{"id":99295,"date":"2019-05-12T00:00:50","date_gmt":"2019-05-17T08:20:41","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/99295\/"},"modified":"2019-05-17T16:20:42","modified_gmt":"2019-05-17T08:20:42","slug":"bcf26224c4","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/99295\/","title":{"rendered":"\u80bf\u7624\u5feb\u62a5 | \u6db2\u4f53\u6d3b\u68c0\u9884\u540e\u610f\u4e49\u88ab\u8bc1\u5b9e"},"content":{"rendered":"
\n

\"\u80bf\u7624\u5feb\u62a5
<\/p>\n

\u80bf\u7624\u65f6\u95f4\u8fd1\u671f\u5feb\u62a5\uff0c\u5e26\u7ed9\u4f60\u6700\u65b0\u7684\u8d44\u8baf\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
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\u963f\u7279\u73e0\u5355\u6297+\u8d1d\u4f10\u73e0\u5355\u6297\u51b2\u51fb\u80be\u764c\u4e00\u7ebf<\/span><\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u6700\u8fd1\u80be\u7ec6\u80de\u764c\u4e00\u7ebf\u6cbb\u7597\u68af\u961f\u5185\u53ef\u8c13\u785d\u70df\u56db\u8d77\u30025 \u6708 9 \u65e5\uff0cIMmotion151 \u7814\u7a76\u7ed3\u679c\u63ed\u6653\uff0c\u5728\u7ebf\u53d1\u8868\u5728 Lancet \u6742\u5fd7\u4e0a[1]<\/span><\/sup>\u3002<\/p>\n


<\/p>\n

\u7814\u7a76\u5bf9\u6bd4\u4e86\u963f\u7279\u73e0\u5355\u6297+\u8d1d\u4f10\u73e0\u5355\u6297\u548c\u8212\u5c3c\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u8fdb\u5c55\u671f\u80be\u7ec6\u80de\u764c\u7684\u7597\u6548\u3002\u5728 PD-L1 \u9633\u6027\u4eba\u7fa4\u4e2d\uff0c\u548c\u8212\u5c3c\u66ff\u5c3c\u76f8\u6bd4\uff0c\u53cc\u73e0\u7ec4\u5408\u5ef6\u957f PFS\uff0c\u6570\u636e\u652f\u6301\u5176\u7528\u4e8e\u7ecf\u9009\u62e9\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u4f46\u8fd8\u4e0d\u6e05\u695a\u8fd9\u4e00\u7ec4\u5408\u662f\u5426\u80fd\u5e26\u6765\u751f\u5b58\u83b7\u76ca\u3002<\/p>\n


<\/p>\n

\n

915 \u540d\u521d\u6cbb\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u60a3\u8005\u968f\u673a\uff081:1\uff09\u63a5\u53d7\u963f\u7279\u73e0\u5355\u6297 1200 mg+\u8d1d\u4f10\u73e0\u5355\u6297 15 mg\/kg Q3W\uff08n = 454\uff09\u6216\u8212\u5c3c\u66ff\u5c3c 50 mg Qd \u7528 4 \u5468\u505c 2 \u5468\uff08n = 461\uff09\u6cbb\u7597\u3002\u9996\u8981\u7814\u7a76\u7ec8\u70b9\u662f PD-L1 \u9633\u6027\u4eba\u7fa4\u7684 PFS \u548c ITT \u4eba\u7fa4\u7684 OS\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/p>\n

40% \u60a3\u8005\u4e3a PD-L1 \u9633\u6027\u3002PD-L1 \u9633\u6027\u4eba\u7fa4\u4e2d\uff0c\u4e2d\u4f4d PFS \u5206\u522b\u662f 11.2 \u6708 vs 7.7 \u6708\uff08HR 0.74\uff1bP = 0.0217\uff09\u3002ITT \u4eba\u7fa4\u4e2d\uff0c\u4e2d\u4f4d OS \u7684 HR 0.93\uff0c\u6ca1\u6709\u663e\u8457\u6027\u5dee\u5f02\u3002<\/span><\/p>\n

3-4 \u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387 40% vs 54%\u3002<\/span><\/p>\n<\/section>\n

\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n


<\/p>\n

\n
\n
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\u6db2\u4f53\u6d3b\u68c0\uff0c\u7ed3\u5c40\u5148\u89c9<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

5 \u6708 6 \u65e5\uff0cJCO \u520a\u767b\u6587\u7ae0\uff0c\u63a2\u7d22\u8180\u80f1\u5c3f\u8def\u4e0a\u76ae\u764c\u4e2d\uff0c\u8840\u6d46 cfDNA \u7684\u8d85\u6df1\u5ea6\u6d4b\u5e8f\u5728\u8f6c\u79fb\u590d\u53d1\u65e9\u671f\u53d1\u73b0\u548c\u7597\u6548\u76d1\u6d4b\u4e2d\u7684\u4f5c\u7528[2]<\/span><\/sup>\u3002\u7814\u7a76\u53d1\u73b0 ctDNA \u5bf9\u4e8e\u8bc4\u4f30\u8180\u80f1\u764c\u7684\u5371\u9669\u5206\u5c42\u3001\u7597\u6548\u76d1\u6d4b\u548c\u65e9\u671f\u53d1\u73b0\u8f6c\u79fb\u590d\u53d1\u5177\u6709\u6781\u9ad8\u7684\u4ef7\u503c\u3002<\/p>\n


<\/p>\n

\u540c\u6837\uff0cJAMA Oncol \u5728 5 \u6708 9 \u65e5\u520a\u767b\u8d85\u6df1\u5ea6\u6d4b\u5e8f\u68c0\u6d4b I\uff5eIII \u671f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u8840\u6d46 cfDNA \u7684\u7814\u7a76\u3002\u5bf9\u4e8e I\uff5eIII \u671f CRC \u60a3\u8005\uff0cctDNA \u540c\u6837\u53ef\u6709\u6548\u8fdb\u884c\u98ce\u9669\u5206\u5c42\uff0c\u5224\u65ad\u7597\u6548\u548c\u65e9\u671f\u53d1\u73b0\u75be\u75c5\u590d\u53d1[3]<\/span><\/sup>\u3002<\/p>\n


<\/p>\n

\u6db2\u4f53\u6d3b\u68c0\u6709\u671b\u6210\u4e3a\u53ca\u65e9\u5224\u65ad\u9884\u540e\u548c\u5236\u5b9a\u6cbb\u7597\u7b56\u7565\u7684\u6709\u529b\u6b66\u5668\u3002<\/p>\n


<\/p>\n

\u6ce8\uff1a\u6db2\u4f53\u6d3b\u68c0\u662f\u4e00\u79cd\u8840\u57fa\u6807\u5fd7\u7269\uff0c\u5b83\u7684\u539f\u7406\u662f\u6536\u96c6\u539f\u53d1\u7076\u6216\u8f6c\u79fb\u7076\u8131\u843d\u8fdb\u5165\u5916\u5468\u8840\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u901a\u8fc7\u7ec6\u80de\u8ba1\u6570\u3001DNA \u68c0\u6d4b\u7b49\u9884\u6d4b\u764c\u75c7\u7684\u8fdb\u5c55\u3002\u5b83\u4eec\u5e7f\u6cdb\u5305\u62ec\u5faa\u73af\u80bf\u7624\u7ec6\u80de\uff08circulating tumor cells, CTCs\uff09\u3001\u5faa\u73af\u80bf\u7624 DNA\uff08circulating tumor DNA, ctDNA\uff09\u3001\u5fae\u5c0f\u6838\u7cd6\u6838\u9178\uff08microRNA, miRNA\uff09\u3001\u5916\u6ccc\u4f53\uff08exosomes\uff09\u3001\u80bf\u7624\u8840\u5c0f\u677f\uff08tumor educated platelets, TEPs\uff09\u3002<\/span><\/span><\/p>\n


<\/p>\n

\n

\u4e3a\u660e\u786e cfDNA \u8d85\u6df1\u5ea6\u6d4b\u5e8f\u7684\u9884\u540e\u53ca\u9884\u6d4b\u4ef7\u503c\uff0c\u5165\u7ec4 68 \u540d\u5c40\u90e8\u8fdb\u5c55\u671f\u8180\u80f1\u764c\u60a3\u8005\uff0c\u5bf9 ctDNA \u4f7f\u7528\u8d85\u6df1\u5ea6\u5168\u5916\u663e\u5b50\u6d4b\u5e8f\u8bc4\u4f30\u60a3\u8005\u7279\u5f02\u6027\u8eaf\u4f53\u7a81\u53d8\uff0c\u5206\u522b\u5728\u8bca\u65ad\u65f6\u3001\u5316\u7597\u4e2d\u3001\u8180\u80f1\u5207\u9664\u672f\u524d\u548c\u968f\u8bbf\u4e2d\u7559\u53d6\u8840\u6d46\u6807\u672c\uff08n = 656\uff09\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/p>\n

\u5728\u8bca\u65ad\u65f6\u5316\u7597\u524d\uff0cctDNA \u7684\u5b58\u5728\u5177\u6709\u6781\u9ad8\u7684\u9884\u540e\u610f\u4e49\uff08HR 29.1\uff1bP = 0.001\uff09\u3002\u8180\u80f1\u5207\u9664\u672f\u540e\uff0cctDNA \u5206\u6790\u53ef\u4ee5\u51c6\u786e\u5730\u53d1\u73b0\u75be\u75c5\u76d1\u6d4b\u4e2d\u8f6c\u79fb\u6027\u590d\u53d1\u7684\u60a3\u8005\uff08\u654f\u611f\u6027 100%\uff0c\u7279\u5f02\u6027 98%\uff09\uff0c\u4e2d\u4f4d\u9886\u5148\u4e8e\u5f71\u50cf\u5b66 96 \u5929\u3002<\/span><\/p>\n

\u6b64\u5916\uff0c\u5bf9\u4e8e\u9ad8\u5371\u60a3\u8005\uff08\u6cbb\u7597\u524d\u6216\u6cbb\u7597\u4e2d ctDNA \u9633\u6027\uff09\uff0c\u5316\u7597\u4e2d ctDNA \u7684\u52a8\u6001\u53d8\u5316\u548c\u75be\u75c5\u590d\u53d1\u76f8\u5173\uff08P = 0.023\uff09\uff0c\u800c\u548c\u75c5\u7406\u964d\u671f\u4e0d\u76f8\u5173\u3002\u80bf\u7624\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\u8868\u660e\u7a81\u53d8\u8fc7\u7a0b\u548c\u75c5\u7406\u964d\u671f\u76f8\u5173\uff08P = 0.024\uff09\u3002\u7ed3\u679c\u8868\u660e ctDNA \u5206\u6790\u548c\u6cbb\u7597\u7597\u6548\u7684\u76f8\u5173\u6027\u4f18\u4e8e\u5176\u4ed6\u65b9\u6cd5\u3002<\/span><\/p>\n

125 \u540d I\uff5eIII \u671f CRC \u60a3\u8005\u4e8e\u672f\u524d\u3001\u672f\u540e 30 \u5929\u3001\u6bcf 3 \u4e2a\u6708\u5171 3 \u5e74\u6536\u96c6\u8840\u6d46\u6807\u672c\uff08n = 829\uff09\u68c0\u6d4b ctDNA\uff0c\u8bb0\u5f55\u4e34\u5e8a\u590d\u53d1\u548c RFS\u3002<\/span><\/p>\n

\u672f\u524d 84\/94 \u60a3\u8005\uff0889.4%\uff09\u53ef\u68c0\u6d4b\u5230 ctDNA\u3002\u6839\u6cbb\u6027\u6cbb\u7597\u540e\uff0cctDNA \u53ef\u53d1\u73b0 14\/16 \u540d\uff0887.5%\uff09\u590d\u53d1\u3002<\/span><\/p>\n

\u672f\u540e 30 \u5929\uff0cctDNA \u9633\u6027\u60a3\u8005\u590d\u53d1\u98ce\u9669\u6bd4\u9634\u6027\u60a3\u8005\u9ad8 7 \u500d\uff08HR 7.2\uff1bP\uff1c0.001\uff09\u3002\u8f85\u52a9\u5316\u7597\u540e ctDNA \u9633\u6027\u60a3\u8005\u590d\u53d1\u98ce\u9669\u6bd4\u9634\u6027\u60a3\u8005\u9ad8 17 \u500d\uff08HR 17.5,\uff1bP\uff1c0.001\uff09\u3002\u8f85\u52a9\u5316\u7597\u540e\u6240\u6709 7 \u540d\u9633\u6027\u60a3\u8005\u90fd\u590d\u53d1\u3002\u6839\u6cbb\u6027\u6cbb\u7597\u7ed3\u675f\u540e\u7684\u76d1\u6d4b\u9636\u6bb5\uff0cctDNA \u9633\u6027\u60a3\u8005\u590d\u53d1\u98ce\u9669\u6bd4\u9634\u6027\u60a3\u8005\u9ad8 40 \u500d\uff08HR 43.5\uff1bP\uff1c0.001\uff09\u3002ctDNA \u53ef\u9886\u5148\u4e8e\u5f71\u50cf\u5b66\u68c0\u67e5 16.5 \u4e2a\u6708\u53d1\u73b0\u75be\u75c5\u590d\u53d1\u3002<\/span><\/p>\n<\/section>\n

\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n


<\/p>\n

\n
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\u5be1\u8f6c\u79fb\u7076\u5c40\u90e8\u6cbb\u7597\u5ef6\u957f\u80ba\u764c\u751f\u5b58<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u4e4b\u524d\u7814\u7a76\u53d1\u73b0\u524d\u7ebf\u5168\u8eab\u6cbb\u7597\u540e\u672a\u8fdb\u5c55\u7684\u5be1\u8f6c\u79fb NSCLC \u60a3\u8005\u4e2d\uff0c\u653e\u7597\u6216\u624b\u672f\u7684\u5c40\u90e8\u5de9\u56fa\u6cbb\u7597\uff08LCT\uff09\u53ef\u4ee5\u6539\u5584 PFS\u30025 \u6708 8 \u65e5\uff0cJCO \u53c8\u62a5\u9053\u4e86\u957f\u671f OS \u7684\u968f\u8bbf\u7ed3\u679c[4]<\/span><\/sup>\u3002<\/p>\n


<\/p>\n

\u5ef6\u957f\u968f\u8bbf\u65f6\u95f4\u53d1\u73b0 PFS \u83b7\u76ca\u6301\u7eed\uff0cLCT \u7ec4\u8fd8\u5177\u6709 OS \u83b7\u76ca\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86 NSCLC \u5be1\u8f6c\u79fb\u75c5\u7076\u5c40\u90e8\u5904\u7406\u7684\u5fc5\u8981\u6027\u3002<\/p>\n


<\/p>\n

\n

\u8fd9\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u968f\u673a II \u671f\u7814\u7a76\uff0c\u7eb3\u5165\u5177\u6709 3 \u5904\u6216\u4ee5\u4e0b\u8f6c\u79fb\u7076\u3001\u524d\u7ebf\u5168\u8eab\u6cbb\u7597\u540e 3 \u4e2a\u6708\u4ee5\u4e0a\u672a\u51fa\u73b0\u8fdb\u5c55\u7684 IV \u671f NSCLC \u60a3\u8005\u3002\u60a3\u8005\u968f\u673a\uff081:1\uff09\u63a5\u53d7 LCT \u6cbb\u7597\u5168\u90e8\u6d3b\u8dc3\u75c5\u7076\u6216\u7ef4\u6301\u6cbb\u7597\/\u89c2\u5bdf\uff08MT\/O\uff09\u3002\u9996\u8981\u7814\u7a76\u7ec8\u70b9\u662f PFS\uff1b\u6b21\u8981\u7ec8\u70b9\u662f OS\uff0c\u6bd2\u6027\u548c\u65b0\u75c5\u7076\u51fa\u73b0\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/p>\n

49 \u540d\u60a3\u8005\u5165\u7ec4\u540e\u7531\u4e8e LCT \u7ec4 PFS \u663e\u8457\u83b7\u76ca\uff0c\u8bd5\u9a8c\u65e9\u671f\u5173\u95ed\u3002\u4e2d\u4f4d\u968f\u8bbf 38.8 \u4e2a\u6708\uff0cPFS \u83b7\u76ca\u6301\u7eed\uff08\u4e2d\u4f4d\uff0c14.2 \u6708 vs 4.4 \u6708\uff0cP = 0.022\uff09\u3002\u6b64\u5916\u53d1\u73b0 LCT \u7ec4 OS \u83b7\u76ca\uff08\u4e2d\u4f4d\uff0c41.2 \u6708 vs 17.0 \u6708\uff0cP = 0.017\uff09\u3002<\/span><\/p>\n

\u6ca1\u6709 3 \u7ea7\u4ee5\u4e0a\u6bd2\u6027\u53d1\u751f\u3002LCT \u7ec4\u7684\u8fdb\u5c55\u540e OS \u66f4\u957f\uff0837.6 \u6708 vs 9.4 \u6708\uff0cP = 0.034\uff09\u3002MT\/O \u7ec4\u7684 20 \u540d\u60a3\u8005\u8fdb\u5c55\u540e\uff0c9 \u540d\u5168\u90e8\u75c5\u7076\u63a5\u53d7 LCT\uff0c\u4e2d\u4f4d OS \u662f 17 \u4e2a\u6708\u3002<\/span><\/p>\n<\/section>\n

\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n


<\/p>\n

\n
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\u963f\u6614\u66ff\u5c3c+K \u836f\u6cbb\u7597\u8089\u7624<\/span><\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

VEGF \u4fc3\u8fdb\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\uff0c\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\uff0c\u56e0\u6b64\u6297 VEGF \u8054\u5408\u514d\u75ab\u6cbb\u7597\u662f\u4e00\u79cd\u6709\u6548\u7684\u6cbb\u7597\u7ec4\u5408\u3002Lancet Oncol \u53d1\u8868\u4e00\u9879 2 \u671f\u7814\u7a76\uff0c\u63a2\u7d22\u963f\u6614\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u8fdb\u5c55\u671f\u8089\u7624\u7684\u6d3b\u6027[5]<\/span><\/sup>\u3002<\/p>\n


<\/p>\n

\u8fd9\u4e00\u7ec4\u5408\u6bd2\u6027\u53ef\u63a7\uff0c\u5728\u8089\u7624\u60a3\u8005\u3001\u7279\u522b\u662f\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\uff08ASPS\uff09\u60a3\u8005\u4e2d 3 \u4e2a\u6708\u7684 PFS \u7387\u8fbe\u5230 65.6%\uff0c\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u503c\u5f97\u884c\u8fdb\u4e00\u6b65\u7684\u968f\u673a\u5bf9\u7167\u7814\u7a76\u3002<\/p>\n


<\/p>\n

\n

\u7eb3\u5165\u81f3\u5c11\u4e00\u7ebf\u5168\u8eab\u6cbb\u7597\u5931\u8d25\u7684\u8089\u7624\u60a3\u8005\u3002\u524d 5 \u540d\u60a3\u8005\u5165\u7ec4\u5148\u5bfc\u961f\u5217\uff0c\u63a5\u53d7\u963f\u6614\u66ff\u5c3c 5 mg Bid+\u5e15\u535a\u5229\u73e0\u5355\u6297 200 mg d8 Q3W \u6cbb\u7597\u76f4\u81f3 2 \u5e74\u3002\u4e4b\u540e\u7684\u60a3\u8005\u63a5\u53d7\u963f\u6614\u66ff\u5c3c\u9012\u589e\u5242\u91cf 2-10 mg+\u56fa\u5b9a\u5242\u91cf\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002\u9996\u8981\u7ec8\u70b9\u662f 3 \u6708 PFS\u3002<\/span><\/p>\n

33 \u540d\u60a3\u8005\u63a5\u53d7\u6cbb\u7597\uff0c12 \u540d\uff0836%\uff09\u4e3a ASPS\u3002\u4e2d\u4f4d\u968f\u8bbf 14.7 \u4e2a\u6708\uff0c3 \u6708 PFS \u7387\u4e3a 65.6%\u3002ASPS \u60a3\u8005\uff0c3 \u6708 PFS \u7387\u662f 72.7%\u3002<\/span><\/p>\n


<\/p>\n

\u6700\u5e38\u89c1 3-4 \u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u9ad8\u8840\u538b\uff0815%\uff09\uff0c\u81ea\u8eab\u514d\u75ab\u6bd2\u6027\uff0815%\uff09\uff0c\u6076\u5fc3\u5455\u5410\uff086%\uff09\u548c\u766b\u75eb\uff086%\uff09\u3002\u4e25\u91cd\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387 21%\u3002\u6ca1\u6709\u6cbb\u7597\u76f8\u5173\u6b7b\u4ea1\u3002<\/span><\/p>\n<\/section>\n

\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n


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\u5371\uff1f\u673a\uff1f2018-2040 \u5168\u7403\u5316\u7597\u53ca\u533b\u5e08\u9700\u6c42 <\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u4ece 2018 \u5e74\u5230 2040 \u5e74\uff0c\u764c\u75c7\u53d1\u751f\u7387\u9884\u8ba1\u5c06\u4ece 1700 \u4e07\u4e0a\u5347\u5230 2600 \u4e07\uff0c\u5f88\u5927\u4e00\u90e8\u5206\u60a3\u8005\u5c06\u4ece\u5316\u7597\u4e2d\u83b7\u76ca\u3002Lancet Oncol \u53d1\u8868\u6587\u7ae0\uff0c\u91cf\u5316\u8bc4\u4f30\u4e86\u5168\u7403\u5316\u7597\u548c\u5bf9\u80bf\u7624\u79d1\u533b\u5e08\u52b3\u529b\u7684\u9700\u6c42[6]<\/span><\/sup>\u3002<\/p>\n


<\/p>\n

\u9884\u8ba1\u4ece 2018 \u5e74\u5230 2040 \u5e74\uff0c\u9700\u8981\u7b2c\u4e00\u7a0b\u5316\u7597\u7684\u60a3\u8005\u6570\u91cf\u6bcf\u5e74\u4ece 980 \u4e07\u589e\u957f\u5230 1500 \u4e07\uff0c\u76f8\u5bf9\u589e\u957f 53%\uff1b2018 \u5e74\uff0c\u5168\u7403\u9700\u8981 6.5 \u4e07\u540d\u80bf\u7624\u533b\u5e08\uff0c2040 \u5e74\u63a8\u6d4b\u9700\u6c42\u91cf\u589e\u957f\u5230 10 \u4e07\u3002<\/p>\n


<\/p>\n

\u56e0\u6b64\uff0c\u547c\u5401\u66f4\u591a\u7b56\u7565\u6027\u6295\u5165\u7528\u4e8e\u5316\u7597\u4f9b\u7ed9\u548c\u80bf\u7624\u533b\u5e08\u4ee5\u6ee1\u8db3\u672a\u6765\u5bf9\u4e8e\u5316\u7597\u7684\u589e\u957f\u9700\u6c42\u3002<\/p>\n


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\n

\u4ece GLOBOCAN 2018 \u4e2d\u83b7\u5f97 2018 \u5e74\u73b0\u6709\u548c 2040 \u5e74\u9884\u8ba1\u7684 183 \u4e2a\u56fd\u5bb6 29 \u79cd\u7c7b\u578b\u764c\u75c7\u7684\u6570\u636e\u3002\u7ed9\u8fd9\u4e9b\u53d1\u751f\u7387\u6570\u636e\u914d\u4e88\u5faa\u8bc1\u6307\u5357\u7684\u6700\u4f73\u5316\u7597\uff0c\u751f\u6210 2018 \u5e74\u548c 2040 \u5e74\u9700\u8981\u7b2c\u4e00\u7a0b\u5316\u7597\u7684\u65b0\u60a3\u8005\u6570\u5b57\u3002\u4e4b\u540e\u63a8\u6d4b\u5b8c\u6210\u8fd9\u4e9b\u5316\u7597\u9700\u8981\u7684\u76f8\u5e94\u7684\u80bf\u7624\u533b\u5e08\uff08\u6839\u636e\u533b\u5e08\u6bcf\u5e74\u770b\u62a4 150 \u4e2a\u9700\u8981\u5316\u7597\u7684\u65b0\u60a3\u8005\uff09\u3002<\/span><\/span><\/span><\/p>\n


<\/p>\n

\u4ece 2018 \u5e74\u5230 2040 \u5e74\uff0c\u9700\u8981\u7b2c\u4e00\u7a0b\u5316\u7597\u7684\u60a3\u8005\u6570\u91cf\u6bcf\u5e74\u4ece 980 \u4e07\u589e\u957f\u5230 1500 \u4e07\uff0c\u76f8\u5bf9\u589e\u957f 53%\u3002\u63a8\u6d4b 2018 \u5e74\u4e2d\u4f4e\u6536\u5165\u56fd\u5bb6\u9700\u8981\u5316\u7597\u7684\u60a3\u8005\u6bd4\u4f8b 63%\uff0c2040 \u5e74\u4e3a 67%\u30022040 \u5e74\u4e16\u754c\u8303\u56f4\u5185\u6700\u9700\u8981\u5316\u7597\u7684\u6307\u5f81\u662f\u80ba\u764c\uff0816.4%\uff09\uff0c\u4e73\u817a\u764c\uff0812.7%\uff09\u548c\u7ed3\u76f4\u80a0\u764c\uff0811.1%\uff09\u3002<\/span><\/p>\n


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\u63a8\u6d4b 2018 \u5e74\uff0c\u5168\u7403\u9700\u8981 6.5 \u4e07\u540d\u80bf\u7624\u533b\u5e08\uff0c2040 \u5e74\u63a8\u6d4b\u589e\u957f\u5230 10 \u4e07\u3002<\/span><\/p>\n<\/section>\n

\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n


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\u7f16\u8f91\uff1adecie | \u8d23\u4efb\u7f16\u8f91\uff1a\u738b\u5f18<\/span><\/p>\n

\u6295\u7a3f\uff1adecie@qq.com
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\u9898\u56fe\uff1a\u7ad9\u9177\u6d77\u6d1bplus<\/span><\/span><\/p>\n


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\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b0\u901a\u8def\uff01<\/a><\/p>\n

\u518d\u5582\u517b\u7efc\u5408\u5f81\uff1a<\/span><\/a>\u8425\u517b\u8865\u5145\u4e0d\u80fd\u64cd\u4e4b\u8fc7\u6025<\/a><\/span><\/p>\n

\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u4e73\u817a\u764c\u6cbb\u7597\u53c8\u6709\u65b0\u65b9\u6848<\/a><\/p>\n

\u4e73\u817a\u764c 21 \u57fa\u56e0\u68c0\u6d4b\u7684\u90a3\u4e9b\u4e8b<\/a><\/p>\n


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\"\u80bf\u7624\u5feb\u62a5<\/p>\n

\u53c2\u8003\u6587\u732e<\/span><\/p>\n

1. Rini BI et al. Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial. Lancet 2019 May 9<\/span><\/p>\n

2. Christensen E et al. Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma -Free DNA in Patients With Urothelial Bladder Carcinoma. J Clin Oncol 2019 May 6<\/span><\/p>\n

3. Reinert T et al. Analysis of Plasma -Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer. JAMA Oncol 2019 May 9<\/span><\/p>\n

4. Gomez DR et al. Local Consolidative Therapy Vs. Maintenance Therapy or Observation for Patients With Oligometastatic Non\u2013Small- Lung Cancer: Long-Term Results of a Multi-Institutional, Phase II, Randomized Study. J Clin Oncol 2019 May 8<\/span><\/p>\n

5. Wilky BA et al. Axitinib plus pembrolizumab in patients with advanced sarcomas including alveolar soft-part sarcoma: a single-centre, single-arm, phase 2 trial. Lancet Oncol 2019 May 8<\/span><\/p>\n

6. Wilson BE et al. Estimates of global chemotherapy demands and corresponding physician workforce requirements for 2018 and 2040: a population-based study. Lancet Oncol 2019 May 8<\/span><\/p>\n


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