{"id":98081,"date":"2019-02-21T00:00:50","date_gmt":"2019-05-17T08:12:59","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/98081\/"},"modified":"2019-05-17T16:13:00","modified_gmt":"2019-05-17T08:13:00","slug":"0af6b60256","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/98081\/","title":{"rendered":"\u773c\u79d1\u836f\u7269\u975e\u4e34\u5e8a\u7814\u7a76\u7684\u8003\u8651"},"content":{"rendered":"
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\u773c\u79d1\u836f\u7269\u975e\u4e34\u5e8a\u7814\u7a76\u7684\u8003\u8651<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Non-clinical study of ophthalmic drugs<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u773c\u7684\u89e3\u5256\u7ed3\u6784\u53ca\u7ed9\u836f\u65b9\u5f0f<\/strong><\/p>\n<\/section>\n<\/section>\n

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1.1\u3000\u773c\u89e3\u5256\u7ed3\u6784<\/span><\/strong><\/span>
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1.2\u3000\u773c\u5c4f\u969c\u7cfb\u7edf<\/span><\/strong><\/span>
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1.3\u3000\u773c\u79d1\u836f\u7269\u5e38\u89c1\u7ed9\u836f\u9014\u5f84<\/span><\/strong>
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\u773c\u90e8\u7ed9\u836f\u9014\u5f84\u5927\u81f4\u53ef\u5206\u4e3a\u4e09\u7c7b\uff1a\u5c40\u90e8\u7ed9\u836f\uff08\u6ef4\u773c\u6db2\u3001\u773c\u818f\u3001\u773c\u51dd\u80f6\u7b49\uff09\u3001\u773c\u5185\uff08\u73bb\u7483\u4f53\u8154\u6ce8\u5c04\u53ca\u524d\u623f\u6ce8<\/span>\u5c04\u7b49\uff09\u6216\u690d\u5165\u7ed9\u836f\u3001\u773c\u5468\u7ed9\u836f\uff08\u7ed3\u819c\u4e0b\u3001\u7403\u540e\u3001\u7403\u5468\u3001<\/span>\u7b4b\u819c\u4e0b\u7ed9\u836f\u7b49\uff09\u3002<\/span><\/p>\n

\u7528\u4e8e\u6cbb\u7597\u773c\u524d\u6bb5\u75be\u75c5\u7684\u836f\u7269\u5e38\u91c7\u7528\u5c40<\/span>\u90e8\u7ed9\u836f\u9014\u5f84\uff0c\u6cbb\u7597\u773c\u540e\u6bb5\u75be\u75c5\u7684\u836f\u7269\u5e38\u91c7\u7528\u773c\u5185\/ \u773c<\/span>\u5468\u6ce8\u5c04\u6216\u690d\u5165\u7ed9\u836f\u9014\u5f84\u3002<\/span><\/p>\n

1.3.1\u3000\u5c40\u90e8\u7ed9\u836f<\/strong>\u3000<\/p>\n

\u5c40\u90e8\u7ed9\u836f\u60a3\u8005\u7528\u836f\u65b9\u4fbf\uff0c\u53ef\u9009\u62e9\u6027\u7684\u5c06\u836f\u7269\u9012\u9001\u5230\u773c\u524d\u6bb5\u7ec4\u7ec7\u4e2d\uff0c\u662f\u76ee\u524d\u773c\u79d1\u836f\u7269\u7684\u4e3b<\/span>\u8981\u7ed9\u836f\u9014\u5f84\u3002<\/span><\/p>\n

\u89d2\u819c\u524d\u6cea\u6db2\u4f53\u79ef\u4ec57 \uff5e 10 \u03bcL\uff0c\u4e14\u6cea\u6db2<\/span>\u6bcf2 \uff5e 3 min \u5468\u8f6c\u4e00\u6b21\uff0c\u56e0\u6b64\u6ef4\u773c\u6db2\u5e38\u91c7\u7528\u4e0b\u7ed3\u819c\u56ca<\/span>\u7ed9\u836f[2]\u3002<\/span><\/p>\n

\u7ed3\u819c\u56ca\u6700\u5927\u4f53\u79ef\u7ea6\u4e3a30 \u03bcL\uff0c\u7531\u4e8e\u7728\u773c\u7b49\u751f<\/span>\u7406\u53cd\u5e94\uff0c\u5927\u90e8\u5206\u836f\u7269\u4f1a\u901a\u8fc7\u9f3b\u6cea\u7ba1\u6216\u9762\u988a\u6392\u51fa\u3002<\/span><\/p>\n

\u7531\u4e8e<\/span>\u773c\u7684\u9759\u6001\u5c4f\u969c\u548c\u52a8\u6001\u5c4f\u969c\uff0c\u6700\u7ec8\u4ec5\u67091% \uff5e 7% \u7684\u836f<\/span>\u7269\u8fdb\u5165\u623f\u6c34\u4e2d\u3002<\/span><\/p>\n

\u836f\u7269\u4e00\u65e6\u8fdb\u5165\u623f\u6c34\uff0c\u53ef\u5f88\u5feb\u5206\u5e03\u5230\u8679\u819c\u548c\u776b\u72b6\u4f53\u4e2d[3]\uff0c\u8fdb\u5165\u623f\u6c34\u7684\u5c11\u91cf\u836f\u7269\u5f88\u96be\u518d\u8fdb\u5165\u773c<\/span>\u540e\u6bb5\u7ec4\u7ec7\u4e2d\u8fbe\u5230\u6709\u6548\u7684\u6cbb\u7597\u6d53\u5ea6\uff0c\u56e0\u6b64\u773c\u540e\u6bb5\u75be\u75c5\u6cbb<\/span>\u7597\u836f\u7269\u4e00\u822c\u4e0d\u91c7\u7528\u5c40\u90e8\u7ed9\u836f\u9014\u5f84\u3002<\/span><\/p>\n

1.3.2\u3000\u73bb\u7483\u4f53\u8154\u6ce8\u5c04\u3000<\/strong><\/p>\n

\u73bb\u7483\u4f53\u8154\u7ed9\u836f\u53ef\u5c06\u6eb6\u6db2\u3001\u6df7\u60ac\u6db2\u7b49\u76f4\u63a5\u6ce8\u5c04\u8fdb\u5165\u73bb\u7483\u4f53\u8154\u4e2d\uff0c\u836f\u7269\u53ef\u76f4\u63a5\u4e0e\u89c6\u7f51\u819c\u63a5<\/span>\u89e6\u3002<\/span><\/p>\n

\u73bb\u7483\u4f53\u8154\u6ce8\u5c04\u836f\u7269\uff0c\u4e00\u822c\u9700\u51e0\u4e2a\u5c0f\u65f6\u624d\u80fd\u6269\u6563\u5206\u5e03<\/span>\u81f3\u6574\u4e2a\u73bb\u7483\u4f53\u8154\u3002\u8fdb\u5165\u73bb\u7483\u4f53\u7684\u836f\u7269\u540c\u65f6\u4e5f\u53ef\u6269\u6563\u5230\u773c<\/span>\u524d\u6bb5\u7ec4\u7ec7\u6216\u8de8\u8fc7\u89c6\u7f51\u819c\u5185\u5c4f\u969c\u8fdb\u5165\u89c6\u7f51\u819c\u6bdb\u7ec6\u8840\u7ba1\u4e2d<\/span>\u6d88\u9664[3]\u3002<\/span><\/p>\n

\u53d7\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u7ec6\u80de\u7d27\u5bc6\u8fde\u63a5\u7684\u963b\u788d\uff0c\u836f\u7269<\/span>\u4ece\u73bb\u7483\u4f53\u8154\u8f6c\u8fd0\u5230\u8109\u7edc\u819c\u7684\u901f\u5ea6\u5f88\u6162\u3002\u5f71\u54cd\u73bb\u7483\u4f53\u8154\u4e2d<\/span>\u836f\u7269\u66b4\u9732\u7684\u56e0\u7d20\u5305\u62ec\u7ed9\u836f\u5242\u91cf\u3001\u5206\u5e03\u5bb9\u79ef\u548c\u6d88\u9664\u901f\u7387\u3002<\/span><\/p>\n

\u73bb\u7483\u4f53\u8154\u4e2d\u836f\u7269\u7684\u6e05\u9664\u901f\u7387\u4e3b\u8981\u548c\u836f\u7269\u5206\u5b50\u91cf\u6709\u5173\uff0c<\/span>\u5c0f\u5206\u5b50\u836f\u7269\u76f8\u5bf9\u5927\u5206\u5b50\u836f\u7269\u6e05\u9664\u901f\u7387\u66f4\u5feb\u3002<\/span><\/p>\n

\u4e0e\u773c\u5468\u7ed9\u836f<\/span>\u9014\u5f84\u76f8\u6bd4\uff0c\u73bb\u7483\u4f53\u8154\u6ce8\u5c04\u53ef\u83b7\u5f97\u66f4\u9ad8\u7684\u73bb\u7483\u4f53\/ \u89c6\u7f51\u819c\/ <\/span> \u8109\u7edc\u819c\u836f\u7269\u6d53\u5ea6\uff0c\u9002\u7528\u4e8e\u773c\u5e95\u75be\u75c5\u6cbb\u7597\u836f\u7269\u3002<\/span><\/p>\n

\u4f46\u8fd9\u79cd\u7ed9\u836f\u65b9\u5f0f\u4f1a\u5e26\u6765\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5982\u773c\u5185\u708e\u75c7\u3001\u6676\u72b6\u4f53<\/span>\u6d51\u6d4a\u3001\u89c6\u7f51\u819c\u8131\u843d\u3001\u89c6\u7f51\u819c\u51fa\u8840\u7b49[4]\u3002<\/p>\n

1.3.3\u3000\u773c\u5468\u7ed9\u836f[3-4]\u3000<\/strong><\/p>\n

\u773c\u5468\u7ed9\u836f\u5305\u62ec\u7ed3\u819c\u4e0b\u3001\u7403\u540e\u3001\u7403\u5468\u53ca\u7b4b\u819c\u4e0b\u7b49\u7ed9\u836f\u9014\u5f84\uff0c\u9760\u8fd1\u5de9\u819c\u90e8\u4f4d\u3002\u5de9\u819c\u662f\u7531\u80f6<\/span>\u539f\u7ea4\u7ef4\u6784\u6210\u7684\u7ea4\u7ef4\u7ec4\u7ec7\uff0c\u836f\u7269\u901a\u900f\u6027\u8f83\u9ad8\u3002\u7ecf\u773c\u5468\u7ed9<\/span>\u836f\uff0c\u836f\u7269\u53ef\u7a7f\u8fc7\u5de9\u819c\uff0c\u5728\u89c6\u7f51\u819c\u548c\u73bb\u7483\u4f53\u8154\u4e2d\u8fbe\u5230\u8f83<\/span>\u9ad8\u7684\u836f\u7269\u6d53\u5ea6\uff0c\u8fd9\u662f\u773c\u540e\u6bb5\u7ec4\u7ec7\u7ed9\u836f\u6700\u5e38\u91c7\u7528\u7684\u7ed9\u836f\u65b9\u5f0f\u3002<\/span><\/p>\n

\u7ed3\u819c\u4e0b\u7ed9\u836f\uff1a<\/strong><\/p>\n

\u7ed3\u819c\u662f\u4e00\u79cd\u8584\u800c\u534a\u900f\u660e\u7684\u9ecf\u6db2\u5206\u6ccc\u7ec4\u7ec7\uff0c\u4e0e\u89d2\u819c\u76f8\u8fde\uff0c\u8986\u76d6\u5728\u5de9\u819c\u4e0a\u65b9\uff0c\u5728\u7ed3\u819c\u548c\u5de9\u819c<\/span>\u4e4b\u95f4\u7684\u7a7a\u9699\u5373\u4e3a\u7ed3\u819c\u4e0b\u3002\u7ed3\u819c\u4e0b\u7ed9\u836f\u4e00\u6b21\u53ef\u7ed9\u4e88\u5927\u7ea6<\/span>500 \u03bcL\u3002<\/span><\/p>\n

\u7b4b\u819c\u4e0b\u7ed9\u836f\uff1a<\/strong><\/p>\n

\u53ef\u5c06\u836f\u7269\u76f4\u63a5\u6ce8\u5c04\u4e8e\u7b4b\u819c\u56ca\u548c\u5de9\u819c\u4e4b\u95f4\u7684\u95f4\u9699\u4e2d\uff0c\u4e00\u6b21\u6700\u5927\u53ef\u6ce8\u5c044 mL\uff0c\u5e38\u7528\u4e8e\u773c\u79d1\u624b<\/span>\u672f\u65f6\u7684\u9ebb\u9189\u5242\u7ed9\u836f\uff0c\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u7ed3\u819c\u4e0b\u51fa\u8840\u3001<\/span>\u7ed3\u819c\u80bf\u80c0\u53ca\u773c\u90e8\u75bc\u75db\u3002<\/span><\/p>\n

\u7403\u5468\u7ed9\u836f\uff1a<\/strong><\/p>\n

\u5728\u4e0a\u4e0b\u76f4\u808c\u548c\u5185\u5916\u76f4\u808c\u5916\u4fa7\u7ed9\u836f\uff0c\u6839\u636e\u6ce8\u5c04\u90e8\u4f4d\u53c8\u5206\u4e3a\u524d\u6216\u540e\u7403\u5468\u6ce8\u5c04\uff0c\u4e00\u822c\u7528\u4e8e\u767d\u5185\u969c<\/span>\u624b\u672f\u65f6\u7684\u9ebb\u9189\u836f\u7269\u7ed9\u836f\uff0c\u4e00\u6b21\u53ef\u6ce8\u5c048 \uff5e 10 mL\u3002<\/span><\/p>\n

\u7403\u540e\u7ed9\u836f\uff1a<\/strong><\/p>\n

\u4e00\u79cd\u76f4\u63a5\u7a7f\u8fc7\u773c\u7751\u548c\u7736\u7b4b\u819c\u5c06\u836f\u7269\u6ce8\u5c04\u5165\u4e0a\u4e0b\u76f4\u808c\u548c\u5185\u5916\u76f4\u808c\u7684\u808c\u95f4\u9699\uff0c\u4e3b\u8981\u7528\u4e8e\u9ebb\u9189\u836f<\/span>\u7269\uff0c\u8fd9\u79cd\u7ed9\u836f\u65b9\u5f0f\u6709\u635f\u4f24\u89c6\u795e\u7ecf\u7684\u98ce\u9669\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n

2<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n

\u773c\u79d1\u836f\u7269\u7684\u975e\u4e34\u5e8a\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\u76f8\u6bd4\u5176\u4ed6\u7ec4\u7ec7\u6216\u5668\u5b98\uff0c\u773c\u7ed3\u6784\u5c0f\u800c\u7cbe\u7ec6\uff0c\u4e14\u5b58\u5728\u5c4f\u969c\u7cfb\u7edf\uff0c\u836f\u7269\u96be\u4ee5\u8fdb\u5165\u773c\u5185\u53d1\u6325\u7597\u6548\uff0c\u8fd9\u7ed9\u773c\u79d1\u836f<\/span>\u7269\u975e\u4e34\u5e8a\u7814\u7a76\u5e26\u6765\u6311\u6218\u3002\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u6709\u9488\u5bf9\u773c\u79d1\u836f<\/span>\u7269\u975e\u4e34\u5e8a\u7814\u7a76\u7684\u6307\u5bfc\u539f\u5219\u3002<\/span><\/p>\n

\u901a\u8fc7\u67e5\u9605\u6587\u732e\uff0c\u7ed3\u5408\u5ba1\u8bc4<\/span>\u5b9e\u4f8b\uff0c\u4ecb\u7ecd\u773c\u79d1\u836f\u7269\u975e\u4e34\u5e8a\u7814\u7a76\u8bbe\u8ba1\u7684\u8003\u8651\uff0c\u4ee5\u4f9b\u7814<\/span>\u53d1\u53c2\u8003\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

2.1\u3000\u975e\u4e34\u5e8a\u6709\u6548\u6027\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

2.1.1\u3000\u4e00\u822c\u8003\u8651\u3000<\/strong><\/p>\n

\u7531\u4e8e\u52a8\u7269\u548c\u4eba\u5b58\u5728\u79cd\u5c5e\u5dee\u5f02\uff0c\u4efb\u4f55\u52a8\u7269\u6a21\u578b\u90fd\u4e0d\u53ef\u80fd\u5b8c\u5168\u6a21\u62df\u836f\u7269\u5728\u4eba\u4f53\u4e2d\u7684\u4f5c\u7528\uff0c\u5efa<\/span>\u8bae\u91c7\u7528\u591a\u79cd\u6a21\u578b\u7ec4\u5408\u9a8c\u8bc1\u836f\u7269\u7684\u7597\u6548\u3002\u773c\u90e8\u7528\u836f\u836f\u6548<\/span>\u5b66\u8bd5\u9a8c\u5173\u952e\u662f\u9009\u62e9\u5408\u9002\u7684\u52a8\u7269\u6a21\u578b\u548c\u836f\u6548\u5b66\u6307\u6807\uff0c\u8bc1<\/span>\u660e\u836f\u7269\u5728\u9776\u7ec4\u7ec7\u4e2d\u8fbe\u5230\u6709\u6548\u6cbb\u7597\u6d53\u5ea6\u3002<\/p>\n

\u52a8\u7269\u6a21\u578b\u5e94\u5173\u6ce8\u4e0e\u4eba\u4f53\u7684\u76f8\u5173\u6027\u548c\u5c40\u9650\u6027[5-6]\uff0c\u5305\u62ec\uff1a<\/span><\/p>\n

\u2460 \u52a8\u7269\u773c\u90e8<\/span>\u89e3\u5256\u548c\u751f\u7406\u7ed3\u6784\u4e0e\u4eba\u7684\u76f8\u4f3c\u6027\u548c\u5dee\u5f02\u6027\uff1b<\/span><\/p>\n

\u2461 \u4e0e\u4eba\u75be\u75c5<\/span>\u7684\u75c5\u7406\u751f\u7406\u5b66\u7684\u76f8\u4f3c\u6027\u548c\u5dee\u5f02\u6027\uff0c\u5305\u62ec\u53d1\u75c5\u673a\u5236\u3001\u75be<\/span>\u75c5\u8fdb\u7a0b\u548c\u4e34\u5e8a\u8868\u73b0\u7b49\u65b9\u9762\uff1b<\/span><\/p>\n

\u2462 \u836f\u7269\u4e0e\u4eba\u548c\u52a8\u7269\u9776\u70b9\u7ed3<\/span>\u5408\u6216\u5360\u4f4d\u7684\u5dee\u5f02\uff1b<\/span><\/p>\n

\u2463 \u836f\u7269\u5728\u52a8\u7269\u548c\u4eba\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u65b9<\/span>\u9762\u7684\u5dee\u5f02\uff0c\u5982\u86cb\u767d\u7ed3\u5408\u7387\u3001\u9ed1\u8272\u7d20\u7ed3\u5408\u7387\u5dee\u5f02\u7b49\u3002<\/span><\/p>\n

\u9009<\/span>\u62e9\u7684\u836f\u6548\u5b66\u6307\u6807\u5e94\u80fd\u591f\u8f83\u597d\u5730\u6d4b\u5b9a\u53ca\u9884\u6d4b\u836f\u7269\u7684\u7597\u6548\uff0c<\/span>\u5c3d\u91cf\u6db5\u76d6\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u4e0d\u80fd\u76d1\u6d4b\u7684\u6307\u6807\uff0c\u5982\u75c5\u7406\u5b66\u6307<\/span>\u6807\u7b49\u3002<\/span><\/p>\n

2.1.2\u3000\u6848\u4f8b\u3000<\/strong><\/p>\n

Aflibercept\uff08\u963f\u67cf\u897f\u666e\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u827e\u529b\u96c5\u00ae\/Eylea\u00ae\uff09\uff1aBayer \u516c\u53f8\u7814\u53d1\u7684\u4eba\u8840\u7ba1\u5185\u76ae\u751f\u957f<\/span>\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53\u878d\u5408\u86cb\u767d\uff0c\u4e8e2011 \u5e74\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c<\/span>\u73bb\u7483\u4f53\u8154\u6ce8\u5c04\u7528\u4e8e\u6cbb\u7597AMD\u3001DME\u3001DR\u3001RVO \u7b49\u773c<\/span>\u5e95\u8840\u7ba1\u75be\u75c5\u3002<\/span><\/p>\n

\u4f53\u5916\u836f\u6548\u5b66\u8bd5\u9a8c\u6d4b\u5b9a\u4e86Aflibercept \u4e0e\u4e0d<\/span>\u540c\u79cd\u5c5e\uff08\u4eba\u3001\u5927\u9f20\u3001\u5c0f\u9f20\u3001\u5154\uff09VEGF-A \u7684\u4eb2\u548c\u529b\uff0c\u91c7<\/span>\u7528\u4eba\u8110\u9759\u8109\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\uff08HUVECs\uff09\u68c0\u6d4bAflibercept<\/span>\u5bf9VEGF \u53d7\u4f53\u4fe1\u53f7\u7684\u963b\u65ad\u4f5c\u7528\uff0cAflibercept \u5bf9VEGF<\/span>\u8bf1\u5bfc\u7684HUVECs \u589e\u6b96\u7684\u6291\u5236\u4f5c\u7528\u3002<\/span><\/p>\n

\u4f53\u5185\u8bd5\u9a8c\u91c7\u7528\u591a<\/span>\u79cd\u89c6\u8840\u7ba1\u75be\u75c5\u6a21\u578b\u8bc4\u4f30Aflibercept \u6291\u5236\u8840\u7ba1\u5f02\u5e38\u901a<\/span>\u900f\u6216\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u7684\u80fd\u529b\uff0c\u5982\u7528\u6fc0\u5149\u8bf1\u5bfc\u7684\u556e\u9f7f\u7c7b\u548c<\/span>\u7334\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\uff08CNV\uff09\u6a21\u578b\uff1b\u5728\u91ce\u751f\u578b\u5c0f\u9f20\uff08\u6ce8<\/span>\u5c04\u7ed9\u4e88VEGF\uff09\u6216\u8fc7\u8868\u8fbehVEGF \u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u4e2d\u8bc4<\/span>\u4f30Aflibercept \u5bf9VEGF \u8bf1\u5bfc\u7684\u89c6\u7f51\u819c\u5c4f\u969c\u635f\u4f24\u7684\u4fdd\u62a4<\/span>\u4f5c\u7528\uff1b\u5728\u94fe\u8132\u9709\u7d20\u8bf1\u5bfc\u7684\u7cd6\u5c3f\u75c5\u5927\u9f20\u89c6\u7f51\u819c\u6c34\u80bf\u6a21\u578b<\/span>\u4e2d\u548c\u9ad8\u538b\u6c27\u8bf1\u5bfc\u7684\u5c0f\u9f20\u7f3a\u8840\u6027\u89c6\u7f51\u819c\u75c5\u53d8\u6a21\u578b\u4e2d\u8bc4<\/span>Aflibercept \u5bf9\u89c6\u7f51\u819c\u6c34\u80bf\u548c\u65b0\u751f\u8840\u7ba1\u7684\u6539\u5584\u4f5c\u7528\u3002<\/span><\/p>\n

\u7ec8<\/span>\u70b9\u6307\u6807\u5305\u62ec\u773c\u5e95\u7167\u76f8\u3001\u8367\u5149\u7d20\u8840\u7ba1\u9020\u5f71\u3001\u7ec4\u7ec7\u75c5\u7406\u5b66<\/span>\u68c0\u67e5\u7b49\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

2.2\u3000\u836f\u4ee3\u52a8\u529b\u5b66\u8bd5\u9a8c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u65b0\u836f\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4e00\u822c\u90fd\u9700\u8981\u5f00\u5c55\u5438\u6536\uff08A\uff09\u3001\u5206\u5e03\uff08D\uff09\u3001\u4ee3\u8c22\uff08M\uff09\u548c\u6392\u6cc4\uff08E\uff09\u7814\u7a76\u3002<\/span><\/p>\n

\u4eba\u773c\u5185\u6709\u591a\u79cd\u5c4f<\/span>\u969c\uff0c\u836f\u7269\u5f88\u96be\u7a7f\u8fc7\u5c4f\u969c\u8fbe\u5230\u9776\u7ec4\u7ec7\u3002\u4e0e\u4e00\u822c\u836f\u7269\u4e0d\u540c\uff0c<\/span>\u773c\u7ec4\u7ec7\u4e2d\u7684\u836f\u7269\u5206\u5e03\u4e0e\u7cfb\u7edf\u66b4\u9732\u65e0\u76f4\u63a5\u5173\u7cfb\uff0c\u773c\u79d1\u836f<\/span>\u7269\u4e0d\u4ec5\u8981\u7814\u7a76\u836f\u7269\u5728\u5168\u8eabADME \u60c5\u51b5\uff0c\u66f4\u5e94\u5173\u6ce8\u836f<\/span>\u7269\u5728\u773c\u7ec4\u7ec7\u4e2d\u7684\u5206\u5e03\uff0c\u5305\u62ec\u773c\u9776\u7ec4\u7ec7\u4e2d\u836f\u7269\u6d53\u5ea6- \u65f6<\/span>\u95f4\u5173\u7cfb\uff0c\u4e3a\u773c\u5c40\u90e8\u7ed9\u836f\u540e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u8bc4\u4ef7\u63d0\u4f9b<\/span>\u652f\u6301\u6027\u6570\u636e\u3002<\/span><\/p>\n

\u773c\u7ec4\u7ec7\u4e2d\u5b58\u5728\u8f83\u9ad8\u6c34\u5e73\u7684\u916f\u9176\uff0c\u5c11\u91cf\u7684<\/span>CYP450 \u9176\u3001\u5355\u80fa\u6c27\u5316\u9176\u3001\u4e8c\u80fa\u6c27\u5316\u9176\u53ca\u5176\u4ed6\u4e00\u4e9b\u2161<\/span>\u76f8\u4ee3\u8c22\u9176\uff0c\u89d2\u819c\u4e2d\u5b58\u5728\u8f83\u9ad8\u6c34\u5e73\u7684\u919b\u8131\u6c22\u9176[7]\uff0c\u56e0\u6b64<\/span>\u5e94\u5173\u6ce8\u836f\u7269\uff08\u5c24\u5176\u662f\u4e00\u4e9b\u524d\u4f53\u836f\u7269\uff09\u5728\u773c\u7ec4\u7ec7\u4e2d\u7684\u4ee3<\/span>\u8c22\u60c5\u51b5\u3002<\/span><\/p>\n

\u6b64\u5916\uff0c\u773c\u8461\u8404\u819c\u548c\u89c6\u7f51\u819c\u7ec4\u7ec7\u4e2d\u542b\u6709\u9ed1\u8272\u7d20\uff0c<\/span>\u9ed1\u8272\u7d20\u542b\u6709\u591a\u4e2a\u7f9f\u57fa\u548c\u7fa7\u57fa\u4f4d\u70b9\uff0c\u53ef\u4e0e\u836f\u7269\uff08\u5c24\u5176\u662f<\/span>\u78b1\u6027\u836f\u7269\uff0c\u5982\u9ebb\u9ec4\u78b1\u3001\u963f\u6258\u54c1\u3001\u5de6\u6c27\u6c1f\u6c99\u661f\u7b49\uff09\u7ed3\u5408\u3002<\/span><\/p>\n

\u836f\u7269\u4e00\u65e6\u4e0e\u9ed1\u8272\u7d20\u7ed3\u5408\u4f1a\u5f62\u6210\u4e00\u4e2a\u836f\u7269\u50a8\u5b58\u5e93\uff0c\u7f13\u6162<\/span>\u91ca\u653e\u5230\u5468\u56f4\u7ec4\u7ec7\u4e2d\uff0c\u8fdb\u800c\u5f71\u54cd\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u6709<\/span>\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u5efa\u8bae\u5c0f\u5206\u5b50\u836f\u7269\u7814\u53d1\u65e9\u671f\u5f00\u5c55\u9ed1\u8272\u7d20<\/span>\u7684\u4f53\u5916\u7ed3\u5408\u7814\u7a76[6-7]\u3002<\/span><\/p>\n

\u65b0\u836f\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4e00\u822c\u90fd\u8981\u5f00\u5c55\u4eba<\/span>\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\uff0c\u4f46\u5bf9\u4e8e\u773c\u79d1\u836f\u7269\uff0c\u8fde\u7eed\u4ece\u4eba\u4f53\u773c<\/span>\u7ec4\u7ec7\u91c7\u96c6\u6837\u54c1\u8fdb\u884c\u751f\u7269\u5206\u6790\uff0c\u65e2\u4e0d\u7b26\u5408\u4f26\u7406\u4e5f\u4e0d\u53ef\u884c\uff0c<\/span>\u5e38\u91c7\u7528\u52a8\u7269\u773c\u7ec4\u7ec7\u5206\u5e03\u7814\u7a76\u6765\u5916\u63a8\u6216\u66ff\u4ee3\u4eba\u773c\u836f\u4ee3\u52a8<\/span>\u529b\u5b66\u7814\u7a76[2-3\uff0c8]\u3002<\/p>\n

\u5154\u3001\u7334\u548c\u4eba\u5177\u6709\u76f8\u4f3c\u7684\u773c\u89e3\u5256\u7ed3\u6784\uff0c\u662f\u773c\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u6700\u5e38\u91c7\u7528\u7684\u52a8\u7269\u3002\u7531\u4e8e\u5154\u6613\u83b7\u5f97\u3001<\/span>\u6210\u672c\u4f4e\uff0c\u5c0f\u5206\u5b50\u836f\u7269\u5e38\u91c7\u7528\u5154\u5f00\u5c55\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\uff1b<\/span>\u5927\u5206\u5b50\u836f\u7269\u53d7\u514d\u75ab\u539f\u6027\u53ca\u4e25\u91cd\u708e\u75c7\u53cd\u5e94\u5f71\u54cd\uff0c\u5e38\u91c7\u7528<\/span>\u7334\u5f00\u5c55\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76[8-9]\u3002<\/span><\/p>\n

Rhopressa\uff08netarsudil 0.02% \u6ef4\u773c\u6db2\uff09\uff0c\u662fAerie \u516c\u53f8\u7814\u53d1\u7684\u4e00\u79cd\u7528\u4e8e\u964d\u4f4e\u5f00\u89d2\u578b\u9752\u5149\u773c\u6216\u9ad8\u773c\u538b\u60a3\u8005\u773c<\/span>\u5185\u538b\u7684\u65b0\u578b\u5c0f\u5206\u5b50\u836f\u7269\uff0c2017 \u5e7412 \u6708\u83b7FDA \u6279\u51c6\u4e0a<\/span>\u5e02\u3002<\/span><\/p>\n

Rhopressa \u6bcf\u65e5\u4e00\u6b21\u6ef4\u773c\u7ed9\u836f\uff0c\u53ef\u8c03\u63a7\u623f\u6c34\u5916\u6d41\uff0c<\/span>\u4ece\u800c\u964d\u4f4e\u5de9\u819c\u9759\u8109\u538b\u3002Rhopressa \u8fdb\u884c\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814<\/span>\u7a76\u6709\uff1a\u4f53\u5916\u9ed1\u8272\u7d20\u7ed3\u5408\u7814\u7a76\u548c\u8840\u6d46\u86cb\u767d\u7ed3\u5408\u7814\u7a76\uff0c\u6709<\/span>\u8272\u5154\u6ef4\u773c\u7ed9\u836f\u773c\u7ec4\u7ec7\u5206\u5e03\u548c\u5168\u8eab\u7ec4\u7ec7\u5206\u5e03\u7814\u7a76\uff08\u653e\u5c04<\/span>\u6027\u540c\u4f4d\u7d20\u6807\u8bb0\u6cd5\uff09\uff0c\u5927\u9f20\u9759\u8109\u7ed9\u836f\u7269\u8d28\u5e73\u8861\u7814\u7a76\u548c\u5168\u8eab<\/span>\u653e\u5c04\u81ea\u663e\u5f71\u5206\u5e03\u7814\u7a76\uff0c\u5154\u6ef4\u773c\u7ed9\u836f\u623f\u6c34\u836f\u7269\u6d53\u5ea6- \u65f6<\/span>\u95f4\u66f2\u7ebf\u7814\u7a76\u3002<\/p>\n

Aflibercept \u5f00\u5c55\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u6709\uff1a<\/p>\n

\u2460 \u6709\u8272\u5154\u548c\u98df\u87f9\u7334\u73bb\u7483\u4f53\u6ce8\u5c04\u7ed9\u836f\u7684\u7ec4\u7ec7\u5206\u5e03\u7814\u7a76\uff0c\u5305\u62ec\u8109\u7edc<\/span>\u819c\u3001\u89c6\u7f51\u819c\u3001\u73bb\u7483\u4f53\u548c\u8840\u6d46\u4e2d\u836f\u7269\u6d53\u5ea6- \u65f6\u95f4\u66f2\u7ebf\u7814<\/span>\u7a76\uff1b<\/span><\/p>\n

\u2461\u5927\u9f20\u9759\u8109\u7ed9\u836f\u540e\u7684\u5168\u8eab\u7ec4\u7ec7\u5206\u5e03\u7814\u7a76\uff08\u540c\u4f4d\u7d20<\/span>\u6807\u8bb0\uff09\uff1b<\/span><\/p>\n

\u2462 \u5c0f\u9f20\u3001\u5927\u9f20\u548c\u98df\u87f9\u7334\u4e2d\u9759\u8109\u7ed9\u836f\u548c\u76ae\u4e0b\u7ed9<\/span>\u836f\u540e\u8840\u6e05\u836f\u7269\u6d53\u5ea6- \u65f6\u95f4\u66f2\u7ebf\u7814\u7a76\u3002<\/p>\n

2.2.1\u3000\u773c\u7ec4\u7ec7\u751f\u7269\u6837\u54c1\u7684\u91c7\u96c6\u548c\u5904\u7406[10]\u3000<\/strong><\/p>\n

\u773c\u7531\u591a\u79cd\u5f02\u8d28\u6027\u7684\u7ec4\u7ec7\u548c\u6db2\u4f53\u7ec4\u6210\uff0c\u5728\u8fdb\u884c\u773c\u7ec4\u7ec7\u836f\u4ee3\u52a8\u529b\u5b66\u7814<\/span><\/p>\n

\u7a76\u65f6\uff0c\u9700\u8981\u5bf9\u5404\u7ec4\u7ec7\/ \u6db2\u4f53\u8fdb\u884c\u7cbe\u7ec6\u5206\u79bb\u3002<\/p>\n

\u6309\u7167\u7ed3\u6784\u7ec4\u6210\u548c\u6837\u54c1\u540e\u7eed\u5904\u7406\u7a0b\u5e8f\u7684\u4e0d\u540c\u5206\u4e3a\uff1a<\/span><\/p>\n

\u2460 \u6cea\u6db2\uff0c\u4e3b\u8981<\/span>\u7531\u86cb\u767d\u3001\u8102\u8d28\u3001\u78b3\u6c34\u5316\u5408\u7269\u548c\u7535\u89e3\u8d28\u7ec4\u6210\uff0c\u53ef\u91c7\u7528\u6cea\u6db2\u68c0\u6d4b\u6ee4\u7eb8\u6761\u91c7\u96c6\uff1b<\/span><\/p>\n

\u2461 \u623f\u6c34\uff0c\u548c\u8840\u6d46\u8d85\u6ee4\u6db2\u7535\u89e3\u8d28\u6d53<\/span>\u5ea6\u57fa\u672c\u76f8\u4f3c\uff0c\u4f46\u623f\u6c34\u4e2d\u86cb\u767d\u542b\u91cf\u5f88\u4f4e\uff0c\u7ea6\u662f\u8840\u6d46\u86cb\u767d<\/span>\u6d53\u5ea6\u76840.5%\uff0c\u6837\u54c1\u5904\u7406\u65b9\u6cd5\u76f8\u5bf9\u7b80\u5355\uff1b<\/span><\/p>\n

\u2462 \u73bb\u7483\u4f53\u6db2\uff0c<\/span>\u4e3b\u8981\u7531\u6c34\u7ec4\u6210\uff0c\u4f46\u542b\u6709\u80f6\u539f\u86cb\u767d\u3001\u900f\u660e\u8d28\u9178\u53ca\u5176\u4ed6\u86cb<\/span>\u767d\u805a\u7cd6\uff0c\u8fd9\u4f7f\u73bb\u7483\u4f53\u6db2\u5177\u6709\u51dd\u80f6\u6837\u6027\u8d28\uff0c\u836f\u7269\u5728\u73bb\u7483<\/span>\u4f53\u6db2\u4e2d\u4e0d\u5747\u5300\u5206\u5e03\uff0c\u56e0\u6b64\u5e94\u5c06\u5168\u90e8\u73bb\u7483\u4f53\u6db2\u6df7\u5300\u540e\u518d<\/span>\u53d6\u6837\u5206\u6790\uff1b<\/span><\/p>\n

\u2463 \u89d2\u819c\u3001\u5de9\u819c\u548c\u6676\u72b6\u4f53\u7ec4\u7ec7\u542b\u6709\u80f6\u539f\u86cb\u767d\u3001<\/span>\u7cd6\u80fa\u805a\u7cd6\u548c\u86cb\u767d\u805a\u7cd6\uff0c\u96be\u4ee5\u5300\u6d46\uff0c\u9700\u8981\u66f4\u957f\u6216\u66f4\u591a\u7684<\/span>\u5300\u6d46\u5904\u7406\u64cd\u4f5c\uff1b<\/span><\/p>\n

\u2464 \u8679\u819c\u3001\u776b\u72b6\u4f53\u3001\u8109\u7edc\u819c\u548c\u89c6\u7f51\u819c\u7ec4<\/span>\u7ec7\u4e2d\u5b58\u5728\u9ed1\u8272\u7d20\uff0c\u82e5\u836f\u7269\u4e0e\u9ed1\u8272\u7d20\u7ed3\u5408\uff0c\u53ef\u80fd\u4f1a\u5f71\u54cd<\/span>\u836f\u7269\u7684\u68c0\u51fa\uff0c\u6837\u54c1\u5904\u7406\u548c\u5206\u6790\u65f6\u5e94\u8003\u8651\u9ed1\u8272\u7d20\u7ed3\u5408\u5bf9<\/span>\u68c0\u6d4b\u7ed3\u679c\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\u52a8\u7269\u5b89\u4e50\u6b7b\u540e\uff0c\u773c\u7ec4\u7ec7\u4e2d\u7684\u751f\u7269\u5c4f\u969c\u4f1a\u8fc5\u901f\u7834\u574f\uff0c\u836f\u7269\u4f1a\u5728\u6574\u4e2a\u773c\u7ec4\u7ec7\u4e2d\u8fc5\u901f\u8fbe\u5230\u5e73\u8861\u3002\u773c\u7ec4\u7ec7\u4e2d\u7684\u916f<\/span>\u9176\u5728\u79bb\u4f53\u6761\u4ef6\u4e0b\u4e5f\u6709\u4e00\u5b9a\u7684\u6d3b\u6027\u3002\u56e0\u6b64\u5904\u7406\u52a8\u7269\u540e\uff0c<\/span>\u5e94\u8fc5\u901f\u6458\u53d6\u773c\u7403\u5e76\u7acb\u5373\u653e\u5165\u6db2\u6c2e\u6216\u5e72\u51b0\u4e2d\u4fdd\u5b58\uff0c\u4ee5\u9632<\/span>\u6b62\u836f\u7269\u8f6c\u79fb\u5230\u90bb\u8fd1\u7ec4\u7ec7\u4e2d\u6216\u88ab\u4ee3\u8c22\u6d88\u9664\uff0c\u89e3\u5256\u5206\u79bb\u773c<\/span>\u7ec4\u7ec7\u65f6\u4e5f\u5e94\u5168\u7a0b\u5728\u51b7\u51bb\u72b6\u6001\u4e0b\u5b8c\u6210\u3002<\/span><\/p>\n

2.2.2\u3000\u66ff\u4ee3\u57fa\u8d28\u7684\u4f7f\u7528<\/strong>\u3000<\/p>\n

\u5728\u8fdb\u884c\u751f\u7269\u5206\u6790\u65f6\uff0c\u4e00\u822c\u91c7\u7528\u4e0e\u5f85\u6d4b\u6837\u54c1\u76f8\u540c\u7684\u751f\u7269\u57fa\u8d28\u5efa\u7acb\u6807\u51c6\u66f2\u7ebf\u3002\u5728\u5bf9\u773c<\/span>\u7ec4\u7ec7\u6837\u54c1\u8fdb\u884c\u751f\u7269\u5206\u6790\u65f6\uff0c\u7531\u4e8e\u773c\u7ec4\u7ec7\u6837\u672c\u8f83\u5c0f\uff0c\u4e0d<\/span>\u53ef\u80fd\u5256\u6740\u5927\u91cf\u52a8\u7269\u6765\u83b7\u5f97\u5bf9\u7167\u57fa\u8d28\uff0c\u53ef\u91c7\u7528\u4e0e\u773c\u7ec4\u7ec7<\/span>\u6837\u54c1\u9ad8\u5ea6\u76f8\u4f3c\u7684\u66ff\u4ee3\u57fa\u8d28\u3002<\/span><\/p>\n

\u82e5\u65e0\u6cd5\u83b7\u5f97\u9ad8\u5ea6\u76f8\u8fd1\u7684\u66ff<\/span>\u4ee3\u57fa\u8d28\uff0c\u4e5f\u53ef\u91c7\u7528\u7565\u5fae\u76f8\u8fd1\u7684\u66ff\u4ee3\u57fa\u8d28\uff08\u5982\u8840\u6d46\uff09\uff0c\u8fd9<\/span>\u65f6\u4e00\u822c\u9700\u7528\u5185\u90e8\u6807\u51c6\u54c1\uff08\u5f53\u4f7f\u7528LC-MS\/MS \u6cd5\u65f6\uff09\u8fdb<\/span>\u884c\u6821\u6b63\uff0c\u6837\u54c1\u5904\u7406\u65b9\u6cd5\u5e94\u4e0e\u5f85\u6d4b\u6837\u54c1\u7684\u5904\u7406\u65b9\u6cd5\u4e00\u81f4\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u5b58\u5728\u9ed1\u8272\u7d20\u7684\u7ec4\u7ec7\uff0c\u82e5\u91c7\u7528\u542b\u6709\u9ed1\u8272\u7d20\u7684\u7ec4\u7ec7\u5efa<\/span>\u7acb\u6807\u51c6\u66f2\u7ebf\uff0c\u53ea\u8981\u5728\u6d4b\u5b9a\u6d53\u5ea6\u8303\u56f4\u5185\uff0c\u836f\u7269\u4e0e\u66ff\u4ee3\u57fa<\/span>\u8d28\u9ed1\u8272\u7d20\u7684\u7ed3\u5408\u7a0b\u5ea6\u4e0e\u5f85\u6d4b\u57fa\u8d28\u4e2d\u9ed1\u8272\u7d20\u7ed3\u5408\u7a0b\u5ea6\u76f8<\/span>\u4f3c\uff0c\u5bf9\u6d4b\u5b9a\u7ed3\u679c\u5f71\u54cd\u4e0d\u5927\uff1b\u82e5\u91c7\u7528\u65e0\u9ed1\u8272\u7d20\u7684\u7ec4\u7ec7\u4f5c<\/span>\u4e3a\u66ff\u4ee3\u57fa\u8d28\u5efa\u7acb\u6807\u51c6\u66f2\u7ebf\uff0c\u53d7\u5185\u6e90\u6027\u9ed1\u8272\u7d20\u7684\u5f71\u54cd\uff0c<\/span>\u66ff\u4ee3\u57fa\u8d28\u4e2d\u7684\u836f\u7269\u54cd\u5e94\u503c\u53ef\u80fd\u4e0e\u5f85\u6d4b\u6837\u54c1\u4e2d\u4e0d\u540c\uff0c\u8fd9<\/span>\u65f6\u9700\u7528\u5185\u90e8\u6807\u51c6\u54c1\u6765\u8fdb\u884c\u6821\u6b63\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
\n
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3<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n

\u975e\u4e34\u5e8a\u5b89\u5168\u6027\u8bd5\u9a8c<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

3.1\u3000\u4e00\u822c\u8003\u8651<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e0e\u5e38\u89c4\u836f\u7269\u7684\u975e\u4e34\u5e8a\u5f00\u53d1\u7b56\u7565\u76f8\u4f3c\uff0c\u773c\u79d1\u836f\u7269\u5e94\u6309\u7167ICH M3\uff08R2\uff09Nonclinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals \u548cICH S6 Preclinical safety evaluation of biotechnology-derived pharmaceuticals \u7684\u8981\u6c42\u5206\u9636\u6bb5\u5f00\u5c55\u652f\u6301\u4e34\u5e8a\u8bd5\u9a8c\u6216\u4e0a\u5e02\u7684\u975e\u4e34\u5e8a\u5b89\u5168\u6027\u8bd5\u9a8c\u3002<\/p>\n

\u5bf9\u4e8e\u773c\u5c40\u90e8\u7ed9\u836f\u7684\u836f\u7269\uff0c\u4e00\u822c\u9700\u8981\u4e34\u5e8a\u62df\u7528\u7ed9\u836f\u9014\u5f84\u548c\u5168\u8eab\u7ed9\u836f\u9014\u5f84\u7684\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u3002<\/p>\n

\u5168\u8eab\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u662f\u4e3a\u4e86\u63d0\u9ad8\u836f\u7269\u7cfb\u7edf\u66b4\u9732\u6c34\u5e73\uff0c\u53d1\u73b0\u773c\u4ee5\u5916\u7684\u6bd2\u6027\u9776\u5668\u5b98\/ \u6bd2\u6027\u53cd\u5e94\uff0c\u4e00\u822c\u91c7\u7528\u4e24\u79cd\u76f8\u5173\u52a8\u7269\u9759\u8109\u7ed9\u836f28 d\uff08\u9664\u975e\u6709\u7279\u6b8a\u7684\u5b89\u5168\u6027\u62c5\u5fe7\uff09\uff0c\u89c2\u5bdf\u6307\u6807\u540c\u5e38\u89c4\u7684\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u3002<\/p>\n

\u773c\u5c40\u90e8\u7ed9\u836f\u7684\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u5e38\u7528\u5154\u548c\u7334\uff0c\u9664\u5e38\u89c4\u89c2\u5bdf\u6307\u6807\u5916\uff0c\u8fd8\u5305\u62ec\u66f4\u8be6\u7ec6\u548c\u7cfb\u7edf\u7684\u773c\u79d1\u68c0\u67e5\u548c\u773c\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\uff08\u5305\u62ec\u773c\u5185\u7ec4\u7ec7\u548c\u773c\u5468\u7ec4\u7ec7\uff09\u3002\u773c\u8868\u5c40\u90e8\u7ed9\u836f\u6700\u5927\u4f53\u79ef\u7ea6\u4e3a30 \u03bcL\uff0c\u73bb\u7483\u4f53\u6ce8\u5c04\u6700\u5927\u7ed9\u836f\u4f53\u79ef\u4e3a100 \u03bcL\uff0c\u7ed9\u836f\u4f53\u79ef<\/p>\n

\u8fc7\u5927\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4e34\u5e8a\u4e0d\u76f8\u5173\u7684\u6bd2\u6027\u51fa\u73b0\uff1b\u4e3a\u6700\u5927\u7a0b\u5ea6\u66b4\u9732\u773c\u6bd2\u6027\uff0c\u4e00\u822c\u91c7\u7528\u53cc\u773c\u540c\u65f6\u7ed9\u836f\u5e76\u63d0\u9ad8\u7ed9\u836f\u9891\u7387\u3002<\/p>\n

\u5373\u4f7f\u4e34\u5e8a\u62df\u7528\u9014\u5f84\u4e0b\u65e0\u660e\u663e\u7684\u5168\u8eab\u66b4\u9732\uff0c\u4ecd\u9700\u5728\u4e24\u79cd\u76f8\u5173\u52a8\u7269\u79cd\u5c5e\u4e2d\u5f00\u5c55\u80da\u80ce- \u80ce\u4ed4\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\uff0c\u63a8\u8350\u91c7\u7528\u5168\u8eab\u7ed9\u836f\u9014\u5f84\u3002\u6839\u636e\u773c\u5c40\u90e8\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u7ed3\u679c\u3001\u80da\u80ce- \u80ce\u4ed4\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\u7ed3\u679c\u4ee5\u53ca\u5168\u8eab\u66b4\u9732\u7684\u5b89\u5168\u8303\u56f4\uff0c\u53ef\u80fd\u8fd8\u9700\u8981\u8ffd\u52a0\u5176\u4ed6\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\uff0c\u5982\u5927\u9f20\u751f\u80b2\u529b\u548c\u65e9\u671f\u80da\u80ce\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\u548c\u56f4\u4ea7\u671f\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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3.2\u3000\u773c\u79d1\u68c0\u67e5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u773c\u79d1\u836f\u7269\u6bd2\u6027\u7814\u7a76\u9700\u8981\u540c\u65f6\u8003\u5bdf\u5168\u8eab\u6bd2\u6027\u548c\u773c\u5c40\u90e8\u6bd2\u6027\u3002\u7531\u4e8e\u773c\u5177\u6709\u900f\u660e\u6027\uff0c\u773c\u79d1\u68c0\u67e5\u53ef\u76f4\u63a5\u5728\u6d3b\u4f53<\/span>\u52a8\u7269\u4e2d\u53cd\u590d\u89c2\u5bdf\u773c\u5185\u7ed3\u6784\uff0c\u53ef\u4e0e\u75c5\u7406\u5b66\u6307\u6807\u76f8\u7ed3\u5408\u7efc<\/span>\u5408\u8bc4\u4f30\u773c\u5c40\u90e8\u6bd2\u6027\u3002<\/span><\/p>\n

\u6839\u636e\u6240\u7528\u52a8\u7269\u79cd\u5c5e\u548c\u7814\u7a76\u76ee\u7684\u4e0d<\/span>\u540c\uff0c\u6240\u5f00\u5c55\u7684\u773c\u79d1\u68c0\u67e5\u9879\u76ee\u4e5f\u6709\u6240\u4e0d\u540c\u3002\u5e38\u89c4\u773c\u79d1\u68c0<\/span>\u67e5\u5e94\u81f3\u5c11\u5305\u62ec\u773c\u9644\u5c5e\u7ed3\u6784\uff08\u773c\u7751\u548c\u7ed3\u819c\uff09\u3001\u773c\u524d\u6bb5\uff08\u89d2<\/span>\u819c\u3001\u524d\u623f\u3001\u8679\u819c\u548c\u73bb\u7483\u4f53\u7b49\uff09\u548c\u773c\u540e\u6bb5\uff08\u73bb\u7483\u4f53\u3001\u89c6\u7f51<\/span>\u819c\u7b49\uff09\u68c0\u67e5\uff0c\u4e00\u822c\u91c7\u7528\u88c2\u9699\u706f\u751f\u7269\u663e\u5fae\u955c\u68c0\u67e5\u548c\u95f4\u63a5\/<\/span>\u76f4\u63a5\u68c0\u9a8c\u955c\u68c0\u67e5\u3002<\/span><\/p>\n

\u7cfb\u7edf\u7684\u773c\u79d1\u68c0\u67e5\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u89d2\u819c<\/span>\u8367\u5149\u7d20\u94a0\u67d3\u8272\u3001\u89d2\u819c\u539a\u5ea6\u6d4b\u91cf\u3001\u773c\u538b\u6d4b\u5b9a\u3001\u773c\u5e95\u7167\u76f8\u3001<\/span>\u8367\u5149\u7d20\u8840\u7ba1\u9020\u5f71\u3001\u89c6\u89c9\u7cfb\u7edf\u7535\u751f\u7406\u68c0\u67e5\uff08\u89c6\u89c9\u8bf1\u53d1\u52a8<\/span>\u4f5c\u7535\u4f4d\u3001\u89c6\u7f51\u819c\u7535\u56fe\uff09\u548c\u5149\u5b66\u76f8\u5e72\u65ad\u5c42\u626b\u63cf\uff08OCT\uff09<\/span>\u7b49\uff0c\u8fd9\u4e9b\u68c0\u67e5\u65b9\u6cd5\u8054\u5408\u4f7f\u7528\u53ef\u63d0\u4f9b\u66f4\u5b8c\u6574\u3001\u66f4\u5168\u9762\u7684<\/span>\u4fe1\u606f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3.3\u3000\u6848\u4f8b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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Rhopressa\uff08\u6ef4\u773c\u6db2\uff09\u5f00\u5c55\u7684\u975e\u4e34\u5e8a\u5b89\u5168\u6027\u7684\u7814\u7a76\u6709\uff1a<\/span><\/p>\n

\u2460 \u5b89\u5168\u836f\u7406\u5b66\u65b9\u9762\uff1a\u4f53\u5916hERG \u8bd5\u9a8c\uff0c\u5728\u6e05\u9192\u9065<\/span>\u6d4b\u72ac\u4e2d\u8fdb\u884c\u7684\u9759\u8109\u7ed9\u836f\u7684\u5b89\u5168\u836f\u7406\u5b66\u8bd5\u9a8c\uff1b<\/span><\/p>\n

\u2461 \u91cd\u590d\u7ed9<\/span>\u836f\u6bd2\u6027\u8bd5\u9a8c\uff1a\u8bc4\u4f30\u4e86Rhopressa \u7684\u5168\u8eab\u6bd2\u6027\u548c\u773c\u5c40\u90e8<\/span>\u6bd2\u6027\uff0c\u5305\u62ec\u5927\u9f20\u548c\u72ac\u76847\u300128 d \u91cd\u590d\u9759\u8109\u7ed9\u836f\u6bd2\u6027\u8bd5<\/span>\u9a8c\uff0c\u5154\uff081\u30013 \u548c6 \u4e2a\u6708\uff09\u548c\u7334\uff081 \u548c9 \u4e2a\u6708\uff09\u91cd\u590d\u6ef4\u773c<\/span>\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\uff1b<\/span><\/p>\n

\u2462 \u6807\u51c6\u7ec4\u5408\u7684\u9057\u4f20\u6bd2\u6027\u8bd5\u9a8c\uff1b<\/span><\/p>\n

\u2463 \u5927\u9f20<\/span>\u548c\u5154\u9759\u8109\u7ed9\u836f\u7684\u80da\u80ce- \u80ce\u4ed4\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\uff08\u867d\u7136\u4e34\u5e8a<\/span>\u62df\u7528\u9014\u5f84\u4e0b\u65e0\u660e\u663e\u7684\u5168\u8eab\u66b4\u9732\uff09\u3002<\/p>\n

\u5728\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u5f00\u5c55\u7684\u773c\u79d1\u68c0\u67e5\u5305\u62ec\uff1a\u89d2\u819c\u8367\u5149\u7d20\u67d3\u8272\uff0b\u88c2\u9699\u706f\u663e<\/span>\u5fae\u955c\u68c0\u67e5\u3001\u95f4\u63a5\u68c0\u9a8c\u955c\u68c0\u67e5\u3001\u773c\u538b\u6d4b\u5b9a\u548c\u89c6\u7f51\u819c\u7535\u56fe<\/span>\u68c0\u67e5\u3002<\/p>\n

\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u9664\u5e38\u89c4\u7ec4\u7ec7\u68c0\u67e5\u5916\uff0c\u8fd8\u5bf9\u773c\u7ec4\u7ec7\u8fdb\u884c\u4e86\u8be6\u7ec6\u7684\u75c5\u7406\u5b66\u68c0\u67e5\u3002<\/span><\/p>\n

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\"\u773c\u79d1\u836f\u7269\u975e\u4e34\u5e8a\u7814\u7a76\u7684\u8003\u8651\"<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u773c\u79d1\u836f\u7269\u975e\u4e34\u5e8a\u7814\u7a76\u7684\u8003\u8651 Non-clinical study of ophthalmic drugs \u6765\u6e90 […]<\/p>\n","protected":false},"author":1,"featured_media":98082,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/98081"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=98081"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/98081\/revisions"}],"predecessor-version":[{"id":98094,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/98081\/revisions\/98094"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/98082"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=98081"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=98081"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=98081"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}