236\u836f\u5de5\u4e1a\u5347\u7ea7\u548c\u533b\u836f\u76d1\u7ba1\u73af\u5883\u8f6c\u578b\u7684\u5927\u52bf\u6240\u8d8b\u3002<\/span><\/p>\n<p style=\"text-align: left;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section style=\"text-align: center;margin: 30px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 95%;vertical-align: top;box-shadow: #b9b9b9 1.41421px 1.41421px 6px 0px;padding: 5px;box-sizing: border-box;\" >\n<section style=\"font-size: 16px;\">\n<section style=\"margin: -20px 0% 5px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-shadow: #000000 0px 0px 0px 0px;box-sizing: border-box;overflow: hidden !important;\"><img class=\"\"     style=\"vertical-align: middle;box-sizing: border-box;width: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558080374.png\" alt=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\" title=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\"  \/><\/section>\n<\/section>\n<\/section>\n<section>\n<section style=\"margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"font-size: 16px;display: inline-block;vertical-align: middle;width: 38%;box-shadow: rgb(0, 0, 0) 0px 0px 0px 0px;padding-left: 10px;box-sizing: border-box;\" >\n<section>\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-shadow: #000000 0px 0px 0px 0px;border-style: solid;border-width: 2px;border-radius: 0px;border-color: #3e3e3e;box-sizing: border-box;overflow: hidden !important;\"><img class=\"\"     style=\"vertical-align: middle;box-sizing: border-box;\" title=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558080374.jpeg\" alt=\"First-in-class\u4e2d\u7f8e\u53cc\u62a5\u8fc8\u6b65 \u541b\u5b9e\u751f\u7269\u542f\u52a8BTLA\u4e34\u5e8a\u5f00\u53d1\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 61.8%;border-style: groove;border-width: 0px;border-radius: 0px;border-color: #3e3e3e;box-sizing: border-box;\" >\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-family:Optima-Regular, PingFangTC-light;\"><strong>\u5a92\u4f53\u5408\u4f5c\u3001\u6295\u7a3f\u5efa\u8bae<\/strong><\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-family:Optima-Regular, PingFangTC-light;\"><strong>\u5165\u7fa4\u4ea4\u6d41<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"font-size: 16px;\">\n<section style=\"margin: 10px 0%;font-size: 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-shadow: #ef7060 0px 0px 0px 0px inset;border-style: solid;border-width: 1px;border-radius: 10%;border-color: #424242;padding: 5px;background-color: #ef7060;box-sizing: border-box;color: #ffffff;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;color: #ef7060;padding-right: 8px;padding-left: 8px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: #ffffff;font-size: 14px;\"><strong style=\"box-sizing: border-box;\" class=\"135brush\" ><span style=\"font-family: Optima-Regular, PingFangTC-light;box-sizing: border-box;\">\u626b\u7801\u52a0\u5c0f\u7f16<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7acb\u523b\u626b\u7801\uff01 \u7275\u624b\u533b\u5c4a\u5927\u5496 \u805a\u7126\u5b66\u672f\u524d\u6cbf \u8bf7\u5173\u6ce8 \u5b50\u53f7\u201c\u514d\u75ab\u65f6\u95f4\u201d \u6765\u6e90\uff1a\u514d\u75ab\u65f6\u95f4 \u3000\u3000\u541b\u5b9e\u751f\u7269\u65e5\u524d\u5ba3\u5e03\uff0c\u5168\u7403\u9996 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":97150,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/97149"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=97149"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/97149\/revisions"}],"predecessor-version":[{"id":97157,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/97149\/revisions\/97157"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/97150"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=97149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=97149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=97149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}