{"id":98302,"date":"2019-03-14T00:00:50","date_gmt":"2019-05-17T08:13:54","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/98302\/"},"modified":"2019-05-17T16:13:57","modified_gmt":"2019-05-17T08:13:57","slug":"35975bdd52","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/98302\/","title":{"rendered":"CDE\u6587\u7ae0|\u6d45\u8c08\u540c\u4e00API \u4e0d\u540c\u6210\u76d0\u836f\u7269\u4e00\u81f4\u6027\u8bc4\u4ef7\u4e2d\u53ef\u80fd\u5b58\u5728\u7684\u95ee\u9898"},"content":{"rendered":"
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\u6d45\u8c08\u540c\u4e00API \u4e0d\u540c\u6210\u76d0\u836f\u7269<\/strong>\u4e00\u81f4\u6027\u8bc4\u4ef7\u4e2d\u53ef\u80fd\u5b58\u5728\u7684\u95ee\u9898<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u300a\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7ba1\u300b\uff0c2019\u5e74\u7b2c1\u671f<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8d3a\u9510\u9510\uff0c\u6768\u8fdb\u6ce2<\/p>\n

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\u8d3a\u9510\u9510<\/span><\/strong><\/span><\/p>\n

\u836f\u5b66\u7855\u58eb\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u7edf\u8ba1\u4e0e\u4e34\u5e8a\u836f<\/span>\u7406\u5b66\u90e8\uff0c\u4e34\u5e8a\u836f\u7406\u5ba1\u8bc4\u5458\uff0c\u52a9\u7406\u7814<\/span>\u7a76\u5458\uff0c\u4e3b\u8981\u4ece\u4e8b\u4e34\u5e8a\u836f\u7406\u5b66\u7814\u7a76\u76f8<\/span>\u5173\u5ba1\u8bc4\u5de5\u4f5c<\/span><\/p>\n

\u6768\u8fdb\u6ce2<\/span><\/strong><\/span><\/p>\n

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\u4eff\u5236\u836f\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u662f\u5c06\u5df2\u4e0a\u5e02\u7684\u836f\u54c1\u5bf9\u7167\u539f\u7814\u4ea7\u54c1\u8fdb\u884c\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u6027\u7684\u8bc4\u4ef7\u3002<\/p>\n

\u6211\u56fd\u65e9\u671f\u6279\u51c6\u7684\u4ea7\u54c1\uff0c\u7531\u4e8e\u7279\u6b8a\u76ee\u7684\u5982\u4e3a\u4e86\u907f\u5f00\u539f\u7814\u4e13\u5229\u3001\u4fbf\u4e8e\u62db\u6807\u91c7\u8d2d\u7b49\u539f\u56e0\uff0c\u5b58\u5728\u5927\u91cf\u6539\u76d0\u57fa\u60c5\u51b5\u3002<\/p>\n

\u4e00\u81f4\u6027\u8bc4\u4ef7\u7684\u4e00\u9879\u91cd\u8981\u5de5\u4f5c\u5c31\u662f\u91cd\u65b0\u8bc4\u4ef7\u6539\u76d0\u57fa\u4ea7\u54c1\u4e0e\u539f\u7814\u4ea7\u54c1\u7684\u8d28\u91cf\u548c\u7597\u6548\u7684\u4e00\u81f4\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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API vs. \u6210\u76d0\u5f62\u5f0f<\/strong><\/p>\n<\/section>\n

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\u5927\u591a\u6570API \u5408\u9002\u7684\u6210\u76d0\u5f62\u5f0f\u5e94\u5728\u5316\u5b66\u5206\u5b50\u5f00\u53d1\u65e9\u671f\u786e\u5b9a\uff0c\u4ee5\u4fbf\u4e8e\u4f18\u5316\u5904\u65b9\u3002\u636e\u4f30\u8ba1\uff0c\u6cbb\u7597\u836f\u7269\u4e2d\u534a\u6570API \u662f\u4ee5\u6210\u76d0<\/span>\u5f62\u5f0f\u7ed9\u836f\uff0c\u786e\u5b9a\u5019\u9009\u836f\u7269\u7684\u6210\u76d0\u5f62\u5f0f\u5df2\u53d8\u6210\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u57fa<\/span>\u672c\u6b65\u9aa4\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u201c\u836f\u5242\u66ff\u4ee3\u54c1\u7684\u4e92\u6362\u6027\u201d\u4e00\u76f4\u662f\u4e00\u4e2a\u6709\u4e89\u8bae\u7684\u8bdd\u9898\uff0c\u7279\u522b\u662f<\/span>\u5728\u8003\u8651\u4eff\u5236\u836f\u4e4b\u95f4\u7684\u53ef\u66ff\u6362\u6027\u65b9<\/span>\u9762\u5c24\u4e3a\u91cd\u8981\uff0c\u5bf9\u76d1\u7ba1\u5f53\u5c40\u4e5f\u662f\u4e00<\/span>\u79cd\u6311\u6218 [1]\u3002 <\/span><\/p>\n

\u201cpharmaceutical <\/span>alternative\u201d\u8fd9\u4e2a\u672f\u8bed\u5728\u6b27\u76df\u6307<\/span>\u5357[2] \u4e2d\uff0c\u7528\u4e8e\u5b9a\u4e49\u836f\u54c1\u5177\u6709\u76f8\u540c<\/span>\u6d3b\u6027\u6210\u5206\uff0c\u4f46\u5316\u5b66\u5f62\u5f0f\uff08\u5982\u916f\u3001<\/span>\u76d0\u7b49\uff09\u3001\u5242\u578b\u3001\u89c4\u683c\u53ef\u80fd\u4e0d\u540c\u60c5\u51b5<\/span>\u4e0b\u7684\u4e92\u6362\u6027\u3002<\/span><\/p>\n

FDA \u6a59\u76ae\u4e66\u4e2d\u4e5f\u6709<\/span>\u76f8\u4f3c\u7684\u6cbb\u7597\u7b49\u6548\u7684\u5b9a\u4e49[3]\u3002<\/span>\u4e0d\u540c<\/span>\u4e4b\u5904\u5728\u4e8e\uff0cFDA \u5f3a\u8c03\uff0c\u53ea\u6709\u6cbb\u7597<\/span>\u7b49\u6548\uff0c\u65b9\u53ef\u8ba4\u4e3a\u836f\u54c1\u662f\u53ef\u66ff\u6362\u7684\u3002<\/span><\/p>\n

\u800cEMA \u8ba4\u4e3a\uff0c\u53ea\u8981\u5904\u65b9\u4e2d\u542b\u6709\u7684\u8f85\u6599\u4e0d\u5f71\u54cd\u5242\u578b\u7684\u5b89\u5168\u6027\u548c\u6709<\/span>\u6548\u6027\uff0c\u4e0d\u8bba\u662f\u836f\u5b66\u7b49\u540c\u8fd8\u662f\u836f\u7269\u66ff\u4ee3\u54c1\uff0c\u5747\u53ef\u88ab\u89c6\u4e3a\u6cbb\u7597\u7b49\u6548\u3002<\/span><\/p>\n

FDA \u6a59\u76ae\u4e66\u4e2d\u5b9a\u4e49\u7684\u836f\u5b66\u7b49\u540c\u6307\u836f\u7269\u542b\u6709\u76f8\u540c\u7684\u6d3b\u6027\u6210\u5206\u3001\u76f8\u540c<\/span>\u7684\u5242\u578b\u3001\u76f8\u540c\u7ed9\u836f\u9014\u5f84\uff0c\u76f8\u540c\u7684\u89c4\u683c\u6216\u6d53\u5ea6\u3002<\/span><\/p>\n

EMA \u5219\u89c4\u5b9a\uff0c \u4e3a<\/span>\u4e86\u8bc1\u660e\u4e00\u4e2a\u4ea7\u54c1\u4e0e\u53e6\u4e00\u4e2a\u4ea7\u54c1\u662f<\/span>\u6cbb\u7597\u7b49\u6548\u7684\u7ed3\u8bba\uff0c\u5fc5\u987b\u5148\u6709\u53d7\u8bd5<\/span>\u4ea7\u54c1\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bc1\u636e\uff0c<\/span>\u56e0\u6b64\u542b\u6709\u4e0d\u540c\u76d0\u5f62\u5f0f\u7684\u4e24\u79cd\u4ea7\u54c1<\/span>\u4e4b\u95f4\u7684\u751f\u7269\u7b49\u6548\u6027\u53ef\u80fd\u5e76\u4e0d\u8db3\u4ee5<\/span>\u652f\u6301\u4ea7\u54c1\u4e4b\u95f4\u7684\u53ef\u66ff\u6362\u6027[2]\u3002<\/span><\/p>\n

\u4e00\u822c\u8ba4\u4e3a\uff0c\u4e0d\u540c\u7684\u5242\u578b\u5373\u4f7f\u6d3b\u6027\u6210\u5206\u542b\u91cf\u76f8\u540c\uff0c\u5176\u6d3b\u6027\u7269\u6210<\/span>\u5206\u7684\u5438\u6536\u901f\u5ea6\uff08Cmax\uff09\u548c\u5438\u6536<\/span>\u7a0b\u5ea6\uff08AUC\uff09\u5373\u751f\u7269\u5229\u7528\u5ea6\u4e5f\u53ef<\/span>\u80fd\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002<\/span><\/p>\n

\u800cFDA[4] \u8981\u6c42\u4ea7\u54c1\u5fc5\u987b\u540c\u65f6\u5177\u6709\u836f\u5b66\u7b49\u540c\u548c\u751f<\/span>\u7269\u7b49\u6548\u6027\uff0c\u624d\u80fd\u5b9e\u73b0\u5904\u65b9\u4e2d\u836f\u54c1<\/span>\u7684\u4e92\u6362\u6027\u3002<\/span><\/p>\n

EMA \u76f8\u5bf9\u8f83\u4e3a\u5f00\u653e\uff0c<\/span>\u751f\u7269\u7b49\u6548\u7684\u836f\u54c1\u5373\u8ba4\u4e3a\u6cbb\u7597\u7b49\u6548\uff0c<\/span>\u800c\u4e0d\u5f3a\u6c42\u836f\u5b66\u7b49\u540c\uff0c\u610f\u5473\u7740\u975e\u836f<\/span>\u5b66\u7b49\u540c\u54c1\u4e4b\u95f4\u662f\u53ef\u66ff\u6362\u7684\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c<\/span>\u5efa\u7acb\u836f\u5242\u66ff\u4ee3\u548c\u6cbb\u7597\u7b49\u6548\u9700\u8003\u8651<\/span>\u51e0\u4e2a\u56e0\u7d20\uff0c\u4f8b\u5982\u4e0d\u540c\u6210\u76d0\u5f62\u5f0f\u3001<\/span>\u4e0d\u540c\u5242\u578b\u548c\u4e0d\u540c\u89c4\u683c\u4ee5\u53ca\u4e0d\u540c\u7ed9<\/span>\u836f\u9014\u5f84\u7b49\u76f8\u5173\u95ee\u9898\u3002<\/span><\/p>\n

\u4f17\u6240\u5468\u77e5\uff0c\u5927\u591a\u6570\u836f\u7269\u4e00\u822c\u90fd\u662f\u5f31\u6709\u673a\u9178\u76d0\u6216\u5f31\u78b1\u76d0\u5f62\u5f0f\u3002<\/span>\u540c\u4e00\u836f\u7269\u6d3b\u6027\u6210\u5206\uff08API\uff09\u53ef\u4ee5\u4ee5\u8bb8\u591a\u79cd\u4e0d\u540c\u7684\u76d0\u57fa\u5f62\u5f0f\u5b58\u5728\u3002<\/span><\/p>\n

\u867d<\/span>\u7136\u5b83\u4eec\u6d3b\u6027\u6210\u5206\u76f8\u540c\uff0c\u6bcf\u4e00\u79cd\u6210<\/span>\u76d0\u836f\u7269\u4ecd\u5e94\u770b\u4f5c\u662f\u4e0d\u540c\u7684\u5316\u5b66\u5b9e<\/span>\u4f53\uff0c\u5177\u6709\u5176\u72ec\u7279\u7684\u5316\u5b66\u548c\u751f\u7269\u5b66<\/span>\u7279\u6027\uff0c\u4ece\u800c\u5bfc\u81f4\u8fd9\u4e9b\u836f\u7269\u7684\u5316\u5b66<\/span>\u7597\u6548\u548c\u5b89\u5168\u6027\u5dee\u5f02\u3002<\/span><\/p>\n

\u5c06API \u8f6c\u6362<\/span>\u4e3a\u7279\u5b9a\u7684\u76d0\u5f62\u5f0f\uff0c\u662f\u9002\u5f53\u4fee\u6539\u548c<\/span>\u4f18\u5316\u7279\u5b9a\u7269\u7406\u5316\u5b66\u6027\u8d28\u7684\u4e00\u79cd\u65b9<\/span>\u6cd5\u3002<\/span><\/p>\n

\u7136\u800c\uff0c\u6539\u53d8\u76d0\u57fa\u5f62\u5f0f\u4e5f\u53ef\u80fd\u6539<\/span>\u53d8\u836f\u7269\u7684\u751f\u7269\u5b66\u6027\u8d28\uff0c\u5e76\u5bf9\u836f\u7269\u4ea7<\/span>\u751f\u663e\u8457\u7684\u5b89\u5168\u6027\u548c\u6bd2\u6027\u5f71\u54cd[5]\u3002<\/p>\n

\u5927\u591a\u6570API \u5408\u9002\u7684\u6210\u76d0\u5f62\u5f0f\u5e94\u5728\u5316<\/span>\u5b66\u5206\u5b50\u5f00\u53d1\u65e9\u671f\u786e\u5b9a\uff0c\u4ee5\u4fbf\u4e8e\u4f18<\/span>\u5316\u5904\u65b9\u3002<\/span><\/p>\n

\u636e\u4f30\u8ba1\uff0c\u6cbb\u7597\u836f\u7269\u4e2d\u534a<\/span>\u6570API \u662f\u4ee5\u6210\u76d0\u5f62\u5f0f\u7ed9\u836f\uff0c\u786e\u5b9a<\/span>\u5019\u9009\u836f\u7269\u7684\u6210\u76d0\u5f62\u5f0f\u5df2\u53d8\u6210\u836f\u7269<\/span>\u5f00\u53d1\u4e2d\u7684\u57fa\u672c\u6b65\u9aa4[6]\u3002<\/span><\/p>\n

\u540c\u4e00API\uff0c<\/span>\u4e0d\u540c\u6210\u76d0\u5f62\u5f0f\uff0c\u5176\u7269\u7406\u5316\u5b66\u6027\u8d28<\/span>\u4e5f\u53ef\u80fd\u4e0d\u540c\uff0c\u5c24\u5176\u662f\u6eb6\u89e3\u5ea6\u3001\u5438<\/span>\u6e7f\u6027\u3001\u7a33\u5b9a\u6027\u3001\u6d41\u52a8\u6027\u7b49\u3002<\/span><\/p>\n

\u53e6\u5916\uff0c<\/span>\u4e0e\u6210\u76d0\u5206\u5b50\u6709\u5173\u7684\u7279\u5b9a\u6742\u8d28\u7684\u5b58<\/span>\u5728\uff0c\u6216\u4e0e\u8be5\u7279\u5b9a\u76d0\u7684\u5408\u6210\u8def\u7ebf\u6709<\/span>\u5173\uff0c\u6216\u56e0\u4e0d\u7a33\u5b9a\u6027\u548c\u964d\u89e3\u4ea7\u7269\u7684<\/span>\u5f62\u6210\u800c\u4ea7\u751f\uff0c\u53ef\u80fd\u4f1a\u4ea7\u751f\u6bd2\u6027\u548c<\/span>\uff0f\u6216\u4e0d\u826f\u7684\u751f\u7269\u6d3b\u6027\uff0c\u4e0e\u9884\u671f\u836f<\/span>\u7269\u4e34\u5e8a\u4f7f\u7528\u6709\u5f88\u5927\u4e0d\u540c[7]\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c<\/span>\u4f7f\u7528\u4e0d\u540c\u6210\u76d0\u5f62\u5f0f\u7684\u836f\u7269\u53ef\u80fd\u5bfc<\/span>\u81f4\u7597\u6548\u4e0d\u540c\uff0c\u5e76\u4e14\u5e26\u6765\u5b89\u5168\u6027\u548c<\/span>\uff0f\u6216\u8d28\u91cf\u65b9\u9762\u7684\u8d1f\u6548\u5e94\u3002<\/span><\/p>\n

\u76ee\u524d\uff0c<\/span>\u5c1a\u6ca1\u6709\u53ef\u9760\u7684\u65b9\u6cd5\u9884\u6d4b\u67d0\u4e00\u7279\u5b9a<\/span>\u76d0\u57fa\u5bf9\u6bcd\u4f53\u5316\u5408\u7269\u4f53\u5185\u884c\u4e3a\u5e26\u6765<\/span>\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\u672c\u6587\u5c06\u4ece\u6539\u76d0\u57fa\u4ea7\u54c1\u7684<\/span>\u6cd5\u5f8b\u6cd5\u89c4\u3001\u5236\u5242\u7279\u6027\u3001\u751f\u7269\u6d3b\u6027<\/span>\u7b49\u65b9\u9762\u8bba\u8ff0\u6539\u76d0\u57fa\u4ea7\u54c1\u53ef\u80fd\u5b58\u5728<\/span>\u7684\u95ee\u9898\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6cd5\u5f8b\u6cd5\u89c4<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\u4e3aAPI \u9009\u62e9\u9002\u5f53\u7684\u6210\u76d0\u5f62\u5f0f\uff0c\u4e0d\u4ec5\u5bf9\u65e9\u671f\u65b0\u53d1\u975e\u5e38\u91cd<\/span>\u8981\uff0c\u5bf9\u4eff\u5236\u836f\u5f00\u53d1\u4e5f\u662f\u5173\u952e\u56e0\u7d20\u3002<\/p>\n

\u4e00\u4e2a\u4f8b\u5b50\u662f\u9499\u901a\u9053\u963b\u6ede\u5242\u2500\u2500\u6c28\u6c2f\u5730\u5e73\uff0c\u8f89\u745e\u516c\u53f8\u7684\u4ea7\u54c1\u662f\u82ef\u78fa<\/span>\u9178\u6c28\u6c2f\u5730\u5e73\u7247\uff0c\u5546\u54c1\u540d\u4e3a\u7edc\u6d3b\u559c\u3002<\/p>\n

\u5176\u539f\u59cb\u4e13\u5229\u4e8e2003 \u5e74\u5230\u671f\uff0c\u4e3a<\/span>\u8865\u507fFDA \u7684\u5ba1\u67e5\u803d\u8bef\u7684\u4e13\u5229\u4fdd\u62a4<\/span>\u65f6\u95f4\uff0c\u8be5\u4e13\u5229\u5ef6\u957f\u81f32007 \u5e74[8]\u3002<\/span><\/p>\n

\u6388\u4e88\u8f89\u745e\u516c\u53f8\u7684\u539f\u59cb\u4e13\u5229\u4fdd\u62a4\u4e86<\/span>\u82ef\u78fa\u9178\u6c28\u6c2f\u5730\u5e73\u7684\u5316\u5b66\u7ed3\u6784\u548c\u4e00<\/span>\u7cfb\u5217\u5176\u4ed6\u6c28\u6c2f\u5730\u5e73\u76d0\u3002<\/p>\n

\u968f\u540e\u5370\u5ea6\u745e\u8fea\u535a\u58eb\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u4e86\u6c28\u6c2f\u5730\u5e73<\/span>\u7684\u9a6c\u6765\u9178\u76d0\uff0c\u5e76\u8bc1\u660e\u5176\u4e0e\u7edc\u6d3b\u559c<\/span>\u751f\u7269\u7b49\u6548[9]\u3002<\/span><\/p>\n

\u745e\u8fea\u535a\u58eb\u5b9e\u9a8c\u5ba4\u79f0\uff0c<\/span>\u8f89\u745e\u7684\u4e13\u5229\u5e76\u672a\u8986\u76d6\u5230\u6c28\u6c2f\u5730\u5e73<\/span>\u7684\u9a6c\u6765\u9178\u76d0\uff0c\u5373\u9a6c\u6765\u9178\u6c28\u6c2f\u5730\u5e73\u3002<\/span><\/p>\n

\u7136\u800c\uff0c2004 \u5e742 \u670827 \u65e5\uff0c\u7f8e\u56fd<\/span>\u8054\u90a6\u5de1\u56de\u4e0a\u8bc9\u6cd5\u9662\u64a4\u9500\u4e86\u65b0\u6cfd\u897f<\/span>\u6d32\u5730\u65b9\u6cd5\u9662\u9a73\u56de\u8f89\u745e\u516c\u53f8\u9488\u5bf9\u745e<\/span>\u8fea\u535a\u58eb\u5b9e\u9a8c\u5ba4\u5bf9\u7edc\u6d3b\u559c\u4eff\u5236\u836f\u7684<\/span>\u4e13\u5229\u4fb5\u6743\u8bc9\u8bbc\uff0c\u6709\u6548\u5730\u963b\u6b62\u4e86\u6c28<\/span>\u6c2f\u5730\u5e73\u4eff\u5236\u836f\u8fdb\u5165\u7f8e\u56fd\u5e02\u573a[10]\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u8c61\u2500\u2500\u5df2\u4e0a\u5e02\u7684\u5927\u591a\u6570\u836f\u54c1\u6765\u8bf4\uff0c\u4e13\u5229\u65b9\u9762\u7684<\/span>\u987e\u8651\u8f83\u5c11\u3002\u4f46\u5bf9\u4e8e\u8fd8\u5728\u4e13\u5229\u4fdd\u62a4\u671f\u7684API \u6765\u8bf4\uff0c\u5f00\u53d1\u65b0\u836f\u4eff\u5236\u836f\uff0c<\/span>\u4e13\u5229\u662f\u5fc5\u987b\u8981\u8003\u8651\u7684\u4e00\u4e2a\u8981\u7d20\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5236\u5242\u7279\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u9664\u4e86\u4e13\u5229\u95ee\u9898\u4e4b\u5916\uff0c \u540c\u4e00API\uff0c\u4e0d\u540c\u6210\u76d0\u5f62\u5f0f\uff0c\u5176\u7269\u7406\u5316\u5b66<\/span>\u6027\u8d28\u4e5f\u53ef\u80fd\u4e0d\u540c\uff0c\u5c24\u5176\u662f\u6eb6\u89e3\u5ea6\u3001\u5438\u6e7f\u6027\u3001\u7a33\u5b9a\u6027\u3001\u6d41\u52a8\u6027\u3001\u591a\u6676<\/span>\u578b\u7b49\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u5316\u5408\u7269\u5728\u91c7\u7528\u66ff\u4ee3<\/span>\u76d0\u57fa\u7684\u65b9\u5f0f\u5f00\u53d1\u4eff\u5236\u836f\u65f6\uff0c\u8fd8\u5fc5<\/span>\u987b\u89e3\u51b3\u5176\u4ed6\u95ee\u9898\uff0c\u5982\u6eb6\u89e3\u6027\u3001\u6eb6<\/span>\u51fa\u5ea6\u3001\u751f\u7269\u5229\u7528\u5ea6\u3001\u6bd2\u6027\u3001\u591a\u6676\u578b\u3001<\/span>\u5904\u65b9\u548c\u751f\u4ea7\u5de5\u827a\u7b49\u65b9\u9762\u3002<\/span><\/p>\n

\u6eb6\u89e3\u6027\u3001<\/span>\u591a\u6676\u578b\u7b49\u65b9\u9762\u53ef\u80fd\u76f4\u63a5\u5f71\u54cd\u836f\u7269\u7684<\/span>\u751f\u7269\u5229\u7528\u5ea6\uff0c\u4ece\u800c\u6539\u53d8\u836f\u7269\u7684\u4f53\u5185<\/span>\u884c\u4e3a\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.1 \u6eb6\u89e3\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6d3b\u6027\u6210\u5206\u4ece\u5176\u5236\u5242\u4e2d\u91ca\u653e\u540e\uff0c\u5728\u80c3\u80a0\u6db2\u4e2d\u7684\u6eb6\u51fa\u901f\u7387\u4e3b\u8981\u662f\u5173<\/span>\u4e8eAPI \u7684\u6c34\u6eb6\u6027\u51fd\u6570\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u76f8\u540c\u6d3b\u6027\u6210\u5206\u4e0d\u540c\u76d0\u57fa\u7684\u56fa\u4f53\u5242\u578b<\/span>\u53ef\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u4f53\u5185\u6eb6\u51fa\u7279\u6027\u3002<\/span><\/p>\n

\u6839\u636e\u751f\u7269\u836f\u5242\u5b66\u5206\u7c7b\u7cfb\u7edf\uff08BCS\uff09<\/span>\u7684\u57fa\u672c\u539f\u7406[11]\uff0c\u5bf9\u4e8e\u9ad8\u6e17\u900f\u6027\u836f<\/span>\u7269\uff0c\u4f53\u5185\u6eb6\u51fa\u901f\u7387\u662f\u9650\u901f\u6b65\u9aa4\uff0c<\/span>\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u8fd8\u5c06\u51b3\u5b9a\u5438\u6536\u7a0b\u5ea6\u3002<\/span><\/p>\n

\u5982\u679c\u836f\u7269\u5177\u6709\u4f4e\u6e17\u900f\u6027\u548c\u76f8\u5bf9\u826f<\/span>\u597d\u7684\u6c34\u6eb6\u6027\uff0c\u4f53\u5185\u6eb6\u51fa\u4e0d\u4f1a\u662f\u5438<\/span>\u6536\u8fc7\u7a0b\u4e2d\u7684\u9650\u901f\u6b65\u9aa4\uff0c\u56e0\u6b64\u6c34\u6eb6<\/span>\u6027\u548c\u6eb6\u51fa\u5ea6\u7684\u5dee\u5f02\u4e0d\u662f\u751f\u7269\u5229\u7528<\/span>\u5ea6\u7684\u91cd\u8981\u51b3\u5b9a\u56e0\u7d20\u3002<\/span><\/p>\n

\u8bb8\u591a\u6587\u732e\u62a5\u9053\u8868\u660e\uff0c\u76f8\u540c\u7684API\uff0c\u4e0d\u540c\u7684\u76d0\u57fa\u53ef\u4ee5\u663e\u8457\u5730\u6539\u53d8<\/span>API \u7684\u6c34\u76f8\u6eb6\u89e3\u5ea6\uff0c\u5e76\u4e14\u4e0d\u540c\u76d0<\/span>\u57fa\u7684\u6eb6\u89e3\u5ea6\u53ef\u4ee5\u5927\u4e0d\u76f8\u540c\u3002<\/span><\/p>\n

\u4f8b\u5982\uff0c<\/span>\u6297\u6291\u90c1\u836f\u66f2\u624e\u916e\uff0c\u76ee\u524d\u5e02\u573a\u4e0a\u4ee5<\/span>\u76d0\u9178\u76d0\u5f62\u5f0f\u5b58\u5728\u3002\u4e3a\u4e86\u5236\u5907\u6c34\u6eb6<\/span>\u6027\u4f4e\u4e8e\u76d0\u9178\u76d0\u7684\u66f2\u624e\u916e\uff0c\u66fe\u7ecf\u5236<\/span>\u5907\u4e86\u591a\u79cd\u6210\u76d0\u5f62\u5f0f[12]\u3002<\/span><\/p>\n

\u5728\u7528\u4e8e\u8bc4<\/span>\u4ef7\u7684\u6240\u9009\u76d0\u57fa\u4e2d\uff0c\u53d1\u73b0\u7532\u82ef\u78fa\u9178<\/span>\u76d0\u548c\u78f7\u9178\u76d0\u6bd4\u786b\u9178\u76d0\u548c\u76d0\u9178\u76d0\u6c34<\/span>\u6eb6\u6027\u5c0f\uff0c\u5e76\u4e14\u7532\u82ef\u78fa\u9178\u76d0\u663e\u793a\u51fa<\/span>\u5728pH 1.0 \u6761\u4ef6\u4e0b3 mg\/ml \u81f3pH<\/span>12.0 \u6761\u4ef60.2 mg\/ml \u8303\u56f4\u5185\u6709\u8da3<\/span>\u7684\u6eb6\u89e3\u5ea6\u5206\u5e03\u3002\u7532\u78fa\u9178\u76d0\u7684\u4f4e\u6c34<\/span>\u6eb6\u6027\uff0c\u9002\u5408\u7528\u4e8e\u8001\u5e74\u4eba\u7684\u5ef6\u91ca\u53e3<\/span>\u670d\u5236\u5242\u7684\u5f00\u53d1\uff0c\u4ece\u800c\u6539\u5584\u8fd9\u4e9b\u60a3<\/span>\u8005\u7684\u4f9d\u4ece\u6027\u3002<\/span><\/p>\n

\u4e0e\u76d0\u9178\u76d0\u76f8\u6bd4\uff0c\u7532<\/span>\u78fa\u9178\u76d0\u663e\u8457\u964d\u4f4e\u7684\u6eb6\u89e3\u5ea6\uff08\u5728pH<\/span>\u503c1~5 \u8303\u56f4\u5185\uff0c\u964d\u4f4e8~10 \u500d\uff09\uff0c<\/span>\u53ef\u80fd\u5bfc\u81f4\u53e3\u670d\u7532\u78fa\u9178\u76d0\u540e\uff0c\u66f2\u5511<\/span>\u916e\u5728\u4f53\u5185\u5438\u6536\u7a0b\u5ea6\u53d7\u9650\u4e8e\u6eb6\u89e3\u901f<\/span>\u7387[12]\u3002<\/span><\/p>\n

\u6eb6\u89e3\u5ea6\u7684\u5de8\u5927\u5dee\u5f02\u4f7f\u5f97\u8fd9<\/span>\u4e24\u79cd\u76d0\u4e0d\u592a\u53ef\u80fd\u5728\u4f53\u5185\u751f\u7269\u7b49\u6548\u3002<\/span>\u901a\u8fc7\u8bc4\u4ef7\u53f3\u65cb\u4e19\u6c27\u57fa\u82ef\u76d0\u9178\u76d0\u548c<\/span>\u8418\u9178\u76d0\u7684\u6eb6\u89e3\u5ea6\uff0c\u8fdb\u4e00\u6b65\u9610\u660e\u4e86<\/span>\u7279\u5b9a\u76d0\u7684\u6c34\u6eb6\u6027\u5dee\u5f02\u5bf9API \u7684\u6cbb<\/span>\u7597\u6d3b\u6027\u548c\u4f5c\u7528\u6301\u7eed\u65f6\u95f4\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\u76d0\u9178\u53f3\u4e19\u6c27\u57fa\u82ef\u662f\u9ad8\u5ea6\u53ef\u6eb6\u7684\uff081\u4efd\u836f\u7269\u5bf9\u5e940.3 \u4efd\u6c34\uff09\uff0c\u800c\u8418\u9178\u76d0<\/span>\u5b9e\u9645\u4e0a\u662f\u4e0d\u6eb6\u7684\uff081 \u4efd\u836f\u7269\u5bf9\u5e94<\/span>10000 \u4efd\u6c34\uff09[13]\u3002\u4e0e\u8418\u9178\u76d0\u76f8\u6bd4\uff0c<\/span>\u53f3\u65cb\u4e19\u6c27\u57fa\u82ef\u76d0\u9178\u76d0\u5177\u6709\u66f4\u5e7f\u6cdb<\/span>\u7684\u9547\u75db\u6d3b\u6027\u548c\u66f4\u957f\u7684\u4f5c\u7528\u6301\u7eed\u65f6<\/span>\u95f4\uff0c\u90e8\u5206\u539f\u56e0\u5728\u4e8e\u4e24\u79cd\u76d0\u7684\u6eb6\u89e3<\/span>\u5ea6\u4e0d\u540c[14]\u3002<\/span><\/p>\n

\u6b64\u5916\uff0c\u4e0e\u8418\u7532\u9178\u76d0\u836f<\/span>\u7269\u76f8\u6bd4\uff0c\u53e3\u670d\u76d0\u9178\u76d0\u836f\u7269\u540e\uff0c\u53f3<\/span>\u65cb\u4e19\u6c27\u57fa\u82ef\u5bf9\u5c0f\u9f20\u7684\u6025\u6027\u6bd2\u6027\u66f4<\/span>\u9ad8\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u76d0\u9178\u76d0\u836f\u7269\u4ece\u80c3<\/span>\u80a0\u9053\u7684\u5438\u6536\u901f\u7387\u66f4\u5feb[15]\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.2 \u751f\u7269\u5229\u7528\u5ea6<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n

\u5df2\u62a5\u9053\u7684\u4e0d\u540c\u76d0\u57fa\u836f\u7269\u7684\u4eba\u4f53\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u663e\u793a\uff0c\u867d\u7136\u4e0d<\/span>\u540c\u76d0\u57fa\u6c34\u6eb6\u6027\u4e0d\u540c\uff0c\u751f\u7269\u5229\u7528\u5ea6<\/span>\u672a\u89c1\u62a5\u9053\u6709\u663e\u8457\u5dee\u5f02\u3002<\/span><\/p>\n

\u4f8b\u5982\uff0c\u78b1<\/span>\u6027\u6297\u9ad8\u8840\u538b\u5242\u7684\u4e0d\u540c\u6210\u76d0\u5f62\u5f0f\uff0c<\/span>\u56fa\u6709\u7684\u6eb6\u89e3\u901f\u7387\u663e\u8457\u4e0d\u540c\uff0c\u672a\u89c1<\/span>\u62a5\u544a\u751f\u7269\u5229\u7528\u5ea6\u6539\u5584\u3002<\/span><\/p>\n

\u5df2\u6709\u6587\u732e<\/span>\u62a5\u9053\u8418\u592b\u80fa\u7684\u8349\u9178\u76d0\u548c\u67e0\u6aac\u9178\u76d0<\/span>\u7684\u751f\u7269\u5229\u7528\u5ea6\u6ca1\u6709\u5dee\u5f02[16]\uff0c\u4ee5\u53ca<\/span>\u5065\u5eb7\u5fd7\u613f\u8005\u5728\u53e3\u670d\u594e\u5b81\u7684\u76d0\u9178\u76d0\u3001<\/span>\u786b\u9178\u76d0\u548c\u78b3\u9178\u4e59\u916f\u76d0\u540e\uff0c\u594e\u5b81\u7684<\/span>Cmax\u3001Tmax \u6216AUC \u6ca1\u6709\u663e\u8457<\/span>\u5dee\u5f02[17]\u3002<\/span><\/p>\n

\u4e3a\u4e86\u8bc1\u660e\u76f8\u540c\u6d3b\u6027\u6210\u5206\u4e0d\u540c\u76d0\u57fa\u836f\u7269\u4e4b\u95f4\u5177\u6709\u6cbb\u7597\u7b49\u6548\u6027\uff0c\u5219\u9700\u8981\u8fdb\u884c\u4f53\u5185\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\uff0c\u7279\u6b8a\u60c5\u51b5\u4e0b\uff0c\u53ef\u4ee5\u8003\u8651\u751f\u7269\u8c41\u514d\uff0c\u5982\u4e24\u79cd\u76d0\u90fd\u662f\u9ad8\u6eb6\u89e3\u6027\u548c\u9ad8\u6e17\u900f\u6027\uff0c\u5373\u4e24\u79cd\u76d0\u90fd\u5c5e\u4e8eBCS \u2160\u7c7b\u5316\u5408\u7269\u3002<\/span><\/strong><\/span><\/p>\n

\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u5982\u679c\u8be5\u53e3<\/span>\u670d\u5e38\u91ca\u5236\u5242\u5728\u4f53\u5916\u5feb\u901f\u6eb6\u51fa\uff0c\u4e14<\/span>\u6ee1\u8db3\u4e00\u4e9b\u9644\u52a0\u6761\u4ef6\uff0c\u53ef\u4ee5\u8bf7\u6c42\u57fa<\/span>\u4e8eBCS \u8c41\u514d\u4f53\u5185BE \u7814\u7a76[18]\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

2.3 \u591a\u6676\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u591a\u6676\u578b\u5e38\u5e38\u662f\u786e\u5b9a\u76d0\u57fa\u7684\u5173\u952e\u56e0\u7d20\u3002\u591a\u6676\u578b\u662f\u6307\u836f\u7269\u4ee5\u4e24\u4e2a<\/span>\u6216\u4e24\u4e2a\u4ee5\u4e0a\u6676\u578b\u5b58\u5728\u7684\u80fd\u529b\uff0c\u6676<\/span>\u578b\u6307\u6676\u683c\u4e2d\u4e0d\u540c\u7684\u5206\u5b50\u7ed3\u6784\u548c\/<\/span>\u6216\u6784\u8c61[9]\u3002<\/span><\/p>\n

\u591a\u6676\u578b\u662f\u6240\u6709API\u4e2d\u666e\u904d\u5b58\u5728\u7684\u73b0\u8c61\uff0c \u4e0eAPI \u7684<\/span>\u591a\u6676\u578b\u6709\u5173\u7684\u6700\u5173\u952e\u95ee\u9898\u662f\u5e73\u8861<\/span>\u6eb6\u89e3\u5ea6\uff0c\u5e73\u8861\u6eb6\u89e3\u5ea6\u662f\u6eb6\u89e3\u901f\u7387<\/span>\u7684\u4e00\u4e2a\u91cd\u8981\u51b3\u5b9a\u56e0\u7d20\uff0c\u800c\u5e73\u8861\u6eb6<\/span>\u89e3\u5ea6\u53c8\u4f1a\u5f71\u54cd\u6d3b\u6027\u836f\u7269\u7684\u751f\u7269\u5229<\/span>\u7528\u5ea6[19]\u3002<\/span><\/p>\n

\u8bb8\u591a\u4f8b\u5b50\u8868\u660e\u591a\u6676\u578b\u4e0e<\/span>\u56fa\u4f53\u5242\u578b\u836f\u7269\u6d3b\u6027\u6210\u5206\u7684\u53e3\u670d\u751f<\/span>\u7269\u5229\u7528\u5ea6\u7684\u5dee\u5f02\u6709\u5173\uff0c\u5305\u62ec\u6c2f\u9709<\/span>\u7d20\u68d5\u6988\u9178\u916f\u548c\u5361\u9a6c\u9a6c\u677e\u78b1[20,21]\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u4e3a\u4e86\u514b\u670d\u6eb6\u89e3\u6027\u548c\u5176\u4ed6\u6311\u6218\uff0c\u751f\u4ea7\u4e0d\u540c\u6210\u76d0\u5f62\u5f0f\u7684\u836f\u7269\uff0c<\/span>\u7814\u7a76\u591a\u6676\u578b\u81f3\u5173\u91cd\u8981\uff0c\u5145\u5206\u7684\u7814<\/span>\u7a76\u6709\u52a9\u4e8e\u4ea7\u751f\u9002\u5f53\u7684API\uff0c\u4ece\u800c<\/span>\u4e3aAPI \u653e\u5927\u751f\u4ea7\u548c\u968f\u540e\u7684\u5236\u5242\u751f<\/span>\u4ea7\u505a\u597d\u51c6\u5907\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

2.4 \u56fa\u6001\u6027\u8d28<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5206\u5b50\u7684\u56fa\u6001\u6027\u8d28\u53ca\u5176\u5728\u6eb6\u6db2\u4e2d\u7684\u6027\u8d28\u53ef\u4ee5\u901a\u8fc7\u4e0d\u540c\u6210\u76d0\u5f62\u5f0f<\/span>\u6539\u53d8\u3002<\/span><\/p>\n

\u9009\u62e9\u5408\u9002\u7684\u7279\u5b9a\u7ed9\u836f\u9014\u5f84\u6216\u7279\u5b9a\u5242\u578b\u4e0b\u7684\u6210\u76d0\u5f62\u5f0f\uff0c\u5219\u8981<\/span>\u6c42\u5728\u4ea7\u54c1\u7ee7\u7eed\u5f00\u53d1\u4e4b\u524d\uff0c\u5f7b\u5e95\u7814<\/span>\u7a76\u5019\u9009\u76d0\u57fa\u7684\u6240\u6709\u76f8\u5173\u56fa\u6001\u7279\u6027\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n

3<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n

\u6bd2\u6027\u3001\u5b89\u5168\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\u9664\u4e86\u4e13\u5229\u95ee\u9898\u4e4b\u5916\uff0c\u8fd8\u6709\u82e5\u5e72\u91cd\u8981\u95ee\u9898\u9700\u8981\u5173\u6ce8\uff1a\u4e3a\u4e86\u786e\u4fdd\u7279\u5b9a<\/span>\u6210\u76d0\u5f62\u5f0f\u7684API \u836f\u54c1\u5177\u6709\u4e0e\u5df2\u6279<\/span>\u51c6\u7684\u4e0d\u540c\u76d0\u57fa\u76f8\u540cAPI \u836f\u54c1\u53ef\u6bd4<\/span>\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u836f\u7406\u5b66\u3001\u6bd2\u7406\u5b66\u548c<\/span>\u5b89\u5168\u6027\u7279\u5f81\uff0c\u9700\u8981\u5f00\u5c55\u54ea\u4e9b\u7814\u7a76\uff1f<\/p>\n

\u6b64\u5916\uff0c\u5df2\u8bc1\u660e\u5177\u6709\u751f\u7269\u7b49\u6548\u7684\u836f\u5b66\u7b49\u6548\u836f\u54c1\uff0c\u5177\u6709\u4e0d\u540c\u4e34\u5e8a\u5b89\u5168\u6027\u548c<\/span>\u6709\u6548\u6027\u7684\u53ef\u80fd\u6027\u6709\u591a\u5927\uff1f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

3.1 \u4e0d\u7a33\u5b9a\u6027\u4ea7\u751f\u7684\u5b89\u5168\u6027\u95ee\u9898<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5982\u524d\u6240\u8ff0\uff0c\u540c\u4e00API \u7684\u4e0d\u540c\u6210\u76d0\u5f62\u5f0f\uff0c\u5176\u7269\u7406\u5316\u5b66\u7279\u6027\u53ef\u80fd<\/span>\u4f1a\u4ea7\u751f\u53d8\u5316\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u6eb6\u89e3<\/span>\u6027\u548c\u5438\u6e7f\u6027\u3002<\/span><\/p>\n

\u5373\u4f7f\u5728\u836f\u7269\u5242\u578b\u5982<\/span>\u7247\u5242\u4e2d\uff0c\u589e\u52a0\u5438\u6e7f\u6027\u4e5f\u53ef\u80fd\u964d\u4f4e<\/span>API \u7684\u7a33\u5b9a\u6027\uff0c\u5c24\u5176\u5f53API \u6613\u4e8e<\/span>\u6c34\u89e3\u964d\u89e3\u65f6\uff0c\u5f71\u54cd\u66f4\u4e3a\u4e25\u91cd\u3002<\/span><\/p>\n

\u6b64<\/span>\u5916\uff0c\u5bf9\u4e8e\u76f8\u540cAPI \u7684\u4e0d\u540c\u6210\u76d0\u5f62<\/span>\u5f0f\uff0c\u70ed\u7a33\u5b9a\u6027\u548c\u964d\u89e3\u9014\u5f84\u4e5f\u53ef\u80fd<\/span>\u4e0d\u540c\uff0c\u9700\u8981\u4f7f\u7528\u9002\u5f53\u7684\u6bd2\u7406\u5b66\u548c\/<\/span>\u6216\u5176\u4ed6\u7814\u7a76\u6765\u8bc4\u4f30\u65b0\u7684\u964d\u89e3\u4ea7\u7269\u3002<\/span><\/p>\n

\u518d\u4ee5\u6c28\u6c2f\u5730\u5e73\u4e3a\u4f8b\uff0c\u4e0e\u82ef\u78fa<\/span>\u9178\u76d0\u76f8\u6bd4\uff0c\u9a6c\u6765\u9178\u76d0\u7684\u4e0d\u7a33\u5b9a\u6027\u5bfc<\/span>\u81f4\u964d\u89e3\u4ea7\u7269\u7684\u5f62\u6210\uff0c\u8be5\u964d\u89e3\u4ea7\u7269\u5bf9<\/span>\u5b89\u5168\u6027\u548c\u6bd2\u6027\u5177\u6709\u663e\u8457\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\u4e0e<\/span>\u82ef\u78fa\u9178\u76d0\u4e0d\u540c\uff0c\u6c28\u6c2f\u5730\u5e73\u7684\u9a6c\u6765\u9178<\/span>\u76d0\u5177\u6709\u5185\u5728\u7684\u5316\u5b66\u4e0d\u7a33\u5b9a\u6027\uff0c\u5bfc\u81f4<\/span>N-\uff082-{[4-\uff082- \u6c2f\u82ef\u57fa\uff09-3-<\/span>\uff08\u4e59\u6c27\u7fb0\u57fa\uff09-5-\uff08\u7532\u6c27\u7fb0\u57fa\uff09-6-<\/span>\u7532\u57fa-1,4- \u4e8c\u6c222- \u5421\u5576\u57fa] \u7532<\/span>\u6c27\u57fa} \u4e59\u57fa\uff09\u5929\u51ac\u6c28\u9178\u7684\u5f62\u6210\u3002<\/span><\/p>\n

\u8fd9\u79cd\u6742\u8d28\u5177\u6709\u751f\u7269\u6d3b\u6027\uff0c\u5e76\u4e14\u662f\u7531\u4e0d\u9971\u548c\u9a6c\u6765\u9178\u4e0e\u6c28\u6c2f\u5730\u5e73\u7684\u4f2f<\/span>\u80fa\u57fa\u56e2\u5206\u5b50\u5185\u53cd\u5e94\u5f62\u6210\u7684\u3002<\/span><\/p>\n

\u5df2\u6709<\/span>\u8bc1\u636e\u8868\u660e\u8fd9\u79cd\u5929\u51ac\u6c28\u9178\u884d\u751f\u7269\u5177<\/span>\u6709\u4e0e\u6c28\u6c2f\u5730\u5e73\u672c\u8eab\u622a\u7136\u4e0d\u540c\u7684\u751f<\/span>\u7269\u5b66\u7279\u6027\u3002<\/span><\/p>\n

\u867d\u7136\u542b\u91cf\u4f4e\u7684\u6742\u8d28\u53ef<\/span>\u80fd\u4e0d\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u4e34\u5e8a\u540e\u679c\uff0c\u4f46<\/span>\u9a6c\u6765\u9178\u76d0\u7684\u4e0d\u7a33\u5b9a\u6027\u8868\u660e\uff0c\u5728\u5236<\/span>\u5242\u751f\u4ea7\u548c\u957f\u671f\u50a8\u5b58\u540e\uff0c\u53ef\u80fd\u8868\u73b0<\/span>\u4e3a\u8f83\u9ad8\u6c34\u5e73\u7684\u6742\u8d28\u3002\u4e24\u79cd\u836f\u7269\u4e4b<\/span>\u95f4\u7684\u6cbb\u7597\u7b49\u6548\u6027\u4e0d\u4ec5\u610f\u5473\u7740\u76f8\u540c<\/span>\u7684\u529f\u6548\uff0c\u800c\u4e14\u610f\u5473\u7740\u76f8\u540c\u7684\u5b89\u5168<\/span>\u6027\u7279\u5f81\u3002<\/span><\/p>\n

\u4e0a\u8ff0\u6c28\u6c2f\u5730\u5e73\u7684\u9a6c\u6765\u9178<\/span>\u76d0\u548c\u82ef\u78fa\u9178\u76d0\u7684\u6bd2\u6027\u548c\u7a33\u5b9a\u6027\u7684<\/span>\u53ef\u80fd\u5dee\u5f02\u8868\u660e\uff0c\u6539\u76d0\u57fa\u4ea7\u54c1\u9664\u4e86<\/span>\u9700\u4e0e\u5df2\u4e0a\u5e02\u4ea7\u54c1\u83b7\u5f97\u4f53\u5185\u751f\u7269\u7b49<\/span>\u6548\u4e4b\u5916\uff0c\u53ef\u80fd\u8fd8\u5fc5\u987b\u5bf9\u6539\u76d0\u57fa\u4ea7<\/span>\u54c1\u8fdb\u884c\u6bd2\u7406\u5b66\u8bc4\u4ef7\uff0c\u624d\u80fd\u5224\u65ad\u662f<\/span>\u5426\u6cbb\u7597\u7b49\u6548\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

3.2 \u6210\u76d0\u6bd2\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

API \u6210\u76d0\u6bd2\u6027\u53ef\u80fd\u662f\u7531\u4e8e\u7528\u4e8e\u6210\u76d0\u7684\u5171\u8f6d\u9634\u79bb\u5b50\u6216\u9633\u79bb\u5b50\u6240<\/span>\u81f4[5]\u3002<\/span><\/p>\n

\u5df2\u6709\u62a5\u9053\u663e\u793a\uff0c\u7531\u4e8e\u5f62\u6210<\/span>\u9a6c\u6765\u9178\u76d0\u7684\u9a6c\u6765\u9178\u9634\u79bb\u5b50\uff0c\u9a6c\u6765<\/span>\u9178\u666e\u62c9\u591a\u6797\u8868\u73b0\u51fa\u80be\u6bd2\u6027\uff0c\u5e76\u80fd<\/span>\u5f15\u8d77\u72d7\u7684\u80be\u5c0f\u7ba1\u75c5\u53d8[22]\u3002<\/span><\/p>\n

\u6210\u76d0\u5242\u7684\u5b89\u5168\u6027\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8e\u5176\u7406\u5316\u6027\u8d28\u53ca\u5176\u751f\u7269\u5b66<\/span>\u7279\u6027\u3002\u7814\u7a76\u7279\u5b9a\u6210\u76d0\u5242\u6bd2\u6027\u7684\u5fc5<\/span>\u8981\u6027\uff0c\u4e00\u822c\u9700\u5148\u4e86\u89e3\u5b83\u662f\u5426\u66fe\u7528<\/span>\u4e8e\u5176\u4ed6\u533b\u836f\u4ea7\u54c1\u3001\u98df\u54c1\u548c\u996e\u6599\uff0c<\/span>\u4ee5\u53ca\u6210\u76d0\u5242\u4e0e\u6d3b\u6027\u7269\u8d28\u7684\u76f8\u5bf9\u6bd4<\/span>\u4f8b\u3002<\/span><\/p>\n

\u5f53\u6d3b\u6027\u7269\u8d28\u6210\u76d0\u5f62\u5f0f\u7531\u4e00\u79cd<\/span>\u65b0\u6210\u76d0\u5242\u5236\u5f97\u65f6\uff0c\u4e14\u5f88\u5c11\u6216\u6ca1\u6709<\/span>\u5176\u6bd2\u6027\u7279\u5f81\u7684\u4fe1\u606f\uff0c\u5219\u9700\u8981\u5bf9\u6d3b<\/span>\u6027\u7269\u8d28\u7684\u6240\u6709\u65b0\u76d0\u5f62\u5f0f\u8fdb\u884c\u6bd2\u6027<\/span>\u7814\u7a76\uff0c\u540c\u65f6\u4e5f\u6709\u5fc5\u8981\u5355\u72ec\u7814\u7a76\u6210<\/span>\u76d0\u5242\u7684\u6bd2\u6027\u3002 <\/span><\/p>\n

API \u591a\u79cd\u76d0\u57fa\u7684\u6bd2<\/span>\u6027\u7279\u5f81\u5dee\u5f02\u53ef\u80fd\u662f\u5728\u5236\u5907\u7279\u5b9a\u6210<\/span>\u76d0\u5f62\u5f0f\u7684API \u671f\u95f4\u5f62\u6210\u4e86\u6f5c\u5728\u7684<\/span>\u6bd2\u6027\u5316\u5b66\u6742\u8d28\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u8bc4<\/span>\u4f30\u5728\u7279\u5b9a\u6210\u76d0\u5f62\u5f0fAPI \u5408\u6210\u8fc7\u7a0b<\/span>\u4e2d\u5f62\u6210\u548c\u5206\u79bb\u7684\u6240\u6709\u6742\u8d28\u7684\u53ef\u80fd<\/span>\u6bd2\u6027\u3002<\/span><\/p>\n

\u4f8b\u5982\uff0c\u7532\u78fa\u9178\u7528\u4e8e\u5236\u5907\u6d3b<\/span>\u6027\u78b1\u6027\u836f\u7269\u5206\u5b50\u5982\u57f9\u9ad8\u5229\u7279\u3001\u5948<\/span>\u975e\u90a3\u97e6\u3001\u4f0a\u9a6c\u66ff\u5c3c\u548c\u6c28\u6c2f\u5730\u5e73\u7684<\/span>\u7532\u78fa\u9178\u76d0\u3002\u836f\u7269\u4e2d\u75d5\u91cf\u7532\u78fa\u9178\u916f\uff0c<\/span>\u5305\u62ec\u7532\u78fa\u9178\u916f\u7532\u916f\u3001\u7532\u78fa\u9178\u4e59\u916f<\/span>\u548c\u7532\u78fa\u9178\u5f02\u4e19\u916f\u7684\u6f5c\u5728\u5065\u5eb7\u5371\u5bb3<\/span>\u5df2\u5f15\u8d77\u536b\u751f\u5f53\u5c40\u7684\u6ce8\u610f[23]\u3002<\/span><\/p>\n

\u4e0a\u8ff0<\/span>\u6742\u8d28\u662f\u5728\u6d3b\u6027\u7269\u8d28\u7532\u78fa\u9178\u76d0\u7684\u5236<\/span>\u9020\u8fc7\u7a0b\u4e2d\uff0c\u7532\u78fa\u9178\u4e0e\u7532\u9187\u3001\u4e59\u9187<\/span>\u548c\u5f02\u4e19\u9187\u7b49\u6eb6\u5242\u53cd\u5e94\u800c\u5f62\u6210\u7684\u3002<\/span><\/p>\n

\u6b64\u5916\uff0c\u5728\u751f\u4ea7\u5236\u5242\u671f\u95f4\u4f7f\u7528\u9187\u6eb6\u5242\u4e5f\u53ef\u80fd\u4ea7\u751f\u8fd9\u4e9b\u6742\u8d28\uff0c\u5bfc\u81f4\u4ea7<\/span>\u751f\u6f5c\u5728\u7684\u4e0d\u5b89\u5168\u5236\u5242\u3002<\/span><\/p>\n

\u7532\u78fa\u9178\u916f<\/span>\u662f\u5df2\u77e5\u7684\u5f3a\u81f4\u7a81\u53d8\u3001\u81f4\u764c\u548c\u81f4\u7578<\/span>\u5316\u5408\u7269\u3002\u56e0\u6b64\uff0c\u53ef\u4ee5\u8ba4\u4e3a\uff0c\u5f53\u751f<\/span>\u4ea7\u548c\u5236\u5907\u76f8\u540cAPI \u7684\u4e0d\u540c\u76d0\u57fa\u7684<\/span>\u5408\u6210\u8def\u7ebf\u5bfc\u81f4\u4e0d\u540c\u7684\u5316\u5b66\u526f\u4ea7\u7269<\/span>\u65f6\uff0c\u8fd9\u4e9b\u6742\u8d28\u7684\u53ef\u80fd\u6bd2\u6027\u5e94\u901a\u8fc7<\/span>\u5bf9\u5408\u6210\/ \u5236\u5907\u7684\u6bcf\u79cd\u76d0\u578b\u7684\u4e34\u5e8a<\/span>\u524d\u8bd5\u9a8c\u6765\u8bc4\u4f30\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3.3 \u8010\u53d7\u6027<\/span><\/strong>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0d\u4f5c\u4e3a\u6ce8\u518c\u7533\u62a5\u7684\u4f9d\u636e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\"CDE\u6587\u7ae0|\u6d45\u8c08\u540c\u4e00API<\/p>\n
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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n

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\"CDE\u6587\u7ae0|\u6d45\u8c08\u540c\u4e00API<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"CDE\u6587\u7ae0|\u6d45\u8c08\u540c\u4e00API<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u6d45\u8c08\u540c\u4e00API \u4e0d\u540c\u6210\u76d0\u836f\u7269\u4e00\u81f4\u6027\u8bc4\u4ef7\u4e2d\u53ef\u80fd\u5b58\u5728\u7684\u95ee\u9898 \u6765\u6e90 \u300a\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7ba1\u300b\uff0c2019\u5e74\u7b2c1\u671f \u4f5c\u8005 \u8d3a […]<\/p>\n","protected":false},"author":1,"featured_media":98303,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/98302"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=98302"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/98302\/revisions"}],"predecessor-version":[{"id":98316,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/98302\/revisions\/98316"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/98303"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=98302"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=98302"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=98302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}