{"id":99248,"date":"2019-05-08T00:00:50","date_gmt":"2019-05-17T08:20:21","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/99248\/"},"modified":"2019-05-17T16:20:22","modified_gmt":"2019-05-17T08:20:22","slug":"b3df38b40c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/99248\/","title":{"rendered":"\u57fa\u56e0\u7a81\u53d8\u4e0e\u80bf\u7624\uff1a\u8bb2\u8ff0\u5b83\u4eec\u7684\u524d\u4e16\u4eca\u751f"},"content":{"rendered":"
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\"\u57fa\u56e0\u7a81\u53d8\u4e0e\u80bf\u7624\uff1a\u8bb2\u8ff0\u5b83\u4eec\u7684\u524d\u4e16\u4eca\u751f\"<\/p>\n


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\u57fa\u56e0\u7a81\u53d8\u5728\u80bf\u7624\u7684\u53d1\u751f\u548c\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u7684\u89d2\u8272\uff0c\u968f\u7740\u8fd1\u4ee3\u5206\u5b50\u751f\u7269\u5b66\u7684\u53d1\u5c55\u53ca\u80bf\u7624\u7cbe\u51c6\u533b\u5b66\u7684\u51fa\u73b0\uff0c\u5728\u57fa\u56e0\u5c42\u9762\u5bf9\u80bf\u7624\u7684\u7814\u7a76\u8d8a\u6765\u8d8a\u6df1\u5165\uff0c\u7279\u522b\u662f\u80bf\u7624\u53d1\u751f\u7684\u673a\u5236\u53ca\u6297\u80bf\u7624\u6cbb\u7597\u65b9\u9762\uff0c\u672c\u6587\u5c31\u51e0\u79cd\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u6765\u9610\u8ff0\u57fa\u56e0\u5728\u80bf\u7624\u53d1\u751f\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\u53ca\u4e34\u5e8a\u6307\u5bfc\u610f\u4e49\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u4e73\u817a\u764c\u4e0e BRCA1\/2 \u57fa\u56e0<\/p>\n<\/section>\n<\/section>\n


<\/p>\n

BRCA1 \u548c BRCA2 \u5747\u5c5e\u80bf\u7624\u6291\u5236\u57fa\u56e0\uff0cBRCA1\/2 \u7f16\u7801\u7684\u86cb\u767d\u4f5c\u7528\u4e8e\u591a\u79cd\u7ec6\u80de\u751f\u547d\u6d3b\u52a8\u8fc7\u7a0b\uff0c\u5305\u62ec DNA \u635f\u4f24\u4fee\u590d\u3001\u57fa\u56e0\u8f6c\u5f55\u8c03\u63a7\u548c\u7ec6\u80de\u5468\u671f\u8c03\u8282\u7b49\uff0c\u643a\u5e26 BRCA1\/2 \u57fa\u56e0\u7a81\u53d8\u7684\u5973\u6027\u4e0d\u4ec5\u4e73\u817a\u764c\u53d1\u75c5\u98ce\u9669\u589e\u52a0\uff0c\u5375\u5de2\u764c\u4ee5\u53ca\u5176\u4ed6\u6076\u6027\u80bf\u7624\u7684\u53d1\u75c5\u7387\u4e5f\u4f1a\u589e\u52a0\u3002<\/span><\/p>\n


<\/p>\n

\u6b27\u7f8e\u7814\u7a76\u6570\u636e\u8868\u660e\uff0c\u5973\u6027 BRCA1 \u57fa\u56e0\u7a81\u53d8\u643a\u5e26\u8005 70 \u5c81\u524d\u53d1\u751f\u4e73\u817a\u764c\u7d2f\u79ef\u98ce\u9669\u4e3a 57.0%-60.0%\uff0c70 \u5c81\u524d\u53d1\u751f\u5375\u5de2\u764c\u7d2f\u79ef\u98ce\u9669\u4e3a 40.0%-59.0%\uff1b\u5973\u6027 BCRA2 \u57fa\u56e0\u7a81\u53d8\u643a\u5e26\u8005\u98ce\u9669\u5206\u522b\u4e3a 49.0%-55.0%\u548c 16.5%-18.0%\u3002<\/span><\/p>\n


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\u76f8\u8f83\u4e8e\u4e00\u822c\u4eba\u7fa4\uff0cBRCA1 \u548c BRCA2 \u57fa\u56e0\u7a81\u53d8\u643a\u5e26\u8005\u4e73\u817a\u764c\u53d1\u75c5\u98ce\u9669\u63d0\u9ad8\u4e86 10-20 \u500d\u3002<\/span><\/p>\n


<\/p>\n

\u4e2d\u56fd\u4eba\u7fa4\u6570\u636e\u663e\u793a\uff0cBRCA1 \u57fa\u56e0\u7a81\u53d8\u643a\u5e26\u8005\u4e73\u817a\u764c\u53d1\u751f\u98ce\u9669\u5728 79 \u5c81\u524d\u4e3a 37.9%\uff0cBRCA2 \u57fa\u56e0\u7a81\u53d8\u643a\u5e26\u8005\u4e3a 36.5%\u3002<\/span><\/p>\n


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PARP \u662f DNA \u5355\u94fe\u65ad\u88c2\u8fdb\u884c\u6709\u6548\u4fee\u590d\u5fc5\u9700\u7684\u7269\u8d28\u3002\u5f53 PARP \u6291\u5236\u5242\u4e0e DNA \u76f8\u5173\u7684 PARP \u6d3b\u6027\u4f4d\u70b9\u7ed3\u5408\uff0c\u6291\u5236\u5176\u9176\u6d3b\u6027\uff0c\u540c\u65f6\u5c06\u5176\u6355\u83b7\u5728 DNA \u4e0a\uff0c\u4ece\u800c\u963b\u6ede\u4fee\u590d\u3002\u5f53\u590d\u5236\u53c9\u9047\u5230 PARP DNA \u590d\u5408\u7269\u65f6\uff0c\u8fd9\u4e5f\u5f15\u8d77 DNA \u53cc\u94fe\u65ad\u88c2\u7684\u5f62\u6210\u3002<\/span><\/p>\n


<\/p>\n

\u5728 BRCA1\/2 \u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u7684\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u529f\u80fd\u7f3a\u9677\u80bf\u7624\u4e2d\uff0cDNA \u53cc\u94fe\u65ad\u88c2\u65e0\u6cd5\u5f97\u5230\u51c6\u786e\u6216\u6709\u6548\u7684\u4fee\u590d\uff0c\u66ff\u4ee3\u6027\u548c\u6613\u9519\u914d\u901a\u8def\u88ab\u6fc0\u6d3b\uff0c\u5982\u5178\u578b\u7684\u975e\u540c\u6e90\u6027\u672b\u7aef\u8fde\u63a5\u901a\u8def\uff0c\u5f15\u8d77\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6027\u589e\u52a0\uff0c\u4ece\u800c\u5f15\u8d77\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1 \u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u9488\u5bf9\u4e0a\u8ff0\u673a\u5236\u4ea7\u751f\u7684\u6297\u80bf\u7624\u65b0\u836f\u5965\u62c9\u5e15\u5229<\/span><\/strong>\u5c31\u5e94\u8fd0\u800c\u751f\u3002<\/p>\n


<\/p>\n

2017 \u5e74 ASCO \u4f1a\u8bae\u62a5\u9053\u4e86 PARP \u6291\u5236\u5242\u5965\u62c9\u5e15\u5229\u7528\u4e8e\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684 \u2162 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/span><\/strong><\/p>\n


<\/p>\n

\u8be5\u7814\u7a76\u7eb3\u5165 302 \u4f8b gBRCAmut \u8f6c\u79fb\u6027\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u6216 TNBC \u60a3\u8005\uff0c\u5165\u7ec4\u60a3\u8005\u524d\u671f\u6700\u591a\u63a5\u53d7\u4e24\u7ebf\u5316\u7597\uff0c\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u4e73\u817a\u764c\u60a3\u8005\u81f3\u5c11\u63a5\u53d7 1 \u4e2a\u7597\u7a0b\u5185\u5206\u6ccc\u6cbb\u7597\u5e76\u5728\u5185\u5206\u6ccc\u6cbb\u7597\u671f\u95f4\u8fdb\u5c55\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5965\u62c9\u5e15\u5229\u7ec4\u4e0e\u6807\u51c6\u5316\u7597\u7ec4\u76f8\u6bd4\u964d\u4f4e\u4e86 gBRCAmut \u4e73\u817a\u764c 42%\u7684\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u5ef6\u957f\u7ea6 2.8 \u4e2a\u6708\u3002<\/span><\/strong><\/p>\n


<\/p>\n

\u5965\u62c9\u5e15\u5229\u7ec4\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe 59.9%\uff0c\u663e\u8457\u9ad8\u4e8e\u5316\u7597\u7ec4\uff0859.9% vs 28.8%\uff09\u3002\u540c\u65f6\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\u5065\u5eb7\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\u66f4\u597d\u3002<\/span><\/strong><\/p>\n


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2018 \u5e74 1 \u6708\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40\u6279\u51c6\u4e86\u7528\u4e8e\u6cbb\u7597\u643a\u5e26 BRCA \u57fa\u56e0\u7a81\u53d8\u7684 HER-2 \u9634\u6027\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u6cbb\u75971<\/sup>\u3002<\/span><\/strong><\/p>\n


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\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e0e EGFR\/ALK \u57fa\u56e0<\/p>\n<\/section>\n<\/section>\n


<\/p>\n

\u86cb\u767d\u916a\u6c28\u9178\u6fc0\u9176\u4e0e\u80bf\u7624\u5173\u7cfb\u975e\u5e38\u5bc6\u5207\uff0c\u5b83\u5177\u6709\u5e7f\u6cdb\u7684\u529f\u80fd\uff0c\u80fd\u591f\u8c03\u8282\u6b63\u5e38\u7ec6\u80de\u7684\u8bb8\u591a\u884c\u4e3a\u3002<\/p>\n


<\/p>\n

\u76ee\u524d\u8ba4\u4e3a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d 1\uff05\u57fa\u56e0\u7f16\u7801\u86cb\u767d\u6fc0\u9176\uff0c\u5927\u7ea6\u6709 90 \u591a\u4e2a\u916a\u6c28\u9178\u6fc0\u9176\u3002\u916a\u6c28\u9178\u6fc0\u9176\u662f\u4e00\u4e2a\u5927\u5bb6\u65cf\uff0c\u6309\u5176\u7ed3\u6784\u5206 EGFR\/ALK \u5c5e\u4e8e\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u3002<\/p>\n


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\u5728\u80bf\u7624\u5f62\u6210\u7684\u8fc7\u7a0b\u4e2d\uff0c\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u4e0e\u914d\u4f53\u7684\u7ed3\u5408\u662f\u5176\u53d1\u6325\u529f\u80fd\u7684\u7b2c\u4e00\u6b65\u3002\u5404\u79cd\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u672a\u4e0e\u914d\u4f53\u7ed3\u5408\u65f6\uff0c\u7ec6\u80de\u5185\u9176\u5904\u4e8e\u65e0\u6d3b\u6027\u72b6\u6001\uff0c\u800c\u4e00\u65e6\u4e0e\u914d\u4f53\u7ed3\u5408\uff0c\u53d7\u4f53\u6784\u8c61\u53d1\u751f\u6539\u53d8\uff0c\u591a\u805a\u4f53\u5f62\u6210\u7b49\u4ece\u800c\u4f7f\u80de\u5185\u7684\u9176\u6fc0\u6d3b\u3002\u5982\u679c\u53d7\u4f53\u7a81\u53d8\u5931\u53bb\u80de\u5916\u8bc6\u522b\u90e8\u4f4d\uff0c\u7ec6\u80de\u5185\u7684\u9176\u6d3b\u6027\u5219\u6301\u7eed\u5904\u4e8e\u8f83\u9ad8\u7684\u6c34\u5e73\uff0c\u800c\u8bc6\u522b\u90e8\u4f4d\u5173\u952e\u7684\u70b9\u7a81\u53d8\u4ea6\u53ef\u80fd\u5bfc\u81f4\u9176\u6d3b\u6027\u6301\u7eed\u5347\u9ad8\uff0c\u8fd9\u4e9b\u53d8\u5316\u5f80\u5f80\u5bfc\u81f4\u7ec6\u80de\u5f02\u5e38\u53ca\u764c\u7684\u53d1\u751f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n


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\u76ee\u524d\u5728\u4e34\u5e8a\u4e0a\u9488\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5e94\u7528\u6700\u591a\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\u4e3b\u8981\u4e3a\u9488\u5bf9 EGFR \u53d7\u4f53\u80de\u5185\u533a\u7684\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242<\/span>\uff1b\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684\u5355\u514b\u9686\u6297\u4f53\u4ee5\u53ca\u9488\u5bf9 ALK \u57fa\u56e0\u7a81\u53d8\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269<\/span>\u4e5f\u9010\u6e10\u5728\u4e34\u5e8a\u4e2d\u6709\u4e86\u8d8a\u6765\u8d8a\u591a\u7684\u8fd0\u7528\u3002<\/p>\n

   <\/p>\n

\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKIs\uff09\u4e3b\u8981\u6709\u5409\u975e\u66ff\u5c3c\u548c\u5384\u6d1b\u66ff\u5c3c\uff0c\u7b2c\u4e8c\u4ee3\u6709\u963f\u6cd5\u66ff\u5c3c\uff1b\u7b2c\u4e09\u4ee3\u6709\u5965\u5e0c\u66ff\u5c3c\u3002<\/span><\/p>\n


<\/p>\n

\u5409\u975e\u66ff\u5c3c\u5728\u7ec6\u80de\u5185\u4e0e\u5e95\u7269\u4e2d\u7684 ATP \u7ade\u4e89\uff0c\u6291\u5236 EGFR \u916a\u6c28\u9178\u6fc0\u9176\u78f7\u9178\u5316\uff0c\u4ece\u800c\u963b\u65ad\u80bf\u7624\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\uff0c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u3001\u8f6c\u79fb\u3001\u548c\u8840\u7ba1\u751f\u6210\uff0c\u5e76\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002 <\/span><\/p>\n


<\/p>\n

\u9488\u5bf9 ALK \u57fa\u56e0\u7a81\u53d8\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\u662f\u514b\u5511\u66ff\u5c3c2-3<\/sup>\u3002<\/span><\/p>\n


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\u7ed3\u80a0\u764c\u4e0e MSH2 \u57fa\u56e0<\/p>\n<\/section>\n<\/section>\n


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\u4eba\u4f53\u7ec6\u80de\u4e2d\u5b58\u5728\u7684\u4e00\u79cd\u80fd\u4fee\u590d DNA \u78b1\u57fa\u9519\u914d\u7684\u5b89\u5168\u4fdd\u969c\u7cfb\u7edf\uff08\u5373MMR \u7cfb\u7edf\uff09\uff0c\u5b83\u662f\u7531\u4e00\u7cfb\u5217\u80fd\u7279\u5f02\u6027\u8bc6\u522b\u3001\u53cc\u5411\u5207\u9664\u5e76\u4fee\u590d\u9519\u914d\u78b1\u57fa\u7684\u9176\u5206\u5b50\u7ec4\u6210\uff0c\u9519\u914d\u4fee\u590d\u57fa\u56e0\u80fd\u7279\u5f02\u6027\u5730\u8bc6\u522b\u548c\u4fee\u590d DNA \u590d\u5236\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u7684\u78b1\u57fa\u9519\u914d\uff0c\u6e05\u9664\u7531\u7b80\u5355\u91cd\u590d\u5e8f\u5217\u590d\u5236\u9519\u8bef\u800c\u5f62\u6210\u7684\u4e0d\u914d\u5bf9\u78b1\u57fa\uff0c\u7ef4\u6301\u57fa\u56e0\u7a33\u5b9a\u6027\uff0c\u964d\u4f4e\u81ea\u53d1\u7a81\u53d8\uff0c\u4ece\u800c\u4fdd\u8bc1 DNA \u590d\u5236\u9ad8\u5ea6\u4fdd\u771f\u6027\u7684\u529f\u80fd\u3002<\/span><\/p>\n


<\/p>\n

\u5df2\u53d1\u73b0\u4eba\u7c7b MMR \u7cfb\u7edf\u7684\u57fa\u56e0\u4e2d hMLHl\uff0chMSH2\uff0chMSH3\uff0chMSH6\uff0chPMSl\uff0chPMS2 \u4e0e\u5927\u80a0\u764c\u6709\u5173\u7684\u57fa\u56e0\uff0c\u76ee\u524d\u7814\u7a76\u6700\u591a\u7684\u662fhMSH2\u3001hMLH1\u3002hMSH2 \u548c hMLH1\u57fa\u56e0\u7a81\u53d8\u5360\u6240\u6709\u68c0\u6d4b\u5230\u7684\u7a81\u53d8\u7684 90%\u4ee5\u4e0a\u3002MMR \u7f3a\u5931\u4f1a\u5bfc\u81f4 DNA \u94fe\u9519\u914d\u7684\u79ef\u805a\uff0c\u4ece\u800c\u5bfc\u81f4\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u3002<\/span><\/p>\n


<\/p>\n

\u9519\u914d\u4fee\u590d\u57fa\u56e0\u7f3a\u5931\u5f15\u8d77\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff0c\u5fae\u536b\u661f\u91cd\u590d\u5e8f\u5217\u4e2d 30 \u591a\u4e2a\u57fa\u56e0\u7a81\u53d8\uff0c \u5982 DNA \u4fee\u590d\u86cb\u767d MRE11A\u3001hRAD50\u3001\u8f6c\u5316\u751f\u957f\u56e0\u5b50 \u03b2 \u53d7\u4f53 \u2161\u3001\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50\u53d7\u4f53 \u2161\u3001\u524d\u51cb\u4ea1\u56e0\u5b50 Bax\u3001\u9519\u914d\u4fee\u590d\u86cb\u767d MSH3 \u548c MSH6 \u7b49\u3002\u8fd9\u4e9b\u57fa\u56e0\u5728\u7ec6\u80de\u529f\u80fd\u53ca\u8f6c\u5bfc\u9014\u5f84\u4e2d\u53d1\u6325\u591a\u79cd\u4f5c\u7528\uff0c\u5176\u7a81\u53d8\u7684\u6025\u901f\u79ef\u805a\u53ef\u8bf1\u53d1\u5927\u80a0\u764c\u7684\u53d1\u751f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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<\/p>\n

2011 \u5e74\u7f8e\u56fd NCCN \u6307\u5357\u63a8\u8350\u5bf9\u8003\u8651\u4f7f\u7528\u6c1f\u5c3f\u5627\u5576\u5355\u836f\u6cbb\u7597\u7684 \u2161 \u671f\u60a3\u8005\u8fdb\u884c MMR \u68c0\u6d4b\u3002<\/span><\/strong><\/p>\n


<\/p>\n

\u2161 \u671f\u7ed3\u80a0\u764c dMMR \u60a3\u8005\u53ef\u80fd\u9884\u540e\u8f83\u597d\uff0c\u5355\u7528\u6c1f\u5c3f\u5627\u5576\u53ef\u80fd\u6709\u5bb3\u3002\u5bf9\uff1c50 \u5c81\u7684\u7ed3\u80a0\u764c\u60a3\u8005\uff0c\u5e94\u8be5\u8003\u8651\u884c MMR \u57fa\u56e0\u68c0\u6d4b\u3002<\/p>\n


<\/p>\n

\u2161 \u671f MSI-H \u7ed3\u80a0\u764c\u60a3\u8005\u9884\u540e\u597d\uff0c\u4f46 5-FU \u4e3a\u4e3b\u7684\u8f85\u52a9\u5316\u7597\u4e0d\u80fd\u4f7f\u5176\u53d7\u76ca\u3002<\/p>\n


<\/p>\n

2018 \u5e74 NCCN \u6307\u5357\u63a8\u8350\u5bf9\u4e8e dMMR\uff0cMSI-H \u7684\u7ed3\u80a0\u764c\u60a3\u8005\u53ef\u4ee5\u7528\u514d\u75ab\u6cbb\u75974<\/span><\/sup>\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\n
\n

\u6076\u6027\u9ed1\u8272\u7d20\u7624\u4e0e BRAFV600E<\/p>\n<\/section>\n<\/section>\n


<\/p>\n


<\/p>\n


<\/p>\n

\n
\n
\n
\n

BRAF \u662f\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u86cb\u767d\u9176\uff0c\u5176\u662f RAF \u6fc0\u9176\u5bb6\u65cf\u7684 3 \u4e2a\u4e3b\u8981\u6210\u5458\uff08ARAF\u3001BRAF\u3001CRAF\uff09\u4e4b\u4e00\uff0c\u8be5\u86cb\u767d\u75313\u4e2a\u4fdd\u5b88\u7ed3\u6784\u57df\u7ec4\u6210\uff0c\u5b83\u53ef\u4ee5\u6fc0\u6d3b\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\u4fe1\u53f7\u901a\u8def\u3002<\/span><\/p>\n


<\/p>\n

BRAF\u4f4d\u4e8e7q34\u67d3\u8272\u4f53\uff0c\u5728\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u7532\u72b6\u817a\u4e73\u5934\u72b6\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u7ec6\u80de\u5747\u53ef\u89c1\u4e0d\u540c\u6bd4\u4f8b\u7684BRAF\u8868\u8fbe\uff0c\u800c\u6076\u6027\u9ed1\u8272\u7d20\u7624\u4e0e\u7532\u72b6\u817a\u4e73\u5934\u72b6\u764c\u7a81\u53d8\u6700\u5e38\u89c1\uff0c\u636e\u76f8\u5173\u7edf\u8ba1\u4e24\u7c7b\u80bf\u7624\u7a81\u53d8\u7387\u5206\u522b\u7ea6\u4e3a60%\uff0d80%\uff0c29%-83%\u3002<\/span><\/p>\n


<\/p>\n

RAS\uff0dRAF-MEK\uff0dERK\u7ea7\u8054\u4fe1\u53f7\u901a\u8def\u662f\u7ec6\u80de\u751f\u957f\u3001\u5897\u6b96\u3001\u5206\u5316\u548c\u8c03\u4ea1\u7684\u5173\u952e\u901a\u8def\uff0cBRAF\u57fa\u56e0\u7a81\u53d8\u662fMAPK\u901a\u8def\u5f02\u5e38\u6d3b\u5316\u673a\u5236\u4e4b\u4e00\u3002<\/span><\/p>\n


<\/p>\n

BRAF\u7684\u7a81\u53d8\u7c7b\u578b\u6709V600E\u3001V600K\u3001V600R\u3001V600D\u7b49\uff0c\u7136\u800c90%\u4ee5\u4e0a\u7a81\u53d8\u662fBRAF\u86cb\u767d\u7b2c600\u4f4d\u7684\u9881\u6c28\u9178\u88ab\u8c37\u6c28\u9178\u53d6\u4ee3\uff0c\u5373BRAFv600E\uff0c\u8fd9\u79cd\u7a81\u53d8\u7684\u53d1\u751f\u80fd\u663e\u8457\u63d0\u9ad9BRAF\u6fc0\u9176\u6d3b\u6027\uff0c\u5176\u6fc0\u6d3bMAPK\u4fe1\u53f7\u901a\u8def\u7684\u4f20\u5bfc\u5f02\u5e38\uff0c\u5bfc\u81f4\u9ed1\u7d20\u7ec6\u80de\u8f6c\u5316\u6210\u9ed1\u7d20\u7624\u7ec6\u80de\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n


<\/p>\n


<\/p>\n

BRAF \u7a81\u53d8\u89c1\u4e8e 50%\u7684\u76ae\u80a4\u6076\u6027\u9ed1\u8272\u7d20\u7624\uff0c\u7ea6 80%\u662f 15 \u53f7\u5916\u663e\u5b50 BRAFV600E\u3002<\/p>\n


<\/p>\n

BRAF \u57fa\u56e0\u7a81\u53d8\u53ef\u7ec4\u6210\u6027\u6fc0\u6d3b BRAF \u86cb\u767d\uff0cBRAF \u86cb\u767d\u8bf1\u5bfc\u6fc0\u6d3b\u4fc3\u5206\u88c2\u5143\u6d3b\u5316\u86cb\u767d\u901a\u8def\uff0c\u4ece\u800c\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u7684\u5897\u6b96\u548c\u963b\u6b62\u7ec6\u80de\u6b7b\u4ea1\uff0c\u7531\u6b64\u53ef\u89c1 BRAF \u57fa\u56e0\u662f\u4e00\u4e2a\u4e0d\u826f\u9884\u540e\u57fa\u56e05<\/sup>\u3002<\/p>\n


<\/p>\n

\u8fd1\u51e0\u5e74\u9776\u5411\u6cbb\u7597\u5728\u665a\u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u7a81\u7834\u6027\u8fdb\u5c55\uff0c\u9488\u5bf9\u9776\u5411\u6cbb\u7597\u7814\u7a76\u8f83\u6210\u719f\u7684\u9776\u5411\u57fa\u56e0\u662f BRAF \u57fa\u56e0\uff0c2011 \u5e74\u548c 2013 \u5e74\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5206\u522b\u6279\u51c6\u7ef4\u7f57\u975e\u5c3c\u548c\u8fbe\u62c9\u83f2\u5c3c\u7528\u4e8e\u6cbb\u7597\u6076\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u5b83\u4eec\u5747\u662f BRAF \u57fa\u56e0\u7a81\u53d8\u7684\u4e24\u79cd\u6291\u5236\u5242\u53e3\uff0c\u663e\u8457\u63d0\u9ad8\u4e86\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002<\/p>\n

  <\/span><\/p>\n

\n
\n

\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u4e0e BCR-ABL \u57fa\u56e0<\/p>\n<\/section>\n<\/section>\n


<\/p>\n


<\/p>\n


<\/p>\n

\n
\n
\n
\n

Abl-1 \u57fa\u56e0\u5b9a\u4f4d\u4e8e 9q34.1\u3002Abl \u539f\u764c\u57fa\u56e0\u7f16\u7801\u4e00\u4e2a\u7ec6\u80de\u8d28\u548c\u6838\u86cb\u767d\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u5728\u7ec6\u80de\u5206\u5316\u3001\u5206\u88c2\u3001\u7ec6\u80de\u7c98\u9644\u548c\u5e94\u6fc0\u53cd\u5e94\u8fc7\u7a0b\u8d77\u91cd\u8981\u4f5c\u7528\u3002\u901a\u8fc7\u67d3\u8272\u4f53\u91cd\u6392\u6216\u75c5\u6bd2\u8f6c\u5316\u6539\u53d8abl-1\u5bfc\u81f4\u6076\u6027\u8f6c\u5316\u5982\u6162\u6027\u7c92\u7ec6\u80de\u6027\u767d\u8840\u75c5\u3002<\/span><\/p>\n


<\/p>\n

SH3\u7ed3\u6784\u57df\u8d1f\u6027\u8c03\u8282C-ABL\u86cb\u767d\u6d3b\u6027\uff0cSHB\u7ed3\u6784\u57df\u7684\u7f3a\u5931\u4f7f abl \u8f6c\u53d8\u4e3a\u764c\u57fa\u56e0\u3002\u57fa\u56e0\u8f6c\u4f4d\u5bfc\u81f4 bcr \u548c abl \u57fa\u56e0\u5934\u5c3e\u878d\u5408\u5f62\u6210\u878d\u5408\u57fa\u56e0 bcr\/abl\u3002\u5728\u6162\u6027\u7c92\u7ec6\u80de\u6027\u767d\u8840\u75c5\u4e2d\uff0cAbl \u57fa\u56e0\u88ab\u4ece 9 \u53f7\u67d3\u8272\u4f53\u8f6c\u4f4d\u81f3 22 \u53f7\u67d3\u8272\u4f53\u7684 bcr \u57fa\u56e0\u4e2d\u95f4\uff0c\u4ea7\u751f\u4e00\u4e2a\u5d4c\u5408 Bcr\uff0dAbl \u7684 mRNA\uff0c\u8868\u8fbe 210kDa \u7684\u86cb\u767d\u3002<\/span><\/p>\n


<\/p>\n

\u916a\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\u5bf9\u4e8eBcr\/Abl\u529f\u80fd\u6765\u8bf4\u662f\u5fc5\u9700\u7684\uff0c\u4f46\u764c\u57fa\u56e0\u8f6c\u5316\u7c92\u7ec6\u80de\u3001\u6dcb\u5df4\u7ec6\u80de\u7684\u673a\u5236\u8fd8\u4e0d\u6e05\u695a\u3002\u8fd9\u53ef\u80fd\u662f\u4e00\u4e2a\u6216\u591a\u4e2a\u6fc0\u9176\u5e95\u7269\u5b58\u5728\uff0c\u4f20\u9012Bcr\/Abl\u4fe1\u53f7\u5bfc\u81f4\u6162\u6027\u7c92\u7ec6\u80de\u6027\u767d\u8840\u75c5\u3002<\/span><\/p>\n


<\/p>\n

\u91cd\u8981\u7684\u5e95\u7269\u5305\u62ecBcr\/Abl\u672c\u8eab\u4ee5\u53ca\u7ec6\u80de\u9aa8\u67b6\u3001\u80de\u819c\u548c\u80de\u6d46\u4e2d\u5176\u4ed6\u9776\u86cb\u767d\u3002Bcr\/Abl\u6fc0\u6d3b\u7684\u67d0\u4e9b\u4fe1\u53f7\u9014\u5f84\u4e5f\u4e0e\u9020\u8840\u751f\u957f\u56e0\u5b50\u6d3b\u9014\u5f84\u76f8\u4f3c\u3002\u8bb8\u591a Bcr\/Abl\u7684\u5e95\u7269\u5728\u8f6c\u5316\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\uff0c\u5176\u4e2d\u5305\u62ecRAS\uff0cCCBL\uff0c PI3K ,CRKL,JAK\/STATs\u9014\u5f84\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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<\/p>\n

\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\uff08\u683c\u5217\u536b\uff09<\/strong><\/span>\u4e3a 2-\u82ef\u80fa\u5627\u5576\u884c\u751f\u7269\uff0c\u662f Abl \u7279\u5f02\u6027\u916a\u6c28\u9178\u6fc0\u9176\u7684\u6291\u5236\u5242\uff0c\u80fd\u7279\u5f02\u6027\u963b\u65ad ATP \u5728 Abl \u6fc0\u9176\u4e0a\u7684\u7ed3\u5408\u4f4d\u7f6e\uff0c\u4f7f\u916a\u6c28\u9178\u6b8b\u57fa\u4e0d\u80fd\u78f7\u9178\u5316\uff0c\u4ece\u800c\u6291\u5236 BCR\/ABL \u9633\u6027\u7ec6\u80de\u7684\u589e\u6b96\u3002<\/p>\n


<\/p>\n

\u4f0a\u9a6c\u66ff\u5c3c\u8fd8\u80fd\u6291\u5236\u53e6\u5916\u4e24\u79cd\u8def\u6c28\u9178\u6fc0\u9176 ckit \u548c PDGF-R\uff08\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff09 \u7684\u6d3b\u6027\u3002\u901a\u8fc7\u6291\u5236\u8def\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\u6291\u5236\u6162\u7c92\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u52a0\u901f\u6162\u7c92\u7ec6\u80de\u7684\u51cb\u4ea1\uff0c\u662f\u6cbb\u7597\u6162\u7c92\u7684\u9996\u9009\u836f\u7269\u3002<\/p>\n


<\/p>\n


<\/p>\n

\u7f16\u8f91\uff1adecie | \u8d23\u4efb\u7f16\u8f91\uff1a\u738b\u5f18<\/span><\/p>\n

\u6295\u7a3f\uff1adecie@qq.com<\/span>
<\/p>\n

\u9898\u56fe\uff1a\u7ad9\u9177\u6d77\u6d1bplus<\/span><\/span><\/p>\n


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<\/p>\n

\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n

\n

\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b0\u901a\u8def\uff01<\/a><\/p>\n

\u518d\u5582\u517b\u7efc\u5408\u5f81\uff1a<\/span><\/a>\u8425\u517b\u8865\u5145\u4e0d\u80fd\u64cd\u4e4b\u8fc7\u6025<\/a><\/span><\/p>\n<\/section>\n

\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u4e73\u817a\u764c\u6cbb\u7597\u53c8\u6709\u65b0\u65b9\u6848<\/a><\/p>\n

\u4e73\u817a\u764c 21 \u57fa\u56e0\u68c0\u6d4b\u7684\u90a3\u4e9b\u4e8b<\/a><\/p>\n


<\/span><\/p>\n

\"\u57fa\u56e0\u7a81\u53d8\u4e0e\u80bf\u7624\uff1a\u8bb2\u8ff0\u5b83\u4eec\u7684\u524d\u4e16\u4eca\u751f\"<\/p>\n

\"\u57fa\u56e0\u7a81\u53d8\u4e0e\u80bf\u7624\uff1a\u8bb2\u8ff0\u5b83\u4eec\u7684\u524d\u4e16\u4eca\u751f\"<\/p>\n


<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/span>
<\/p>\n

1. \u90b5\u5fd7\u654f\uff0c\u5f90\u5175\u6cb3\u7b49\uff0c\u4e2d\u56fd\u4e73\u817a\u764c\u60a3\u8005BRCA1\/2\u57fa\u56e0\u68c0\u6d4b\u4e0e\u4e34\u5e8a\u5e94\u7528\u4e13\u5bb6\u5171\u8bc6\uff082018\u5e74\u7248\uff09\uff0c\u300cJ\u300d\u4e2d\u56fd\u764c\u75c7\u6742\u5fd7\uff0c2018\u5e74\u7b2c28\u5377\u7b2c10\u671f\uff0c787-800.<\/span><\/p>\n

2. \u5f90\u745e\u534e\uff0c\u59dc\u6587\u5947\uff0c\u7ba1\u5fe0\u9707\u7b49\uff0c\u300cM\u300d\u4e34\u5e8a\u80bf\u7624\u5185\u79d1\u5b66\uff0c2014\u5e74\uff0c\u4eba\u6c11\u536b\u751f\u51fa\u7248\u793e.<\/span><\/p>\n

3. Feng, J, et al.\u300cJ\u300dMechanism of EGFR Over-expression and Mutations Leading to Biological Characteristics Changes of Human Lung Adenocarcinoma s through CXCR4\/CXCL12 Signaling Pathway. Zhongguo Fei Ai Za Zhi,2018, 21(7): 503-512.<\/span><\/p>\n

4. Yan, W. Y., et al. \u300cJ\u300d Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI\/MMR in the Chinese population.Onco Targets Ther ,2016,9: 7415-7424.<\/span><\/p>\n

5. Hugdahl, E., et al. \u300cJ\u300dBRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival.Br J Cancer ,2016,114(7): 801-808.<\/span><\/p>\n

6. Skorski, T. BCR\/ABL, \u300cJ\u300dDNA damage and DNA repair: implications for new treatment concepts.Leuk Lymphoma,2008, 49(4): 610-614.<\/span><\/p>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

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