{"id":99152,"date":"2019-04-26T00:00:50","date_gmt":"2019-05-17T08:19:38","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/99152\/"},"modified":"2019-05-17T16:19:39","modified_gmt":"2019-05-17T08:19:39","slug":"1b5507c579","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/99152\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b0\u901a\u8def\uff0c\u6216\u53ef\u5f25\u8865PD-1\/PD-L1\u77ed\u677f\uff01"},"content":{"rendered":"
\n

\"\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b0\u901a\u8def\uff0c\u6216\u53ef\u5f25\u8865PD-1\/PD-L1\u77ed\u677f\uff01\"
<\/p>\n

\n

\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u6388\u4e88\u4e86\u7f8e\u56fd\u548c\u65e5\u672c\u7684\u4e24\u4f4d\u514d\u75ab\u5b66\u5bb6\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\uff08CTLA-4 \u548c PD-1\u9776\u70b9\uff09\u505a\u51fa\u7684\u5353\u8d8a\u8d21\u732e\u3002<\/span>\u7136\u800c\uff0cPD-L1 \u5206\u5b50\u7684\u53d1\u73b0\u8005\u3001\u6700\u65e9\u7684 PD-1 \u6297\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u52a8\u8005\u3001\u8457\u540d\u534e\u4eba\u514d\u75ab\u5b66\u5bb6\u9648\u5217\u5e73\u6559\u6388\uff0c\u4e0e\u8bfa\u5956\u64e6\u80a9\u800c\u8fc7\uff0c\u6210\u4e3a\u5b66\u672f\u754c\u4e00\u65f6\u95f4\u4e89\u8bba\u7684\u7126\u70b9\u8bdd\u9898\u3002<\/span><\/span><\/strong>
<\/h1>\n


<\/p>\n

\u4e0d\u8fc7\u9648\u5217\u5e73\u6559\u6388\u5e76\u6ca1\u6709\u53d7\u5230\u5f71\u54cd\uff0c\u5f88\u5feb\uff0c\u4ed6\u53c8\u53d1\u73b0\u4e86\u65b0\u7684\u514d\u75ab\u6291\u5236\u5206\u5b50 Siglec-15\u3002\u5e76\u5728\u8457\u540d\u671f\u520a\u300a\u81ea\u7136\u00b7\u533b\u5b66\u300b\u4e0a\u53d1\u5e03\u4e86\u8fd9\u4e00\u91cd\u78c5\u7814\u7a76\u6210\u679c\u3002<\/span><\/p>\n


<\/p>\n

\u6211\u4eec\u77e5\u9053\uff0c\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u4f1a\u8bc6\u522b\u5e76\u6740\u6b7b\u764c\u7ec6\u80de\u3002\u4f46\u72e1\u733e\u7684\u764c\u7ec6\u80de\u5229\u7528\u201c\u514d\u75ab\u9003\u9038\u201d\u673a\u5236\uff0c\u8ba9\u514d\u75ab\u7cfb\u7edf\u8bef\u4ee5\u4e3a\u5b83\u662f\u6b63\u5e38\u7ec6\u80de\uff0c\u4e5f\u5c31\u8eb2\u8fc7\u4e86\u514d\u75ab\u7cfb\u7edf\u7684\u67e5\u6740\u3002PD-1\/PD-L1\u3001CTLA-4 \u7b49\u90fd\u5c5e\u4e8e\u514d\u75ab\u6291\u5236\u5206\u5b50\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
<\/section>\n
  Siglec-15 \u4e0e PD-L1 \u8868\u8fbe\u4e92\u65a5  <\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u6b64\u6b21\u53d1\u73b0\u7684 Siglec-15 \u662f\u4e00\u79cd\u65b0\u7684\u514d\u75ab\u7597\u6cd5\u9776\u70b9\u3002<\/span><\/p>\n


<\/p>\n

<\/span>Siglec-15 \u662f\u4e00\u4e2a\u553e\u6db2\u9178\u7ed3\u5408\u6027\u514d\u75ab\u7403\u86cb\u767d\u6837\u51dd\u96c6\u7d20\u5bb6\u65cf\uff08Siglec family\uff09\u57fa\u56e0\uff0c\u7f16\u7801\u4e00\u4e2a\u975e\u5e38\u77ed\u7684\u80de\u5916\u7ed3\u6784\u57df\uff08ECD\uff09\u3002<\/span><\/strong>\u86cb\u767d\u8d28\u5e8f\u5217\u5206\u6790\u663e\u793a\uff0cSiglec-15 ECD \u5305\u542b\u4e00\u4e2a\u514d\u75ab\u7403\u86cb\u767d\u53ef\u53d8\u533a\uff08IgV\uff09\u548c\u4e00\u4e2a 2 \u578b\u6052\u5b9a\u533a\uff08IgC2\uff09\u3002<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u8ba9\u4eba\u6fc0\u52a8\u7684\u662f\uff0c\u5728\u7edd\u5927\u591a\u6570 PD-L1 \u9634\u6027\u80bf\u7624\u4e2d\uff0cSiglec-15 \u662f\u5176\u4e3b\u8981\u514d\u75ab\u6291\u5236\u56e0\u5b50\uff0c\u5373\u8be5\u9776\u70b9\u7684\u6297\u764c\u4f5c\u7528\u5f88\u53ef\u80fd\u4e0ePD-1\u662f\u4e92\u65a5\u7684\u3002\u4e5f\u5c31\u662f\u8bf4\uff1a\u5bf9\u7edd\u5927\u591a\u6570\u80bf\u7624\u800c\u8a00\uff0c\u6709 PD-L1 \u9ad8\u8868\u8fbe\u5c31\u6ca1\u6709 Siglec-15\uff1b\u6709 Siglec-15 \u9ad8\u8868\u8fbe\u5c31\u6ca1\u6709 PD-L1\u3002<\/span><\/p>\n


<\/p>\n

\u76ee\u524d\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u6709\u6548\u7387\u5f98\u5f8a\u5728 20%\u5de6\u53f3\uff0c\u800cSiglec-15\u6297\u4f53\u7684\u6297\u764c\u4f5c\u7528\u53ef\u80fd\u4e0e PD-1\/PD-L1 \u6297\u4f53\u662f\u4e92\u8865\u7684\uff0c\u56e0\u6b64\u90a3\u4e9b\u5bf9 PD-1\/PD-L1 \u6297\u4f53\u4e0d\u54cd\u5e94\u7684\u80bf\u7624\uff0cSiglec-15 \u6297\u4f53\u53ef\u80fd\u5c31\u662f\u5b83\u4eec\u7684\u514b\u661f\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
<\/section>\n
<\/section>\n
  \u7814\u7a76\u8be6\u60c5  <\/strong><\/span><\/section>\n
<\/section>\n
<\/span><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u4e3a\u4e86\u5728\u514d\u75ab\u7ec6\u80deT\u7ec6\u80de\u8868\u9762\u7b5b\u9009\u5230\u5408\u9002\u7684\u9776\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u5148\u6784\u5efa\u4e86\u4e00\u4e2a\u9ad8\u901a\u91cf\u7b5b\u9009\u5e73\u53f0(genome-scale T cell activity array, TCAA)\uff0c\u8be5\u5e73\u53f0\u5305\u542b\u8d85\u8fc7 6500 \u4e2a\u4eba\u7c7b\u57fa\u56e0\uff0c\u7f16\u7801\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u8d85\u8fc7 90%\u7684\u8de8\u819c\u86cb\u767d\uff0c\u5355\u4e2a\u57fa\u56e0\u5728\u9635\u5217\u4e2d\u77ed\u6682\u8868\u8fbe\u3002<\/span><\/p>\n


<\/p>\n

\u7ecf\u8fc7\u5927\u89c4\u6a21\u7684\u7b5b\u9009\uff0c\u7ec8\u4e8e\u53d1\u73b0 Siglec-15 \u53ef\u4ee5\u6301\u7eed\u6291\u5236 T \u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u5e76\u4e14\u8868\u73b0\u51fa\u4e86\u6ee1\u8db3\u6b63\u5e38\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u4e3b\u8981\u7279\u5f81\u3002<\/span><\/p>\n


<\/p>\n

\"\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b0\u901a\u8def\uff0c\u6216\u53ef\u5f25\u8865PD-1\/PD-L1\u77ed\u677f\uff01\"<\/p>\n

TCAA\u7b5b\u9009\u7cfb\u7edf\u56fe\u793a<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u4eba\u5458\u7ecf\u8fc7\u5206\u6790\u53d1\u73b0\uff0c\u5728\u591a\u79cd\u80bf\u7624\u4e2d\uff0cSiglec-15mRNA \u8868\u8fbe\u91cf\u90fd\u4e0a\u8c03\uff0c\u4f8b\u5982\u7ed3\u80a0\u764c\u3001\u7532\u72b6\u817a\u764c\u3001\u5b50\u5bab\u764c\u3001\u8180\u80f1\u764c\u3001\u80be\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u7b49\u3002\u8fd9\u5c31\u6697\u793a Siglec-15 \u662f\u80bf\u7624\u7ec6\u80de\u9003\u8131\u514d\u75ab\u7ec6\u80de\u8ffd\u6740\u7684\u901a\u8def\u4e4b\u4e00\uff0c\u53ef\u7528\u4e8e\u514d\u75ab\u6cbb\u7597\u65b0\u9776\u6807\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5b9e\u9a8c\u8bc1\u5b9e\uff0c\u963b\u65ad Siglec-15\uff0c\u53ef\u4ee5\u8ba9\u80bf\u7624\u5fae\u73af\u5883\u7684\u514d\u75ab\u6b63\u5e38\u5316\uff0c\u4e14\u4e0d\u4f1a\u5f15\u8d77\u4e25\u91cd\u7684\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n

\"\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b0\u901a\u8def\uff0c\u6216\u53ef\u5f25\u8865PD-1\/PD-L1\u77ed\u677f\uff01\"<\/p>\n

Siglec-15\u6291\u5236\u514d\u75ab\u7ec6\u80de\u6d3b\u6027\u7684\u5b9e\u9a8c<\/span><\/p>\n


<\/p>\n

\u5b9e\u9a8c\u8fd8\u53d1\u73b0\uff0c\u90a3\u4e9b\u5bf9 PD-1\/PD-L1 \u6297\u4f53\u4e0d\u54cd\u5e94\u7684\u80bf\u7624\uff0cSiglec-15 \u6297\u4f53\u53ef\u80fd\u5c31\u662f\u5b83\u4eec\u7684\u514b\u661f\u3002Siglec-15 \u6297\u4f53\u7684\u6297\u764c\u4f5c\u7528\u5f88\u53ef\u80fd\u6b63\u597d\u4e0e PD-1 \u6297\u4f53\u4e92\u8865\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b0\u901a\u8def\uff0c\u6216\u53ef\u5f25\u8865PD-1\/PD-L1\u77ed\u677f\uff01\"<\/p>\n

Siglec-15 \u6297\u4f53\u5728\u5c0f\u9f20\u6a21\u578b\u4e0a\u5177\u6709\u826f\u597d\u7684\u6291\u5236\u80bf\u7624\u751f\u957f\u6548\u679c<\/span><\/p>\n

WT: Siglec-15 \u6b63\u5e38\u8868\u8fbe\u7684\u5c0f\u9f20\uff1b<\/span><\/p>\n

KO\uff1a\u4e0d\u8868\u8fbeSiglec-15 \u7684\u5c0f\u9f20<\/span><\/p>\n


<\/p>\n

\n
\n
\n
<\/p>\n

  \u660e\u661f\u836f\u7269Siglec-15\u6297\u4f53  <\/span><\/strong><\/p>\n

  NC318\u5df2\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c  <\/span><\/strong><\/span>
<\/p>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

NC318 \u662f\u4e00\u79cd Siglec-15(S15) \u6297\u4f53\uff0c\u963b\u65ad S15 \u6709\u671b\u51cf\u5c11\u514d\u75ab\u6291\u5236\u5e76\u4f7f\u514d\u75ab\u5e94\u7b54\u6b63\u5e38\u5316\uff0c\u4ece\u800c\u4ea7\u751f\u4e34\u5e8a\u76f8\u5173\u7684\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002NC318 \u662f NextCure \u516c\u53f8\u9996\u4e2a\u5c06\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u7684\u514d\u75ab\u7597\u6cd5\uff0c\u76ee\u524d\uff0cNC318 \u9488\u5bf9\u5b9e\u4f53\u7624\u7684 \u2160\/\u2161 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u542f\u52a8\uff0c\u5c06\u9488\u5bf9\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u8fdb\u884c\u8bc4\u4f30\uff0c\u540c\u65f6\u786e\u5b9a\u5176\u836f\u7406\u6d3b\u6027\u4e0e\u6700\u5927\u8010\u53d7\u5242\u91cf\u3002<\/span><\/p>\n


<\/p>\n

\u76ee\u524d\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u6253\u5f97\u706b\u70ed\uff0c\u4e34\u5e8a\u4f7f\u7528\u60c5\u51b5\u4e5f\u5353\u6709\u6210\u6548\uff0c\u53ef\u4ee5\u663e\u8457\u7f13\u89e3\u548c\u6539\u5584\u764c\u75c7\u60a3\u8005\u75c5\u60c5\uff0c\u53ef\u662f\u5bf9\u4e8e\u76ee\u524d\u73b0\u6709\u7684\u4e3b\u6d41 PD-(L)1 \u6297\u4f53\uff0c\u4ecd\u6709\u76f8\u5f53\u4e00\u90e8\u5206\u7684\u60a3\u8005\u65e0\u6cd5\u8fbe\u5230\u9884\u671f\u6cbb\u7597\u6548\u679c\u3002<\/span><\/p>\n


<\/p>\n

\u800c\u5173\u4e8e S15 \u7684\u5b9e\u9a8c\u5ba4\u7814\u7a76\u6570\u636e\u8868\u660e\uff0cSiglec-15 \u80fd\u591f\u4ee5\u72ec\u7acb\u4e8e PD-1\/PD-L1 \u901a\u8def\u7684\u65b9\u5f0f\u8c03\u8282\u514d\u75ab\u6291\u5236\uff0c\u8fd9\u8868\u660e NC318 \u53ef\u80fd\u6709\u6f5c\u529b\u7528\u4e8e\u4e0d\u8868\u8fbe PD-L1 \u7684\u60a3\u8005\uff01\u7528 NC318 \u963b\u65ad S15 \u6709\u671b\u51cf\u5c11\u514d\u75ab\u6291\u5236\uff0c\u5e76\u4f7f\u514d\u75ab\u5e94\u7b54\u6b63\u5e38\u5316\uff0c\u4ece\u800c\u4ea7\u751f\u4e34\u5e8a\u76f8\u5173\u7684\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002<\/span><\/p>\n


<\/p>\n

\u672a\u6765\uff0cNC318 \u5f88\u5927\u53ef\u80fd\u5c06\u4f1a\u6210\u4e3a\u4e00\u6d41\u7684\u514d\u75ab\u836f\u7269\uff0c\u4ee5\u586b\u8865 PD-(L)1 \u5728\u67d0\u4e9b\u65b9\u9762\u7684\u75db\u70b9\u4e0e\u96be\u70b9\uff01<\/span><\/p>\n


<\/p>\n

\u53c2\u8003\uff1aJun Wang 1,5 , Jingwei Sun 1,5 , Linda N. Liu. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature medicine. https:\/\/doi.org\/10.1038\/s41591-019-0374-x.<\/span><\/p>\n


<\/p>\n<\/section>\n


<\/p>\n

\u7f16\u8f91\uff1adecie | \u8d23\u4efb\u7f16\u8f91\uff1a\u738b\u5f18<\/span><\/p>\n

\u6295\u7a3f\uff1adecie@qq.com<\/span>
<\/p>\n

\u9898\u56fe\uff1a\u7ad9\u9177\u6d77\u6d1bplus<\/span><\/span><\/p>\n


<\/p>\n


<\/p>\n

\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n

\u9884\u9632\u7532\u764c\u672f\u540e\u590d\u53d1\uff0c\u6cbb\u7597\u76d1\u63a7\u8981\u505a\u597d<\/span><\/a><\/p>\n

\u518d\u5582\u517b\u7efc\u5408\u5f81\uff1a<\/span><\/a>\u8425\u517b\u8865\u5145\u4e0d\u80fd\u64cd\u4e4b\u8fc7\u6025<\/span><\/a><\/p>\n

2019 CSCO BC \u6307\u5357\u66f4\u65b0\u89e3\u8bfb<\/a><\/span><\/p>\n

\u4e73\u817a\u764c 21 \u57fa\u56e0\u68c0\u6d4b\u7684\u90a3\u4e9b\u4e8b<\/a><\/span><\/h2>\n

\"\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b0\u901a\u8def\uff0c\u6216\u53ef\u5f25\u8865PD-1\/PD-L1\u77ed\u677f\uff01\"<\/p>\n

\"\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b0\u901a\u8def\uff0c\u6216\u53ef\u5f25\u8865PD-1\/PD-L1\u77ed\u677f\uff01\"<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u6388\u4e88\u4e86\u7f8e\u56fd\u548c\u65e5\u672c\u7684\u4e24\u4f4d\u514d\u75ab\u5b66\u5bb6\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\uff08CTLA-4 \u548c PD […]<\/p>\n","protected":false},"author":1,"featured_media":99153,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/99152"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=99152"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/99152\/revisions"}],"predecessor-version":[{"id":99160,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/99152\/revisions\/99160"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/99153"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=99152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=99152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=99152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}