{"id":98198,"date":"2019-03-07T00:00:50","date_gmt":"2019-05-17T08:13:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/98198\/"},"modified":"2019-05-17T16:13:36","modified_gmt":"2019-05-17T08:13:36","slug":"da95400003","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/98198\/","title":{"rendered":"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"box-sizing: border-box;font-size: 16px;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;padding: 3px;border-radius: 1.6em;background-color: rgb(255, 129, 36);box-sizing: border-box;\">\n<section style=\"padding: 2px 8px;border-width: 1px;border-style: dotted;border-color: rgb(255, 255, 255);border-radius: 1.6em;color: rgb(255, 255, 255);line-height: 1.4em;font-size: 21px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558080811.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5bfc\u8bfb<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558080811.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u539f\u6587\u4f5c\u8005\u5c55\u793a\u4e86FDA\u4eff\u5236\u836f\u529e\u516c\u5ba4\u901a\u8fc7\u5efa\u6a21\u4e0e\u6a21\u62df\u65b9\u6cd5\u8bc4\u4f30\u4eff\u5236\u836f\u8d28\u91cf\u53d8\u5316\u5bf9\u751f\u7269\u7b49\u6548\u6027\u7684\u5f71\u54cd\u3002\u901a\u8fc7PBPK\u673a\u5236\u6027\u5438\u6536\u6a21\u578b\u6865\u63a5\u836f\u54c1\u4f53\u5916\u8d28\u91cf\u53d8\u5316\u548c\u4f53\u5185PK\u884c\u4e3a\uff0c\u4ece\u800c\u5206\u6790\u5f71\u54cd\u4f53\u5185PK\u53c2\u6570\u7684\u5173\u952e\u56e0\u7d20\uff0c\u5236\u5b9a\u4e86\u4fdd\u8bc1BE\u7684\u6eb6\u51fa\u8303\u56f4\uff1b\u8fd9\u5bf9\u4eff\u5236\u836f\u4f01\u4e1a\u91c7\u7528\u5efa\u6a21\u4e0e\u6a21\u62df\u65b9\u6cd5\u786e\u4fdd\u5728\u7814\u836f\u54c1\u7684\u751f\u7269\u7b49\u6548\u6027\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558080812.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<p style=\"margin-bottom:8px;text-align:center;\"><strong><span style=\"font-family:\u5b8b\u4f53;\">\u7814\u7a76\u6d41\u7a0b\u56fe<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558080812.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u53c2\u8003\u6587\u732e\u4f5c\u8005\u5355\u4f4d<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558080812-1.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">Zhang, X. , Wen, H. , Fan, J. , Vince, B. , Li, T. , Gao, W. , Kinjo, M. , Brown, J. , Sun, W. , Jiang, W. and Lionberger, R.<\/p>\n<p style=\"box-sizing: border-box;\">\u7f8e\u56fdFDA\u4eff\u5236\u836f\u529e\u516c\u5ba4OGD<\/p>\n<p style=\"box-sizing: border-box;\">\u7f8e\u56fdVince and Associates \u4e34\u5e8a\u7814\u7a76\u516c\u53f8<\/p>\n<p style=\"box-sizing: border-box;\">\u666e\u6e21\u5927\u5b66<\/p>\n<p style=\"box-sizing: border-box;\">\u7f8e\u56fdFDA\u7814\u7a76\u4e0e\u6807\u51c6\u5316\u529e\u516c\u5ba4ORS<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558080812.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6587\u7ae0\u89e3\u8bfb\u4eba<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558080812.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u738b\u94b0\u73ba\uff0c\u4e0a\u6d77\u6280\u672f\u90e8<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558080812.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558080812-1.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">Integrating&nbsp;In Vitro, Modeling, and&nbsp;In Vivo&nbsp;Approaches to Investigate Warfarin Bioequivalence. CPT Pharmacometrics Syst. Pharmacol., 6: 523-531.&nbsp;&nbsp;<\/p>\n<p style=\"box-sizing: border-box;\">&nbsp;IF: 6.544<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558080812.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558080813.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8f6f\u4ef6\u7528\u9014<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558080813.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u539f\u6587\u4f5c\u8005\u91c7\u7528GastroPlus\u8f6f\u4ef6\u642d\u5efaPBPK\u673a\u5236\u6027\u5438\u6536\u6a21\u578b\uff0c\u901a\u8fc7\u6a21\u578b\u8fde\u63a5\u4e86\u4f53\u5916\u8bd5\u9a8c\u6570\u636e\u548c\u4f53\u5185PK\u6570\u636e\uff0c\u5e76\u901a\u8fc7\u53c2\u6570\u654f\u611f\u6027\u5206\u6790\u8003\u5bdf\u4e86\u5f71\u54cd\u4f53\u5185PK\u53c2\u6570\u7684\u5173\u952e\u56e0\u7d20\uff0c\u5982\u6eb6\u89e3\u5ea6\u3001\u7c92\u5f84\u3001\u6eb6\u51fa\u901f\u7387\u7b49\uff0c\u63a5\u7740\u5728\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u6a21\u578b\u4e0a\u8fdb\u884c\u865a\u62df\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4f30\uff0c\u4e3a\u5236\u5b9a\u8d28\u91cf\u63a7\u5236\u7684\u4f53\u5916\u6eb6\u51fa\u8303\u56f4\u63d0\u4f9b\u4e86\u4f9d\u636e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558080813-1.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6848\u4f8b\u6458\u8981<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558080813.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u6709\u6587\u732e\u62a5\u9053\uff1a\u534e\u6cd5\u6797\u7ed3\u6676\u5305\u5408\u7269\u4e2d\u5f02\u4e19\u9187\u7684\u51cf\u5c11\u548c\u9178\u6027pH\u6761\u4ef6\uff08\u6bd4\u59824.5\uff09\u4e0b\u6eb6\u51fa\u7684\u53d8\u6162\u5c06\u5bf9\u5176\u4f53\u5185\u7684PK\u6709\u663e\u8457\u7684\u5f71\u54cd\u3002\u539f\u6587\u4f5c\u8005\u901a\u8fc7\u5efa\u6a21\u4e0e\u6a21\u62df\u7684\u65b9\u6cd5\uff0c\u63a2\u8ba8\u534e\u6cd5\u6797\u7ed3\u6676\u5305\u5408\u7269\u7684\u8d28\u91cf\u63a7\u5236\u5e94\u91c7\u7528pH 4.5\u8fd8\u662fpH 6.8\u7684\u6eb6\u51fa\u4ecb\u8d28\u6765\u8bc4\u4ef7\u5176\u751f\u7269\u7b49\u6548\u6027\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u672c\u7814\u7a76\u901a\u8fc7\u6784\u5efa\u57fa\u4e8e\u751f\u7406\u5b66\u7684\u673a\u5236\u6027\u5438\u6536\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\uff0c\u5e76\u5c06\u5236\u5242\u76f8\u5173\u7684\u53c2\u6570\u548c\u4f53\u5916\u6eb6\u51fa\u76f8\u5173\u6570\u636e\u8f93\u5165\u5230\u6a21\u578b\u4e2d\u3002\u6a21\u578b\u7684\u53c2\u6570\u654f\u611f\u6027\u5206\u6790\u8868\u660e\uff1a\u6eb6\u89e3\u5ea6\u3001\u7c92\u5f84\u3001\u5bc6\u5ea6\u4e0d\u662f\u5f71\u54cd\u534e\u6cd5\u6797\u5728\u4f53\u5185\u7684PK\u884c\u4e3a\u7684\u5173\u952e\u56e0\u7d20\uff0cpH 4.5\u6eb6\u51fa\u4ecb\u8d28\u4e2d\u7684\u6eb6\u51fa\u4e0e\u4f53\u5185PK\u76f8\u5173\u6027\u4e0d\u5f3a\uff0c\u4f46\u5728pH 6.8\u7684\u6eb6\u51fa\u4ecb\u8d28\u4e2d\uff0c\u5176\u6eb6\u51fa\u901f\u7387\u548c\u6eb6\u51fa\u80fd\u529b\u4e0e\u4f53\u5185PK\u6709\u8f83\u5f3a\u7684\u76f8\u5173\u6027\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u865a\u62df\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u8868\u660e\uff0c\u7ecf\u52a0\u901f\u964d\u89e3\u5b9e\u9a8c\uff08\u9ad8\u6e29\u9ad8\u6e7f\u5904\u7406\uff09\u540e\u7684\u534e\u6cd5\u6797\u94a0\u7247\u5728pH 4.5\u6eb6\u51fa\u4ecb\u8d28\u4e2d\u7684\u6eb6\u51fa\u901f\u7387\u5c06\u53d8\u6162\uff0c\u4f46\u4e0d\u5f71\u54cd\u751f\u7269\u7b49\u6548\u6027\u7ed3\u679c\uff1b\u53ea\u8981\u5728pH 6.8\u6eb6\u51fa\u4ecb\u8d28\u4e2d\u7684\u6eb6\u51fa\u4e0e\u672a\u7ecf\u52a0\u901f\u964d\u89e3\u7684\u5236\u5242\u7684\u6eb6\u51fa\u76f8\u4f3c\uff0c\u5c31\u80fd\u786e\u4fdd\u4e8c\u8005\u751f\u7269\u7b49\u6548\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u63a5\u7740\uff0c\u672c\u7814\u7a76\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u4e86BE\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\u6a21\u62df\u7ed3\u679c\u662f\u6b63\u786e\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558080813.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7814\u7a76\u4eae\u70b9<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558080813.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8be5\u7814\u7a76\u5f53\u524d\u5df2\u83b7\u5f97\u54ea\u4e9b\u4fe1\u606f\uff1f<\/strong><\/p>\n<p style=\"box-sizing: border-box;\">\u7814\u7a76\u8868\u660e\uff0c\u5728\u77ed\u65f6\u95f4\u66b4\u9732\u4e8e\u8f83\u9ad8\u7684\u6e29\u5ea6\u548c\u6e7f\u5ea6\u4e4b\u540e\uff0c\u534e\u6cd5\u6797\u94a0\u7247\u53ef\u80fd\u5bb9\u6613\u53d1\u751f\u6676\u578b\u7684\u53d8\u5316\uff0c\u4f46\u662f\u8fd9\u79cd\u836f\u54c1\u8d28\u91cf\u7684\u53d8\u5316\u5e26\u6765\u7684\u4e34\u5e8a\u610f\u4e49\uff08\u751f\u7269\u5229\u7528\u5ea6\uff09\u662f\u672a\u77e5\u7684\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8be5\u7814\u7a76\u60f3\u89e3\u51b3\u7684\u95ee\u9898\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n<p style=\"box-sizing: border-box;\">\u672c\u7814\u7a76\u91c7\u7528\u5efa\u6a21\u548c\u6a21\u62df\u8bc4\u4f30\u836f\u54c1\u8d28\u91cf\u7684\u53d8\u5316\u5bf9\u5176\u4f53\u5185\u884c\u4e3a\u7684\u5f71\u54cd\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8be5\u7814\u7a76\u80fd\u589e\u52a0\u54ea\u4e9b\u77e5\u8bc6\uff1f<\/strong><\/p>\n<p style=\"box-sizing: border-box;\">\u9664\u4e86\u83b7\u5f97\u5173\u4e8e\u836f\u54c1\u8d28\u91cf\u5bf9\u534e\u6cd5\u6797\u4f53\u5185PK\u6027\u80fd\u5f71\u54cd\u7684\u65b0\u89c1\u89e3\u4e4b\u5916\uff0c\u8be5\u7814\u7a76\u8fd8\u663e\u793a\u4e86PBPK\u673a\u5236\u6027\u5438\u6536\u5efa\u6a21\u4e0e\u6a21\u62df\u5728\u79d1\u5b66\u7814\u7a76\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5c06\u5982\u4f55\u6539\u53d8\u836f\u7269\u53d1\u73b0\u3001\u5f00\u53d1\u6216\u6cbb\u7597\u7684\u51b3\u7b56\uff1f<\/strong><\/p>\n<p style=\"box-sizing: border-box;\">\u56e0\u5236\u5242\u5904\u65b9\u3001\u751f\u7269\u836f\u5242\u5b66\u7684\u53d8\u66f4\u53ef\u80fd\u5bfc\u81f4\u836f\u7269\u751f\u7269\u5229\u7528\u5ea6\u7684\u6539\u53d8\uff0c\u53ef\u901a\u8fc7\u5efa\u6a21\u4e0e\u6a21\u62df\u5de5\u5177\u8bc4\u4f30\u8be5\u53d8\u5316\u7ed9\u60a3\u8005\u5e26\u6765\u7684\u6f5c\u5728\u98ce\u9669\uff0c\u5f53\u8fbe\u5230\u7684\u98ce\u9669\u6c34\u5e73\u53ef\u80fd\u4ea7\u751f\u65b0\u7684\u4f53\u5185BE\u6216\u751f\u7269\u5229\u7528\u5ea6\u6570\u636e\u65f6\uff0c\u4f1a\u5f71\u54cd\u836f\u7269\u5f00\u53d1\u548c\u836f\u7269\u76d1\u7ba1\u65b9\u9762\u7684\u51b3\u7b56\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 18px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">1<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u57fa\u4e8e\u751f\u7406\u5b66\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5efa\u6a21\u4e0e\u6a21\u62df\u5df2\u7ecf\u5728\u836f\u7269\u5236\u5242\u5f00\u53d1\u548c\u76d1\u7ba1\u5ba1\u8bc4\u65b9\u9762\u5c55\u73b0\u51fa\u5b9e\u7528\u6027\uff0c\u57fa\u4e8e\u751f\u7406\u7684\u673a\u5236\u6027\u5438\u6536\u6a21\u578b\u8fde\u63a5\u4e86\u836f\u7269\u7684\u7406\u5316\u6027\u8d28\u3001\u5236\u5242\u7684\u4f53\u5916\u884c\u4e3a\u548c\u4f53\u5185\u884c\u4e3a\u3002\u5728\u751f\u7269\u7b49\u6548\u6027\uff08BE\uff09\u3001\u5efa\u7acb\u4f53\u5185\u5916\u5173\u7cfb\u548c\u836f\u54c1\u5f00\u53d1\u4e2d\u7684\u8d28\u91cf\u6e90\u4e8e\u8bbe\u8ba1\u65b9\u9762\uff0c\u673a\u5236\u6027\u7684\u5438\u6536\u6a21\u578b\u5df2\u88ab\u7528\u4e8e\u7814\u7a76\u5904\u65b9\u3001\u4f53\u5916\u884c\u4e3a\u5bf9\u53e3\u670d\u7ed9\u836f\u540e\u836f\u7269\u4f53\u5185\u884c\u4e3a\u7684\u5f71\u54cd\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u5c06\u4ee5\u534e\u6cd5\u6797\u94a0\u7247\u4e3a\u4f8b\uff0c\u8bf4\u660e\u5efa\u6a21\u548c\u6a21\u62df\u5728\u63a2\u7a76\u4eff\u5236\u836fBE\u95ee\u9898\u4e2d\u7684\u4f5c\u7528\u3002\u534e\u6cd5\u6797\u5c5e\u4e8e\u5f31\u9178\uff0cpKa 5.05\uff0c\u5728\u4f4epH\u6761\u4ef6\u4e0b\u6eb6\u89e3\u5ea6\u8f83\u4f4e\uff0c\u9ad8pH\u6761\u4ef6\u4e0b\u6eb6\u89e3\u5ea6\u8f83\u9ad8\u3002\u534e\u6cd5\u6797\u94a0\u662f\u534e\u6cd5\u6797\u7684\u94a0\u76d0\uff0c\u4ee5\u65e0\u5b9a\u578b\u5f62\u5f0f\u6216\u7ed3\u6676\u5305\u5408\u7269\u5f62\u5f0f\u5b58\u5728\u3002\u7ed3\u6676\u5305\u5408\u7269\u662f\u4e00\u79cd\u534e\u6cd5\u6797\u94a0\u5f02\u4e19\u9187\uff08IPA\uff09\u590d\u5408\u7269\uff0c\u5728\u9ad8\u6e7f\u5ea6\uff08RH\uff09\u73af\u5883\u4e2dIPA\u51cf\u5c11\uff0c\u7ed3\u6676\u5305\u5408\u7269\u8f6c\u53d8\u6210\u65e0\u5b9a\u578b\u5e76\u4e14\u6b64\u8f6c\u53d8\u4e0d\u53ef\u9006\u3002\u5bf9\u4e8e\u6d74\u5ba4\u8fd9\u79cd\u9ad8\u6e7f\u5ea6\u7684\u73af\u5883\uff0c\u662f\u5426\u4f1a\u5f15\u8d77IPA\u7684\u51cf\u5c11\u4ece\u800c\u5f71\u54cd\u836f\u7269\u7684\u4f53\u5185\u884c\u4e3a\uff0c\u8fd9\u662f\u63a5\u4e0b\u6765\u7684\u7814\u7a76\u65b9\u5411\u3002\u6587\u732e\u62a5\u9053\u6307\u51fa\u786c\u5ea6\u3001\u5d29\u89e3\u65f6\u95f4\u3001\u542b\u91cf\u3001\u5747\u4e00\u6027\u3001IPA\u3001\u542b\u6c34\u91cf\u3001\u7ed3\u6676\u5ea6\u3001\u6eb6\u51fa\u7b49\u5173\u952e\u8d28\u91cf\u5c5e\u6027\u90fd\u4f1a\u5f71\u54cd\u534e\u6cd5\u6797\u94a0\u5236\u5242\u7684\u8d28\u91cf\uff0c\u5e76\u4e14\u8fd8\u89c2\u5bdf\u5230\u4ece\u7ed3\u6676\u5305\u5408\u7269\u5230\u65e0\u5b9a\u578b\u7684\u6676\u578b\u8f6c\u53d8\u3001\u9178\u6027\u6761\u4ef6\u4e0b\uff08pH 1.2 \u548cpH 4.5\uff09\u6eb6\u51fa\u901f\u7387\u7684\u964d\u4f4e\u90fd\u4f1a\u5f71\u54cd\u534e\u6cd5\u6797\u94a0\u7684\u836f\u54c1\u8d28\u91cf\uff0c\u800c\u4e2d\u6027\u6761\u4ef6\u4e0b\uff08\u5982pH 6.8\uff09\u6eb6\u51fa\u901f\u7387\u7684\u964d\u4f4e\u5bf9\u4e0d\u4f1a\u5bf9\u5176\u4ea7\u751f\u5f71\u54cd\u3002\u7531\u4e8e\u534e\u6cd5\u6797\u94a0\u7247\u4e2dIPA\u7684\u51cf\u5c11\uff0c\u5728\u9178\u6027pH\u6761\u4ef6\u4e0b\u91ca\u653e\u53d8\u6162\uff0c\u5bfc\u81f4\u7ecf\u52a0\u901f\u964d\u89e3\uff08\u9ad8\u6e29\u3001\u9ad8\u6e7f\u5904\u7406\uff09\u548c\u672a\u7ecf\u52a0\u901f\u964d\u89e3\u4e4b\u95f4\u751f\u7269\u7b49\u6548\u6027\u7684\u95ee\u9898\u3002\u7531\u4e8e\u534e\u6cd5\u6797\u7684\u5242\u91cf\u6216\u8840\u6d46\u6d53\u5ea6\u7684\u5fae\u5c0f\u53d8\u5316\u90fd\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u7684\u6cbb\u7597\u5931\u8d25\u6216\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u88abFDA\u5f52\u7c7b\u4e3a\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 21px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">2<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7814\u7a76\u65b9\u6cd5<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 18px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">2.1 \u4f53\u5916\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u7814\u7a76\u5185\u5bb9\u5305\u62ec\u542b\u91cf\u3001\u7eaf\u5ea6\u3001IPA\u542b\u91cf\u3001\u4f53\u5916\u6eb6\u51fa\u3001\u65e0\u5b9a\u578b\u6676\u578b\u542b\u91cf\u7684\u6d4b\u5b9a\uff0c\u4f53\u5916\u6eb6\u51fa\u5b9e\u9a8c\u91c7\u7528USPII\u6cd5\uff0c\u6eb6\u51fa\u4ecb\u8d28\u5305\u62ec\u6c34\u3001pH4.5\u78f7\u9178\u76d0\u7f13\u51b2\u6db2\u3001\u53cc\u9636\u6bb5\u6eb6\u51fa\u4ecb\u8d28\uff080.1 N HCl\u6eb6\u51fa30\u5206\u949f\uff0c\u7136\u540e\u52a0\u5165100 mL\u5f3a\u78f7\u9178\u76d0\u7f13\u51b2\u6db2\u5c06pH\u5347\u81f37.4\u00b10.1\uff0c50rpm\uff0c37\u2103\u3002\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"color: rgb(255, 129, 36);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">2.2 \u5efa\u6a21\u4e0e\u6a21\u62df\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u5efa\u6a21\u53c2\u6570\uff1a<\/p>\n<table cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td width=\"274\" valign=\"top\" style=\"border-width: 1px;border-style: solid;border-color: windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\"><strong>Parameter &nbsp;(unit)<\/strong><\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: 1px solid windowtext;border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\"><strong>Gastroplus<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"274\" valign=\"top\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\"><strong>PhysChem<\/strong><\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\"><br  \/><\/td>\n<\/tr>\n<tr>\n<td width=\"274\" valign=\"top\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">Molecular weight (g\/mol)<\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;\"><span style=\"font-size: 14px;\">308.3<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"274\" valign=\"top\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">log <em>P<sub>o:w<\/sub><\/em><\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;\"><span style=\"font-size: 14px;\">3.27<sup>d<\/sup><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"274\" valign=\"top\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">p<em>K<sub>a<\/sub><\/em><\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;\"><span style=\"font-size: 14px;\">5.28<sup>d<\/sup><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"274\" valign=\"top\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">Fraction unbound in plasma<\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;\"><span style=\"font-size: 14px;\">0.009<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"274\" valign=\"top\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">Jejunal P<em><sub>eff<\/sub><\/em> &nbsp;(x10<sup>-4<\/sup> cm\/s)<\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">12<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"274\" valign=\"top\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">V<sub>ss<\/sub> (L\/kg)<\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\"><br  \/><\/td>\n<\/tr>\n<tr>\n<td width=\"274\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;\"><span style=\"font-size: 14px;\">k<sub>12<\/sub> &nbsp;(1\/h)<\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">0.117<sup>e<\/sup><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"274\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;\"><span style=\"font-size: 14px;\">k<sub>21<\/sub>(1\/h)<\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">0.215<sup>e<\/sup><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"274\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;\"><span style=\"font-size: 14px;\">V<sub>2<\/sub> &nbsp;(L\/kg)<\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">0.05981<sup>e<\/sup><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"274\" style=\"border-right: 1px solid windowtext;border-bottom: 1px solid windowtext;border-left: 1px solid windowtext;border-top: none;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;\"><span style=\"font-size: 14px;\">V<sub>c<\/sub> &nbsp;(L\/kg)<\/span><\/p>\n<\/td>\n<td width=\"157\" valign=\"top\" style=\"border-top: none;border-left: none;border-bottom: 1px solid windowtext;border-right: 1px solid windowtext;padding: 0px 7px;\">\n<p style=\"margin-bottom:8px;text-autospace:none;\"><span style=\"font-size: 14px;\">0.156<sup>e<\/sup><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"margin-bottom:8px;\"><span style=\"font-size: 15px;\"><sup>d<\/sup>:Gastroplus predictor;<sup> e<\/sup>: Fitted<\/span><\/p>\n<p style=\"box-sizing: border-box;\">\u4e3a\u4e86\u7814\u7a76\u9178\u6027pH\u6761\u4ef6\u4e0b\u4f53\u5916\u6eb6\u89e3\u901f\u7387\u964d\u4f4e\u5f71\u54cd\u836f\u7269\u5236\u5242\u7684\u4f53\u5185\u884c\u4e3a\uff0c\u91c7\u7528\u5efa\u6a21\u4e0e\u6a21\u62df\u7684\u65b9\u6cd5\u642d\u5efa\u4e86\u57fa\u4e8e\u751f\u7406\u7684\u5438\u6536\u6a21\u578b\u3002\u5efa\u6a21\u5de5\u5177\u5305\u62ecGastroPlus v9.0\u7b49\u8f6f\u4ef6\uff1bGastroPlus\u91c7\u7528Johnson\u6eb6\u51fa\u6a21\u578b\uff0c\u53cc\u9636\u6bb5\u6eb6\u51fa\u7ed3\u679c\u4f7f\u7528Z-factor\u6a21\u578b\u8fdb\u884c\u6570\u636e\u7684\u6574\u5408\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u5bf9\u6eb6\u89e3\u5ea6\u3001\u7c92\u5f84\u3001\u5bc6\u5ea6\u3001\u5242\u91cf\u3001Z\u503c\u8fdb\u884c\u4e86\u654f\u611f\u6027\u5206\u6790\uff0c\u5e76\u8fdb\u884c\u4e09\u7ef4\u53c2\u6570\u5206\u6790\u4ee5\u63a2\u7a76pH\u503c4.5\u548cpH 6.8\u7684Z\u503c\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u53ca\u5176\u5bf9Cmax\u7684\u5f71\u54cd\uff0c\u8fd8\u5bf9\u5bc6\u5ea6\u3001\u7c92\u5f84\u8fdb\u884c\u4e86\u4e09\u7ef4\u53c2\u6570\u654f\u611f\u6027\u5206\u6790\uff0c\u4ee5\u63a2\u7d22\u4e24\u8005\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u53ca\u5176\u5bf9Cmax\u7684\u5f71\u54cd\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u901a\u8fc7\u865a\u62dfBE\u8bd5\u9a8c\u6a21\u62df\u5404\u6bd4\u8f83\u7ec4\u7684BE\u901a\u8fc7\u7387,\u91c7\u752830\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\u53cc\u5904\u7406\u3001\u4e24\u5e8f\u5217\u3001\u56db\u5468\u671f\u3001\u5b8c\u5168\u91cd\u590d\u4ea4\u53c9\u4f53\u5185\u865a\u62dfBE\u8bd5\u9a8c\u8bbe\u8ba1\u3002\u968f\u673a\u9009\u62e91,200\u540d\u865a\u62df\u5065\u5eb7\u53d7\u8bd5\u8005\u57fa\u4e8eZ\u56e0\u5b50\u6a21\u62df\u672a\u7ecf\u52a0\u901f\u964d\u89e3\u6216\u7ecf\u52a0\u901f\u964d\u89e3\u7684PK\uff0c\u5bf9\u4e8e\u6bcf\u4e2aBE\u6a21\u62df\u8bd5\u9a8c\uff0c\u968f\u673a\u9009\u62e930\u540d\u53d7\u8bd5\u8005\uff0c\u5e76\u4e14\u5bf9\u6bcf\u4e2a\u6bd4\u8f83\u7ec4\u8fdb\u884c100\u6b21\u865a\u62dfBE\u6a21\u62df\u8bd5\u9a8c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"color: rgb(255, 129, 36);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">2.3 \u4f53\u5185\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u4e34\u5e8a\u7814\u7a76\u5728\u7a7a\u8179\u6761\u4ef6\u4e0b\uff0c\u5bf932\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\u8fdb\u884c\u5355\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u8bb0\u3001\u5355\u5242\u91cf\u3001\u968f\u673a\u56db\u4ea4\u53c9BE\u7814\u7a76\uff0c\u56db\u4e2a\u7ed9\u836f\u7ec4\u5206\u522b\u4e3a\uff1a<\/p>\n<p style=\"box-sizing: border-box;\">A\uff1a5 mg\u50a8\u5b58\u5728\u7ea620-25\u2103\u7684\u5bc6\u95ed\u5bb9\u5668\u4e2d\u7684\u534e\u6cd5\u6797\u94a0\u7247\uff08\u53d7\u8bd5\u5236\u5242\u672a\u7ecf\u52a0\u901f\u964d\u89e3\uff09\uff1b<\/p>\n<p style=\"box-sizing: border-box;\">B\uff1a5 mg\u50a8\u5b58\u4e8e40\u2103\u300175\uff05\u6e7f\u5ea6\u7684\u5f00\u53e3\u74f6\u4e2d24\u5c0f\u65f6\u7684\u534e\u6cd5\u6797\u94a0\u7247\uff08\u53d7\u8bd5\u5236\u5242\u7ecf\u52a0\u901f\u964d\u89e3\uff09\uff1b<\/p>\n<p style=\"box-sizing: border-box;\">C\uff1a5 mg\u50a8\u5b58\u5728\u7ea620-25\u2103\u7684\u5bc6\u95ed\u5bb9\u5668\u4e2d\u7684\u9999\u8c46\u5b9a\uff08\u53c2\u6bd4\u5236\u5242\u672a\u7ecf\u52a0\u901f\u964d\u89e3\uff09\uff1b<\/p>\n<p style=\"box-sizing: border-box;\">D\uff1a5 mg\u50a8\u5b58\u4e8e40\u2103\u300175\uff05\u6e7f\u5ea6\u7684\u5f00\u53e3\u74f6\u4e2d24\u5c0f\u65f6\u7684\u9999\u8c46\u5b9a\uff08\u53c2\u6bd4\u5236\u5242\u7ecf\u52a0\u901f\u964d\u89e3\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 21px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">3<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7ed3\u679c\u4e0e\u5206\u6790<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;color: rgb(255, 129, 36);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">3.1 \u4f53\u5916\u7814\u7a76\u7ed3\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u534e\u6cd5\u6797\u94a0\u7ecf\u52a0\u901f\u964d\u89e3\u4e2d\u7684IPA\u542b\u91cf\u4f4e\u4e8e\u8d28\u91cf\u6807\u51c6\uff0c\u5e76\u4e14\u572840\u2103\u300175\uff05\u6e7f\u5ea6\u7684\u73af\u5883\u4e2d4\u5c0f\u65f6\u5373\u68c0\u6d4b\u4e0d\u5230IPA\u3002\u534e\u6cd5\u6797\u94a0\u7ecf\u52a0\u901f\u964d\u89e3\u548c\u9999\u8c46\u5b9a\u7ecf\u52a0\u901f\u964d\u89e3\u5747\u53d1\u751f\u4e86\u7ed3\u6676\u5305\u5408\u7269\u5230\u65e0\u5b9a\u578b\u6676\u578b\u7684\u8f6c\u53d8\uff0c\u4f46\u542b\u91cf\u53ca\u6742\u8d28\u5747\u6ca1\u6709\u663e\u8457\u53d8\u5316\u3002\u7ecf\u52a0\u901f\u964d\u89e3\u5728\u4f4epH\u6761\u4ef6\u4e0b\u7684\u6eb6\u51fa\u901f\u7387\u964d\u4f4e\u3002IPA\u7684\u51cf\u5c11\u6709\u52a9\u4e8e\u7ed3\u6676\u5305\u5408\u7269\u8f6c\u53d8\u4e3a\u65e0\u5b9a\u578b\u3001\u964d\u4f4e\u5728\u6c34\u3001pH 4.5\u548c1.2\u4e2d\u7684\u6eb6\u51fa\u5ea6\u548c\u5728\u4f4epH\u6761\u4ef6\u4e0b\u7684\u6eb6\u51fa\u901f\u7387\uff0c\u800c\u5bf9\u9ad8pH\u4ecb\u8d28\uff08\u5982pH 7.5\uff09\u7ecf\u52a0\u901f\u964d\u89e3\u548c\u975e\u7ecf\u52a0\u901f\u964d\u89e3\u7684\u524d120 min\u7684\u6eb6\u51fa\u5ea6\u6ca1\u6709\u5dee\u5f02\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"color: rgb(255, 129, 36);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">3.2 \u5efa\u6a21\u4e0e\u6a21\u62df\u7814\u7a76\u7ed3\u679c\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u4f7f\u7528PBPK\u673a\u5236\u6027\u5438\u6536\u6a21\u578b\u9884\u6d4b\u534e\u6cd5\u6797\u7684PK\u66f2\u7ebf\uff0c\u5e76\u5c06\u6a21\u578b\u7528\u4e8e\u5206\u6790\u4e0d\u540cpH\u5bf9\u5e94\u7684\u6eb6\u89e3\u5ea6\u548cZ\u56e0\u5b50\u5bf9\u534e\u6cd5\u6797PK\u66f2\u7ebf\u7684\u5f71\u54cd\u3002\u53c2\u6570\u654f\u611f\u6027\u5206\u6790\u8868\u660e\uff0c\u534e\u6cd5\u6797\u7684PK\u66f2\u7ebf\u5bf9\u6eb6\u89e3\u5ea6\uff08\u5982Figure 2c\uff09\u3001\u7c92\u5f84\u548c\u5bc6\u5ea6\u7684\u53d8\u5316\u4e0d\u654f\u611f\u3002\u4f4e\u6eb6\u89e3\u5ea6\u4f1a\u5ef6\u8fdfTmax\uff0c\u800cCmax\u548cAUC\u5bf9\u6eb6\u89e3\u5ea6\u7684\u53d8\u5316\u4e0d\u654f\u611f\u3002\u6bd4\u8f83\u6eb6\u89e3\u5ea6-pH\u66f2\u7ebf\uff08Figure 2a\uff09\u548c\u4f53\u5185\u6eb6\u51fa\u66f2\u7ebf\uff08Figure 2b\uff09\uff0c\u53ef\u77e5\u5373\u4f7f\u6765\u6e90B\u7684\u6eb6\u89e3\u5ea6\u5f88\u4f4e\uff0c\u4f46\u5728\u7ed9\u836f\u540e\u76841h\u4f53\u5185\u4e5f\u80fd\u8fbe\u5230\u5b8c\u5168\u91ca\u653e\u3002\u53c2\u6570\u654f\u611f\u6027\u5206\u6790\u8fd8\u8868\u660e\u534e\u6cd5\u6797\u7684PK\u53c2\u6570\u5982AUC\u3001Cmax\u548c\u5242\u91cf\u6210\u6b63\u76f8\u5173\uff0c\u800c\u4e14\u534e\u6cd5\u6797\u4e5f\u662f\u7a84\u6cbb\u7597\u7a97\u836f\u7269\uff0c\u6700\u8fd1\u7f8e\u56fd\u836f\u5178\u4e5f\u89c4\u5b9a\u4e86\u534e\u6cd5\u6797\u94a0\u7247\u542b\u91cf\u4e0d\u5f97\u5c11\u4e8e95.0\uff05\u4e14\u4e0d\u8d85\u8fc7105.0\uff05\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u4f7f\u7528\u56fe 2\u4e2d\u7684\u6eb6\u51fa\u66f2\u7ebf\u9884\u6d4b\u534e\u6cd5\u6797\u7684\u4f53\u5185PK\uff0cBE\u6a21\u62df\u7ed3\u679c\u8868\u660e\u6240\u6709\u6bd4\u8f83\u7ec4\u90fd\u5177\u6709\u9ad8\u901a\u8fc7\u7387\uff0c\u7ed3\u679c\u5982\u4e0b\u56fe\uff0c\u6240\u6709\u7684\u6bd4\u8f83\u7ec4\u901a\u8fc7\u70b9\u4f30\u8ba1\uff08PE\uff09\u8ba1\u7b97\u90fd\u63a5\u8fd11\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558080813.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<p style=\"margin-bottom: 8px;text-align: center;\"><strong><span style=\"font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53;\">\u56fe<\/span>2.<span style=\"font-family: \u5b8b\u4f53;\">\uff08<\/span>a<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u56db\u79cd\u4e0d\u540c\u6765\u6e90\u7684\u6eb6\u89e3\u5ea6\u6570\u636e\uff1b\uff08<\/span>b<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u56db\u79cd\u4e0d\u540c\u6765\u6e90\u7684\u6eb6\u89e3\u5ea6\u6570\u636e\u5bf9\u5e94\u4e8e<\/span>ACAT<span style=\"font-family: \u5b8b\u4f53;\">\u6a21\u578b\uff08\u9ad8\u7ea7\u623f\u5ba4\u5438\u6536\u4e0e\u8f6c\u8fd0\u6a21\u578b\uff09\u4e2d\u7684\u4f53\u5185\u6eb6\u51fa\u66f2\u7ebf\uff1b\uff08<\/span>c<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u4f7f\u7528<\/span>a<span style=\"font-family: \u5b8b\u4f53;\">\u56fe\u4e2d\u7684\u6eb6\u89e3\u5ea6\u6570\u636e\u901a\u8fc7<\/span>ACAT<span style=\"font-family: \u5b8b\u4f53;\">\u6a21\u578b\u9884\u6d4b\u5230\u7684\u4f53\u5185<\/span>PK<span style=\"font-family: \u5b8b\u4f53;\">\u66f2\u7ebf<\/span><\/span><\/strong><span style=\"font-size:12px;font-family:\u5b8b\u4f53;\">\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558080813.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558080814.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558080814.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<p style=\"margin-bottom: 8px;text-align: center;\"><strong><span style=\"font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53;\">\u56fe<\/span>3.<span style=\"font-family: \u5b8b\u4f53;\">\u4f7f\u7528<\/span>Z-factor<span style=\"font-family: \u5b8b\u4f53;\">\u6a21\u578b\u9884\u6d4b\u56db\u79cd\u5236\u5242\u7684\u4f53\u5185<\/span>PK<span style=\"font-family: \u5b8b\u4f53;\">\uff0c<\/span>A<span style=\"font-family: \u5b8b\u4f53;\">\uff1a<\/span>5mg<span style=\"font-family: \u5b8b\u4f53;\">\u50a8\u5b58\u5728\u7ea6<\/span>20-25<span style=\"font-family: \u5b8b\u4f53;\">\u2103\u7684\u5bc6\u95ed\u5bb9\u5668\u4e2d\u7684\u534e\u6cd5\u6797\u94a0\u7247\uff08\u672a\u7ecf\u52a0\u901f\u964d\u89e3\uff0c<\/span>T<span style=\"font-family: \u5b8b\u4f53;\">\uff09\uff1b<\/span>B<span style=\"font-family: \u5b8b\u4f53;\">\uff1a<\/span>5mg<span style=\"font-family: \u5b8b\u4f53;\">\u50a8\u5b58\u4e8e<\/span>40<span style=\"font-family: \u5b8b\u4f53;\">\u2103\u3001<\/span>75<span style=\"font-family: \u5b8b\u4f53;\">\uff05\u6e7f\u5ea6\u7684\u5f00\u53e3\u74f6\u4e2d<\/span>24<span style=\"font-family: \u5b8b\u4f53;\">\u5c0f\u65f6\u7684\u534e\u6cd5\u6797\u94a0\u7247\uff08\u7ecf\u52a0\u901f\u964d\u89e3\uff0c<\/span>T<span style=\"font-family: \u5b8b\u4f53;\">\uff09\uff1b<\/span>C<span style=\"font-family: \u5b8b\u4f53;\">\uff1a<\/span>5mg<span style=\"font-family: \u5b8b\u4f53;\">\u50a8\u5b58\u5728\u7ea6<\/span>20-25<span style=\"font-family: \u5b8b\u4f53;\">\u2103\u7684\u5bc6\u95ed\u5bb9\u5668\u4e2d\u7684\u9999\u8c46\u5b9a\uff08\u672a\u7ecf\u52a0\u901f\u964d\u89e3\uff0c<\/span>R<span style=\"font-family: \u5b8b\u4f53;\">\uff09\uff1b<\/span>D<span style=\"font-family: \u5b8b\u4f53;\">\uff1a<\/span>5mg<span style=\"font-family: \u5b8b\u4f53;\">\u50a8\u5b58\u4e8e<\/span>40<span style=\"font-family: \u5b8b\u4f53;\">\u2103\u3001<\/span>75<span style=\"font-family: \u5b8b\u4f53;\">\uff05\u6e7f\u5ea6\u7684\u5f00\u53e3\u74f6\u4e2d<\/span>24<span style=\"font-family: \u5b8b\u4f53;\">\u5c0f\u65f6\u7684\u9999\u8c46\u5b9a\uff08\u7ecf\u52a0\u901f\u964d\u89e3\uff0c<\/span>R<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u3002<\/span><\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\">\u5404\u7ec4\u6bd4\u8f83\u7684\u7edf\u8ba1\u7ed3\u679c\u5982\u4e0bTable 1\uff0c\u4f7f\u7528ABE\u6807\u51c6\uff08\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u6807\u51c6\uff0c90%\u7684\u7f6e\u4fe1\u5ea6\uff09\u6bcf\u4e2a\u6bd4\u8f83\u7ec4\u7684Cmax BE\u901a\u8fc7\u7387\u5747\u9ad8\u4e8e80\uff05\uff0cAUC\u901a\u8fc7\u7387\u5747\u4e3a100%\uff1b\u6309\u7167RSABE\uff08reference scaled average bioequivalence\uff09\u6807\u51c6\uff0cA vs.B\u6bd4\u8f83\u7ec4\u901a\u8fc7\u7387\u6700\u4f4e\uff0cCmax\u901a\u8fc7\u7387\u4e3a78%\u3001AUC0-72\u901a\u8fc7\u7387\u4e3a84%\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558080814.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">PBPK\u6a21\u578b\u7528\u4e8e\u5236\u5b9a\u4f53\u5185\u5916\u76f8\u5173\u7684\u6eb6\u51fa\u7a7a\u95f4\uff0c\u901a\u8fc7\u591a\u4e2a\u53c2\u6570\u654f\u611f\u6027\u5206\u6790\u63a2\u7d22\u786e\u4fddBE\u7684\u6eb6\u51fa\u7a7a\u95f4\uff0c\u6d4b\u8bd5\u4e86pH 4.5\u548cpH 6.8\u6761\u4ef6\u4e0b\u7684\u591a\u4e2aZ\u56e0\u5b50\u4ee5\u4ea7\u751f\u865a\u62df\u6eb6\u51fa\u66f2\u7ebf\uff0c\u5982\u4e0b\u56fe\uff08Figure 4b\uff09\u5c55\u793a\u4e86\u5728pH 4.5\u548c6.8\u6761\u4ef6\u4e0bPE\uff08Cmax\uff09\u4e0eZ\u56e0\u5b50\u4e4b\u95f4\u7684\u5173\u7cfb\u4e09\u7ef4\u56fe\uff0c\u8be5\u533a\u57df\u7684\u5927\u90e8\u5206\u7a7a\u95f4PE\u5747\u57280.95-1.00\u7684\u8303\u56f4\u5185\u3002\u6839\u636eRSABE\u6807\u51c6\uff0c\u5982\u679cCmax\u7684PE\u4e3a0.955\u4e14\u5408\u683c\u7387\u4e3a80\uff05(Figure 4a)\uff0c\u5219\u5728pH4.5\u6761\u4ef6\u4e0b30\u5206\u949f\u81f3\u5c11\u91ca\u653e30\uff05\uff0c\u5728pH6.8\u6761\u4ef6\u4e0b30\u5206\u949f\u81f3\u5c11\u91ca\u653e80\uff05(Figure 4c, d)\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558080814.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558080815.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<p style=\"margin-bottom: 8px;text-align: center;\"><strong><span style=\"font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53;\">\u56fe<\/span>4.<span style=\"font-family: \u5b8b\u4f53;\">\u5bf9<\/span>pH 4.5<span style=\"font-family: \u5b8b\u4f53;\">\u548c<\/span>6.8<span style=\"font-family: \u5b8b\u4f53;\">\u5bf9\u5e94\u7684<\/span>Z<span style=\"font-family: \u5b8b\u4f53;\">\u56e0\u5b50\u8fdb\u884c\u4e09\u7ef4\u654f\u611f\u6027\u5206\u6790\uff0c\uff08<\/span>a<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u4f7f\u7528<\/span>RSABE<span style=\"font-family: \u5b8b\u4f53;\">\u7684\u65b9\u6cd5\u8bc4\u4f30\u51e0\u4f55\u5e73\u5747\u6bd4\uff08<\/span>GMR<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u5bf9\u5047\u8bbe\u7684\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\uff08<\/span>r<sub>WR<\/sub>=0.10<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u7684\u5f71\u54cd\uff0c\uff08<\/span>b<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u5bf9<\/span>pH4.5<span style=\"font-family: \u5b8b\u4f53;\">\u548c<\/span>6.8<span style=\"font-family: \u5b8b\u4f53;\">\u5bf9\u5e94\u7684<\/span>Z<span style=\"font-family: \u5b8b\u4f53;\">\u56e0\u5b50\u8fdb\u884c\u53c2\u6570\u654f\u611f\u6027\u5206\u6790\uff0c\uff08<\/span>c<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u5728<\/span>pH6.8<span style=\"font-family: \u5b8b\u4f53;\">\u4e0b\u5404<\/span>Z<span style=\"font-family: \u5b8b\u4f53;\">\u56e0\u5b50\u5bf9\u5e94\u7684\u865a\u62df\u6eb6\u51fa\u66f2\u7ebf\uff0c\uff08<\/span>d<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u5728<\/span>pH4.5<span style=\"font-family: \u5b8b\u4f53;\">\u4e0b\u5404<\/span>Z<span style=\"font-family: \u5b8b\u4f53;\">\u56e0\u5b50\u5bf9\u5e94\u7684\u865a\u62df\u6eb6\u51fa\u66f2\u7ebf\u3002<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;color: rgb(255, 129, 36);box-sizing: border-box;\">3.3 \u4f53\u5185\u7814\u7a76\u7ed3\u679c<\/span><\/strong><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">4\u79cd\u5236\u5242\u7684\u4f53\u5185PK\u66f2\u7ebf\u8f83\u4e3a\u63a5\u8fd1\uff0c\u4e3b\u8981\u7684\u836f\u52a8\u5b66\u53c2\u6570\u5982\u4e0b\u8868\uff0c\u4e14AUC0-72\u3001Cmax\u7684CV%\u503c\u5747\u5c0f\u4e8e30%\uff0c\u6309\u7167ABE\u6807\u51c6\uff0c\u5404\u6bd4\u8f83\u7ec4\u90fd\u662f\u751f\u7269\u7b49\u6548\u7684\uff0c\u5982Table 3\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558080815.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 21px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">4<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7ed3\u679c\u4e0e\u8ba8\u8bba<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u672c\u6587\u5c55\u793a\u4e86\u4eff\u5236\u836f\u529e\u516c\u5ba4\u4f7f\u7528\u5efa\u6a21\u4e0e\u6a21\u62df\u7684\u65b9\u6cd5\u89e3\u51b3\u5728\u4eff\u5236\u836f\u66ff\u4ee3\u65b9\u9762\u7684\u5e94\u7528\u3002\u534e\u6cd5\u6797\u5236\u5242\u8d28\u91cf\u7684\u53d8\u5316\u4f1a\u4ea7\u751f\u751f\u7269\u4e0d\u7b49\u6548\u7684\u98ce\u9669\uff0c\u534e\u6cd5\u6797\u4f5c\u4e3a\u957f\u671f\u670d\u7528\u7684\u7a84\u6cbb\u7597\u6307\u6570\u7684\u836f\u7269\uff0c\u75c5\u4eba\u53ef\u80fd\u4f1a\u628a\u836f\u7269\u50a8\u5b58\u5728\u9ad8\u6e7f\u7684\u6d74\u5ba4\u4e2d\uff0c\u800c\u5728\u9ad8\u6e29\u548c\u9ad8\u6e7f\u73af\u5883\u4e2d\u534e\u6cd5\u6797\u4f1a\u53d1\u751f\u5236\u5242\u989c\u8272\u6539\u53d8\u3001\u5728pH4.5\u7f13\u51b2\u6db2\u4e2d\u6eb6\u51fa\u964d\u4f4e\u3001IPA\u51cf\u5c11\u3001\u534e\u6cd5\u6797\u94a0\u6676\u578b\u8f6c\u53d8\u7684\u53d8\u5316\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63a2\u7a76\u534e\u6cd5\u6797\u7684\u4f53\u5185PK\u884c\u4e3a\u662f\u5426\u53d1\u751f\u53d8\u5316\uff0c\u5efa\u7acb\u4e86\u673a\u5236\u6027\u5438\u6536\u6a21\u578b\uff0c\u5e76\u5c06\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u5bfc\u5165\u5230\u6a21\u578b\u4e2d\u8003\u5bdf\u4f53\u5185PK\u7684\u53d8\u5316\uff0c\u53ea\u8981\u5728pH6.8\u6761\u4ef6\u4e0b120 min\u53ef\u4ee5\u5b8c\u5168\u91ca\u653e\uff0c\u65e0\u8bba\u662fIPA\u51cf\u5c11\u6216\u8005\u5728pH4.5\u7f13\u51b2\u6db2\u4e2d\u6eb6\u51fa\u964d\u4f4e\u90fd\u4e0d\u4f1a\u5f71\u54cdBE\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u4f53\u5185\u7814\u7a76\u7ed3\u679c\u4e5f\u8bc1\u660e\u4e86\u4f53\u5916\u5236\u5242\u7279\u6027\u7684\u53d8\u5316\u5e76\u6ca1\u6709\u5bf9\u4f53\u5185PK\u4ea7\u751f\u5f71\u54cd\uff0c\u4e0e\u5efa\u6a21\u4e0e\u6a21\u62df\u7684\u7ed3\u679c\u4e00\u81f4\u3002\u8fdb\u4e00\u6b65\u5229\u7528PBPK\u673a\u5236\u6027\u5438\u6536\u6a21\u578b\u7ed8\u5236\u4e86\u4f53\u5185\u76f8\u5173\u7684\u4f53\u5916\u6eb6\u51fa\u7a7a\u95f4\uff0c\u4ee5\u7528\u4e8e\u5bf9\u7591\u4f3c\u6279\u6b21\u8fdb\u884c\u4f53\u5185PK\u884c\u4e3a\u7684\u68c0\u9a8c\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u603b\u4e4b\uff0c\u901a\u8fc7\u672c\u7814\u7a76\u4f5c\u8005\u83b7\u77e5\u4e86\u534e\u6cd5\u6797\u94a0\u7247\u4e2dIPA\u51cf\u5c11\u5bf9\u5176\u4f53\u5185PK\u884c\u4e3a\u7684\u5f71\u54cd\uff0c\u5e76\u4e14\u8bc1\u660e\u4e86\u673a\u5236\u6027\u7684\u5438\u6536\u6a21\u578b\u5728\u6865\u63a5\u4f53\u5916\u7814\u7a76\u548c\u836f\u7269\u4f53\u5185\u884c\u4e3a\u53ca\u5728\u76d1\u7ba1\u5ba1\u8bc4\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u6210\u529f\u9884\u6d4b\u4e86\u534e\u6cd5\u6797\u94a0\u7247\u4ea7\u54c1\u8d28\u91cf\u53d1\u751f\u53d8\u5316\u540e\u7684BE\u60c5\u51b5\u3002\u5728\u4f53\u5185\u7814\u7a76\u5f00\u5c55\u4e4b\u524d\uff0cFDA\u6709\u8db3\u591f\u7684\u4fe1\u5fc3\u4f7f\u7528\u5efa\u6a21\u548c\u6a21\u62df\u8fdb\u884c\u521d\u59cb\u98ce\u9669\u8bc4\u4f30\uff0c\u4eff\u5236\u836f\u529e\u516c\u5ba4\u901a\u5e38\u5728\u79d1\u5b66\u8c03\u67e5\u8fc7\u7a0b\u4e2d\u52a0\u5165\u5efa\u6a21\u548c\u6a21\u62df\u7684\u5de5\u4f5c\uff0cFDA\u5728\u76d1\u7ba1\u5ba1\u67e5\u4e2d\u5229\u7528\u5efa\u6a21\u548c\u6a21\u62df\u65b9\u6cd5\u83b7\u5f97\u4e86\u7ecf\u9a8c\u548c\u4fe1\u5fc3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 21px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">5<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5e94\u7528\u8f6f\u4ef6\u4e0e\u6a21\u5757<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u8be5\u6848\u4f8b\u5e94\u7528\u7684\u8f6f\u4ef6\uff1aGastroPlus (version 9.0)\uff0c\u6d89\u53ca\u6a21\u5757\u6709Base, ADMET Predictor, PKPlus.<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558080815.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558080815.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u901a\u8fc7\u6574\u5408\u4f53\u5916\u3001\u5efa\u6a21\u3001\u4f53\u5185\u4e09\u79cd\u65b9\u6cd5\u63a2\u8ba8\u534e\u6cd5\u6797\u7684\u751f\u7269\u7b49\u6548\u6027\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u82f1\u6587\u539f\u6587\uff1a<\/p>\n<p style=\"box-sizing: border-box;\">Zhang, X. , Wen, H. , Fan, J. , Vince, B. , Li, T. , Gao, W. , Kinjo, M. , Brown, J. , Sun, W. , Jiang, W. and Lionberger, R. (2017), Integrating&nbsp;In Vitro, Modeling, and&nbsp;In Vivo&nbsp;Approaches to Investigate Warfarin Bioequivalence. CPT Pharmacometrics Syst. Pharmacol., 6: 523-531.&nbsp;<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 100%;height: 1.8em;padding-top: 0.9em;box-sizing: border-box;\">\n<section style=\"padding-right: 5px;padding-left: 5px;box-sizing: border-box;\">\n<section style=\"border-bottom: 1px solid rgb(95, 156, 239);width: 100%;box-sizing: border-box;\"><\/section>\n<section style=\"margin-top: -3px;box-sizing: border-box;\">\n<section style=\"float: left;width: 5px;height: 5px;margin-left: -5px;border-radius: 100%;background-color: rgb(95, 156, 239);box-sizing: border-box;\"><\/section>\n<section style=\"float: right;width: 5px;height: 5px;margin-right: -5px;border-radius: 100%;background-color: rgb(95, 156, 239);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-radius: 1em;display: inline-block;vertical-align: top;background-image: linear-gradient(to right, rgb(9, 82, 180) 0%, rgb(237, 64, 151) 100%);height: 1.8em;line-height: 1.8em;padding-left: 12px;padding-right: 12px;color: rgb(255, 255, 255);margin-top: -1em;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u514d\u8d23\u58f0\u660e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: 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