{"id":992,"date":"2018-07-04T01:00:00","date_gmt":"2018-07-27T06:24:44","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e8%bf%91%e4%b8%80%e4%b8%aa%e6%9c%88%e8%8d%af%e7%89%a9%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e5%a4%a7%e4%ba%8b%e8%ae%b0\/"},"modified":"2018-07-27T14:24:47","modified_gmt":"2018-07-27T06:24:47","slug":"%e8%bf%91%e4%b8%80%e4%b8%aa%e6%9c%88%e8%8d%af%e7%89%a9%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e5%a4%a7%e4%ba%8b%e8%ae%b0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/992\/","title":{"rendered":"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"margin-bottom: 15px;\"><img class=\"\"           style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532672685.jpeg\" alt=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\" title=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\"  \/><\/p>\n<section >\n<article class=\"yead_editor\"  style=\"font-size:14px;margin:5px auto;\">\n<p style=\"margin-right: auto;margin-left: auto;text-align: center;margin-bottom: 15px;\"><br  \/><\/p>\n<section style=\"display: inline-block;\">\n<section style=\"padding-top: 3px;padding-bottom: 3px;border-top: 1px solid rgb(224, 224, 224);border-bottom: 1px solid rgb(224, 224, 224);\">\n<section class=\"yead_bgc\" style=\"padding-right: 5px;padding-left: 5px;display: inline-block;background-color: rgb(51, 184, 108);color: rgb(255, 255, 255);line-height: 25px;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\"><span style=\"display: none;line-height: 0px;\">\u200d<\/span>\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u79ef\u6781\u4e8b\u4ef6<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<\/article>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u7ecfInforma\u6570\u636e\u5e93\u68c0\u7d22\uff0c2018\u5e745\u670811\u65e5-2018\u5e746\u67087\u65e5\u671f\u95f4\uff0c\u5171\u670959\u9879\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u79ef\u6781\u8fdb\u5c55\uff08\u88681\uff0c\u6309\u65f6\u95f4\u6392\u5e8f\uff09\uff0c\u5176\u4e2d\u670914\u9879\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u9884\u5b9a\u7ec8\u70b9\u3002\u4e0b\u9762\u5bf9\u90e8\u5206\u836f\u7269\u7684\u91cd\u8981\u4e34\u5e8a\u8bd5\u9a8c\u60c5\u51b5\u8fdb\u884c\u4ecb\u7ecd\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: center;margin-bottom: 15px;\"><span style=\"color: rgb(252, 180, 43);font-family: \u5b8b\u4f53, SimSun;\"><strong><span style=\"font-size: 14px;\">\u88681\uff1a2018\u5e745\u670811\u65e5~2018\u5e746\u67087\u65e5\u4e34\u5e8a\u8bd5\u9a8c\u6709\u79ef\u6781\u8fdb\u5c55\u7684\u836f\u7269<\/span><\/strong><strong><span style=\"font-size: 14px;\"><\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 2em;text-align: center;margin-bottom: 15px;\"><img loading=\"lazy\" class=\"\"        height=\"853\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\" width=\"600\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532672685.jpeg\" alt=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\"  \/><\/p>\n<p style=\"line-height: 2em;text-align: center;margin-bottom: 15px;\"><img loading=\"lazy\" class=\"\"        height=\"789\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\" width=\"600\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532672686.jpeg\" alt=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\"  \/><\/p>\n<article class=\"yead_editor\"  style=\"font-size:14px;margin:5px auto;\">\n<p style=\"margin-bottom: 15px;\"><br  \/><\/p>\n<section style=\"display: inline-block;\">\n<section class=\"yead_bgc\" style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(255, 255, 255);text-align: center;line-height: 25px;vertical-align: middle;background-color: rgb(51, 184, 108);border-radius: 4px;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">01<\/span><\/p>\n<\/section>\n<section class=\"yead_bdlc\" style=\"width: 0px;border-left: 4px solid rgb(51, 184, 108);border-top: 4px solid rgb(255, 255, 255);border-bottom: 4px solid rgb(255, 255, 255);display: inline-block;vertical-align: middle;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(51, 51, 51);text-align: center;line-height: 25px;vertical-align: middle;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Erdafitinib<\/span><\/p>\n<\/section>\n<p><br  \/><\/p>\n<\/article>\n<p style=\"line-height: 2em;text-align: center;margin-bottom: 15px;\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532672686.jpeg\" alt=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\" title=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\"  \/><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Erdafitinib\u662f\u5f3a\u751f\u65d7\u4e0b\u7684\u4e00\u6b3e\u53e3\u670d\u6cdb\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08FGFR\uff09\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u2161\u671f\u548c\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5728\u4eca\u5e74\u53ec\u5f00\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u5b66\u4f1a(ASCO)\u829d\u52a0\u54e5\u5e74\u4f1a\u4e0a\uff0c\u5f3a\u751f\u516c\u5e03\u4e86\u4e00\u9879\u5173\u4e8eErdafitinib\u5bf9\u8f6c\u79fb\u6216\u624b\u672f\u65e0\u6cd5\u5207\u9664\u7684\u5c3f\u8def\u4e0a\u76ae\u764c(mUC)\u53caFGFR\u6539\u53d8\u7684\u60a3\u8005\u6cbb\u7597\u7684\u7684\u4e34\u5e8a\u2161\u671f\u7814\u7a76\uff08BLC2001\uff09\u7ed3\u679c\uff0c\u8fd9\u7c7b\u60a3\u8005\u7684\u53ef\u7528\u7597\u6cd5\u4e00\u822c\u9884\u540e\u8f83\u5dee\uff0c\u5177\u6709\u9ad8\u5ea6\u7684\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">BLC2001\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684\u2161\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30Erdafitinib\u6cbb\u7597\u6210\u4eba\u5c40\u90e8\u665a\u671f\u6216mUC\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u5176\u4e2d\u60a3\u8005\u80bf\u7624\u6709\u7279\u5b9a\u7684FGFR\u6539\u53d8\u3002\u8be5\u7814\u7a76\u91c7\u7528\u836f\u6548\u5b66\u6307\u5bfc\u5242\u91cf\u6ef4\u5b9a\u6cd5\u5bf999\u4f8b\u60a3\u8005\u8fdb\u884c\u4e86\u4f18\u5316\u7ed9\u836f\u65b9\u6848\uff1aErdafitinib\u8d77\u59cb\u5242\u91cf\u4e3a\u6bcf\u59298mg\uff0c\u5e76\u53ef\u6839\u636e\u8840\u6e05\u78f7\u9178\u76d0\u6c34\u5e73\u5c06\u5242\u91cf\u63d0\u9ad8\u81f3\u6bcf\u59299mg\u300212%\u7684\u60a3\u8005\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\uff0c89%\u7684\u60a3\u8005\u63a5\u53d7\u8fc7\u4e00\u79cd\u6216\u591a\u79cd\u6cbb\u7597\uff0c43%\u7684\u60a3\u8005\u63a5\u53d7\u8fc7\u4e24\u79cd\u6216\u4e24\u79cd\u4ee5\u4e0a\u7684\u6cbb\u7597\uff0c78%\u7684\u60a3\u8005\u6709\u5185\u810f\u8f6c\u79fb\u3002\u786e\u8ba4\u7684\u603b\u7f13\u89e3\u7387\u4e3a40%\uff08RECIST 1.1\uff1b3%\u5b8c\u5168\u7f13\u89e3\uff0c37%\u90e8\u5206\u7f13\u89e3\uff09\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a5.5\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a13.8\u4e2a\u6708\u3002\u5728\u53d1\u751f\u4e09\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u662f\u53e3\u8154\u708e(9%)\u3001\u624b\u8db3\u7efc\u5408\u5f81(5%)\u548c\u8179\u6cfb(4%)\u3002\u8be5\u836f\u5728\u4eca\u5e743\u6708\u4efd\u83b7\u5f97FDA\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u4e00\u9879\u5728FGFR\u7a81\u53d8\u7684\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u4e2d\u5c55\u5f00\u7684Erdafitinib\u4e0e\u957f\u6625\u6c1f\u5b81\u3001\u591a\u897f\u7d2b\u6749\u9187\u6216Pembrolizumab\u7597\u6548\u5bf9\u7167\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n<article class=\"yead_editor\"  style=\"font-size:14px;margin:5px auto;\">\n<p style=\"margin-bottom: 15px;\"><br  \/><\/p>\n<section style=\"display: inline-block;\">\n<section class=\"yead_bgc\" style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(255, 255, 255);text-align: center;line-height: 25px;vertical-align: middle;background-color: rgb(51, 184, 108);border-radius: 4px;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">02<\/span><\/p>\n<\/section>\n<section class=\"yead_bdlc\" style=\"width: 0px;border-left: 4px solid rgb(51, 184, 108);border-top: 4px solid rgb(255, 255, 255);border-bottom: 4px solid rgb(255, 255, 255);display: inline-block;vertical-align: middle;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(51, 51, 51);text-align: center;line-height: 25px;vertical-align: middle;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Lefamulin<\/span><\/p>\n<\/section>\n<p><br  \/><\/p>\n<\/article>\n<p style=\"line-height: 2em;text-align: center;margin-bottom: 15px;\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532672686.jpeg\" alt=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\" title=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\"  \/><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Lefamulin\u662fNabriva Therapeutics\u516c\u53f8\u7814\u53d1\u7684\u521b\u65b0\u622a\u77ed\u4fa7\u8033\u7d20(pleuromutilin)\u7c7b\u6297\u751f\u7d20\uff0c\u7528\u4e8e\u4e2d\u91cd\u5ea6\u793e\u533a\u83b7\u5f97\u6027\u7ec6\u83cc\u6027\u80ba\u708e\uff08CABP\uff09\u7684\u6f5c\u5728\u6cbb\u7597\u3002\u5b83\u901a\u8fc7\u4e0e\u7ec6\u83cc\u6838\u7cd6\u4f53\u7684\u80bd\u57fa\u8f6c\u79fb\u9176\u4e2d\u5fc3(peptidyl transferase center, PTC)\u76f8\u7ed3\u5408\uff0c\u80fd\u591f\u6291\u5236\u7ec6\u83cc\u7684\u86cb\u767d\u5408\u6210\uff0c\u4ece\u800c\u8fbe\u5230\u6291\u5236\u7ec6\u83cc\u751f\u957f\u7684\u6548\u679c\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cLefamulin\u80fd\u591f\u6709\u6548\u5730\u9776\u5411\u9020\u6210\u547c\u5438\u9053\u75be\u75c5\u7684\u75c5\u539f\u4f53\uff0c\u540c\u65f6\u7ec6\u83cc\u4e0d\u5bb9\u6613\u5bf9\u5b83\u4ea7\u751f\u6297\u6027\uff0c\u800c\u4e14\u4e0d\u4f1a\u56e0\u4e3a\u5b83\u800c\u4ea7\u751f\u5bf9\u5176\u5b83\u7c7b\u578b\u6297\u751f\u7d20\u7684\u6297\u6027\u3002\u65e5\u524d\uff0c\u5176\u5173\u952e\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08LEAP 2\uff09\u8fbe\u5230\u7f8e\u56fdFDA\u548c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u7684\u6240\u6709\u4e3b\u8981\u7ec8\u70b9\uff0c\u540c\u65f6\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">LEAP 2\u7814\u7a76\u662f\u5168\u7403\u6027\u968f\u673a\u53cc\u76f2\u3001\u53cc\u6a21\u62df\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\uff0c738\u540dCABP\u60a3\u8005\u63a5\u53d7\u4e86\u53e3\u670dLefamulin\u6216\u8005\u53e3\u670d\u83ab\u897f\u6c99\u661f\u6cbb\u7597\u3002\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0cLefamulin\u8fbe\u5230\u4e86\u7f8e\u56fdFDA\u8bbe\u5b9a\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u5728\u610f\u5411\u6cbb\u7597\uff08intent totreat, ITT\uff09\u60a3\u8005\u7fa4\u4e2d\u7684\u65e9\u671f\u4e34\u5e8a\u53cd\u5e94\uff08early clinical response, ECR\uff09\u4e0e\u83ab\u897f\u6c99\u661f\u76f8\u6bd4\u8fbe\u5230\u975e\u52a3\u6548\u6027\u3002\u63a5\u53d75\u5929Lefamulin\u6cbb\u7597\u7684\u60a3\u8005\u7684ECR\u4e3a90.8%\uff0c\u800c\u63a5\u53d77\u5929\u83ab\u897f\u6c99\u661f\u6cbb\u7597\u7684\u60a3\u8005\u7684ECR\u540c\u6837\u4e3a90.8%\u3002Lefamulin\u540c\u65f6\u8fbe\u5230\u4e86EMA\u8bbe\u5b9a\u7684\u4e3b\u8981\u7ec8\u70b9\u3002\u5728\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u675f\u540e5\uff5e10\u5929\u5185\u60a3\u8005\u57fa\u4e8e\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u4e34\u5e8a\u53cd\u5e94\uff08investigator assessment of clinicalresponse, IACR\uff09\u4e0e\u83ab\u897f\u6c99\u661f\u76f8\u6bd4\u8fbe\u5230\u4e86\u975e\u52a3\u6548\u6027\u3002\u5728\u4fee\u6539\u7684\u610f\u5411\u6cbb\u7597\u60a3\u8005\u7fa4\u4e2d\uff0cLefamulin\u7684IACR\u4e3a87.5%\uff0c\u83ab\u897f\u6c99\u661f\u7684IACR\u4e3a89.1%\u3002\u5728\u6cbb\u7597\u6d4b\u8bd5\u4e2d\u53ef\u4e34\u5e8a\u8bc4\u4f30\u60a3\u8005\u7fa4(clinically evaluable at test of cure)\u4e2d\uff0cLefamulin\u7684IACR\u4e3a89.7%\uff0c\u83ab\u897f\u6c99\u661f\u7684IACR\u4e3a93.6%\u3002\u6b64\u5916\uff0cLefamulin\u4e5f\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u516c\u53f8\u9884\u8ba1\u57282018\u5e74\u7b2c\u56db\u5b63\u5ea6\u9012\u4ea4Lefamulin\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff0c\u57fa\u4e8e\u5176\u826f\u597d\u7684\u4e34\u5e8a\u6570\u636e\uff0cFDA\u6216\u53ef\u6279\u51c6Lefamulin\u4f5c\u4e3aCABP\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n<article class=\"yead_editor\"  style=\"font-size:14px;margin:5px auto;\">\n<p style=\"margin-bottom: 15px;\"><br  \/><\/p>\n<section style=\"display: inline-block;\">\n<section class=\"yead_bgc\" style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(255, 255, 255);text-align: center;line-height: 25px;vertical-align: middle;background-color: rgb(51, 184, 108);border-radius: 4px;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">03<\/span><\/p>\n<\/section>\n<section class=\"yead_bdlc\" style=\"width: 0px;border-left: 4px solid rgb(51, 184, 108);border-top: 4px solid rgb(255, 255, 255);border-bottom: 4px solid rgb(255, 255, 255);display: inline-block;vertical-align: middle;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(51, 51, 51);text-align: center;line-height: 25px;vertical-align: middle;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Keytruda<\/span><\/p>\n<\/section>\n<p><br  \/><\/p>\n<\/article>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Keytruda\u662f\u7531Merck\u7814\u53d1\u7684\u9996\u4e2a\u88abFDA\u6279\u51c6\u7684PD-1\u5355\u6297\uff0c\u5df2\u88ab\u6279\u51c6\u7684\u9002\u5e94\u75c7\u6709\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u7279\u5b9a\u57fa\u56e0\u7a81\u53d8\u7684\u5b9e\u4f53\u7624\u3001\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80c3\u764c\u3001\u8180\u80f1\u764c\u3001\u5934\u9888\u764c\u3001\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u53ca\u5bab\u9888\u764c\u3002\u6b64\u5916\uff0c\u8be5\u836f\u9488\u5bf9\u5176\u4ed6\u591a\u79cd\u764c\u75c7\u6b63\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002\u5728\u4eca\u5e74\u53ec\u5f00\u7684ASCO\u4f1a\u8bae\u4e0a\uff0cKeytruda\u516c\u5e03\u4e86\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e00\u7ebf\u6570\u636e\uff0c\u5747\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\uff0c\u9488\u5bf9\u98df\u7ba1\u764c\u3001\u80be\u7ec6\u80de\u764c\u53ca\u524d\u5217\u817a\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u7a81\u7834\u6027\u8fdb\u5c55\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u5728KEYNOTE-199\u7814\u7a76\u4e2d\uff0cKeytruda\u5355\u836f\u6cbb\u7597\u591a\u897f\u4ed6\u8d5b\u8010\u836f\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08mCRPC\uff091\uff5e3\u961f\u5217\uff08n=258\uff09\u7684\u521d\u6b65\u7ed3\u679c\uff0c\u663e\u793aKeytruda\u5e94\u7528\u4e8e\u6b64\u7c7b\u60a3\u8005\u65f6\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u53ef\u4ee5\u5b9e\u73b0\u826f\u597d\u7684\u75be\u75c5\u63a7\u5236\u7387\uff0c\u4e14\u5b89\u5168\u6027\u5c1a\u53ef\u3002\u8be5\u7814\u7a76\u4e2d\u961f\u52171\uff08C1\uff09\u548c\u961f\u52172\uff08C1\uff09\u4e2d\u5206\u522b\u7eb3\u5165PD-L1\u9633\u6027\u548c\u9634\u6027\u7684\u57fa\u4e8e RECIST\u6807\u51c6\u53ef\u8bc4\u4f30\u75c5\u53d8\u60a3\u8005\uff08\u5206\u522b\u4e3a131\u4f8b\u548c67\u4f8b\uff09\uff0c\u800c\u961f\u52173\uff08C3\uff09\u4e2d\u5219\u7eb3\u5165\u5b58\u5728\u4e0d\u53ef\u8bc4\u4f30\u75c5\u53d8\uff08\u4ee5\u9aa8\u8f6c\u79fb\u4e3a\u4e3b\uff09\u7684\u60a3\u8005\uff0860\u4f8b\uff09\u3002\u6240\u6709\u60a3\u8005ECOG PS\u5747\u4e3a0\uff5e2\u5206\uff0c\u4e14\u63a5\u53d7\u8fc7\u22651\u79cd\u65b0\u578b\u5185\u5206\u6ccc\u836f\u7269\u6cbb\u7597\uff08\u4f8b\u5982\u963f\u6bd4\u7279\u9f99\u3001\u6069\u6742\u9c81\u80fa\uff09\u548c1\uff5e2\u79cd\u5316\u7597(\u5305\u62ec\u591a\u897f\u4ed6\u8d5b)\u3002\u60a3\u8005\u63a5\u53d7Keytruda\u6cbb\u7597\uff08200 mg Q3W)\u76f4\u81f3\u53d1\u751f\u8fdb\u5c55\u6216\u6bd2\u6027\u53cd\u5e94\u4e0d\u53ef\u8010\u53d7\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3aORR\u3002\u81f32017\u5e7410\u670813\u65e5\uff0cC1\uff5eC3\u60a3\u8005\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u5206\u522b\u4e3a 8.1\u30017.9\u548c11.8\u4e2a\u6708\u3002\u7ed3\u679c\u663e\u793a\uff0c\u6240\u6709\u961f\u5217\u4e2d\u5747\u89c2\u5bdf\u5230Keytruda\u5b58\u5728\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5b9e\u73b0\u75be\u75c5\u63a7\u5236\u65f6\u95f4\u22656\u4e2a\u6708\u7684\u6bd4\u4f8b\u4e3a11%\u3002C1\u548cC2\u4e2d\u67099%\u60a3\u8005\u5b9e\u73b0\u9776\u75c5\u53d8\u90e8\u4f4d\u7f29\u5c0f\u226530%\uff0c48%\u60a3\u8005\u7684\u9776\u75c5\u53d8\u53d8\u5316\u4ecb\u4e8e-30%\uff5e+20%\u4e4b\u95f4\u3002\u5728\u643a\u5e26BRCA1\/2\u6216ATM\u7a81\u53d8\u7684\u60a3\u8005\u4e2d\u5e94\u7b54\u7387\u66f4\u9ad8\uff0812%\uff09\u3002C1\uff5eC3\u4e2d3\uff5e5\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u5206\u522b\u4e3a13%\u300112%\u548c17%\u3002\u8fd9\u662fPD-1\u6291\u5236\u5242\u9996\u6b21\u5728\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u6cbb\u7597\u4e2d\u663e\u793a\u76ca\u5904\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u5728KEYNOTE-046\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cKeytruda\u8054\u5408\u7ec6\u80de\u7597\u6cd5ADXS-PSA\u6cbb\u7597\u591a\u897f\u4ed6\u8d5b\u8010\u836f\u7684mCRPC\uff0c56.8%\u7684\u60a3\u8005\u65e0\u75be\u75c5\u8fdb\u5c55\uff0c40.5%\u60a3\u8005\u51fa\u73b0PSA\u6c34\u5e73\u964d\u4f4e\u3002\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u5927\u591a\u662f\u8f7b\u5ea6\u6216\u4e2d\u5ea6\u4f53\u8d28\u75c7\u72b6\uff0c\u5982\u53d1\u70e7\u3001\u5bd2\u6218\u3001\u50f5\u76f4\u3001\u4f4e\u8840\u538b\u3001\u6076\u5fc3\u548c\u75b2\u52b3\uff0c\u4e0e\u514d\u75ab\u6fc0\u6d3b\u4e00\u81f4\u3002<\/span><\/p>\n<article class=\"yead_editor\"  style=\"font-size:14px;margin:5px auto;\">\n<p style=\"margin-bottom: 15px;\"><br  \/><\/p>\n<section style=\"display: inline-block;\">\n<section class=\"yead_bgc\" style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(255, 255, 255);text-align: center;line-height: 25px;vertical-align: middle;background-color: rgb(51, 184, 108);border-radius: 4px;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">04<\/span><\/p>\n<\/section>\n<section class=\"yead_bdlc\" style=\"width: 0px;border-left: 4px solid rgb(51, 184, 108);border-top: 4px solid rgb(255, 255, 255);border-bottom: 4px solid rgb(255, 255, 255);display: inline-block;vertical-align: middle;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(51, 51, 51);text-align: center;line-height: 25px;vertical-align: middle;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Elenbecestat<\/span><\/p>\n<\/section>\n<p><br  \/><\/p>\n<\/article>\n<p style=\"line-height: 2em;text-align: center;margin-bottom: 15px;\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532672686-1.jpeg\" alt=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\" title=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\"  \/><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u536b\u624d\u548c\u767e\u5065\u5408\u4f5c\u7814\u53d1\u7684Elenbecestat\u662f\u03b2-\u5206\u6ccc\u9176(BACE)\u6291\u5236\u5242\uff0c\u7528\u4e8e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\uff08AD\uff09\u7684\u6f5c\u5728\u6cbb\u7597\uff0c\u76ee\u524d\u5904\u4e8e\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u8fd9\u662f\u7ee7\u793c\u6765\/\u963f\u65af\u5229\u5eb7Lanabecestat\u5931\u8d25\u540e\u552f\u4e00\u4e00\u4e2a\u5904\u4e8e\u4e34\u5e8a\u2162\u671f\u7684BACE\u6291\u5236\u5242\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u8fd1\u671f\uff0c\u536b\u624d\u548c\u767e\u5065\u66f4\u65b0\u4e86Elenbecestat\u7684\u4e00\u9879\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff08Study 202\uff09\u7684\u6570\u636e\u3002\u8be5\u7814\u7a76\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5e73\u884c\u7ec4\u300118\u4e2a\u6708\u7814\u7a76\uff0c\u5728\u7531AD\u5f15\u8d77\u7684\u8f7b\u5ea6\u8ba4\u77e5\u635f\u5bb3\uff08MCI\uff09\u6216\u56e0AD\u5f15\u8d77\u7684\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u75f4\u5446\u7684\u60a3\u8005\u4e2d\u5f00\u5c55\uff0c\u8fd9\u4e9b\u60a3\u8005\u7ecfPET\u7b5b\u67e5\u8bc1\u5b9e\u5b58\u5728\u6dc0\u7c89\u6837\u75c5\u53d8\u3002\u7814\u7a76\u4e2d\uff0c70\u4f8b\u60a3\u8005\u968f\u673a\u5206\u62104\u4e2a\u6cbb\u7597\u7ec4\uff0c\u5206\u522b\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21Elenbecestat\uff085mg\uff0c15mg\uff0c50mg\uff09\u6216\u5b89\u6170\u5242\u6cbb\u7597\u3002\u5728\u7814\u7a76\u671f\u95f4\uff0cElenbecestat 5mg\u548c15mg\u6cbb\u7597\u7ec4\u4e2d\u6709\u8d85\u8fc7\u4e00\u534a\u7684\u60a3\u8005\u8f6c\u541150mg\u6cbb\u7597\u7ec4\u6cbb\u75973\u4e2a\u6708\u6216\u66f4\u957f\u65f6\u95f4\u300250mg\u6cbb\u7597\u7ec4\u52a0\u4e0a\u5207\u6362\u81f350mg\u6cbb\u7597\u7684\u60a3\u8005\u88ab\u79f0\u4e3a\u201c50mg\u603b\u7ec4\uff0838\u4f8b\uff09\u201d\uff0c\u63a5\u53d7Elenbecestat 50mg\u6cbb\u7597\u7684\u4e2d\u4f4d\u6301\u7eed\u65f6\u95f4\u7ea611\u4e2a\u6708\u3002\u6570\u636e\u663e\u793a\uff0c\u7ecf\u8fc718\u4e2a\u6708\u7684\u6cbb\u7597\uff0cElenbecestat\u8868\u73b0\u51fa\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u8be5\u7814\u7a76\u5728\u6cbb\u7597\u7b2c18\u4e2a\u6708\u65f6\u91c7\u7528\u6dc0\u7c89\u6837\u4f53PET\u8bc4\u4f30\u4e86\u60a3\u8005\u5927\u8111\u4e2d\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\uff08A\u03b2\uff09\u7684\u6c34\u5e73\u4ee5\u53ca\u4e34\u5e8a\u75c7\u72b6\u65b9\u9762\u7684\u529f\u6548\uff0c\u6570\u636e\u663e\u793a\uff0c\u572850mg\u603b\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c50mg\u603b\u7ec4\u5728\u5927\u8111A\u03b2\u6c34\u5e73\u8868\u73b0\u51fa\u4e86\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u5dee\u5f02\uff0c\u5728CDR-SB\u65b9\u9762\u8868\u73b0\u51fa\u6570\u503c\u4e0a\u7684\u5c0f\u5e45\u5ea6\u4e0b\u964d\uff0c\u5177\u6709\u6f5c\u5728\u7684\u4e34\u5e8a\u4e0a\u91cd\u8981\u5dee\u5f02\uff0c\u4f46\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u5728\u8bc4\u4f30\u91cf\u8868ADCOMS\u7684\u5206\u6790\u4e2d\uff0c50mg\u603b\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u89c2\u5bdf\u5230\u4e86\u76f8\u4f3c\u7684\u5e45\u5ea6\u548c\u65b9\u5411\u7684\u4e0b\u964d\uff0c\u4e0d\u8fc7\uff0c\u8be5\u7814\u7a76\u7684\u76ee\u7684\u5e76\u4e0d\u662f\u8bc1\u5b9eElenbecestat\u76f8\u5bf9\u4e8e\u5b89\u6170\u5242\u5728\u4e34\u5e8a\u75c7\u72b6\u7684\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u89c2\u5bdf\u5230\u76846\u79cd\u6700\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u63a5\u89e6\u6027\u76ae\u708e\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u5934\u75db\u3001\u8179\u6cfb\u3001\u8dcc\u5012\u548c\u76ae\u708e\uff0c\u672a\u89c2\u5bdf\u5230\u809d\u6bd2\u6027\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002\u8fd9\u662f\u9996\u6b21\u5728\u8f7b\u5ea6\u8ba4\u77e5\u635f\u5bb3\u81f3\u4e2d\u5ea6AD\u75f4\u5446\u60a3\u8005\u4e34\u5e8a\u7814\u7a76\u4e2d\u8bc1\u5b9e\u4e00\u79cdBACE\u6291\u5236\u5242\u53ef\u5bf9\u5927\u8111A\u03b2\u6c34\u5e73\u4ea7\u751f\u663e\u8457\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<article class=\"yead_editor\"  style=\"font-size:14px;margin:5px auto;\">\n<p style=\"margin-right: auto;margin-left: auto;text-align: center;margin-bottom: 15px;\"><br  \/><\/p>\n<section style=\"display: inline-block;\">\n<section style=\"padding-top: 3px;padding-bottom: 3px;border-top: 1px solid rgb(224, 224, 224);border-bottom: 1px solid rgb(224, 224, 224);\">\n<section class=\"yead_bgc\" style=\"padding-right: 5px;padding-left: 5px;display: inline-block;background-color: rgb(51, 184, 108);color: rgb(255, 255, 255);line-height: 25px;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u4e34\u5e8a\u8bd5\u9a8c\u7814\u53d1\u8fdb\u5c55\u4e0d\u4f73\u4e8b\u4ef6<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<\/article>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u68c0\u7d22\u65e5\u671f\u5185\u67097\u4e2a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4e0d\u7406\u60f3\uff0c\u5176\u4e2d3\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u4e2d\u6b62\uff08\u88682\uff09\uff0c\u5206\u522b\u4e3a\u963f\u65af\u5229\u5eb7\u7684\u54ee\u5598\u6cbb\u7597\u836fFasenra\u7528\u4e8e\u6162\u6027\u963b\u585e\u6027\u80ba\u75be\u75c5\u7684\u2162\u671f\u7814\u7a76\uff0c\u5f3a\u751f\u5df2\u4e0a\u5e02\u7684\u6297\u80bf\u7624\u836fDarzalex\u4e0ePD-1\/PD-L1\u6291\u5236\u5242\u7684\u8054\u5408\u5e94\u7528\uff0c\u5305\u62ecJNJ-63723283\uff08PD-1\u5355\u6297\uff09\u3002\u4ee5\u4e0b\u5c06\u5bf9\u90e8\u5206\u4e2d\u6b62\u7814\u53d1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u60c5\u51b5\u8fdb\u884c\u4ecb\u7ecd\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: center;margin-bottom: 15px;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-family: \u5b8b\u4f53, SimSun;color: rgb(252, 180, 43);\">\u88682\uff1a2018\u5e745\u670811\u65e5-2018\u5e746\u67087\u65e5\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4e0d\u4f73\u7684\u836f\u7269<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><img loading=\"lazy\" class=\"\"        height=\"290\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\" width=\"600\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532672686.jpeg\" alt=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\"  \/><\/p>\n<article class=\"yead_editor\"  style=\"font-size:14px;margin:5px auto;\">\n<p style=\"margin-bottom: 15px;\"><br  \/><\/p>\n<section style=\"display: inline-block;\">\n<section class=\"yead_bgc\" style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(255, 255, 255);text-align: center;line-height: 25px;vertical-align: middle;background-color: rgb(51, 184, 108);border-radius: 4px;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">01<\/span><\/p>\n<\/section>\n<section class=\"yead_bdlc\" style=\"width: 0px;border-left: 4px solid rgb(51, 184, 108);border-top: 4px solid rgb(255, 255, 255);border-bottom: 4px solid rgb(255, 255, 255);display: inline-block;vertical-align: middle;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(51, 51, 51);text-align: center;line-height: 25px;vertical-align: middle;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Fasenra<\/span><\/p>\n<\/section>\n<p><br  \/><\/p>\n<\/article>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Fasenra\uff08benralizumab\uff09\u662f\u963f\u65af\u5229\u5eb7\u7814\u53d1\u7684\u4e00\u6b3e\u5355\u514b\u9686\u6297\u4f53\uff0c\u9776\u5411\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u767d\u7ec6\u80de\u4ecb\u7d20-5\uff08IL-5\uff09\u53d7\u4f53\uff0c\u53ef\u4ee5\u52df\u96c6\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u76f4\u63a5\u3001\u5feb\u901f\u5730\u8bf1\u5bfc\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u51e0\u4e4e\u5b8c\u5168\u8017\u7aed\u30022017\u5e74\u88abFDA\u6279\u51c6\u7528\u4e8e12\u5c81\u53ca\u4ee5\u4e0a\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u6027\u91cd\u5ea6\u54ee\u5598\u60a3\u8005\u7684\u9644\u52a0\u7ef4\u6301\u6cbb\u7597\u3002\u963f\u65af\u5229\u5eb7\u5e0c\u671bFasenra\u9002\u5e94\u75c7\u6269\u5927\u5230\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u9886\u57df\uff0c\u5907\u53d7\u671f\u5f85\u7684\u4e24\u9879\u5173\u952e\u6027\u2162\u671f\u7814\u7a76\u7ed3\u679c\u4e8e5\u6708\u4efd\u9646\u7eed\u516c\u5e03\uff0c\u5747\u6ca1\u6709\u8fbe\u5230\u9884\u5b9a\u7684\u4e34\u5e8a\u7ec8\u70b9\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u8fd9\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\uff08GALATHEA\u548cTERRANOVA\uff09\u662f\u968f\u673a\u3001\u53cc\u76f2\u300156\u5468\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u8bd5\u9a8c\uff0c\u5171\u67098000\u591a\u540d\u60a3\u8005\u53c2\u4e0e\uff0c\u7528\u4e8e\u8bc4\u4f30Fasenra\u4f5c\u4e3a\u53cc\u91cd\u6216\u4e09\u91cd\u5438\u5165\u7597\u6cd5\u7684\u9644\u52a0\u6cbb\u7597\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u5728\u5177\u6709\u8840\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u6025\u6027\u589e\u591a\u53f2\u7684\u4e2d\u91cd\u5ea6COPD\u60a3\u8005\u6cbb\u7597\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u4f46\u4e24\u9879\u8bd5\u9a8c\u5747\u6ca1\u6709\u8fbe\u5230\u7edf\u8ba1\u5b66\u4e0a\u663e\u8457\u964d\u4f4e\u75c5\u60c5\u6076\u5316\u7684\u4e3b\u8981\u7ec8\u70b9\u3002<\/span><\/p>\n<article class=\"yead_editor\"  style=\"font-size:14px;margin:5px auto;\">\n<p style=\"margin-bottom: 15px;\"><br  \/><\/p>\n<section style=\"display: inline-block;\">\n<section class=\"yead_bgc\" style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(255, 255, 255);text-align: center;line-height: 25px;vertical-align: middle;background-color: rgb(51, 184, 108);border-radius: 4px;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">02<\/span><\/p>\n<\/section>\n<section class=\"yead_bdlc\" style=\"width: 0px;border-left: 4px solid rgb(51, 184, 108);border-top: 4px solid rgb(255, 255, 255);border-bottom: 4px solid rgb(255, 255, 255);display: inline-block;vertical-align: middle;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;padding-right: 5px;padding-left: 5px;color: rgb(51, 51, 51);text-align: center;line-height: 25px;vertical-align: middle;\">\n<p><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Darzalex\u548cJNJ-63723283<\/span><\/p>\n<\/section>\n<p><br  \/><\/p>\n<\/article>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">Darzalex\uff08Daratumumab\uff09\u662f\u5f3a\u751f\u7814\u53d1\u7684\u5168\u7403\u9996\u4e2a\u4e0a\u5e02\u7684\u9776\u5411CD38\u7684\u5355\u6297\u836f\u7269\uff0c\u5177\u6709\u5e7f\u8c31\u6740\u4f24\u6d3b\u6027\uff0c\u53ef\u9776\u5411\u7ed3\u5408\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u53ca\u591a\u79cd\u5b9e\u4f53\u7624\u7ec6\u80de\u8868\u9762\u9ad8\u5ea6\u8868\u8fbe\u7684\u8de8\u819c\u80de\u5916\u9176CD38\u5206\u5b50\uff0c\u901a\u8fc7\u591a\u79cd\u514d\u75ab\u4ecb\u5bfc\u7684\u4f5c\u7528\u673a\u5236\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u7684\u5feb\u901f\u6b7b\u4ea1\u3002\u6b64\u5916\uff0cDarzalex\u4e5f\u8868\u73b0\u51fa\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u901a\u8fc7\u51cf\u5c11\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\u7ec6\u80de\u6570\u91cf\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u7684\u6b7b\u4ea1\u3002Darzalex\u4e8e2015\u5e7411\u6708\u9996\u6b21\u83b7\u6279\uff0c\u4f5c\u4e3a\u4e00\u79cd\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u4e09\u3001\u56db\u7ebf\u6cbb\u7597\uff1b\u968f\u540eFDA\u8fdb\u4e00\u6b65\u6279\u51c6Darzalex\u8054\u54082\u79cd\u6807\u51c6\u62a4\u7406\u65b9\u6848\uff08\u6765\u90a3\u5ea6\u80fa+\u5730\u585e\u7c73\u677e\uff0c\u787c\u66ff\u4f50\u7c73+\u5730\u585e\u7c73\u677e\uff09\u7528\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u65e5\u524d\uff0cDMC\uff08\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a\uff09\u5efa\u8bae\u7ec8\u6b62Daratumumab\u4e0e\u6297PD-L1\u836f\u7269Atezolizumab\u8054\u5408\u7597\u6cd5\u4e34\u5e8a\u7814\u7a76\u7684\u7ee7\u7eed\u8fdb\u884c\u3002\u88ab\u5efa\u8bae\u7ec8\u6b62\u7684\u8bd5\u9a8c\u4e3a\u8be5\u8054\u5408\u7597\u6cd5\u4e0eAtezolizumab\u5355\u72ec\u7528\u836f\u76f8\u5bf9\u7167\u7684\uff0c\u7528\u4e8e\u5148\u524d\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002\u8054\u5408\u6cbb\u7597\u4e0e\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u6545\u800c\u5efa\u8bae\u7ed3\u675f\u7ee7\u7eed\u7814\u7a76\u3002\u9664\u4e86\u7f3a\u4e4f\u83b7\u76ca\u5916\uff0cDMC\u8fd8\u6ce8\u610f\u5230\u8054\u5408\u81c2\u4e2d\u4e0e\u6b7b\u4ea1\u7387\u6709\u5173\u7684\u4e8b\u4ef6\u7684\u6570\u91cf\u589e\u52a0\u3002\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4e2d\u8fdb\u884c\u7684Daratumumab\u8054\u5408PD-1\u6297\u4f53JNJ-63723283\uff08PD-1\u5355\u6297\uff09\u7684\u4e34\u5e8a\u2160\u671fMMY2036\u7814\u7a76\u4e5f\u88ab\u505c\u6b62\u3002\u6b64\u524d\uff0cDarzalex\u9488\u5bf9\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001DLBCL\u3001\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u4e5f\u8fdb\u884c\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u76ee\u524d\u5747\u5df2\u88ab\u6682\u505c\u3002<\/span><\/p>\n<p style=\"line-height: 2em;text-align: center;margin-bottom: 15px;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><strong><span style=\"color: rgb(252, 180, 43);\">\u9644\u8868\uff1a2018\u5e745\u670811\u65e5-2018\u5e746\u67087\u65e5\u5f00\u5c55\u65b0\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u836f\u7269<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\"><img loading=\"lazy\" class=\"\"        height=\"936\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\" width=\"600\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532672687.jpeg\" alt=\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u5927\u4e8b\u8bb0\"  \/><\/p>\n<p style=\"line-height: 2em;text-align: justify;margin-bottom: 15px;\">\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">1. Informa\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2018\u5e746\u670819\u65e5.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;margin-bottom: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">2. ClarivateAnalyticsCortellis\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2018\u5e746\u670819\u65e5.<\/span><\/p>\n<\/section>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u521b\u836f\u7f51                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u200d\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u79ef\u6781\u4e8b\u4ef6 \u7ecfInforma\u6570\u636e\u5e93\u68c0\u7d22\uff0c2018\u5e745\u670811\u65e5-2018\u5e746\u67087\u65e5\u671f\u95f4\uff0c\u5171\u670959\u9879\u4e34 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":993,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/992"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=992"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/992\/revisions"}],"predecessor-version":[{"id":1002,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/992\/revisions\/1002"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/993"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}