{"id":98359,"date":"2019-03-20T00:00:50","date_gmt":"2019-05-17T08:14:15","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/98359\/"},"modified":"2019-05-17T16:14:19","modified_gmt":"2019-05-17T08:14:19","slug":"aabec67a56","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/98359\/","title":{"rendered":"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"box-sizing: border-box;font-size: 16px;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;padding: 3px;border-radius: 1.6em;background-color: rgb(255, 129, 36);box-sizing: border-box;\">\n<section style=\"padding: 2px 8px;border-width: 1px;border-style: dotted;border-color: rgb(255, 255, 255);border-radius: 1.6em;color: rgb(255, 255, 255);line-height: 1.4em;font-size: 21px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558080856.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5bfc\u8bfb<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558080856-1.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u672c\u7814\u7a76\u901a\u8fc7PBPK\u5efa\u6a21\u4e0e\u6a21\u62df\uff0c\u8003\u5bdf\u548c\u5206\u6790\u5316\u5408\u7269X\u51fa\u73b0\u98df\u7269\u6548\u5e94\u7684\u53ef\u80fd\u673a\u7406\u3002\u5e76\u501f\u52a9\u53c2\u6570\u654f\u611f\u6027\u5206\u6790\u529f\u80fd\uff0c\u53d1\u73b0\u964d\u4f4e\u539f\u6599\u836f\u7684\u7c92\u5f84\u53ef\u964d\u4f4e\u98df\u7269\u6548\u5e94\uff0c\u63a2\u5bfb\u901a\u8fc7\u5236\u5242\u624b\u6bb5\u907f\u514d\u98df\u7269\u6548\u5e94\u7684\u53ef\u884c\u65b9\u6848\uff0c\u4e3a\u5236\u5242\u5f00\u53d1\u63d0\u4f9b\u51b3\u7b56\u6307\u5bfc\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u901a\u8fc7\u672c\u6848\u4f8b\u7684\u5b66\u4e60\uff0c\u7c7b\u4f3c\u5316\u5408\u7269\u5236\u5242\u5f00\u53d1\u65f6\u53ef\u8003\u5bdf\u98df\u7269\u6548\u5e94\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558080856.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u53c2\u8003\u6587\u732e\u4f5c\u8005\u5355\u4f4d<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558080856.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">Hefei Zhang, Binfeng Xia, Jennifer Sheng,Tycho Heimbach, Tsu-Han Lin, Handan He, Yanfeng Wang,&nbsp;<span style=\"letter-spacing: 0px;box-sizing: border-box;\">Steven Novick, Ann Comfort<\/span><\/p>\n<p style=\"box-sizing: border-box;\">\u7f8e\u56fd\u8bfa\u534e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558080856.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6587\u7ae0\u89e3\u8bfb\u4eba<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558080856.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u9648\u6d9b\uff0c\u4e0a\u6d77\u6280\u672f\u90e8<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558080856-1.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558080856.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;text-align: left;\">Zhang H,&nbsp;Xia B,&nbsp;Sheng J, et al., Application&nbsp;of&nbsp;physiologically&nbsp;based&nbsp;absorption&nbsp;modeling&nbsp;to&nbsp;formulation development&nbsp;of a&nbsp;lowsolubility,&nbsp;low&nbsp;permeability&nbsp;weak&nbsp;base: mechanistic investigation of food effect. AAPS PharmSciTech.&nbsp;2014 Apr; 15(2): 400-6.&nbsp;&nbsp; IF: 2.666<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558080856.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8f6f\u4ef6\u7528\u9014<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558080856-2.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u672c\u6848\u4f8b\u901a\u8fc7GastroPlus\u8f6f\u4ef6\u642d\u5efa\u5316\u5408\u7269X\u5728\u4eba\u7a7a\u8179\u548c\u9910\u540e\u7ed9\u836f\u540e\u7684PBPK\u6a21\u578b\uff0c\u901a\u8fc7\u6a21\u578b\u53c2\u6570\u7684\u8f93\u5165\u548c\u4f18\u5316\uff0c\u4e3b\u8981PK\u53c2\u6570(C<span style=\"font-size: 14px;box-sizing: border-box;\">max<\/span>, AUC, T<span style=\"font-size: 14px;box-sizing: border-box;\">max<\/span>)\u7684\u9884\u6d4b\u7ed3\u679c\u5747\u5728\u89c2\u6d4b\u6570\u503c\u7684\u00b125%\u8303\u56f4\u5185\uff1b\u901a\u8fc7\u6a21\u578b\u7684\u5efa\u7acb\u548c\u5206\u6790\uff0c\u8fd8\u5bfb\u627e\u5230\u8be5\u836f\u7269\u51fa\u73b0\u98df\u7269\u6548\u5e94\u7684\u53ef\u80fd\u673a\u7406\uff1b\u501f\u52a9\u8f6f\u4ef6\u7684\u53c2\u6570\u654f\u611f\u6027\u5206\u6790(PSA)\u529f\u80fd\uff0c\u53d1\u73b0\u5728\u4e34\u5e8a\u7ed9\u836f\u5242\u91cf\u8303\u56f4\u5185\uff0c\u901a\u8fc7\u964d\u4f4eAPI\u7684\u7c92\u5f84\u53ef\u4ee5\u964d\u4f4e\u5176\u98df\u7269\u6548\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558080857.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6848\u4f8b\u6458\u8981<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558080857-1.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u751f\u7406\u836f\u4ee3\u52a8\u529b\u5b66(PBPK)\u6a21\u578b\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u6307\u5bfc\u836f\u7269\u7684\u7814\u53d1\u5de5\u4f5c\uff0c\u672c\u6848\u4f8b\u5efa\u7acb\u4e86\u5316\u5408\u7269X\u7684PBPK\u6a21\u578b\u4ee5\u7cfb\u7edf\u6027\u5730\u7814\u7a76\u8be5\u836f\u6240\u89c2\u6d4b\u5230\u7684\u6b63\u5411\u98df\u7269\u6548\u5e94\u7684\u6f5c\u5728\u673a\u7406\uff0c\u5e76\u63a2\u7d22\u5728\u5236\u5242\u5f00\u53d1\u4e2d\u907f\u514d\u98df\u7269\u6548\u5e94\u7684\u53ef\u884c\u7b56\u7565\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u901a\u8fc7\u6a21\u578b\u7684\u642d\u5efa\u4e0e\u5206\u6790\uff0c\u5bf9\u5316\u5408\u7269X\u51fa\u73b0\u98df\u7269\u6548\u5e94\u7684\u6f5c\u5728\u673a\u7406\u8fdb\u884c\u4e86\u5408\u7406\u7684\u89e3\u91ca\uff0c\u5e76\u53d1\u73b0\u964d\u4f4e\u539f\u6599\u836f(API)\u7684\u7c92\u5f84\u53ef\u4ee5\u63d0\u9ad8\u5316\u5408\u7269X\u7a7a\u8179\u72b6\u6001\u4e0b\u7684\u53e3\u670d\u5438\u6536\uff0c\u8fdb\u800c\u964d\u4f4e\u8be5\u836f\u98df\u7269\u6548\u5e94\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 18px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">1<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u5316\u5408\u7269 X\u662f\u4e00\u4e2a\u4eb2\u8102\u6027\u5316\u5408\u7269\uff0c\u8868\u73b0\u51fapH\u4f9d\u8d56\u6027\u7684\u4f4e\u6eb6\u89e3\u7279\u6027\u4ee5\u53ca\u4e2d\u7b49\u7a0b\u5ea6\u7684\u80a0\u9053\u6e17\u900f\u6027\u80fd\uff0c\u5c5e\u4e8e\u751f\u7269\u836f\u5242\u5b66\u5206\u7c7b\u7cfb\u7edf(BCS)\u7684II\u7c7b\u6216IV\u7c7b\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u5316\u5408\u7269 X\u4ee5\u901f\u91ca\u80f6\u56ca\u5236\u5242\u4e0a\u5e02\uff0c\u5176\u7cfb\u7edf\u66b4\u9732\u4f1a\u5728\u9910\u540e\u5347\u9ad8\u3002\u5316\u5408\u7269X 400mg\u5355\u5242\u91cf\u53e3\u670d\u7ed9\u836f\uff0c\u4f4e\u8102\u9910\u7ed9\u836f\u540e\uff0cAUC\u548cCmax\u5206\u522b\u8f83\u7a7a\u8179\u7ed9\u836f\u63d0\u9ad8\u4e8629%\u548c55%\uff0c\u9ad8\u8102\u9910\u7ed9\u836f\u540e\uff0c\u5176AUC\u548cCmax\u5206\u522b\u8f83\u7a7a\u8179\u7ed9\u836f\u63d0\u9ad8\u4e8682%\u548c112%\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u98df\u7269\u5f71\u54cd\u836f\u7269\u5438\u6536\u7684\u673a\u7406\u5305\u62ec\u5ef6\u8fdf\u80c3\u6392\u7a7a\u3001\u6539\u53d8\u80c3\u80a0\u9053pH\u4ee5\u53ca\u4fc3\u8fdb\u80c6\u6c41\u5206\u6ccc\u7b49\u3002\u7531\u4e8e\u8fdb\u98df\u5bfc\u81f4\u80c6\u9178\u76d0\u6d53\u5ea6\u589e\u52a0\u800c\u8d77\u5230\u589e\u6eb6\u4f5c\u7528\uff0c\u4eb2\u6c34\u6027\u6eb6\u89e3\u5ea6\u5dee\u7684\u8102\u6eb6\u6027\u5316\u5408\u7269\u901a\u5e38\u8868\u73b0\u51fa\u6b63\u5411\u7684\u98df\u7269\u6548\u5e94\uff08\u5438\u6536\u589e\u5927\uff09\uff0c\u8fd9\u5728\u5176\u5b83\u5f88\u591a\u7814\u7a76\u6848\u4f8b\u548c\u6587\u7ae0\u4e2d\u6709\u62a5\u9053\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u57fa\u4e8e\u4f53\u5916\u751f\u7269\u4f53\u76f8\u5173\u7684\u6eb6\u89e3\u5ea6\u3001\u6eb6\u51fa\u6570\u636e\u4ee5\u53ca\u6240\u7814\u7a76\u7684\u52a8\u7269\u4f53\u5185\u6570\u636e\uff0c\u53ef\u4ee5\u6574\u5408\u5230PBPK\u6a21\u578b\u4e2d\u4ee5\u5b9a\u91cf\u8bc4\u4f30\u4e0e\u9884\u6d4b\u53e3\u670d\u836f\u7269\u7684\u5438\u6536\u548c\u98df\u7269\u6548\u5e94\u7684\u60c5\u51b5\u3002\u8be5\u6848\u4f8b\u91c7\u7528\u7c7b\u4f3c\u7684\u65b9\u6cd5\uff0c\u4ee5\u7406\u89e3\u98df\u7269\u5bf9\u5316\u5408\u7269 X\u5438\u6536\u5f71\u54cd\u7684\u673a\u7406\uff0c\u5e76\u5bfb\u627e\u53ef\u884c\u7684\u5236\u5242\u624b\u6bb5\u4ee5\u514b\u670d\u8be5\u836f\u7269\u7684\u98df\u7269\u6548\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 21px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">2<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">&nbsp;<strong style=\"box-sizing: border-box;\">\u5efa\u6a21\u6570\u636e\u4e0e\u5904\u7406<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 18px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">2.1&nbsp;<span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u5316\u5408\u7269 X\u5efa\u6a21\u7684\u76f8\u5173\u53c2\u6570<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558080857.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"color: rgb(255, 129, 36);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">2.2 \u6570\u636e\u83b7\u53d6\u53ca\u5904\u7406<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">pKa, logP, solubility, Caco-2\u6e17\u900f\u6027\u7b49\u6570\u636e\u5747\u6765\u81ea\u4f53\u5916\u5b9e\u9a8c\u7684\u6d4b\u5b9a\u6570\u503c\uff1b\u91c7\u7528\u6587\u732e\u62a5\u9053\u7684\u76f8\u5173\u516c\u5f0f\uff0c\u5c06Caco-2\u7ec6\u80de\u7684\u8868\u89c2\u6e17\u900f\u6027\u6570\u503c\u8f6c\u5316\u4e3a\u4eba\u4f53\u6709\u6548\u6e17\u900f\u6027(Peff)\uff1b\u4e3a\u51c6\u786e\u8003\u5bdf\u836f\u7269\u4f53\u5185\u7684\u6eb6\u89e3\u7279\u6027\uff0c\u8fdb\u4e00\u6b65\u6d4b\u5b9a\u4e86SGF, FaSSIF, FeSSIF\u7b49\u4ecb\u8d28\u4e0b\u5316\u5408\u7269\u7684\u6eb6\u89e3\u5ea6\u5e76\u8f93\u5165\u5230\u8f6f\u4ef6\u6a21\u578b\u4e2d\uff1b\u7531\u4e8e\u6ca1\u6709\u5f88\u53ef\u884c\u7684\u65b9\u6cd5\u5b9a\u91cf\u6d4b\u5b9a\u6c89\u6dc0\u65f6\u95f4\uff0c\u56e0\u6b64\u5316\u5408\u7269 X\u7684\u4f53\u5185\u6c89\u6dc0\u65f6\u95f4\u662f\u57fa\u4e8e\u89c2\u6d4b\u7684\u4eba\u4f53\u836f\u4ee3\u66f2\u7ebf\u8fdb\u884c\u62df\u5408\u7684\u6570\u503c\uff1b<\/p>\n<p style=\"box-sizing: border-box;\">\u9ed8\u8ba4\u4eba\u7684\u751f\u7406\u5b66\u6a21\u578b(Opt LogD model SA\/V 6.1)\u9009\u62e9\u7528\u4e8e\u63cf\u8ff0\u836f\u7269\u5728\u4eba\u80c3\u80a0\u9053\u7684\u6e17\u900f\u6027\u884c\u4e3a\uff1b\u836f\u7269\u7684\u4eb2\u6c34\u6027\u53ca\u751f\u7269\u4f53\u76f8\u5173\u6eb6\u89e3\u5ea6\uff0c\u4ee5\u53ca\u6269\u6563\u7cfb\u6570\u3001\u7c92\u5f84\u7b49\u53c2\u6570\u6574\u5408\u5230\u8f6f\u4ef6\u7684\u6eb6\u51fa\u6a21\u578b(Johnson)\u4e2d\u4ee5\u63cf\u8ff0\u836f\u7269\u5728\u7a7a\u8179\u548c\u9910\u540e\u72b6\u6001\u4f53\u5185\u7684\u6eb6\u51fa\u884c\u4e3a\uff1b<\/p>\n<p style=\"box-sizing: border-box;\">\u4e3a\u51c6\u786e\u53cd\u6620\u98df\u7269\u5f15\u8d77\u80c3\u4e2dpH\u503c\u7684\u52a8\u6001\u53d8\u5316\uff0c\u672c\u6848\u4f8b\u4e2d\u6839\u636e\u6587\u732e\u62a5\u9053\u7684\u7ed3\u679c\uff0c\u5c06\u80c3pH\u8bbe\u7f6e\u4e3a\u4e00\u6761\u968f\u65f6\u95f4\u8fde\u7eed\u53d8\u5316\u7684\u66f2\u7ebf\uff0c\u76f8\u5173\u7684\u53c2\u6570\u8bbe\u7f6e\u5982\u4e0b\uff1a<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558080857.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u4eba\u4f53\u5355\u5242\u91cf\u7a7a\u8179\u53e3\u670d400mg \u5316\u5408\u7269 X\u7684\u7269\u8d28\u5e73\u8861\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5927\u90e8\u5206\u7684\u836f\u7269(~70%)\u5728\u7caa\u4fbf\u4e2d\u4ee5\u539f\u578b\u7684\u5f62\u5f0f\u6536\u96c6\uff0c\u8868\u660e\u8be5\u836f\u7269\u5728\u7a7a\u8179\u72b6\u6001\u4e0b\u5177\u6709\u8f83\u5dee\u7684\u53e3\u670d\u5438\u6536\uff1b\u836f\u7269\u7684\u4ee3\u8c22\u4e3b\u8981\u53d1\u751f\u5728\u809d\u810f\u7ec4\u7ec7\uff0c\u7ecfCYP3A4\u4ecb\u5bfc\u7684\u7f9f\u57fa\u5316\u548c\u6c27\u5316\u53cd\u5e94\uff1b\u539f\u578b\u836f\u7269\u662f\u8840\u6d46\u5faa\u73af\u4e2d\u7684\u4e3b\u8981\u6210\u5206\u5e76\u4ea7\u751f\u4e3b\u8981\u7684\u836f\u7406\u6d3b\u6027\uff1b\u7531\u4e8e\u7f3a\u5c11\u5408\u9002\u7684\u9759\u8109\u7ed9\u836f\u5242\u578b\uff0c\u672a\u7814\u7a76\u4eba\u4f53\u9759\u8109\u7ed9\u836f\u540e\u7684\u4f53\u5185\u884c\u4e3a\uff0c\u751f\u7269\u5229\u7528\u5ea6\u4f30\u7b97\u4e3a\u5c0f\u4e8e30%\uff1b<\/p>\n<p style=\"box-sizing: border-box;\">\u5316\u5408\u7269 X\u4eba\u4f53\u4e3b\u8981\u7684\u5904\u7f6e\u53c2\u6570(\u6e05\u9664\u7387\u548c\u5206\u5e03\u4f53\u79ef)\u6536\u96c6\u4e8e\u6587\u732e\u9a8c\u8bc1\u540e\u7684\u6a21\u578b\u6570\u636e\uff0c\u5176\u4e2dCL\/F\u7684\u6570\u636e\u6839\u636eNCA\u7684\u8ba1\u7b97\u7ed3\u679c\u505a\u4e86\u5fae\u5c0f\u7684\u8c03\u6574\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 21px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">3<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7ed3\u679c\u4e0e\u5206\u6790<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;color: rgb(255, 129, 36);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">3.1 \u5316\u5408\u7269 X \u7684PK\u6a21\u578b\u7684\u642d\u5efa\u4e0e\u9a8c\u8bc1<\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558080857.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"margin-bottom:8px;\"><strong><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">a. 200mg<span style=\"color: rgb(0, 0, 0);font-family: \u5b8b\u4f53;\">\u7a7a\u8179\u548c\u9910\u540e\u7ed9\u836f\u540e\u9884\u6d4b<\/span>PK<span style=\"color: rgb(0, 0, 0);font-family: \u5b8b\u4f53;\">\u66f2\u7ebf\u4e0e\u89c2\u6d4b\u70b9<\/span><\/span><\/strong><\/p>\n<p style=\"margin-bottom:8px;\"><strong><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">b. 400mg<span style=\"color: rgb(0, 0, 0);font-family: \u5b8b\u4f53;\">\u7a7a\u8179\u548c\u9910\u540e\u7ed9\u836f\u540e\u9884\u6d4b<\/span>PK<span style=\"color: rgb(0, 0, 0);font-family: \u5b8b\u4f53;\">\u66f2\u7ebf\u4e0e\u89c2\u6d4b\u70b9<\/span><\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 16px;color: rgb(51, 51, 51);\">200mg\u548c400mg \u5316\u5408\u7269 X\u7a7a\u8179\u548c\u9910\u540e\u72b6\u6001\u4e0b\u7ed9\u836f\u540e\u6a21\u62df\u7684PK\u66f2\u7ebf\u7ed3\u679c\u5982\u4e0a\u56fe\u6240\u793a\uff0c\u6a21\u578b\u7ed3\u679c\u7684\u51c6\u786e\u6027\u901a\u8fc7\u5bf9\u6bd4\u9884\u6d4b\u7684PK\u53c2\u6570(AUC, Cmax, tmax)\u4e0e\u89c2\u6d4b\u6570\u503c\u95f4\u7684\u5dee\u5f02\u8fdb\u884c\u8bc4\u4f30\u548c\u9a8c\u8bc1\uff0c\u7ed3\u679c\u8868\u660e\u4e24\u79cd\u98df\u7269\u72b6\u6001\u4e0b\uff0c\u4e0d\u540c\u5242\u91cf\u7684\u9884\u6d4b\u7ed3\u679c\u5747\u5728\u89c2\u6d4b\u5747\u503c\u7684\u00b125%\u8303\u56f4\u5185\uff0c\u6240\u6709\u5242\u91cf\u7684\u9884\u6d4b\u4e0e\u5b9e\u6d4b\u7ed3\u679c\u7684PK\u53c2\u6570\u5217\u4e3e\u5728\u4e0b\u8868\uff1a<\/span><br  \/><strong style=\"box-sizing: border-box;\"><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558080858.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"color: rgb(255, 129, 36);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">3.2 \u5316\u5408\u7269 X\u7684\u4f53\u5185\u5438\u6536\u7279\u5f81<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u901a\u8fc7PBPK\u6a21\u578b\u9884\u6d4b\u5f97\u5230\u5316\u5408\u7269 X\u5728\u80c3\u80a0\u9053\u4e0d\u540c\u90e8\u4f4d\u7684\u53e3\u670d\u5438\u6536\u767e\u5206\u6570\uff0c\u7ed3\u679c\u5217\u4e3e\u5728\u4e0b\u56fe\u3002\u6a21\u578b\u53d1\u73b0\u8be5\u836f\u7269\u7684\u5438\u6536\u4e3b\u8981\u53d1\u751f\u5341\u4e8c\u6307\u80a0\u548c\u7a7a\u80a0\u7b49\u4e0a\u7aef\u80a0\u6bb5\uff1b\u56de\u80a0\u4e2d\u7684\u5438\u6536\u5f88\u5c11\uff1b\u6b64\u5916\u7a7a\u8179\u548c\u8fdb\u98df\u4e24\u79cd\u72b6\u6001\u4e0b\u8be5\u836f\u7269\u5728\u7ed3\u80a0\u4e2d\u90fd\u6709\u4e0d\u5c11\u4e8e5%\u7684\u5438\u6536\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u8be5\u836f\u7269\u5728\u9ad8pH\u6761\u4ef6\u4e0b\u9650\u5236\u4e86\u5176\u6eb6\u89e3\u6027\u80fd\u3002\u5316\u5408\u7269 X\u8fd8\u5c55\u73b0\u51fa\u4e86\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u5438\u6536\uff0c\u5176\u53e3\u670d\u5438\u6536\u767e\u5206\u6570Fa\u4f1a\u968f\u7740\u5242\u91cf\u7684\u589e\u52a0\u800c\u964d\u4f4e\uff0c\u5982\u7a7a\u8179\u72b6\u6001\u4e0b\u7ed9\u836f200 \u5230600mg\u540e\uff0c\u5176Fa\u5c06\u4ece29.7% \u964d\u81f315.6%\uff1b\u9910\u540e\u72b6\u6001\u4e0b\u7ed9\u836f200\u5230400mg \u540e\uff0c\u5176Fa\u5c06\u4ece41.8%\u964d\u81f333.2%\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558080858.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"margin-bottom:8px;text-align:center;\"><strong><span style=\"font-family: \u5b8b\u4f53;font-size: 14px;\">\u5316\u5408\u7269<\/span><\/strong><strong><span style=\"font-size: 14px;\"> X<span style=\"font-size: 14px;font-family: \u5b8b\u4f53;\">\u5355\u5242\u91cf\u7ed9\u836f\u540e\u7a7a\u8179\u548c\u9910\u540e\u72b6\u6001\u4e0b\u80c3\u80a0\u9053\u5c40\u90e8\u5438\u6536\u7279\u5f81<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 18px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">3.3 \u5316\u5408\u7269 X\u7684\u4f53\u5185\u6eb6\u51fa\u66f2\u7ebf<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u9884\u6d4b\u5f97\u5230\u5316\u5408\u7269 X\u7684\u4f53\u5185\u6eb6\u51fa\u66f2\u7ebf\u5982\u4e0b\u56fe\u6240\u793a\u3002\u5728\u7a7a\u8179\u72b6\u6001\u4e0b\uff0c\u7ed9\u836f\u540e\u4e00\u4e2a\u5c0f\u65f6\u5185\u836f\u7269\u5728\u80c3\u4e2d\u5feb\u901f\u6eb6\u51fa\uff0c\u7136\u540e\u5728\u5230\u8fbe\u9ad8pH\u7684\u80a0\u6bb5\u90e8\u5206\u4fbf\u5feb\u901f\u4ea7\u751f\u6c89\u6dc0\u3002\u5728\u8be5\u72b6\u6001\u4e0b\u5242\u91cf\u4ece200\u5230400mg\u65f6\uff0c\u5176\u6eb6\u51fa\u7684\u836f\u7269\u91cf\u4ece30%\u964d\u81f320%\u3002\u76f8\u53cd\uff0c\u5728\u9910\u540e\u72b6\u6001\u4e0b\u89c2\u5bdf\u5230\u5316\u5408\u7269 X\u5448\u73b0\u7f13\u6162\u4e0a\u5347\u7684\u6eb6\u51fa\u7279\u5f81\uff1b\u5f53\u996d\u540e3h\u4e14\u80c3pH\u4ece4.9\u964d\u81f33.5\u65f6\uff0c\u6b64\u65f6\u5316\u5408\u7269 X \u8868\u73b0\u51fa\u5feb\u901f\u7684\u6eb6\u51fa\u884c\u4e3a\uff1b\u6240\u5f97\u5230\u7684\u4e09\u76f8\u6eb6\u51fa\u66f2\u7ebf\uff0c\u53ef\u80fd\u63d0\u793a\u836f\u7269\u7684\u6eb6\u51fa\u901f\u7387\u4e0e\u9ad8\u8102\u9910\u540e\u80c3pH\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u53d8\u5316\u6709\u5173\u3002\u6b64\u5916\uff0c\u9910\u540e\u72b6\u6001\u4e0b\u836f\u7269\u7684\u6c89\u6dc0\u5bf9\u836f\u7269\u5438\u6536\u7684\u5ef6\u8fdf\u4f5c\u7528\u5f88\u5c0f\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558080858.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"margin-bottom:8px;text-align:center;\"><strong><span style=\"font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53;\">\u5316\u5408\u7269<\/span> X<span style=\"font-family: \u5b8b\u4f53;\">\u5355\u5242\u91cf<\/span>200<span style=\"font-family: \u5b8b\u4f53;\">\u548c<\/span>400mg<span style=\"font-family: \u5b8b\u4f53;\">\u7ed9\u836f\u540e\u7a7a\u8179\u548c\u9910\u540e\u72b6\u6001\u4e0b\u4f53\u5185\u6eb6\u51fa\u66f2\u7ebf<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(255, 129, 36);font-size: 18px;box-sizing: border-box;\">3.4 \u5316\u5408\u7269 X\u6a21\u578b\u5e94\u7528-\u53c2\u6570\u654f\u611f\u6027\u5206\u6790<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u4e3a\u7814\u7a76\u7c92\u5f84\u548c\u7ed9\u836f\u5242\u91cf\u5bf9\u53e3\u670d\u5438\u6536\u7684\u76f8\u4e92\u5f71\u54cd\uff0c\u6a21\u578b\u5f00\u5c55\u4e86\u7a7a\u8179\u548c\u9910\u540e\u72b6\u6001\u4e0b\u7684\u4e09\u7ef4\u53c2\u6570\u654f\u611f\u6027\u5206\u6790(PSA)\uff0c\u6b64\u5916\u6b63\u5411\u98df\u7269\u6548\u5e94\u7684\u7279\u5f81(\u901a\u8fc7\u7a7a\u8179\u548c\u9910\u540e\u72b6\u6001\u4e0bAUC0-inf\u7684\u6bd4\u4f8b\u8fdb\u884c\u53cd\u6620)\u4e5f\u57fa\u4e8ePSA\u7ed3\u679c\u9884\u6d4b\u7684AUC\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u5728\u7a7a\u8179\u72b6\u6001\u4e0b\uff0c\u5f53\u7c92\u5f84\u589e\u52a0\u52300.05\u03bcm\u4ee5\u4e0a\u65f6\uff0c\u6b64\u65f6\u5316\u5408\u7269 X\u7684Fa\u968f\u6cbb\u7597\u5242\u91cf(200\u5230400mg)\u7684\u589e\u52a0\u6025\u5267\u964d\u4f4e\u3002\u6b64\u5916\uff0c\u5728\u6cbb\u7597\u5242\u91cf\u8303\u56f4\u5185\uff0c\u5f53\u7c92\u5f84\u4e0d\u5927\u4e8e0.1\u03bcm\u65f6\u8be5\u836f\u7269\u7684Fa\u53ef\u4ee5\u63d0\u9ad8\u81f360\u201380%\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u9910\u540e\u72b6\u6001\u4e0b\uff0c\u53ea\u8981\u7c92\u5f84\u5c0f\u4e8e0.1\u03bcm\u65f6\u8be5\u836f\u7269\u7684Fa\u5747\u53ef\u63a5\u8fd1\u5b8c\u5168\u5438\u6536(&gt;85%)\uff0c\u65e0\u8bba\u5242\u91cf\u9009\u62e9\u5728\u54ea\u4e2a\u8303\u56f4(200\u2013800 mg)\u3002\u5f53\u7c92\u5f84\u57280.1\u20131\u03bcm\u8303\u56f4\u65f6\uff0cFa\u4f1a\u964d\u4f4e\u81f335\u201380%\uff0c\u4e14Fa\u964d\u4f4e\u7684\u5e45\u5ea6\u4f1a\u968f\u7740\u5242\u91cf\u7684\u589e\u52a0\u800c\u52a0\u5927\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u5bf9\u6bd4\u7a7a\u8179\u548c\u9910\u540e\u7684\u72b6\u6001\uff0c\u53d1\u73b0\u7c92\u5f84\u5728\u5927\u4e8e0.1 \u03bcm\u65f6\uff0c\u8be5\u836f\u7684Fa\u4ecd\u5177\u6709\u8f83\u5927\u7684\u5dee\u5f02\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u5dee\u5f02\u5c06\u4f34\u968f\u836f\u7269\u7c92\u5f84\u51cf\u5c0f\u81f3\u7eb3\u7c73\u8303\u56f4(0.01\u20130.1\u03bcm)\u65f6\u800c\u663e\u8457\u964d\u4f4e\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558080858.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"text-align:center;text-autospace:none;\"><strong><span style=\"font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53;\">\u7c92\u5f84\u548c\u5242\u91cf\u5bf9<\/span>Fa<span style=\"font-family: \u5b8b\u4f53;\">\u4ea4\u4e92\u5f71\u54cd\u7684\u54cd\u5e94\u9762\u66f2\u7ebf<\/span> (a) <span style=\"font-family: \u5b8b\u4f53;\">\u7a7a\u8179\u72b6\u6001<\/span> (b) <span style=\"font-family: \u5b8b\u4f53;\">\u9910\u540e\u72b6\u6001<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 21px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">4<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6a21\u578b\u8ba8\u8bba<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u98df\u7269\u53ef\u4ee5\u901a\u8fc7\u6539\u53d8\u751f\u7406\u6761\u4ef6\u6216\u8005\u76f4\u63a5\u4ea7\u751f\u836f\u7269-\u98df\u7269\u76f8\u4e92\u4f5c\u7528\u7b49\u65b9\u5f0f\u663e\u8457\u5f71\u54cd\u836f\u7269\u7684\u5438\u6536\u548c\u5904\u7f6e\u884c\u4e3a\uff0c\u901a\u5e38\u4f4e\u6eb6\u89e3\u5ea6\u7684BCS II\u6216IV\u7c7b\u836f\u7269\u4f1a\u89c2\u6d4b\u5230\u6b63\u5411\u7684\u98df\u7269\u6548\u5e94\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u8fd9\u7c7b\u8102\u6eb6\u6027\u3001\u5f31\u78b1\u6027\u4e14\u5448\u73b0pH\u4f9d\u8d56\u6027\u6eb6\u89e3\u7279\u5f81\u7684\u5316\u5408\u7269\uff0c\u5c06\u4f1a\u5728\u80a0\u9053pH\u6761\u4ef6\u4e0b\u8868\u73b0\u51fa\u4f4e\u6eb6\u89e3\u884c\u4e3a\u5e76\u56e0\u6b64\u4ea7\u751f\u8fc7\u9971\u548c\u800c\u6c89\u6dc0\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u6c89\u6dc0\u7684\u836f\u7269\u5c06\u8fdb\u4e00\u6b65\u805a\u96c6\u6210\u4e3a\u7ec6\u5c0f\u7684\u9897\u7c92\uff0c\u4e14\u5728\u9ad8pH\u503c\u6eb6\u89e3\u9650\u5236\u7684\u6761\u4ef6\u4e0b\u4ec5\u6709\u90e8\u5206\u80fd\u591f\u590d\u6eb6\uff0c\u4f1a\u5bfc\u81f4\u7a7a\u8179\u72b6\u6001\u4e0b\u836f\u7269\u7684\u4e0d\u5b8c\u5168\u5438\u6536\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u4f34\u968f\u7740\u8fdb\u98df\u7684\u53d1\u751f\uff0c\u836f\u7269\u53ef\u4ee5\u5728\u80c3\u4e2d\u505c\u7559\u8f83\u957f\u65f6\u95f4\u4ee5\u5ef6\u957f\u836f\u7269\u6eb6\u51fa\u8fc7\u7a0b\uff0c\u8fdb\u800c\u63d0\u9ad8\u836f\u7269\u7684\u5438\u6536\u3002\u6b64\u5916\uff0c\u8fdb\u98df\u540e\u5206\u6ccc\u7684\u80c6\u9178\u76d0\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u5316\u5408\u7269 X\u5728\u80a0\u9053\u73af\u5883\u4e2d\u7684\u6eb6\u89e3\u5ea6\uff0c\u4e5f\u80fd\u8fdb\u4e00\u6b65\u63d0\u9ad8\u5176\u53e3\u670d\u5438\u6536\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u7a7a\u8179\u72b6\u6001\u4e0b\uff0c\u5316\u5408\u7269 X\u89c2\u5bdf\u5230\u5feb\u901f\u4e14\u663e\u8457\u7684\u6c89\u6dc0\u73b0\u8c61\uff0c\u76f8\u53cd\u9910\u540e\u72b6\u6001\u5219\u6781\u5927\u5730\u5ef6\u8fdf\u4e86\u836f\u7269\u7684\u6c89\u6dc0\uff1b\u8fd9\u63d0\u793a\u98df\u7269\u7684\u5b58\u5728\u53ef\u4ee5\u963b\u6b62\u5316\u5408\u7269 X\u7684\u6c89\u6dc0\u53d1\u751f\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u6b64\u5916\uff0c\u5316\u5408\u7269 X 400mg\u9910\u540e\u7ed9\u836f\u540e\uff0c\u5176tmax\u4ece4\u5c0f\u65f6\u5ef6\u957f\u52305\u5c0f\u65f6\uff0c\u8fd9\u8bf4\u660e\u8fdb\u98df\u540e\u836f\u7269\u5316\u5408\u7269 X\u53ef\u4ee5\u4e00\u76f4\u7ef4\u6301\u7740\u6eb6\u89e3\u7684\u72b6\u6001\u5e76\u5728\u80a0\u9053\u4e0b\u7aef\u4e5f\u6709\u8fde\u7eed\u7684\u5438\u6536\u8fc7\u7a0b\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u4f53\u5185\u771f\u5b9e\u7684\u6c89\u6dc0\u65f6\u95f4\uff0c\u5373\u8fc7\u9971\u548c\u72b6\u6001\u7684\u836f\u7269\u5728\u5c40\u90e8\u6d53\u5ea6\u8d85\u8fc7\u836f\u7269\u6eb6\u89e3\u5ea6\u65f6\u4ece\u6eb6\u89e3\u72b6\u6001\u4ea7\u751f\u6c89\u6dc0\u9897\u7c92\u7684\u5e73\u5747\u65f6\u95f4\uff0c\u5176\u6570\u503c\u7684\u6d4b\u5b9a\u4e00\u76f4\u662f\u6280\u672f\u96be\u9898\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u5728\u672c\u6848\u4f8b\u4e2d\uff0c\u6c89\u6dc0\u65f6\u95f4\u662f\u6839\u636e\u4e34\u5e8a\u83b7\u5f97\u7684\u4e00\u7cfb\u5217\u8840\u836f\u6d53\u5ea6\u6570\u636e\u901a\u8fc7PBPK\u6a21\u578b\u62df\u5408\u5f97\u5230\u7684\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u6a21\u578b\u6700\u7ec8\u786e\u5b9a\u7684\u4e24\u7ec4\u6c89\u6dc0\u65f6\u95f4(2000\u548c450s)\u53ef\u4ee5\u53cd\u6620\u9910\u540e\u548c\u7a7a\u8179\u72b6\u6001\u4e0b\u5316\u5408\u7269 X\u4f53\u5185\u771f\u5b9e\u7684\u6c89\u6dc0\u901f\u7387\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u9910\u540e\u72b6\u6001\u80fd\u591f\u964d\u4f4e\u5316\u5408\u7269 X\u7684\u6c89\u6dc0\uff0c\u53ef\u80fd\u662f\u56e0\u4e3a\u98df\u7269\u4e2d\u7684\u8102\u7c7b\u6210\u5206\u63d0\u9ad8\u4e86\u836f\u7269\u7684\u6da6\u6e7f\u6027\uff0c\u4ee5\u964d\u4f4e\u5316\u5408\u7269 X\u56fa\u4f53\u9897\u7c92\u4e0e\u80c3\u80a0\u9053\u6db2\u4f53\u95f4\u7684\u754c\u9762\u8868\u9762\u80fd\uff0c\u4ece\u800c\u63d0\u9ad8\u5316\u5408\u7269 X\u5728\u80c3\u80a0\u9053\u4e2d\u7684\u6eb6\u89e3\u7279\u6027\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u5df2\u7ecf\u62a5\u9053\u8fc7\u80c6\u9178\u76d0\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0\u836f\u7269\u5728\u80c3\u80a0\u9053\u4e2d\u7684\u6eb6\u89e3\u5ea6\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u5438\u6536\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u8be5\u6848\u4f8b\u4e2d\uff0c\u91c7\u7528\u5305\u542b\u80c6\u9178\u76d0\u548c\u5375\u78f7\u8102\u7684\u751f\u7269\u4f53\u76f8\u5173\u4ecb\u8d28\u6d4b\u5b9a\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\uff0c\u53ef\u4ee5\u8bc4\u4f30\u751f\u7406\u6761\u4ef6\u4e0b\u7684\u836f\u7269\u4f53\u5185\u6eb6\u89e3\u7279\u6027\uff0c\u8fd9\u5bf9<span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u51c6\u786e\u8003\u5bdf\u836f\u7269\u7684\u5438\u6536\u548c\u751f\u7269\u5229\u7528\u5ea6\u63d0\u4f9b\u6709\u7528\u7684\u4fe1\u606f\u3002<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u6a21\u62df\u8fc7\u7a0b\u4e2d\uff0c\u5728FaSSIF\u548cFeSSIF\u4ecb\u8d28\u4e2d\u6d4b\u5b9a\u7684\u5316\u5408\u7269 X\u6eb6\u89e3\u5ea6\u4e00\u5e76\u8f93\u5165\u5230\u6a21\u578b\u4e2d\uff0c\u4ee5\u8f85\u52a9\u66f4\u597d\u5730\u9884\u6d4b\u5176\u8840\u836f\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u3002<\/span><\/p>\n<p style=\"box-sizing: border-box;\">\u964d\u4f4e\u6b63\u5411\u98df\u7269\u6548\u5e94\u7684\u5e38\u7528\u7b56\u7565\u662f\u63d0\u9ad8\u836f\u7269\u5728\u7a7a\u8179\u72b6\u6001\u4e0b\u7684\u53e3\u670d\u5438\u6536\uff0c\u4ee5\u51cf\u5c0f\u836f\u7269\u5728\u7a7a\u8179\u548c\u9910\u540e\u72b6\u6001\u4e0b\u53e3\u670d\u5438\u6536\u7684\u5dee\u5f02\u3002\u901a\u5e38\uff0c\u5982\u679c\u4e00\u4e2a\u836f\u7269\u5728\u7a7a\u8179\u72b6\u6001\u4e0b\u6709\u8f83\u597d\u7684\u5438\u6536(Fa&gt;70%)\uff0c\u4e34\u5e8a\u4e2d\u89c2\u5bdf\u5230\u6b63\u5411\u98df\u7269\u6548\u5e94\u7684\u60c5\u51b5\u4e0d\u662f\u7279\u522b\u663e\u8457\uff0c\u56e0\u4e3a\u8fdb\u98df\u6240\u8d77\u5230\u4fc3\u8fdb\u53e3\u670d\u5438\u6536\u7684\u4f5c\u7528\u6709\u9650\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u53c2\u6570\u654f\u611f\u6027\u5206\u6790\u7ed3\u679c\u6307\u793a\uff0c\u5316\u5408\u7269 X\u53ef\u901a\u8fc7\u51cf\u5c0f\u7c92\u5f84\u7684\u65b9\u5f0f\u6d88\u9664\u98df\u7269\u6548\u5e94\u7684\u53d1\u751f\uff1a\u5242\u91cf\u4e0d\u9ad8\u4e8e400mg\u65f6\uff0c\u4fdd\u6301\u836f\u7269\u7684\u7c92\u5f84\u5c0f\u4e8e0.1\u03bcm\u4ee5\u4e0b\u53ef\u4ee5\u4f7f\u5f97\u5316\u5408\u7269 X\u7a7a\u8179\u72b6\u6001\u4e0b\u7684Fa\u5927\u4e8e70%\uff1b\u5728\u66f4\u9ad8\u7684\u7ed9\u836f\u5242\u91cf\u4e0b\uff0c\u9700\u8981\u5c06\u7c92\u5f84\u63a7\u5236\u57280.05\u03bcm\u4ee5\u4e0b\u624d\u80fd\u8fbe\u5230\u76f8\u4f3c\u7684\u53e3\u670d\u5438\u6536\u3002<\/p>\n<p style=\"box-sizing: border-box;\">\u56e0\u6b64\uff0c\u5316\u5408\u7269 X\u7c92\u5f84\u964d\u4f4e\u5230\u7eb3\u7c73\u7c92\u5b50\u8303\u56f4\u5185\uff0c\u5bf9\u6d88\u9664\u5316\u5408\u7269 X\u7684\u98df\u7269\u6548\u5e94\u4f3c\u4e4e\u662f\u4e00\u79cd\u6709\u6548\u7684\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 21px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">5<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7ed3\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u8be5\u5de5\u4f5c\u5efa\u7acb\u4e86PBPK\u6a21\u578b\u4ee5\u9610\u8ff0\u5316\u5408\u7269 X\u51fa\u73b0\u98df\u7269\u6548\u5e94\u7684\u673a\u7406\uff0c\u8be5\u836f\u7269\u4f4e\u751f\u7269\u5229\u7528\u5ea6\u7684\u4e3b\u8981\u539f\u56e0\u662f\u7a7a\u8179\u72b6\u6001\u4e0b\u836f\u7269\u7684\u663e\u8457\u6c89\u6dc0\u800c\u5bfc\u81f4\u7684\u5438\u6536\u4e0d\u5b8c\u5168\uff1b\u8fdb\u98df\u7684\u4f5c\u7528\u4f1a\u5ef6\u957f\u5316\u5408\u7269 X \u7684\u6c89\u6dc0\u65f6\u95f4\uff0c\u5e76\u589e\u52a0\u836f\u7269\u7684\u4f53\u5185\u6eb6\u89e3\u5ea6\u3002<\/p>\n<p style=\"box-sizing: border-box;\">PBPK\u6a21\u578b\u63d0\u793a\u836f\u7269\u7684\u7c92\u5f84\u662f\u53e3\u670d\u5438\u6536\u7684\u654f\u611f\u53c2\u6570\uff1a\u964d\u4f4e\u7c92\u5f84\u53ef\u80fd\u4f1a\u63d0\u9ad8\u836f\u7269\u7a7a\u8179\u72b6\u6001\u4e0b\u7684\u53e3\u670d\u5438\u6536\uff0c\u540c\u65f6\u51cf\u5c11\u7a7a\u8179\u548c\u9910\u540e\u72b6\u6001\u4e0b\u4f53\u5185\u836f\u7269\u66b4\u9732\u7684\u5dee\u5f02\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.55em;margin-bottom: 0.55em;font-size: 12px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;height: 3em;color: rgb(249, 110, 87);width: 3em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(255, 129, 36);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"line-height: 1.5;font-size: 21px;color: rgb(255, 129, 36);text-align: center;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\">6<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"float: left;margin-top: -2.9em;margin-left: 0.1em;line-height: 2.9em;border-radius: 1.5em;background-color: rgb(255, 129, 36);box-sizing: border-box;min-height: 2.9em !important;\">\n<section style=\"padding-right: 10px;padding-left: 2em;margin-left: 5px;float: left;display: inline-block;vertical-align: top;font-size: 18px;color: rgb(255, 255, 255);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5e94\u7528\u8f6f\u4ef6\u4e0e\u6a21\u5757<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u8be5\u6848\u4f8b\u5e94\u7528\u7684\u8f6f\u4ef6\u662fGastroPlus (version 8.0)\uff0c\u6d89\u53ca\u6a21\u5757\u6709Base, PBPK\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;text-align: center;box-sizing: border-box;\"><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558080859.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<section style=\"display: inline-block;vertical-align: top;max-width: 100%;border-radius: 3px 3px 0px 0px;margin-right: 3px;margin-left: 3px;background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;padding-left: 6px;padding-right: 6px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n<p><img     style=\"display: inline-block;vertical-align: bottom;width: 0.8em;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558080859.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"width: 100%;font-size: 0px;margin-top: -2px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 100%;margin-right: -6px;margin-left: -6px;border-bottom: 2px solid rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;margin-top: -2px;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u82f1\u6587\u539f\u6587\uff1a<\/p>\n<p style=\"box-sizing: border-box;text-align: left;\">Zhang H,&nbsp;Xia B,&nbsp;Sheng J, et al., Application&nbsp;of&nbsp;physiologically&nbsp;based&nbsp;absorption&nbsp;modeling&nbsp;to&nbsp;formulation development&nbsp;of a&nbsp;lowsolubility,&nbsp;low&nbsp;permeability&nbsp;weak&nbsp;base: mechanistic investigation of food effect. AAPS PharmSciTech.&nbsp;2014 Apr; 15(2): 400-6.&nbsp;&nbsp; IF: 2.666<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 100%;height: 1.8em;padding-top: 0.9em;box-sizing: border-box;\">\n<section style=\"padding-right: 5px;padding-left: 5px;box-sizing: border-box;\">\n<section style=\"border-bottom: 1px solid rgb(95, 156, 239);width: 100%;box-sizing: border-box;\"><\/section>\n<section style=\"margin-top: -3px;box-sizing: border-box;\">\n<section style=\"float: left;width: 5px;height: 5px;margin-left: -5px;border-radius: 100%;background-color: rgb(95, 156, 239);box-sizing: border-box;\"><\/section>\n<section style=\"float: right;width: 5px;height: 5px;margin-right: -5px;border-radius: 100%;background-color: rgb(95, 156, 239);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-radius: 1em;display: inline-block;vertical-align: top;background-image: linear-gradient(to right, rgb(9, 82, 180) 0%, rgb(237, 64, 151) 100%);height: 1.8em;line-height: 1.8em;padding-left: 12px;padding-right: 12px;color: rgb(255, 255, 255);margin-top: -1em;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u514d\u8d23\u58f0\u660e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u672c\u516c\u4f17\u53f7\u53d1\u5e03\u7684\u6587\u7ae0\u5747\u4e3a\u4fc3\u8fdb\u5236\u836f\u754c\u540c\u884c\u7684\u4ea4\u6d41\u4e0e\u5b66\u4e60\uff1b\u672c\u6587\u5185\u5bb9\u7531\u6280\u672f\u56e2\u961f\u539f\u521b\u89e3\u8bfb\u3002\u5982\u8f6c\u8f7d\uff0c\u8bf7\u6ce8\u660e\u6765\u6e90\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u9009\u53d6\u7684\u6587\u7ae0\u5df2\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u7248\u6743\u5f52\u539f\u4f5c\u8005\u6240\u6709\uff0c\u5982\u6d89\u53ca\u4f5c\u54c1\u5185\u5bb9\u3001\u7248\u6743\u6216\u5176\u4ed6\u95ee\u9898\uff0c\u8bf7\u8054\u7cfb\u6211\u4eec\u8fdb\u884c\u5220\u9664\u3002<\/strong><\/p>\n<p style=\"box-sizing: border-box;\">\u6587\u7ae0\u5185\u5bb9\u4e3a\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u516c\u4f17\u53f7\u7acb\u573a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 100%;height: 1.8em;padding-top: 0.9em;box-sizing: border-box;\">\n<section style=\"padding-right: 5px;padding-left: 5px;box-sizing: border-box;\">\n<section style=\"border-bottom: 1px solid rgb(95, 156, 239);width: 100%;box-sizing: border-box;\"><\/section>\n<section style=\"margin-top: -3px;box-sizing: border-box;\">\n<section style=\"float: left;width: 5px;height: 5px;margin-left: -5px;border-radius: 100%;background-color: rgb(95, 156, 239);box-sizing: border-box;\"><\/section>\n<section style=\"float: right;width: 5px;height: 5px;margin-right: -5px;border-radius: 100%;background-color: rgb(95, 156, 239);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-radius: 1em;display: inline-block;vertical-align: top;background-image: linear-gradient(to right, rgb(9, 82, 180) 0%, rgb(237, 64, 151) 100%);height: 1.8em;line-height: 1.8em;padding-left: 12px;padding-right: 12px;color: rgb(255, 255, 255);margin-top: -1em;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6587\u7ae0\u641c\u7d22<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u672c\u516c\u4f17\u53f7\u5f00\u901a\u5f80\u671f\u6587\u7ae0\u4efb\u610f\u641c\u529f\u80fd\u5566<br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u5728\u516c\u4f17\u53f7\u83dc\u5355\u680f\u4e2d\u8f93\u5165\u201c\u641c\u7d22\u201d\uff0c\u5373\u53ef\u641c\u7d22\u5f80\u671f\u5fae\u4fe1\u5185\u5bb9<\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;text-align: center;\"><img class=\"\"     style=\"box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 0px;text-align: center;white-space: normal;widows: 1;vertical-align: middle;width: 370px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;visibility: visible !important;height: 419px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558080859.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u91c7\u7528\u751f\u7406\u5438\u6536\u6a21\u578b\u8003\u5bdf\u5236\u5242\u5904\u65b9\u5f00\u53d1\u4e2d\u98df\u7269\u6548\u5e94\u5bf9\u4f4e\u6eb6\u4f4e\u6e17\u5f31\u78b1\u6027\u836f\u7269\u7684\u5f71\u54cd \u5bfc\u8bfb \u672c\u7814\u7a76\u901a\u8fc7PBPK\u5efa\u6a21\u4e0e\u6a21\u62df\uff0c\u8003\u5bdf [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":98360,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/98359"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=98359"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/98359\/revisions"}],"predecessor-version":[{"id":98383,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/98359\/revisions\/98383"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/98360"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=98359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=98359"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=98359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}